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Table 1 Summary of study characteristics of the included studies. Results and further details are available in Additional file 5

From: Relational continuity may give better clinical outcomes in patients with serious mental illness – a systematic review

Author

Year

Study type

Country

Population

n

Measure of exposure

(continuity)

Outcome(s)

Overall risk of bias

Adair et al.

2005

Prospective cohort study

Canada, Alberta

SMI

n = 486

65% mood disorders

35% psychotic

disorders

Alberta Continuity of Services Scale

(ACSS-MH)

EQ-5D

High

Adnanes et al.

2019

National cross-sectional survey

Norway

SMI or non-SMI patients receiving specialist outpatient psychiatric treatment

n = 155 SMI

n = 835 non-SMI

Perception of COC using the CONTINUUM measure

QOL measured with the Manchester Short Assessment of Quality of Life (MANSA) questionnaire

Moderate

Bindman et al.

2000

Prospective cohort study

England, south London

SMI

n = 100

91% psychotic illness

Contact with number of community “keyworkers” over a period of time

BPRS (Brief Psychiatric Rating Scale)

HoNOS (Health of the Nation Outcome Score)

GAF (Global Assessment of Functioning)

Moderate

Catty et al.

2013

Prospective cohort study

England

Psychotic disorders

n = 180

User rated overall “experienced” continuity using the CONTINUUM

measure

BPRS (Brief Psychiatric Rating Scale

GAF (Global Assessment of Functioning)

Quality of Life - MANSA and SEQoL

High

Chien et al.

2000

Register study

USA, Maryland

Schizophrenia

n = 351

Continuity of care (COC)

Usual provider continuity (UPC)

Sequential continuity (SECON)

Medicaid costs

Lehman Quality of Health

Moderate

Conti et al. 2012

Register study

Italy, Lombardy

SMI

n = 11 797

42% schizophrenia

8% bipolar disorder

50% depression

Continuity of Care defined as receiving at least one psychiatric contact every 90 days

Lack of persistence with pharmacological treatment defined as a gap of at least 30 days between subsequent medication fills

Moderate

Desai et al. 2005

Register study from the VA health system

USA

SMI with or without alcoholism, substance abuse or PTSD

n = 121 933

Continuity of outpatient of care measured as the number of two-month periods in the six months after discharge in which the patient had at least two outpatient visits for his or her primary discharge diagnosis

(range = 0–3)

Suicide

Moderate

Farley et al. 2011

Register study

USA, North Carolina

Schizophrenia

n = 7 868

Number of unique prescribers of medication for schizophrenia

Adherence to medication measured by the medication possession ratio (MPR) from Medicaid data

Moderate

Giacco et al. 2018

Prospective natural experiment

Follow-up 1 year

Belgium, England, Germany, Italy,

Poland

Psychiatric in-patients

41% psychotic disorders

49% mood disorders

18% other disorders

n = 7 302

Personal continuity, i.e., a patient is under the care of the same psychiatrist for in- and out- patient treatment; or specialization, i.e., a patient is under the care of different psychiatrists for in- and out-patient treatment.

Readmission to hospital within one year following the index admission

Moderate

Hoertel et al. 2014

Observational study

France

Patients who visited a psychiatrist at least twice over six months

n = 114 515

diagnosis available for n = 2 863

17% schizophrenia

29% major depressive disorder

10% bipolar disorder

38% personality disorder

COC Index

All-cause mortality

Moderate

Kaltsidis et al.

2020

Retrospective observational study

Canada, Quebec

Patients visiting emergency department for mental health reasons

n = 210

Exploring predictors for ED visits based on predisposing, enabling and needs factors

One of the enabling factors was a regular source of care over the 12 months prior to the research interview at the emergency department

Number of visits to the emergency department for mental health reasons over the 12 months prior to the index visit

Moderate

Macdonald et al.

2019

Register study

England,

south London

Schizophrenia or delusional disorders

83% schizophrenia

17% delusional disorders

n = 5 552

Modified Continuity Index (MMCI) measuring the number of teams caring for the patient over time

Health of the Nation Outcomes Scales (HoNOS)

Moderate

Mitton et al.

2005

Observational study

Alberta, Canada

SMI

n = 486

65% mood disorders

35% psychotic

disorders

Alberta Continuity of Services Scale

(ACSS-MH)

Quality of Life (EQ-5D)

Community functioning (Multnomah Community Ability Scale)

Administrative data concerning service use events and health care costs

Moderate

Puntis et al.

2016

Prospective cohort study

England

Patients with psychosis diagnosis who were to be discharged from compulsory hospital treatment

n = 323

Average gap between face-to-face contacts

Number of 60-day gaps without contact

Number of different mental health professions seen

Number of care coordinators

Number of psychiatrists

Readmission to hospital

Time to readmission

Number of days in hospital

Moderate

Ride et al.

2019

Observational study

England

SMI

53% schizophrenia and other psychoses

35% bipolar disorder

12% both diagnoses

n = 19 324

Family physician relational continuity measured by:

COC

Continuity of Care

UPC

Usual Provider Care

SECON

Sequential Continuity

Emergency presentations

Unplanned admissions for SMI

Ambulatory care-sensitive conditions (ACSC)

Moderate

van der Lee et al. 2016

Retrospective register-based cohort study

The Netherlands

Schizophrenia

n = 7 392

The number of follow-up years of elective psychiatric care

Acute treatment events

Inpatient care and somatic care

Medical costs

High

Watkins et al.

2016

Retrospective cohort study

USA

Co-occurring mental illness (schizophrenia, bipolar disorder type 1, PTSD or depression) and substance use disorder

n = 144 045

Continuous care over time defined as receiving ≥ 1 visit each quarter over a one-year period from any type of provider

Mortality after 12 and 24 months after the end of the observation period (main outcome)

Avoidable excessive mortality number

Moderate

  1. Notes: COC = Continuity of Care; ED = emergency department; EQ-5D = Euro Quality of Life 5 dimensions