|  | ΔPDSS |  |
|---|
Î’ | t | p-value | FDR p value |
|---|
ΔACTH | 0.178 | 1.472 | 0.146 | 0.272 |
ΔCortisol | 0.431 | 3.879 | < 0.001 | 0.006 |
ΔFKBP51 | 0.156 | 1.216 | 0.229 | 0.275 |
ΔHSP90 | -0.017 | -0.140 | 0.889 | 0.889 |
ΔNR3C1 | 0.167 | 1.351 | 0.181 | 0.272 |
ΔPOMC | 0.223 | 1.927 | 0.058 | 0.174 |
- Δ: changes in PDSS, ACTH and cortisol levels, and the expression of HPA axis related-genes from baseline to 12 weeks later. All results of multivariate regression analysis with the Δ changes in the PDSS as dependent variable and the biomarkers as explanatory variable. All results are adjusted for possible effects of age, sex, body mass index, smoking and drinking behavior by forced entry of those variables in the regression. Not one of these variables had a significant effect
- ACTH: Adreno-cortico-tropic-hormone; PDSS: Panic Disorder Severity Scale; FKBP51: FKBP Prolyl Isomerase 51; HSP90: Heat Shock Protein 90; NR3C1: Nuclear Receptor Subfamily 3 Group C Member 1; POMC: Proopiomelanocortin
