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Table 4 Multivariable analysis of past anxiety disorder (predictor) and candidate brain volumes (outcome, in cm3), adjusting for sociodemographic indicators

From: Brain volumes, behavioral inhibition, and anxiety disorders in children: results from the adolescent brain cognitive development study

Candidate brain structure

Past Anxiety

β

95% CI

Whole-brain

-6.907

-12.156 -1.658

Cortical Gray

-0.993

-2.442 0.457

White matter

-1.737

-2.961 -0.512

Amygdala

-0.019

-0.036 -0.001

Hippocampus

-0.029

-0.064 0.006

Nucleus accumbens

-0.004

-0.013 0.005

Insula

-0.060

-0.125 0.005

Anterior cingulate

-0.021

-0.125 0.082

Postetrior cingulate

-0.044

-0.097 0.009

Orbitofrontal cortex

-0.009

-0.128 0.108

Prefrontal

-0.446

-1.016 0.124

Caudate

0.001

-0.046 0.049

Putamen

-0.011

-0.069 0.048

Thalamus

-0.031

-0.081 0.018

Precuneus

-0.029

-0.154 0.096

Cuneus

-0.008

-0.061 0.046

Entorhinal

0.004

-0.030 0.038

Parahippocampus

0.004

-0.033 0.041

Precentral gyrus

-0.043

-0.185 0.099

Pallidum

0.005

-0.013 0.023

  1. Whole brain volume models do not include adjustment for ICV; sensitivity analyses including adjustment for ICV yielded similar conclusions
  2. In bold: associations with a p-value < 0.05. Underlined: p-value close to significance 0.05 < p-value ≤ 0.1
  3. CI confidence interval