Open Access
Open Peer Review

This article has Open Peer Review reports available.

How does Open Peer Review work?

Attitudes to antipsychotic drugs and their side effects: a comparison between general practitioners and the general population

  • Josef Helbling1,
  • Vladeta Ajdacic-Gross1Email author,
  • Christoph Lauber1,
  • Ruth Weyermann1,
  • Tom Burns2 and
  • Wulf Rössler1
BMC Psychiatry20066:42

DOI: 10.1186/1471-244X-6-42

Received: 04 August 2006

Accepted: 18 October 2006

Published: 18 October 2006

Abstract

Background

Attitudes towards antipsychotic medication play an important part in the treatment for schizophrenia and related disorders. We aimed measuring general practitioners' attitudes to antipsychotic drugs and their adverse side effects and comparing these with the attitudes of the general population.

Methods

Analysis and comparison of two representative samples, one comprising 100 General Practitioners (GPs), the other 791 individuals randomly selected from the general population. The setting was the German speaking cantons of Switzerland.

Results

General practitioners have significantly more positive attitudes towards anti-psychotic drugs than the general public. They reject widespread prejudices about the use of anti-psychotic medication significantly more than the general population. In particular the risk of dependency was assessed as 'low' by GP's (80%), in contrast to only 18% of the general population sample. In no instance did a majority of the GPs advise not tolerating any of the 10 possible adverse effects presented in this study. This is in marked contrast to the general population sample, where a majority recommended discontinuation for movement disorder (63%), strong tremor (59%), risk of dependency (55%) and feelings of unrest (54%).

Conclusion

As well as effective management of side-effects being a vital aspect of patient and carer education, prescribing doctors need to be aware that their mentally ill patients are likely to be confronted with extremely negative public attitudes towards antipsychotic medication and with strong pressures to stop taking their medication in the event of side-effects.

Background

Attitudes towards antipsychotic medication play an important part in the treatment for schizophrenia and related disorders. The effectiveness of antipsychotic medication is evident in acute and maintenance treatment of these disorders, and most mental health professionals recognize antipsychotic drugs as a cornerstone in treating affected people [1]. The general public, on the other hand, are often sceptical and negative in their attitudes to anti-psychotic drugs. They believe the risks of such drugs outweigh the possible benefits [2], and they are negatively stereotyped as being only "symptom alleviating", only "masking the actual problems"[3]. Negative attitudes of people with mental illness towards antipsychotic treatment are known to have a negative impact on their treatment adherence [46].

Side effects of antipsychotic drugs such as extrapyramidal symptoms contribute to their poor public perception [3], and there is extensive evidence that distress from side effects is an important contribution to noncompliance [7]. Tolerance of adverse side effects by patients is influenced, among others, by a good doctor patient relationship [8, 9], the attitudes of prescribing doctors, and their ability to explain the proposed treatment in an understandable way and to address patients' concerns [10].

Most General Practitioners (GPs) give medical care to psychotic patients. GPs ought to know the attitudes of these patients and should able to make allowances for the divergent perspectives. The goal of this study was to assess GPs attitudes towards anti-psychotic medications and their adverse side effects, and to what extent medical and public opinion on these subjects diverge.

Methods

This study design compared attitudes towards antipsychotic drugs and their side effects of general practitioners' and the general public using computer assisted telephone (CATI) interviews.

Samples

GPs

A letter outlining the study was sent to 190 general practitioners, selected at random from all GPs in the German speaking part of Switzerland in 2000. The sample was stratified by gender (50%:50%) in order to achieve comparability with the general population sample which had been investigated in a preliminary study [11]. One week after the letter, attempts were made to reach all 190 GPs by telephone. 23 could not be reached having moved, given up their practices, or were long term absent. Of the remaining 167, 100 agreed to participate, resulting in a response rate of 59.8%.

