Table 1 Baseline characteristics and risk factors
(a) Death | ||
Case (n = 144) | Control (n = 504) | |
Baseline characteristics | ||
Age (years), mean ± SD | 42.0 ± 14.0 | 42.0 ± 13.7 |
Sex (male) | 87 (60.4%) | 311 (61.7%) |
Follow-up period (month), median (IQR) | 6.0 (3.0, 20.5) | 5.0 (3.0, 15.0) |
Risk factors | ||
Hospitalization (in 6 months) | 24 (16.7%) | 55 (10.9%) |
Depression | 43 (29.9%) | 116 (23.0%) |
CCI score, mean ± SD | 2.3 ± 3.0 | 0.6 ± 1.2 |
Hypnotics prescription | 93 (64.6%) | 252 (50.0%) |
Benzodiazepines prescription | 98 (68.1%) | 299 (59.3%) |
Sedatives prescription | 108 (75.0%) | 324 (64.3%) |
Laxatives prescription | 60 (41.7%) | 73 (14.5%) |
Anticholinergics prescription | 19 (13.2%) | 60 (11.9%) |
Antidiabetics prescription | 17 (11.8%) | 33 (6.5%) |
Antihypertensives prescription | 46 (31.9%) | 90 (17.9%) |
Antidyslipidemics prescription | 8 (5.6%) | 56 (11.1%) |
(b) Hospitalization | ||
Case (n = 1,520) | Control (n = 5,432) | |
Baseline characteristics | ||
Age (years), mean ± SD | 29.2 ± 14.6 | 28.9 ± 14.7 |
Sex (male) | 636 (41.8%) | 2278 (41.9%) |
Follow-up period (month), median (IQR) | 6.0 (3.0, 19.0) | 5.0 (2.0, 15.0) |
Risk factors | ||
Depression | 433 (28.5%) | 1179 (21.7%) |
CCI score, mean ± SD | 0.4 ± 0.9 | 0.3 ± 0.8 |
Hypnotics prescription | 1093 (71.9%) | 2144 (39.5%) |
Benzodiazepines prescription | 1148 (75.5%) | 2769 (51.0%) |
Sedatives prescription | 1227 (80.7%) | 3035 (55.9%) |
Laxatives prescription | 452 (29.7%) | 358 (6.6%) |
Anticholinergics prescription | 368 (24.2%) | 524 (9.6%) |
Antidiabetics prescription | 35 (2.3%) | 103 (1.9%) |
Antihypertensives prescription | 161 (10.6%) | 406 (7.5%) |
Antidyslipidemics prescription | 67 (4.4%) | 224 (4.1%) |
(c) Resignation | ||
Case (n = 811) | Control (n = 2,866) | |
Baseline characteristics | ||
Age (years), mean ± SD | 33.6 ± 10.3 | 33.5 ± 10.0 |
Sex (male) | 563 (69.4%) | 2060 (71.9%) |
Follow-up period (month), median (IQR) | 5.0 (3.0, 15.0) | 5.0 (2.0, 12.0) |
Risk factors | ||
Depression | 238 (29.3%) | 860 (30.0%) |
CCI score, mean ± SD | 0.4 ± 0.9 | 0.3 ± 0.8 |
Hypnotics prescription | 455 (56.1%) | 1424 (49.7%) |
Benzodiazepines prescription | 542 (66.8%) | 1807 (63.1%) |
Sedatives prescription | 567 (69.9%) | 1916 (66.9%) |
Laxatives prescription | 73 (9.0%) | 206 (7.2%) |
Anticholinergics prescription | 120 (14.8%) | 289 (10.1%) |
Antidiabetics prescription | 23 (2.8%) | 63 (2.2%) |
Antihypertensives prescription | 66 (8.1%) | 210 (7.3%) |
Antidyslipidemics prescription | 38 (4.7%) | 143 (5.0%) |
(d) Sick leave from work | ||
Case (n = 4,590) | Control (n = 17,027) | |
Baseline characteristics | ||
Age (years), mean ± SD | 36.3 ± 10.8 | 36.3 ± 10.8 |
Sex (male) | 3227 (70.3%) | 12,094 (71.0%) |
Follow-up period (month), median (IQR) | 3.0 (2.0, 5.0) | 3.0 (2.0, 5.0) |
Risk factors | ||
Depression | 1733 (37.8%) | 4776 (28.1%) |
CCI score, mean ± SD | 0.6 ± 1.2 | 0.4 ± 0.9 |
Hypnotics prescription | 3083 (67.2%) | 8100 (47.6%) |
Benzodiazepines prescription | 3450 (75.2%) | 10,401 (61.1%) |
Sedatives prescription | 3673 (80.0%) | 11,160 (65.5%) |
Laxatives prescription | 713 (15.5%) | 1295 (7.6%) |
Anticholinergics prescription | 541 (11.8%) | 1581 (9.3%) |
Antidiabetics prescription | 199 (4.3%) | 440 (2.6%) |
Antihypertensives prescription | 634 (13.8%) | 1796 (10.5%) |
Antidyslipidemics prescription | 282 (6.1%) | 958 (5.6%) |