Impact of depersonalization on the course of depression: longitudinal observations from the gutenberg health study

Table 2 Medical disease and biomarkers

	Not depressed (PHQ-9 < 5) and no DP/DR (CDS-2 = 0) (n = 9,301)	Depressed (PHQ-9 ≥ 10)		Cohen’s d^§	Test for depression with DP/DR versus depression only
		no DP/DR (CDS-2 = 0) (n = 599)	DP/DR (CDS-2 ≥ 1) (n = 522)	Cohen’s d^§	Test for depression with DP/DR versus depression only
Hypertension, % (n)	50.2% (4664/9300)	48.8% (292/598)	46.4% (241/519)		0.44
Systolic blood pressure in mm Hg, mean (SD)	132.3 (17.6)	128.1 (16.1)	127.6 (15.9)	-0.03	0.61
LDL/HDL ratio, mean (SD)	2.58 (0.92)	2.56 (0.94)	2.70 (1.00)	0.14	0.017
C-reactive protein (CRP) in mg/dl, median (Q1/Q3)	1.50 (0.50/3.00)	2.00 (0.93/4.10)	1.90 (0.89/4.20)	0.00	0.77
Coronary artery disease, % (n)	4.0% (367/9187)	5.4% (32/589)	5.8% (30/514)		0.79
Peripheral artery disease, % (n)	2.8% (256/9233)	4.2% (25/590)	6.8% (35/513)		0.063
Stroke, % (n)	1.6% (148/9272)	3.0% (18/594)	2.5% (13/517)		0.72
Heart Failure, % (n)	1.0% (95/9297)	2.8% (17/599	2.5% (13/521)		0.85
CKD, % (n)	0.8% (78/9299)	1.3% (8/599)	1.1% (6/522)		0.36
COPD, % (n)	3.9% (366/9297)	9.3% (56/599)	10.9% (57/522)		0.43
Diabetes, % (n)	8.4% (782/9301)	10.9% (65/599)	11.9% (62/522)		0.64
Cancer, % (n)	8.5% (791/9294)	8.7% (52/598)	10.2% (53/521)		0.41

Continuous variables are described by mean values with standard deviation in brackets (SD) or median values with 1st and 3rd Quantil in brackets (Q1 / Q3) if they are skew. Discrete variables are described through relative and absolute frequencies. Baseline data were compared by Chi-square test for dichotomous variables, t-tests for normally distributed continuous variables, and Wilcox rank sum test for more skewed continuous data
Note: In the comparison of participants who are depressed with those not depressed, all variables differed significantly except for hypertension, CKD, and cancer
^§Cohen’s for continuous variables

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