Table 1 Differential metabolites screened from the N-MA and control groups

1

Adenosine

0.027

29.103

0.256

↓

2

Psilocybin

0.013

16.409

0.557

↓

3

PE(0:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))

0.017

15.318

2.575

↑

4

LysoPC(0:0/16:0)

0.038

14.020

1.708

↑

5

1-Pentanesulfenothioic acid

0.007

11.427

1.444

↑

6

PC(18:1(11Z)/0:0)

0.030

11.171

1.903

↑

7

Adenosine 3’-monophosphate

0.005

11.133

0.308

↓

8

Oxidized glutathione

0.009

10.776

0.515

↓

9

PS(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)

0.001

10.690

2.711

↑

10

Mahaleboside

0.032

10.226

0.619

↓

11

LysoPE(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)

0.017

9.542

2.969

↑

12

Pyrrolidonecarboxylic acid

0.012

9.494

0.807

↓

13

LysoPC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)

0.015

8.706

3.258

↑

14

Prostaglandin E2 p-benzamidophenyl ester

0.001

8.629

2.017

↑

15

Adenosine monophosphate

0.005

8.497

0.285

↓

16

LysoPC(20:4(8Z,11Z,14Z,17Z)/0:0)

0.018

8.454

2.647

↑

17

Choline

0.024

8.366

1.230

↑

18

LysoPE(0:0/20:4(8Z,11Z,14Z,17Z))

0.037

8.329

2.085

↑

19

Guanidylic acid (guanosine monophosphate)

0.010

8.045

0.341

↓

20

Guanosine 3’-monophosphate

0.008

8.034

0.326

↓

21

Hypoxanthine

0.038

7.531

1.260

↑

22

Citric acid

0.022

7.061

1.262

↑

23

p-hydroxyfosinoprilat

0.000

6.772

2.858

↑

24

Pyridine N-oxide glucuronide

0.008

6.549

2.377

↑

25

Isocitrate

0.029

5.888

1.214

↑

26

Calcimycin

0.003

5.743

2.159

↑

27

PI(20:4(5Z,8Z,11Z,14Z)/0:0)

0.001

5.657

2.036

↑

28

 L-Carnitine

0.024

5.438

0.791

↓

29

LysoPE(20:4(5Z,8Z,11Z,14Z)/0:0)

0.026

5.226

2.469

↑

30

PE(18:1(9Z)/0:0)

0.040

5.176

1.601

↑

31

Uridine diphosphate-N-acetylglucosamine

0.002

4.957

0.619

↓

32

LysoPE(18:0/0:0)

0.047

4.775

1.560

↑

33

Adenylsuccinic acid

0.006

4.678

0.162

↓

34

PC(18:1(9Z)/0:0)

0.041

4.646

1.979

↑

35

Benthiavalicarb isopropyl

0.015

4.526

0.237

↓

36

D-Gluconic acid Mn(II) salt

0.003

4.419

0.321

↓

37

FAPy-adenine

0.033

4.407

0.273

↓

38

 L-Acetylcarnitine

0.018

4.380

0.645

↓

39

Dehydroepiandrosterone (DHEA)

0.036

4.126

2.597

↑

40

N2,N2-Dimethylguanosine

0.041

4.095

0.183

↓

41

(R)-(+)-2-Pyrrolidone-5-carboxylic acid

0.010

4.061

1.510

↑

42

PC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)

0.017

4.034

3.717

↑

43

Glucose-uridine-C1,5’-diphosphate

0.032

4.014

0.569

↓

44

PC(20:4(5Z,8Z,11Z,14Z)/0:0)

0.019

3.934

2.890

↑

45

Glycolic acid

0.020

3.474

1.766

↑

46

Xanthine

0.008

3.417

1.568

↑

47

3-Methyl sulfolene

0.007

3.390

1.344

↑

48

p-CHLOROPHENYLALANINE

0.040

3.340

0.937

↓

49

PG(18:3(6Z,9Z,12Z)/0:0)

0.023

3.061

2.151

↑

50

4’-Demethyldeoxypodophyllotoxin

0.029

2.963

1.687

↑

51

LysoPE(18:1(9Z)/0:0)

0.043

2.824

1.645

↑

52

Uridine

0.046

2.789

1.279

↑

53

5-Hydroxy-N-formylkynurenine

0.031

2.707

0.246

↓

54

PHODiA-PA

0.002

2.616

2.569

↑

55

2,3,4-Trihydroxybutanoic acid

0.045

2.557

1.498

↑

56

PS-PE

0.001

2.478

2.476

↑

57

1-(2-methoxy-6Z-heptadecenyl)-sn-glycero-3-phosphoethanolamine

0.047

2.440

1.594

↑

58

Tiocarbazil

0.046

2.331

1.642

↑

59

Norepinephrine sulfate

0.011

2.311

2.146

↑

60

Metam-sodium

0.035

2.290

0.708

↓

61

C16 Sphinganine

0.023

2.262

0.871

↓

62

DL-Acetylcarnitine

0.040

2.197

0.706

↓

63

2,4-Diamino-6,7-dimethoxyquinazoline

0.018

2.188

1.305

↑

64

PC(22:4(7Z,10Z,13Z,16Z)/0:0)

