From: Prevalence of cognitive impairment in patients with rheumatoid arthritis: a cross sectional study
 | Total | Cognitively Impaired (MoCA ≤27/30) | Non-impaired (MoCA > 27/30) | P value†|
---|---|---|---|---|
N | 661 | 458 | 176 | Â |
Age (years) | 67.6 (8.1) [55, 89] | 68.8 (8.4) [55, 89] | 64.7 (6.5) [55, 85] | <.001 |
Sex | Â | Â | Â | .158 |
 Male | 217 (32.8) | 157 (34.3) | 50 (28.4) |  |
 Female | 444 (67.2) | 301 (65.7) | 126 (71.6) |  |
Educational attainment | Â | Â | Â | <.001 |
  ≤ 12 years | 386 (58.4) | 306 (66.8) | 80 (46.2) |  |
  > 12 years | 245 (37.1) | 152 (33.2) | 93 (53.8) |  |
 Missing | 30 (4.5) | – | – |  |
ESR (mm/hr) (n = 532) | 22.6 (21.1) [1, 137] | 23.7 (21.4) [1, 137] | 17.1 (16.9) [1, 105] | .002 |
DAS28-ESRscore (n = 337) | 3.5 (1.5) [0.63, 7.85] | 3.6 (1.5) [0.63, 7.85] | 3.1 (1.3) [1.21, 6.74] | .007 |
Disease duration (years) (n = 556) | 12.6 (12.9) [0, 73] | 12.8 (13.2) [0, 73] | 12.2 (12.0) [0, 60] | .618 |
Disease activity | Â | Â | Â | .079 |
 Remission (DAS28 ≤ 2.6) | 92 (13.9) | 61 (13.3) | 31 (17.6) |  |
 Low (2.6 < DAS ≤ 3.2) | 60 (9.1) | 38 (8.3) | 21 (11.9) |  |
 Moderate (3.2 < DAS ≤ 5.1) | 135 (20.4) | 101 (21.1) | 31 (17.6) |  |
 High (DAS > 5.1) | 50 (7.6) | 40 (8.7) | 9 (5.1) |  |
 Missing | 324 (49.0) | 218 (47.6) | 84 (47.7) |  |
Anti-CCP | Â | Â | Â | .505 |
 Positive | 267 (40.4) | 201 (43.9) | 56 (31.8) |  |
 Negative | 156 (23.6) | 113 (24.7) | 37 (21.0) |  |
 Missing | 238 (36.0) | 144 (31.4) | 83 (47.2) |  |
RF | Â | Â | Â | .141 |
 Positive | 300 (45.4) | 223 (48.7) | 68 (38.6) |  |
 Negative | 137 (20.7) | 93 (20.3) | 40 (22.7) |  |
 Missing | 224 (33.9) | 142 (31.0) | 68 (38.6) |  |
RA Medication | Â | Â | Â | .731 |
 csDMARD + TNFi | 125 (18.9) | 97 (21.2) | 26 (14.8) |  |
 csDMARD only | 393 (59.5) | 293 (64.0) | 86 (48.9) |  |
 TNFi only | 74 (11.2) | 54 (11.8) | 19 (10.8) |  |
 Missing | 69 (10.4) | 14 (3.1) | 45 (25.6) |  |
Taking prednisolone | Â | Â | Â | .743 |
 Yes | 37 (5.6) | 27 (5.9) | 9 (5.1) |  |
 No | 555 (84.0) | 417 (91.0) | 122 (69.3) |  |
 Missing | 69 (10.4) | 14 (3.1) | 45 (25.6) |  |
Taking NSAID | Â | Â | Â | .149 |
 Yes | 80 (12.1) | 56 (12.2) | 23 (13.1) |  |
 No | 512 (77.5) | 388 (84.7) | 108 (61.4) |  |
 Missing | 69 (10.4) | 14 (3.1) | 45 (25.6) |  |