Table 2 Schedule of trial procedures and assessments

ENROLMENT

 Phone screen (eligibility)

X

 Medical screen/assessment (eligibility)^a

X

 Urine drug screen and βhcG

X

 Blood test (LFTs)

X

 Informed consent

X

 Enrol and Randomisation

X

INTERVENTION

 Medication [CBD or placebo] dispensed

X

X

X

X

 Adverse Events Assessments^b

X

X

X

X

 Concomitant Medications^b

X

X

X

X

 CBT counselling intervention^c

X

X

RESEARCH ASSESSMENTS

 Research Interviews^d: Collection of UDS, TLFB, Quantity of Cannabis Use, SUG, Rates of Abstinence, PROMIS-29, Testing of the Blind, CWS, MCQ, ATOP, FTND

X

X

X

X

X

X

 DSM-5, PTSD, MPQ

X

X

X

 TSQM, DEQ-5

X

X

X

X

X

 PSIa

X

X

X

X

 Treatment Retention

X

 Cognitive assessments^e: RAVLT, NART-17, Eriksen Arrow Flankers Task, N-Back, Digit Span Task, TMT

X

X

 Interviews with Indigenous Australian participants + m-EDS^f

X

X