Table 2 Differences in GMV of the hippocampal subregions between MD, NMD, and HCs
Subregions | MD (n = 72) | NMD (n = 74) | HCs (n = 81) | F | P | Effect size (partial η2) | Post-hoc [P (95%CI)] | ||
|---|---|---|---|---|---|---|---|---|---|
MD vs. NMD | MD vs. HCs | NMD vs. HCs | |||||||
Left hemisphere | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Parasubiculum | 62.52(11.31) | 63.79(11.53) | 64.50(11.89) | 0.371 | 0.691 | 0.003 | 0.907(-3.382 to 3.809) | 0.502(-4.666 to 2.294) | 0.430(-4.890 to 2.091) |
Presubiculum | 310.00(34.09) | 315.39(39.58) | 317.50(46.66) | 0.254 | 0.776 | 0.002 | 0.905(-10.932 to 12.343) | 0.589(-14.357 to 8.172) | 0.508(-15.095 to 7.498) |
Subiculum | 425.94(40.93) | 437.71(49.07) | 444.61(55.61) | 1.993 | 0.139 | 0.018 | 0.603(-17.374 to 10.107) | 0.056(-26.266 to 0.334) | 0.169(-22.670 to 4.006) |
CA1 | 610.84(61.98) | 619.01(64.43) | 624.93(68.58) | 0.574 | 0.564 | 0.005 | 0.784(-16.092 to 21.307) | 0.456(-24.959 to 11.241) | 0.305(-27.619 to 8.685) |
CA3 | 198.30(23.52) | 200.08(25.70) | 201.56(25.29) | 0.153 | 0.858 | 0.001 | 0.873(-7.238 to 8.513) | 0.709(-9.066 to 6.180) | 0.592(-9.726 to 5.564) |
CA4 | 242.47(21.64) | 242.48(24.67) | 245.91(24.87) | 0.551 | 0.577 | 0.005 | 0.482(-4.632 to 9.784) | 0.760(-8.057 to 5.895) | 0.304(-10.654 to 3.339) |
GC-ML-DG | 282.80(24.70) | 284.23(28.83) | 287.35(28.70) | 0.428 | 0.652 | 0.004 | 0.606(-5.997 to 10.259) | 0.695(-9.435 to 6.299) | 0.356(-11.589 to 4.191) |
ML | 544.84(45.16) | 551.51(49.86) | 560.57(54.31) | 1.534 | 0.218 | 0.014 | 0.851(-12.669 to 15.335) | 0.164(-23.166 to 3.940) | 0.114(-24.538 to 2.646) |
HATA | 54.33(9.57) | 54.98(8.50) | 53.52(8.40) | 0.500 | 0.607 | 0.005 | 0.711(-2.249 to 3.294) | 0.325(-1.338 to 4.027) | 0.548(-1.869 to 3.512) |
Fimbria | 80.28(16.80) | 82.33(16.16) | 81.56(14.72) | 0.088 | 0.916 | 0.001 | 0.679(-3.607 to 5.525) | 0.876(-4.069 to 4.770) | 0.787(-5.041 to 3.823) |
Tail | 599.10(62.59) | 607.27(77.67) | 626.71(77.95) | 2.347 | 0.098 | 0.021 | 0.931(-23.583 to 21.596) | 0.058(-42.965 to 0.765) | 0.072(-42.035 to 1.821) |
Fissure | 146.32(25.96) | 147.05(29.82) | 150.08(25.94) | 0.361 | 0.697 | 0.003 | 0.732(-7.209 to 10.245) | 0.624(-10.551 to 6.344) | 0.400(-12.093 to 4.850) |
Whole hippocampus | 3411.43(260.91) | 3458.79(306.12) | 3508.71(331.67) | 1.608 | 0.203 | 0.014 | 0.863(-73.677 to 87.794) | 0.150(-135.361 to 20.930) | 0.107(-142.645 to 14.096) |
Right hemisphere | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Parasubiculum | 60.95(8.75) | 62.29(11.08) | 60.91(10.17) | 0.301 | 0.741 | 0.003 | 0.837(-3.469 to 2.812) | 0.593(-2.214 to 3.866) | 0.456(-1.894 to 4.203) |
Presubiculum | 292.00(34.62) | 301.05(40.60) | 297.60(38.52) | 0.211 | 0.810 | 0.002 | 0.519(-14.612 to 7.398) | 0.785(-12.126 to 9.179) | 0.694(-8.549 to 12.816) |
Subiculum | 425.60(45.65) | 440.44(49.66) | 443.57(48.45) | 1.730 | 0.180 | 0.015 | 0.294(-20.409 to 6.209) | 0.065(-25.018 to 0.746) | 0.443(-17.955 to 7.883) |
CA1 | 660.47(68.13) | 673.85(75.85) | 682.20(82.83) | 1.015 | 0.364 | 0.009 | 0.935(-22.426 to 20.643) | 0.208(-34.195 to 7.492) | 0.241(-33.363 to 8.444) |
CA3 | 219.55(26.08) | 225.79(28.24) | 222.04(28.21) | 0.241 | 0.786 | 0.002 | 0.535(-11.122 to 5.786) | 0.955(-8.416 to 7.949) | 0.559(-5.771 to 10.641) |
CA4 | 253.08(24.09) | 258.08(25.97) | 256.38(26.80) | 0.080 | 0.923 | 0.001 | 0.691(-9.173 to 6.087) | 0.818(-8.248 to 6.522) | 0.857(-6.726 to 8.087) |
GC-ML-DG | 294.87(27.90) | 302.27(30.30) | 300.27(31.78) | 0.250 | 0.779 | 0.002 | 0.503(-11.801 to 5.803) | 0.593(-10.835 to 6.204) | 0.875(-7.861 to 9.227) |
ML | 571.30(51.31) | 584.29(54.84) | 588.70(61.05) | 1.014 | 0.364 | 0.009 | 0.633(-19.265 to 11.75) | 0.164(-25.647 to 4.373) | 0.369(-21.933 to 8.174) |
HATA | 58.27(9.50) | 58.27(9.58) | 57.30(9.38) | 0.463 | 0.630 | 0.004 | 0.627(-2.306 to 3.817) | 0.337(-1.516 to 4.411) | 0.647(-2.280 to 3.664) |
Fimbria | 75.95(14.74) | 80.37(13.89) | 78.78(15.74) | 0.466 | 0.628 | 0.004 | 0.340(-6.450 to 2.236) | 0.545(-5.497 to 2.909) | 0.704(-3.402 to 5.029) |
Tail | 600.55(59.79) | 625.55(67.67) | 648.47(84.88) | 7.659 | < 0.001* | 0.065 | 0.175(-35.920 to 6.568) | < 0.001*(-60.705 to -19.581) | 0.016(-46.088 to -4.846) |
Fissure | 151.92(24.46) | 162.03(34.13) | 159.49(29.66) | 1.643 | 0.196 | 0.015 | 0.085(-18.080 to 1.181) | 0.177(-15.735 to 2.909) | 0.668(-7.313 to 11.385) |
Whole hippocampus | 3512.59(294.61) | 3612.26(322.89) | 3636.24(368.49) | 1.712 | 0.183 | 0.015 | 0.386(-127.254 to 49.412) | 0.066(-165.671 to 5.328) | 0.344(-126.997 to 44.494) |