Epigenetic clock analysis of blood samples in drug-naive first-episode schizophrenia patients

BMC Psychiatry

Table 2 No correlations of epigenetic aging acceleration estimated by three clocks with the cognitive function in drug-naive first-episode SCZ and healthy controls

Cognition Valuable	Horvath’s AgeAccel		Hannum’s AgeAccel		Levine’s PhenoAgeAccel
Cognition Valuable	β	P value	β	P value	β	P value
DST-F	0.06	0.58	0.06	0.60	− 0.06	0.62
DST-B	0.20	0.09	−0.02	0.90	0.01	0.92
VFT	−0.04	0.74	−0.01	0.94	0.05	0.69
Stroop-W	0.06	0.64	0.04	0.72	0.11	0.35
Stroop-C	−0.06	0.60	0.02	0.88	0.07	0.57
Stroop-I	−0.02	0.88	0.03	0.81	0.17	0.18
TMT-A	−0.08	0.52	−0.17	0.17	0.00	0.98
TMT-B	−0.05	0.68	−0.04	0.74	−0.01	0.91
WCST-C	−0.20	0.11	−0.18	0.14	−0.14	0.24
WCST-PE	0.17	0.16	0.02	0.87	0.10	0.41

DST-F Digit Span Tests Forward, DST-B Digit Span Tests Backward, VFT Verbal Fluency Test, TMT-A Trail Making Test-Part A, TMT-B Trail Making Test-Part B, Stroop-W Stroop Tests Words, Stroop-C Stroop Tests Colors, Stroop-I Stroop Tests Interference, WCST-C Wisconsin Card Sorting Test categories, WCST-P Wisconsin Card Sorting Test perseverative errors. Multiple linear regression analyses were conducted to assess the relationship between epigenetic age acceleration and cognitive function in 38 SCZ patients and 38 controls at baseline adjusting for age, sex and tobacco use

ISSN: 1471-244X