Table 1 Schedule of key study activities

Days relative to dosing

-20

-7

-1

0

+ 1

+ 7

+ 35

+ 190

Key assessments

Informed consent

X

Psychiatric screening

X

Physical screening

X

Key outcomes

Clinical outcomes

Heavy drinking

X

X

X

Drinking days

X

X

X

Abstinence

X

X

X

PEth

X

Mood

X

X

X

X

X

Anxiety

X

X

X

X

X

Trauma

X

X

X

X

X

Global functioning

X

X

X

Safety

Adverse events

X

X

X

X

X

X

X

X

Feasibility

Insclusion rates

X

Retention rates

X

X

X

X

X

X

X

Neurocog. outcomes

Neuroplasticity (LTP)

X

X

X

Cue reactivity

X

X

X

Inhibition

X

X

X

Drug experience

Mystical (MEQ)

X

Acceptance/Avoidance (APEQ)

X

Trauma access/process.

(Helioscope Q.)

X

Psychological processes

Flexibility (AAQQ II)

X

X

X

X

X

Interoception (MAIA)

X

X

X

X

X

Connectedness (WCS)

X

X

X

X

X

Alcohol-related parameters

Craving (PACS)

X

X

X

X

X

Abstinence self-efficacy (AASE)

X

X

X

X

X

Readiness to change

X

X

X

X

X