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Table 2 The changes of depression-related scale scores in each group

From: Effects of chronotype on antidepressant treatment and symptoms in patients with depression: a multicenter, parallel, controlled study

Items

Group

Case

Access Point

F value and p value

0wk

2wk

4wk

8wk

12wk

 

MEQ

late-type group

23

37.96 ± 2.87

42.39 ± 6.60

50.70 ± 7.24

52.96 ± 7.80

55.00 ± 8.20

FT=13.888, P<0.001

FI=9.669, P<0.001

FT*I=43.828, P<0.001

middle-type group

87

50.02 ± 4.51

52.11 ± 6.24

52.99 ± 8.09

53.55 ± 9.15

53.60 ± 10.05

early-type group

44

64.91 ± 3.85

60.43 ± 6.49

60.93 ± 8.96

60.89 ± 9.55

60.86 ± 9.42

HAMD-17

late-type group

23

21.61 ± 8.16

13.57 ± 10.30

7.35 ± 7.91

4.83 ± 4.93

2.52 ± 2.75

FT=479.759, P<0.001

FI=0.619, P = 0.706

FT*I=0.352, P = 0.407

middle-type group

87

23.02 ± 5.66

14.01 ± 7.33

7.72 ± 6.17

5.43 ± 5.84

4.09 ± 4.15

early-type group

44

22.07 ± 3.92

13.41 ± 4.53

8.05 ± 3.61

5.89 ± 2.66

4.27 ± 2.68

HAMA

late-type group

23

19.61 ± 9.44

12.26 ± 9.41

6.83 ± 7.80

4.52 ± 5.15

2.35 ± 2.39

FT=319.528, P<0.001

FI=0.156, P = 0.996

FT*I=0.640, P = 0.529

middle-type group

87

21.16 ± 9.36

13.56 ± 8.84

8.11 ± 7.51

5.36 ± 5.01

4.07 ± 4.68

early-type group

44

21.30 ± 5.09

13.07 ± 4.51

8.64 ± 4.08

5.48 ± 2.54

3.95 ± 3.50

PQSI

late-type group

23

14.91 ± 2.21

10.70 ± 3.04

8.04 ± 3.48

6.65 ± 3.24

4.83 ± 2.76

FT=141.134, P<0.001

FI=2.858, P = 0.004

FT*I=8.916, P<0.001

middle-type group

87

14.23 ± 3.54

9.77 ± 4.38

6.37 ± 4.22

5.76 ± 3.99

4.52 ± 3.37

early-type group

44

14.55 ± 3.58

12.07 ± 4.44

9.68 ± 3.63

8.30 ± 3.32

7.70 ± 3.14

SHAPS

late-type group

23

44.87 ± 4.35

44.09 ± 4.11

44.22 ± 3.36

44.30 ± 3.75

41.43 ± 4.27

FT=3.629, P = 0.007

FI=2.193, P = 0.028

FT*I=2.898, P = 0.058

middle-type group

87

46.64 ± 6.92

46.55 ± 6.63

45.93 ± 6.25

44.62 ± 5.71

40.17 ± 5.79

early-type group

44

43.57 ± 2.19

43.25 ± 2.88

43.20 ± 2.74

43.57 ± 3.69

43.32 ± 3.97

MFI-20

late-type group

23

81.82 ± 8.41

65.61 ± 15.05

54.61 ± 13.58

50.91 ± 10.87

46.61 ± 10.82

FT=94.316, P<0.001

FI=1.982, P = 0.048

FT*I=16.579, P<0.001

middle-type group

87

75.47 ± 12.50

56.82 ± 16.05

47.84 ± 16.85

42.63 ± 14.55

40.52 ± 16.37

early-type group

44

85.34 ± 10.13

74.02 ± 15.77

57.52 ± 12.58

51.36 ± 13.90

46.02 ± 12.12

  1. FT: Test of significance of difference in different time points
  2. FI: Significance test of the difference among the three groups
  3. FT*I: Test of interaction significance between different scales and different types of time