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Table 3 Treatment of psychiatric patients with depressive disorders during an eight-week follow-up (n = 107)

From: Prospective study of antidepressant treatment of psychiatric patients with depressive disorders: treatment adequacy and outcomes

 

All patients n = 107

 N (%)a

TRD n = 20b

N (%)

non-TRD n = 87

 N (%)

p-value*

Follow-up appointments

 - Psychiatrist (A)

73 (68.2)

13 (65)

60 (69)

0.963c

 - Other health care worker (B)

74 (69.2)

13 (65)

61 (70.1)

0.884c

 - Any appointment overall (A, B, or A + B)

94 (87.9)

17 (85)

77 (88.5)

1d

 - No follow-up appointments

12 (11.2)

2 (10)

10 (11.5)

 

Psychotherapy and other treatment sessions

 - Psychotherapy

14 (13.1)

4 (20)

10 (11.5)

 

 - Supportive meetings at another service provider

64 (59.8)

14 (70)

50 (57.5)

 

 - Family meetings

1 (0.9)

0

1 (1.1)

 

 - Group counselling

5 (4.7)

0

5 (5.7)

 

 - Visits at occupational health care unit

2 (1.9)

1 (5)

1 (1.1)

 

Use of antidepressants (ADs) at eight weeks

Patients using ADs (ntot for AD use):

97 (90.7)

18 (90)

79 (90.8)

1d

 - using AD monotherapy only

67 (69.1)

14 (77.8)

53 (67.1)

 

 - using a combination of ADs

30 (30.9)

4 (22.2)

26 (32.9)

0.439c

 - AD dosage compatible with Finnish DCG recommendations for a therapeutic dose

91 (93.8)

18 (100)

73 (92.4)

0.298d

Did the patient continue using the index AD prescribed at BL until eight weeks?

 - Yes, used index AD as only AD

50 (51.5)

10 (55.6)

40 (50.6)

 

 - Yes, used index AD in combination with other AD(s)

27 (25.2)

3 (16.7)

24 (30.4)

 

 - No, index AD switched to another AD, which was used alone or combined with other AD(s)

15 (15.5)

4 (22.2)

11 (13.2)

 

 - No, index AD terminated, patient continued using previously prescribed AD(s)

5 (4.7)

1 (5.6)

4 (5.1)

 

 - No, all ADs terminated

8 (7.5)

1 (5.6)

7 (8.9)

 

 - No, never started using the index AD and not using any other AD

1 (0.9)

0

1 (1.3)

 

Augmentation pharmacotherapy (combined with ADs)

 

1d

 - Atypical antipsychotic (AA) (quetiapine, minimum 50 mg/day)

9 (9.3)

1 (5.6)

8 (10.1)

1d

 - Mood stabilizer (lamotrigine)

1 (1.0)

0

1 (1.3)

 

Monotherapy: using one AD or one AA only (quetiapine ≥ 50 mg/day)

62 (58.0)

 

ECT during follow-up (n = 107)

1 (0.9)

0

1 (1.5)

 

New hospitalization during follow-up (n = 107)

2 (1.9)

0

2 (2.3)

 
  1. AD, antidepressant; index AD, antidepressant assigned to study patient at baseline; AA, atypical antipsychotic; ECT, electroconvulsive therapy; BL, baseline; TRD, patient classified with treatment-resistant depression at baseline; non-TRD, patient classified as not having treatment-resistant depression at baseline
  2. aMissing data for 1/107 patients (0.9%)
  3. bMissing data for 1/20 TRD patients (5%)
  4. cChi-square test
  5. dFisher exact test
  6. *TRD vs. non-TRD