0.014

2.082

3.391

↑

65

Dimethoate

0.034

2.071

0.239

↓

66

PC(2:0/1:0)[U]

0.049

2.028

2.656

↑

67

LysoPI(16:0/0:0)

0.030

2.009

2.483

↑

68

Phosphoribosyl-AMP

0.006

2.000

0.419

↓

69

Uracil

0.013

1.998

1.304

↑

70

Ribose 1-phosphate

0.020

1.986

0.886

↓

71

Thioperamide

0.035

1.962

2.071

↑

72

Thiabendazole

0.042

1.931

0.939

↓

73

Adenosine 3’,5’-diphosphate

0.008

1.876

0.707

↓

74

PIM1(17:0/18:1(9Z))

0.025

1.861

9.323

↑

75

LysoPC(16:1(9Z))

0.011

1.826

1.653

↑

76

PC(24:0/P-18:1(11Z))

0.024

1.822

0.869

↓

77

LysoPC(20:3(5Z,8Z,11Z)/0:0)

0.011

1.818

2.985

↑

78

D-Tagatose 1,6-bisphosphate

0.015

1.788

1.877

↑

79

Uridine monophosphate (UMP)

0.011

1.780

0.324

↓

80

Isopropalin

0.036

1.735

1.797

↑

81

3b,16a-Dihydroxyandrostenone sulfate

0.048

1.696

2.890

↑

82

MG(0:0/20:4(5Z,8Z,11Z,14Z)/0:0)

0.001

1.655

1.722

↑

83

Succinyladenosine

0.036

1.651

0.781

↓

84

Caffeic acid 3-sulfate

0.008

1.638

2.054

↑

85

5-(2’-Carboxyethyl)-4,6-Dihydroxypicolinate

0.020

1.609

1.248

↑

86

Aminoparathion

0.040

1.606

1.417

↑

87

1-Oleoylglycerophosphoserine

0.010

1.567

2.641

↑

88

Deoxyguanosine diphosphate (dGDP)

0.001

1.559

0.685

↓

89

LysoPC(18:2(9Z,12Z))

0.043

1.544

1.803

↑

90

Diethyl disulfide

0.000

1.413

0.749

↓

91

Retinylphosphate mannose

0.013

1.387

1.799

↑

92

FAD

0.001

1.384

0.875

↓

93

Tetracenomycin D1

0.010

1.372

2.931

↑

94

5’-CMP

0.000

1.370

0.687

↓

95

LysoPE(0:0/18:2(9Z,12Z))

0.025

1.357

2.291

↑

96

GDP-L-fucose

0.007

1.341

0.689

↓

97

Isosorbide Dinitrate

0.033

1.332

1.487

↑

98

Tazobactam

0.039

1.322

2.204

↑

99

Tetrahydrodipicolinate

0.005

1.309

0.626

↓

100

Dibutyl sulfide

0.021

1.307

1.322

↑

101

Hirsutin

0.000

1.291

6.223

↑

102

PG(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)

0.015

1.277

2.922

↑

103

Suprofen

0.043

1.269

1.442

↑

104

Sphinganine

0.025

1.239

0.894

↓

105

5β-Chola-3,8(14),11-trien-24-oic Acid

0.036

1.239

4.146

↑

106

alpha-D-Glucose 1,6-bisphosphate

0.010

1.217

1.679

↑

107

Ethyl 3-mercaptobutyrate

0.034

1.216

0.813

↓

108

7b-Hydroxy-3-oxo-5b-cholanoic acid

0.038

1.215

2.328

↑

109

2,7-Anhydro-alpha-N-acetylneuraminic acid

0.032

1.205

1.206

↑

110

Imidazoleacetic acid riboside

0.022

1.201

0.693

↓

111

N-(2,3-Dihydroxybenzoyl)-L-serine

0.017

1.193

1.657

↑

112

Myristic acid

0.028

1.189

0.758

↓

113

PE(18:2(9Z,12Z)/0:0)

0.033

1.186

2.724

↑

114

gamma-Glutamylalanine

0.035

1.148

0.776

↓

115

D-Glycerate 3-phosphate

0.029

1.108

2.097

↑

116

Penciclovir

0.039

1.099

1.576

↑

117

N-Acetyl-b-neuraminic acid

0.017

1.098

0.611

↓

118

CDP-ethanolamine

0.047

1.080

0.674

↓

119

DPA

0.039

1.066

2.617

↑

120

8,11,14-Eicosatrienoic acid

0.024

1.063

1.122

↑

121

Mangold’s acid

0.026

1.056

1.373

↑

122

2-Hydroxy-6-ketononatrienedioate

0.035

1.053

0.719

↓

123

1-O-(2R-methoxy-hexadecyl)-sn-glycerol

0.002

1.047

2.111

↑

124

SULFAMONOMETHOXINE

0.001

1.045

0.729

↓

125

Xanthosine

0.005

1.030

2.011

↑

126

1-Acetoxy-2-hydroxy-16-heptadecen-4-one

0.001

1.027

0.574

↓

127

PI(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/0:0)

0.003

1.021

0.514

↓

128

D-Erythrose 4-phosphate

0.040

1.016

1.271

↑

129

2-Hydroxyadenine

0.012

1.003

0.374

↓