General population

The lay sample was derived from a public opinion survey on attitudes towards the mentally ill carried out in 1999. It is a representative sample of the Swiss residential population aged 16 to 76 years (N = 1737). Details about the public opinion survey have been published elsewhere [11, 12]. In this analysis, only the interviews from the German speaking part of Switzerland (N = 791) were used. The methodology of the public opinion survey (CATI, questions about antipsychotic medication and tolerance of side effects) was replicated in the present study.

Variables examined

Firstly, general attitudes towards anti-psychotic drugs were assessed by asking for agreement or disagreement with 7 statements [2] about their effectiveness, benefits and risks and about some widespread prejudices against them (specific questions see table 1). The interviewees were asked to rate each statement on a five point scale from 1 "completely correct" to 5 "completely wrong".
Table 1

Percentage distribution of GP's (N = 100) and public attitudes (N = 791) towards statements about antipsychotic medication

 

General Practitioners

lay persons

P

 

disagree

rather disagree

undecided

rather agree

agree

disagree

rather disagree

undecided

rather agree

agree

 

1. Antipsychotic drug treatment is the most effective way to treat mental illness

7.1

4

33.3

29.3

26.3

9

17.7

37.1

26.5

9.7

***

2. Antipsychotic drug treatment carries a high risk of dependency

45

35

12

3

5

3.7

14

27.8

33.6

20.9

***

3. The benefits of antipsychotic drug treatment far outweighs the risk associated with it

1

0

13

36

50

2.9

12

40.1

32.9

12.1

***

4. Treatment with antipsychotic drugs can only calm patients down

68.7

19.2

6

5.1

1

15.2

20

28.2

24.8

11.7

***

5. In the long run antipsychotic drugs make one even more ill than before

69

23

7

0

1

15

29.7

29.3

17.2

8.8

***

6. Mentally ill people are only tolerable for their relatives due to antipsychotic drug treatment

3

1

17.2

40.4

38.4

2.4

9

29.3

42.8

16.5

***

7. Since the introduction of antipsychotic drugs, the duration of stay in psychiatric hospitals has become much shorter

0

0

0

24.2

75.8

2.6

9.9

22.7

45.6

19.2

***

*** = p < 0.001 approximate significance level

Secondly, a vignette describing a person who met the DSM-III-R diagnostic criteria for schizophrenia was presented to all interviewees in the GP's sample and to 398 out of the 791 general population sample. Subjects were asked how long the person depicted should be willing to tolerate some side effects of medication (mouth dryness, sweating, tiredness, sexual dysfunction, feeling of unrest, weight gain, visible movement disorders, anhedonia, risk of drug addiction, tremor). The answers were represented by three response categories (never, up to 2–3 weeks, for longer periods). For more details about the questionnaire, see Lauber et al. [12].

Data analysis

The Mann-Whitney U-test was used to detect differences between the two samples. We performed no correction for multiple testing. The data were computed using the computer package SPSS, Version 9.0 for Windows.

Results

General attitudes towards antipsychotic medication

GPs reported generally very positive attitudes towards antipsychotic drugs. A vast majority (86%) thought that the benefits of antipsychotic drug treatment far outweigh the risk associated with it.

All GP's agreed with the assertion that the duration of stay in psychiatric hospitals has shortened since the introduction of antipsychotic drugs, and 79% state, that people with mental illness can only be supported by their relatives due to these treatments. However only 56% agreed with the assertion that antipsychotic drug treatment is the most effective way to treat psychotic illness.

All comparisons between GPs' and the general population's assessments show significant differences, most noticeably on whether antipsychotic drug treatment carries a high risk of dependency. Here 80% of the GPs assessed the risk as low but only 18% of the general population shared this opinion. Also, generalised prejudices against the medication were judged incorrect by the vast majority of general practitioners, whereas only a minority of the general population sample rejected them (Drugs can only calm down patients 88% vs. 35%, and make them even more ill 92% vs. 45%. For complete results see Table 1). On questions about the usefulness of anti-psychotic medication treatment (1, 3, 6 and 7), doctors assessed positive aspects significantly higher.

