Study protocol for a randomized controlled trial investigating the effect of online interpretation bias intervention on stress reactivity in the children of parents with depression: the CoCo study

Table 1 Overview of screening and outcome measures

Purpose	Construct	Instrument / Response Indices	Session
Inclusion criteria	Parental diagnosis or no diagnosis	DIPS interview	T0
Inclusion criteria	Child no diagnosis	K-DIPS interview (parent + child report)	T0
Outcome measures	Interpretation bias	SST (computer task)	T1, T2
	Physiological stress reactivity	Cortisol delta (via cortisol swabs at pre, 10 min post, 20 min post and 30 min post stressor)	T1, T2
	Physiological stress recovery	Cortisol levels at 45 min post stressor	T1, T2
	Subjective stress	SAM (self-reported change in current mood measured at pre, 10 min post, 20 min post, 30 min post and 45 min post stressor)	T1, T2
Confounding variables	Pubertal status	Tanner self-report and saliva sample	T1
	Depressive symptoms	R-CADS (self-report)	T1
	Anxiety symptoms	R-CADS (self-report)	T1
	Childhood trauma	CTQ (self-report)	T1

CTQ Childhood Trauma Questionnaire [77], DIPS Diagnostic Interview for Mental Disorders [78], K-DIPS Diagnostic Interview for Mental Disorders in Children and Adolescents [79], R-CADS Children’s Anxiety and Depression Scale [80], SST Scrambled Sentences Task [30], SAM Self-Assessment Manikin Scale [81]

ISSN: 1471-244X