Fig. 2

Group-by-time interaction on ALFF among SZ, GHR and HC at baseline and follow-up. A Significant group-by-time interaction effect of ALFF values in left MOF (peak at x, y, z = -18, 48, -12; F = 8.27; cluster size = 172). Significance level was set as p < 0.05 at voxel level with GRF for multiple comparisons. B ALFF values in left MOF of SZ, GHR and HC at baseline and follow-up. The solid lines indicate the mean value. Significance level was set as p < 0.05. In SZ, ALFF in left MOF did not significantly change from baseline to follow-up (P > 0.05). In GHR, ALFF in left MOF significantly decreased from baseline to follow-up, while ALFF in left MOF significantly increased in HC. HC, Healthy control; SZ, Schizophrenia; GHR, Genetic high risk; MOF, medial orbital frontal cortex; GRF, Gaussian random field correction. *, p < 0.05