Tolerance of side effects

GPs show themselves to be more ambivalent on questions about how long certain antipsychotic drug side effects of should be tolerated (see Table 2). Long-term tolerance was advised despite dry-mouth (83%), heavy sweating (59%), significant weight gain (50%) and risk of drug dependency (68%). In eight out of 10 side effects, more than one third of the general practitioners opted to continue treatment for a further two to three weeks. Advice not to tolerate a side effect at all was never given by a majority of the GPs.

Table 2

Percentage distribution of GPs' (N = 100) and lay people's opinions (N = 398) as to how long the side effects of antipsychotic drugs should be tolerated

 

General Practitioners

lay persons

P

 

No tolerance

2–3 weeks

Long-term

No tolerance

2–3 weeks

Long-term

 

Unpleasant dry mouth

2

15.2

82.8

18.3

49.5

32.2

***

Heavy sweating

3

38.4

58.6

26.1

50.1

23.8

***

Continuous tiredness

5.1

54.5

40.4

24.4

56.9

18.7

***

Frequent sexual dysfunction

4.1

52.6

43.3

27.1

51

21.9

***

Continuous feeling of unrest

43.4

45.5

11.1

53.5

38.3

8.2

n.s.

Significant weight gain

9.3

41.2

49.5

35.9

46.4

17.7

***

Visible movement disorder

48.5

40.4

11.1

62.8

27.8

9.4

*

Continuous anhedonia

24.5

60.2

15.3

33.9

55.4

10.7

*

Risk of drug dependency

22.7

9.1

68.2

55.2

30.1

14.7

***

Marked tremor

33.7

54.1

12.2

58.9

33.7

7.4

***

*** = p < 0.001 * = p < 0.05 approximate significance level

This is in marked contrast to the general population sample. Here a majority voted not to tolerate treatment in the presence of movement disorder (63%), marked tremor (59%), risk of dependency (55%) and feeling of unrest (54%). GPs voted significantly more often for long-term tolerance than did the general population concerning the occurrence of all side effects with the exception of 'continuous feeling of unrest'. In spite of these differences, general practitioners and the public show some similar patterns: Both groups were least accepting of apparent movement disorders, continuing feeling of unrest, marked tremor and persisting anhedonia. Accordingly, the Spearman's r for "no tolerance" of side effects was .88 (p < .001) between GPs and the general population.

Discussion

The attitudes of mental health professionals and those of the public towards antipsychotic medication may be assumed to diverge. In addition to any personal reservations they may have about their treatment patients taking antipsychotic drugs are under pressure from public attitudes to doubt their benefits and efficacy. It is crucial for successful therapy that patients are well-informed by the prescribing physician and that they are also given comprehensive and appropriate information. Traditionally this is assumed to come from psychiatrists but Kendrick et al. [13] showed that long-term psychotic patients have frequent contact with their GPs and are influenced by their opinions. This study investigated the attitudes of general practitioners towards antipsychotic medication and compared them with the attitudes of the public.

Principal findings

General practitioners have significantly more positive attitudes towards the use of anti-psychotic drugs and opinions of their effectiveness than do the general public. They reject widespread prejudice about the use of such drugs significantly more strongly than the general public. It is highly likely that they will advise their patients to tolerate possible adverse side effects of these medications longer than lay persons do. There is no published literature on the attitudes of psychiatrists in this area so it is difficult to know if patients are exposed to differing professional opinions.

This study showed that the general population and the GPs have contrary ideas on the risk of drug dependency and whether or not drug dependency should be tolerated, with 80% of the GPs not agreeing that antipsychotics have a risk of dependency whereas the majority of the general population does. The two groups have comparable opinions on how long patients should accept visible movement disorders. Moreover, they both believe that the duration of inpatient stay has become much shorter since the introduction of antipsychotics, but reject the belief that people with mental illness are only tolerable for their relatives due to antipsychotic drug treatment.

