Systemic therapy in children and adolescents with mental disorders: a systematic review and meta-analysis

BMC Psychiatry

Table 4 Statistically significant effects for outcomes for which the data provided evidence (proof, indication or hint) of greater or lesser benefit of ST as an add-on to CBT compared with CBT alone (from [9])

Outcome		Operationalisation	Length of follow-up	Effect measure	Effect esti-mate	95% CI	p-value	Study	Directionof effect
II: Anxiety disorders and obsessive–compulsive disorders
No. 6	Overall improvement in clinical condition	CGI-I ≤ 2	Week 14	OR	3.15	[1.10; 8.99]	0.03	Peris et al. [105,106,107,108]	▲
No. 9	Obsessive-compulsive disorder symptoms	CY-BOCS ≤ 14	Week 14	OR	3.81	[1.29; 11.20]	0.01	Peris et al. [105,106,107,108]	▲
No. 10	Overall functioning	COIS-R	Week 14	Hedges’ g	− 0.75	[− 1.27; − 0.23]	0.004	Peris et al. [105,106,107,108]	▲

▲ Effect in favour of ST
CI confidence interval, CGI-I Clinical Global Impression – Improvement, COIS-R Child Obsessive Compulsive Impact Scale-Revised, CY-BOCS Children's Yale-Brown Obsessive Compulsive Scale, MD mean difference, No. number, OR odds ratio

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