Table 1 Specific aims and hypotheses
From: The genetic architecture of youth anxiety: a study protocol
| Â | Specific Aim | Hypothesis |
|---|---|---|
1 | Identify genetic risk factors associated with clinical symptoms and vulnerability markers of youth anxiety. | Each clinical symptom and vulnerability marker will be associated with common genetic variations. |
2 | Identify genetic factors that are unique to anxiety in different age groups. | If the overlap in genetic risk factors is partial between different age groups, then the non-overlapping part will be driven by associations with common genetic variants. |
3 | Identify genetic factors that are shared and unique between anxiety and its common comorbidities. | If pleiotropy is driving co-occurrence of anxiety and common comorbidities, then these traits will have shared genetic risks. |
4 | Identify a prediction model of treatment response in youth with anxiety disorders. | Response to CBT in youth anxiety will be predicted using data from common genetic variation, clinical symptoms, and vulnerability markers. |