Strengths and weaknesses of the study

This is the first study to assess GPs' attitudes towards antipsychotic drugs, and to compare these results with attitudes in a representative sample of the general population. There is likely to be a degree of bias in our findings as our subjects are likely to be drawn from amongst the more communicative and cooperative members of these populations., Respondents' answers could also be biased by social desirability. However we attempted to minimise this influence by choosing telephone interviews, which are generally considered superior to face-to-face interviews in terms of confidentiality and social desirability. [14].

Implications for clinicians and policymakers

Patients often doubt the benefits and the efficacy of antipsychotic drugs. They are also less tolerant of adverse side effects than their GPs would consider acceptable for the therapeutic benefits. GPs and the public differ very much in their opinions as to how long side effects should be tolerated. The ability to anticipate, manage and tolerate these side effects is a vital component of patient and carer education [8]. Prescribing doctors need also to recognise that their mentally ill patients will be exposed to extremely negative public attitudes towards antipsychotic medication. This will often be accompanied by advice to stop them in the event of side effects. Patients report a general lack of information on the reasons for prescribing anti-psychotics and on the side effects that may accompany them [15, 16]. Being better informed, particularly about side effects, should strengthen their resistance to ill-informed public opinion and prejudice.

New developments in psychiatric care such as "shared decision making" [17, 18] and an improved assessment and management of side effects [19] need to be more effectively communicated to the public, to improve general understanding and, consequently, attitudes to their use. There is a pressing need for public awareness programmes to raise understanding in this area.

The GPs' attitudes uncovered in this study also call for action. Their willingness to tolerate side effects for two to three weeks and their certain lack of understanding that antipsychotic drugs do not create dependency underline the need to develop education programmes specifically aimed at general practitioners about the rapidly developing field of antipsychotic medication.

Conclusion

In the context of mental disorders, the premisses regarding the use of antipsychotic drugs differ broadly. Prescribing doctors need to be aware that their mentally ill patients are likely to be confronted with extremely negative public attitudes towards antipsychotic medication. Doctors should anticipate the most relevant prejudices and address them explicitely.

Declarations

Acknowledgements

This study was supported by the Swiss National Research Foundation (grant no 32-52571.97) and an unconditional grant by Organon (Switzerland). We would like to thank the participants in the general practitioners survey and in the population survey who allowed us to learn about attitudes.

Authors’ Affiliations

(1)
Research Unit for Clinical and Social Psychiatry, Psychiatric University Hospital
(2)
Department of Psychiatry, University of Oxford

