Table 1 Characteristics of studies included in the present meta-analysis
From: Association between mitochondrial DNA levels and depression: a systematic review and meta-analysis
ID | First author | Year | location | Sample size | Age of DepressionMean(SD) | Age of ControlsMean(SD) | Gender of Depression(M/F) | Gender of Controls (M/F) | Specimen | Detection Method | Diagnostic method | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Depression | Controls | |||||||||||
1 | Karen M Ryan [17] | 2023 | Ireland | 100 | 89 | 56.36 (14.28) | 53.42 (10.39) | 38/62 | 30/59 | whole blood | qRT-PCR | HDRS |
2a | Emi Ampo [18] | 2022 | USA | 9 | 16 | 67.7 (6.5) | 69.9 (7.6) | 2/7 | 8/8 | Plasma | qRT-PCR | MADRS |
2b | Emi Ampo [18] | 2022 | USA | 23 | 5 | 70.6 (10.3 ) | 68.2 (6.9 ) | 7/16 | 2/3 | Plasma | qRT-PCR | MADRS |
3 | Vanessa F Gonçalves [19] | 2021 | Canada | 32 | 21 | 68.3 (6.7) | 70.1 (8.1) | 9/23 | 10/11 | Plasma | qRT-PCR | MADRS |
4 | Johan Fernström [20] | 2021 | Sweden | 47 | 11 | 35.0 (10.7) | 35.1 (11.1) | 21/26 | 5/6 | Plasma | qRT-PCR | MADRS |
5 | Jae Kyung Chung [21] | 2019 | Republic of Korea | 118 | 116 | 47.6 (16.7) | 47.7 (16.8) | 46/72 | 46/70 | peripheral blood | qPCR | NR |
6 | Kerstin Kuffner [22] | 2020 | Germany | 16 | 16 | 31 (3.12) | 32 (2.81) | 11/5 | 11/5 | Skin Fibroblasts | qRT-PCR | HDRS |
7a | Daniel Lindqvist [23] | 2018 | Sweden | 50 | 55 | 39.6 (14.7) | 37.6 (13.9) | 23/27 | 22/33 | Plasma | rt-PCR | HDRS |
7b | Daniel Lindqvist [23] | 2018 | Sweden | 50 | 55 | 39.6 (14.7) | 37.6 (13.9) | 23/27 | 22/33 | PBMCs | rt-PCR | HDRS |
8 | Cheng Chen Chang [24] | 2015 | China | 40 | 70 | 42.00 (18.75) | 38.00 (16.50) | 12/28 | 28/42 | Leukocyte | rt-PCR | MINI |
9 | Ying He [25] | 2014 | China | 210 | 217 | 30.2 (8.10) | 30.8 (7.05) | 100/110 | 109/108 | Leukocyte | qPCR | HDRS |
10 | Kato T [26] | 1997 | Japan | 14 | 20 | 48.2 (17.7) | 61.2 (10.6) | 8/6 | 10/10 | Leukocyte | qPCR | NR |