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Table 1 Demographic and clinical features at baseline

From: Early antidepressant treatment response prediction in major depression using clinical and TPH2 DNA methylation features based on machine learning approaches

Variables

Responders

(N = 180)

Non-responders

(N = 111)

Total

P value

Gender, male (n (%))

53 (29.4)

49 (44.1)

102 (35.1)

0.011

Age (mean (SD))

46.94 (13.19)

45.63 (14.25)

46.40 (13.65)

0.335

NLES (median [IQR])

16.00 [5.75, 32.00]

12.00 [3.00, 37.00]

13.00 [4.00, 32.00]

0.558

CTQ (mean (SD))

47.58 (9.11)

48.50 (8.56)

47.93 (8.90)

0.399

Family history, yes (n (%))

33 (18.4)

19 (17.1)

52 (17.9)

0.776

Years of education (mean (SD))

10.80 (3.68)

10.51 (4.34)

10.69 (3.94)

0.537

Marital status, yes (n (%))

150 (84.7)

85 (79.4)

235 (80.8)

0.325

First occurrence or not, yes (n (%))

88 (48.9)

48 (43.2)

136 (46.7)

0.414

Age of onset (mean (SD))

42.09 (13.25)

39.84 (14.54)

41.24 (13.77)

0.185

Illness duration (median [IQR])

24.00 [6.00, 72.00]

24.00 [11.50, 84.00]

24.00 [6.00, 72.00]

0.268

Number of occurrences (mean (SD))

1.89 (1.29)

2.24 (1.68)

2.02 (1.46)

0.046

Baseline HAMD-17 (mean (SD))

22.55 (3.86)

23.59 (4.06)

22.95 (3.97)

0.030