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Table 4 Stratified analyses of the rs10932201, rs2253206, and rs162209 polymorphisms in depression patients

From: Correlation between variants of the CREB1 and GRM7 genes and risk of depression

Variables

Frequency

 

Adjusted OR (95% CI)

Adjusted P value

%

%

  

rs10932201

Depressive episode

Severe

Mild

  

 AA

102 (40.5)

76 (33.3)

1.00 (Ref)

 

 GA

124 (49.2)

128 (56.1)

1.38 (0.93–2.05)

0.10

 GG

26 (10.3)

24 (10.5)

1.32 (0.69–2.53)

0.40

 GA/GG

150 (59.5)

152 (66.7)

1.37 (0.94–2.00)

0.10

Suicide attempt

Yes

No

  

 AA

115 (39.4)

63 (33.5)

1.00 (Ref)

 

 GA

142 (48.6)

110 (58.5)

1.44 (0.95–2.18)

0.09

 GG

35 (12)

15 (8)

0.81 (0.39–1.68)

0.56

 GA/GG

177 (60.6)

125 (66.5)

1.32 (0.88–1.97)

0.18

First episode

Yes

No

  

 AA

97 (39.1)

81 (34.9)

1.00 (Ref)

 

 GA

127 (51.2)

125 (53.9)

1.17 (0.79–1.73)

0.43

 GG

24 (9.7)

26 (11.2)

1.45 (0.75–2.81)

0.27

 GA/GG

151 (60.9)

151 (65.1)

1.20 (0.82–1.76)

0.34

rs2253206

Depressive episode

Severe

Mild

  

 GG

107 (42.5)

94 (41.4)

1.00 (Ref)

 

 GA

118 (46.8)

103 (45.4)

1.01 (0.68–1.50)

0.96

 AA

27 (10.7)

30 (13.2)

1.24 (0.68–2.26)

0.49

 GA/AA

145 (57.5)

133 (58.6)

1.05 (0.73–1.53)

0.78

Suicide attempt

Yes

No

  

 GG

120 (41.2)

81 (43.1)

1.00 (Ref)

 

 GA

140 (48.1)

81 (43.1)

0.87 (0.57–1.32)

0.51

 AA

31 (10.7)

26 (13.8)

1.26 (0.67–2.38)

0.48

 GA/AA

171 (58.8)

107 (56.9)

0.93 (0.63–1.38)

0.73

First episode

Yes

No

  

 GG

107 (43.1)

94 (40.7)

1.00 (Ref)

 

 GA

112 (45.2)

109 (47.2)

1.17 (0.79–1.74)

0.43

 AA

29 (11.7)

28 (12.1)

1.06 (0.58–1.93)

0.86

 GA/AA

140 (56.9)

136 (59.3)

1.14 (0.79–1.66)

0.48

rs162209

Depressive episode

Severe

Mild

  

 AA

163 (64.7)

158 (69.3)

1.00 (Ref)

 

 GA/GG

89 (35.3)

70 (30.7)

0.83 (0.56–1.22)

0.34

 Suicide attempt

Yes

No

  

 AA

191 (65.4)

130 (69.2)

1.00 (Ref)

 

 GA/GG

101 (34.6)

58 (30.9)

0.87 (0.58–1.32)

0.52

First episode

Yes

No

  

 AA

162 (65.3)

159 (68.5)

1.00 (Ref)

 

 GA/GG

86 (34.7)

73 (31.5)

0.90 (0.61–1.32)

0.58

  1. OR and P value were adjusted by age and gender