Table 3 Baseline characteristics of patients stratified by IL-1β
From: Impacts of inflammatory cytokines on depression: a cohort study
Variable | IL-1β | P value | |||
|---|---|---|---|---|---|
< 25% (21) | 25–50% (20) | 50–75% (21) | > 75% (20) |  | |
Age, year | 39.1 ± 12.1 | 38.2 ± 12.5 | 34.6 ± 8.0 | 37.0 ± 15.1 | 0.66 |
Male gender | 9 (42.8) | 4 (20.0) | 6 (28.5) | 7 (35.0) | 0.44 |
BMI, kg/m2 | 22.9 (8.5) | 23.7 (4.4) | 23.4 (5.8) | 22.7 (5.0) | 0.55 |
Married | 17 (81.0) a | 12 (60.0) a,b | 13 (61.9) a,b | 6 (30.0) b | 0.01* |
Education (≥ high school) | 17 (81.0) | 16 (80.0) | 20 (95.2) | 18 (90.0) | 0.41 |
Employed | 13 (61.9) | 10 (50.0) | 17 (81.0) | 12 (60.0) | 0.21 |
Income (RMB per year) | Â | Â | Â | Â | 0.36 |
 < 50,000  50,000-100,000  > 100,000  Unknown | 5 (23.8) 7 (33.3) 8 (38.1) 1 (4.8) | 9 (45.0) 2 (10.0) 8 (40.0) 1 (5.0) | 2 (9.5) 5 (23.8) 11 (52.4) 3 (14.3) | 4 (20.0) 5 (25.0) 9 (45.0) 2 (10.0) |  |
Current smoker | 4 (19.0) | 4 (20.0) | 5 (23.8) | 4 (20.0) | 1.00 |
Current drinker | 5 (23.8) | 9 (45.0) | 7 (33.3) | 6 (30.0) | 0.53 |
Physical activity | Â | Â | Â | Â | 0.39 |
 None  Minor  Moderate  Severe | 4 (19.0) 13 (61.9) 4 (19.0) 0 (0.0) | 8 (40.0) 6 (30.0) 6 (30.0) 0 (0.0) | 8 (38.1) 8 (38.1) 4 (19.0) 1 (4.8) | 8 (40.0) 6 (30.0) 4 (20.0) 2 (10.0) |  |
Hypertension | 5 (23.8) | 7 (35.0) | 1 (4.8) | 2 (10.0) | 0.05 |
Diabetes | 3 (14.3) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0.05 |
Hyperlipidemia | 4 (19.0) | 4 (20.0) | 3 (14.3) | 5 (25.0) | 0.85 |
Heart disease | 3 (14.3) | 2 (10.0) | 2 (9.5) | 2 (10.0) | 1.00 |
Brain stroke | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (5.0) | 0.48 |
Tumor | 0 (0.0) | 0 (0.0) | 1 (4.8) | 1 (5.0) | 0.86 |
Insomnia | 12 (57.1) | 11 (55.0) | 14 (66.7) | 7 (35.0) | 0.22 |
Sleep apnea hypopnea syndrome | 2 (9.5) | 2 (10.0) | 1 (4.8) | 0 (0.0) | 0.68 |
Family history of mental disease | 2 (9.5) | 2 (10.0) | 4 (19.0) | 6 (30.0) | 0.29 |
Duration of depression | 248 (729) | 319.5 (837) | 208 (1554) | 82 (1418) | 0.93 |
Antidepressant drugs | 14 (66.7) | 8 (40.0) | 11 (52.4) | 13 (65.0) | 0.28 |
Social support | 33.2 ± 8.4 | 30.2 ± 7.2 | 31.6 ± 9.8 | 31.3 ± 8.3 | 0.71 |
Life stress | 160.6 ± 124.0 | 247.9 ± 133.5 | 234.8 ± 115.9 | 217.7 ± 123.2 | 0.16 |
PHQ-9 | 9.0 (11.0) | 14.5 (10.0) | 16.0 (9.0) | 12.0 (3.0) | 0.05 |
IL-1β | 0.53 (0.73) | 1.33 (0.36) | 2.24 (0.74) | 3.63 (2.56) | < 0.01* |