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Table 3 Adjusted linear regression model (Multiple Regression) of change scores from baseline to Week 8 in depressive symptoms among those with clinically elevated levels of baseline depressive symptoms: PHQ-8 ≥ 10

From: Demographic and clinical characteristics associated with anxiety and depressive symptom outcomes in users of a digital mental health intervention incorporating a relational agent

Characteristics of Interest

PHQ-8: Week 8 Change Scores

Estimates

95% CI

p-value

(Intercept)

-2.46

-10.16 – 5.24

0.53

Used the app in at least 4 of 8 weeks

0.20

-1.75 – 2.15

0.84

Age

0.05

-0.03 – 0.14

0.23

Sex at Birth

 Male

Reference Level

 Female

-0.96

-3.24 – 1.32

0.41

Sexual Orientation

 Heterosexual

Reference Level

 Sexual Minority

5.71

2.88 – 8.54

< 0.01

Education

 High School

Reference Level

 College Degree

-1.63

-4.33 – 1.07

0.23

 Graduate or postgraduate degree

-0.24

-3.18 – 2.70

0.87

 Some college or technical school

0.88

-2.26 – 4.01

0.58

Marital Status

 Married/Partnered/Cohabiting

Reference Level

 Divorced/Separated/Widowed

-3.86

-7.38 – -0.34

0.03

 Single

-3.75

-5.78 – -1.72

< 0.01

BL Depressive Symptom Severity

 Moderate

Reference Level

 Moderate-Severe

-0.09

-2.44 – 2.25

0.94

 Severe

-5.32

-8.16 – -2.47

< 0.01

BL Anxiety Symptom Severity

 Minimal

Reference Level

 Mild

-3.97

-10.29 – 2.35

0.215

 Moderate

-4.50

-11.02 – 2.02

0.17

 Severe

-5.59

-12.17 – 0.99

< 0.01

 Concurrent Mental Health Treatmenta

2.62

0.80 – 4.43

< 0.01

  1. Final models did not consider race/ethnicity, employment, or insurance status because of multicollinearity
  2. BL baseline, PHQ-8 Patient Health Questionnaire-8 item scale
  3. a Concurrent mental health treatment = any psychotherapy or psychotropic medication use at any time during the study