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Table 3 Multivariate analysis of covariance of NR3C1 methylation levels between cases and control group

From: Association between academic pressure, NR3C1 gene methylation, and anxiety symptoms among Chinese adolescents: a nested case-control study

CpG unit#

Group

Model 1

(Statistics: Wilks λ = 0.949, F (2, 130) = 3.498, P = 0.033)

Model 2

(Statistics: Wilks λ = 0.960, F (2, 128) = 2.690, P = 0.072)

F

P *

\( {{\varvec{\eta }}_{\varvec{p}}}^{2}\)

F

P *

\( {{\varvec{\eta }}_{\varvec{p}}}^{2}\)

NR3C1-16 CpG 9

1.208

0.274

0.009

1.091

0.298

0.008

NR3C1-16 CpG 10

6.188

0.014

0.045

4.512

0.036

0.034

  1. #: Only the NR3C1 CpG units observed with a significant association of anxiety symptoms in the unadjusted model were reported here
  2. Model 1: MANCOVA demonstrated significant between-group difference after controlling for age, sex, BMI, cortisol, living arrangement, classmate relations, and teacher-classmate relations
  3. Model 2: MANCOVA demonstrated significant between-group difference after controlling for age, sex, BMI, cortisol, living arrangement, classmate relations, teacher-classmate relations, and academic pressure
  4. *: Statistical significance was set at P < 0.025 after Bonferroni correction for 2 CpG sites
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BMC Psychiatry

ISSN: 1471-244X

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