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Table 2 Association of Reproductive factors with the risk of SCZ using IVW methods in both UVMR and MVMR models

From: Identifying causal associations between women’s reproductive traits and risk of schizophrenia: a multivariate validated two-sample Mendelian randomization analysis

Exposure

Mode

SNPs

P-Value

OR

95%LCI

95%UCI

AFB

UVMR

62

0.709

0.982

0.893

1.080

 

MVMR

18

0.761

1.017

0.902

1.147

AFS

UVMR

176

1.473*10−5

0.632

0.512

0.777

 

MVMR

88

6.294*10−3

0.592

0.407

0.862

AAM

UVMR

66

0.130

1.085

0.976

1.207

 

MVMR

37

0.248

0.926

0.814

1.054

ALB*

UVMR

26

0.224

1.265

0.866

1.848

 

MVMR

1

0.156

1.278

0.910

1.794

AMP

UVMR

107

0.344

1.045

0.954

1.143

 

MVMR

66

0.619

1.028

0.922

1.146

  1. AFB Age at first birth, AFS Age at first sexual intercourse, ALB Age at last live birth, AAM Age at menarche, AMP Age at menopause, MVMR Multivariable Mendelian randomization, UVMR Univariable Mendelian randomization
  2. *P-value cut-offs for instrumental variables are loosened to 1*10−6
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BMC Psychiatry

ISSN: 1471-244X

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