References

  1. Lehman AF, Lieberman JA, Dixon LB, McGlashan TH, Miller AL, Perkins DO, Kreyenbuhl J: Practice guideline for the treatment of patients with schizophrenia, second edition. Am J Psychiatry. 2004, 161 (2 Suppl): 1-56.PubMedGoogle Scholar
  2. Angermeyer MC, Daumer R, Matschinger H: Benefits and risks of psychotropic medication in the eyes of the general public: results of a survey in the Federal Republic of Germany. Pharmacopsychiatry. 1993, 26 (4): 114-120.View ArticlePubMedGoogle Scholar
  3. Benkert O, Graf-Morgenstern M, Hillert A, Sandmann J, Ehmig SC, Weissbecker H, Kepplinger HM, Sobota K: Public opinion on psychotropic drugs: an analysis of the factors influencing acceptance or rejection. J Nerv Ment Dis. 1997, 185 (3): 151-158. 10.1097/00005053-199703000-00004.View ArticlePubMedGoogle Scholar
  4. Donohoe G, Owens N, O'Donnell C, Burke T, Moore L, Tobin A, O'Callaghan E: Predictors of compliance with neuroleptic medication among inpatients with schizophrenia: a discriminant function analysis. Eur Psychiatry. 2001, 16 (5): 293-298. 10.1016/S0924-9338(01)00581-8.View ArticlePubMedGoogle Scholar
  5. Kampman O, Laippala P, Vaananen J, Koivisto E, Kiviniemi P, Kilkku N, Lehtinen K: Indicators of medication compliance in first-episode psychosis. Psychiatry Res. 2002, 110 (1): 39-48. 10.1016/S0165-1781(02)00030-6.View ArticlePubMedGoogle Scholar
  6. Lambert M, Conus P, Eide P, Mass R, Karow A, Moritz S, Golks D, Naber D: Impact of present and past antipsychotic side effects on attitude toward typical antipsychotic treatment and adherence. Eur Psychiatry. 2004, 19 (7): 415-422. 10.1016/j.eurpsy.2004.06.031.View ArticlePubMedGoogle Scholar
  7. Loffler W, Kilian R, Toumi M, Angermeyer MC: Schizophrenic patients' subjective reasons for compliance and noncompliance with neuroleptic treatment. Pharmacopsychiatry. 2003, 36 (3): 105-112. 10.1055/s-2003-39985.View ArticlePubMedGoogle Scholar
  8. Rettenbacher MA, Hofer A, Eder U, Hummer M, Kemmler G, Weiss EM, Fleischhacker WW: Compliance in schizophrenia: psychopathology, side effects, and patients' attitudes toward the illness and medication. J Clin Psychiatry. 2004, 65 (9): 1211-1218.View ArticlePubMedGoogle Scholar
  9. Vauth R, Loschmann C, Rusch N, Corrigan PW: Understanding adherence to neuroleptic treatment in schizophreniai. Psychiatry Res. 2004, 126 (1): 43-49. 10.1016/j.psychres.2003.07.004.View ArticlePubMedGoogle Scholar
  10. O'Donnell C, Donohoe G, Sharkey L, Owens N, Migone M, Harries R, Kinsella A, Larkin C, O'Callaghan E: Compliance therapy: a randomised controlled trial in schizophrenia. Bmj. 2003, 327 (7419): 834-10.1136/bmj.327.7419.834.View ArticlePubMedPubMed CentralGoogle Scholar
  11. Lauber C, Nordt C, Falcato L, Rossler W: Lay recommendations on how to treat mental disorders. Soc Psychiatry Psychiatr Epidemiol. 2001, 36 (11): 553-556. 10.1007/s001270170006.View ArticlePubMedGoogle Scholar
  12. Lauber C, Nordt C, Falcato L, Rossler W: Do people recognise mental illness? Factors influencing mental health literacy. Eur Arch Psychiatry Clin Neurosci. 2003, 253 (5): 248-251. 10.1007/s00406-003-0439-0.View ArticlePubMedGoogle Scholar
  13. Kendrick T, Burns T, Freeling P, Sibbald B: Provision of care to general practice patients with disabling long-term mental illness: a survey in 16 practices. Br J Gen Pract. 1994, 44 (384): 301-305.PubMedPubMed CentralGoogle Scholar
  14. Frey JH, Mertens Oishi S: How to conduct interviews by telephone and in person. 1995, Thousand Oaks, London, New Delhi , SageGoogle Scholar
  15. Allen MH, Carpenter D, Sheets JL, Miccio S, Ross R: What do consumers say they want and need during a psychiatric emergency?. J Psychiatr Pract. 2003, 9 (1): 39-58. 10.1097/00131746-200301000-00005.View ArticlePubMedGoogle Scholar
  16. Happell B, Manias E, Roper C: Wanting to be heard: mental health consumers' experiences of information about medication. Int J Ment Health Nurs. 2004, 13 (4): 242-248. 10.1111/j.1440-0979.2004.00340.x.View ArticlePubMedGoogle Scholar
  17. Hamann J, