Serum levels of interleukin-33 and mesencephalic astrocyte derived neurotrophic factors in patients with major depressive disorder: a cross-sectional comparative design

Table 2 Clinical profile and laboratory findings of the study population

Parameters	MDD patients (n = 129) Mean ± SEM	Healthy controls (n = 125) Mean ± SEM	p-value
Age (years)	30.67 ± 0.86	30.18 ± 0.82	0.675
Male (P/C:34/33)	29.97 ± 1.80	30.88 ± 1.85	0.725
Female (P/C:95/92)	30.93 ± 0.98	29.92 ± 0.89	0.451
BMI (kg/m²)	23.44 ± 0.44	24.38 ± 0.37	0.105
Male (P/C:34/33)	23.78 ± 0.88	25.87 ± 0.68	0.066
Female (P/C:95/92)	23.32 ± 0.51	23.85 ± 0.43	0.430
Ham-D score	17.95 ± 0.44	1.00 ± 0.14	< 0.001
Male (P/C:34/33)	17.71 ± 0.77	1.00 ± 0.27	< 0.001
Female (P/C:95/92)	18.04 ± 0.53	1.00 ± 0.17	< 0.001
Serum IL-33 (pg/ml)	159.12 ± 6.07	180.60 ± 8.64	0.042
Male (P/C:34/33)	149.87 ± 11.30	169.94 ± 11.88	0.225
Female (P/C:95/92)	162.43 ± 7.18	184.42 ± 10.95	0.093
Serum MANF (ng/ml)	5.40 ± 0.19	4.46 ± 0.21	0.001
Male (P/C:34/33)	4.99 ± 0.37	3.13 ± 0.30	< 0.001
Female (P/C:95/92)	5.56 ± 0.21	4.94 ± 0.25	0.065

Abbreviations: BMI, body mass index; Ham-D, 17-item Hamilton depression rating scale; IL-33, interleukin-33; MANF, mesencephalic astrocyte derived neurotrophic factor; MDD, major depressive disorder; P/C, patients/control; SEM, standard error mean

ISSN: 1471-244X