Table 1 Data sources used in the MR analyses for the current study

Exposures

AFB

418,758 females

European

Year increase in AFB

36 studies

34,211,149

https://www.ebi.ac.uk/

gwas/studies/GCST90000050

AFS

214,547 females

European

SD increase in AFS

36 studies

34,211,149

https://www.ebi.ac.uk/

gwas/studies/GCST90000047

AAM

182,416 females

European

Year increase in AAM

ReproGen

25,231,870

https://www.reprogen.org/data_download.html

ALB

184,996 females

European

SD increase in ALB

MRC-IEU

UK Biobank

https://gwas.mrcieu.ac.uk/datasets/ukb-b-8727/

http://www.nealelab.is/uk-biobank

AMP

176,881 females

European

SD increase in AMP

MRC-IEU

UK Biobank

https://gwas.mrcieu.ac.uk/datasets/ukb-b-17422/

http://www.nealelab.is/uk-biobank

Outcome

Risk of SCZ

320,404 individuals

(76,755 cases and 243,649 controls)

Mixed(74.3% were European)

logOR

PGC consortium

35,396,580

https://doi.org/10.6084/m9.figshare.19426775

Confounders

BMI

461,460 individuals

European

SD

MRC-IEU

UK Biobank

https://gwas.mrcieu.ac.uk/datasets/ukb-b-19953/

http://www.nealelab.is/uk-biobank

YS

766,345 individuals

European

Years

SSGAC consortium

30,038,396

https://thessgac.com/papers/

PA

460,376 individuals

European

SD

MRC-IEU

UK Biobank

https://gwas.mrcieu.ac.uk/datasets/ukb-b-8764/

http://www.nealelab.is/uk-biobank

SI

607,291 individuals

European

standardized log odds

GSCAN consortium

30,643,251

https://genome.psych.umn.edu/ index.php/GSCAN

AD

335,394 individuals

European

SD

GWAS and Sequencing Consortium of Alcohol and Nicotine use

30,643,251

CI

428,860 individuals

European

SD

UK Biobank

http://www.nealelab.is/uk-biobank

http://gwas.mrcieu.ac.uk/datasets/ukb-b-5237