Fig. 2

The causal effect of genetically predicted age at first sexual intercourse on the risk of SCZ. a Forrest plot. The MR findings of the MR-Egger test and the inverse variance weighted (IVW) method are the significance of the red lines. b MR leave-one-out sensitivity analysis. The leave-one-out sensitivity analysis found no single genetic variant-driven causality. c Scatter plot. The slope of each line in the SNP scatterplot corresponds to the MR effect estimated by each method, and the slopes differ in magnitude but are in the same direction for the five methods. d Funnel plot. The blue line in the SNP funnel plot indicates the IVW estimate and the dark blue line indicates the Mendelian randomization-Egger estimate. No evidence of asymmetry on either side of the blue line of the funnel plot