Fig. 1

Analysis of gene-environment interactions between HTR2A rs3125 and negative life events using GMDR. The dark gray cell represents the high risk factors and the light gray cell represents the low risk factors. The left and right columns represent the maximum likelihood estimates of the weights for the MDD-SA and MDD-NSA groups, and are expressed as positive and negative scores. The sum of positive and negative score is used to judge the high or low risk of the combination. NO and YES denote no negative life events and have negative life events, respectively. Among them, individuals with GG genotype of rs3125 when exposed negative life events had the highest SA risk with the highest sum score. HTR2A, serotonin 2 A receptor; GMDR, generalized multifactor dimensionality reduction; MDD-SA group, major depressive depression with suicide attempts; MDD-NSA group, major depressive depression without suicide attempt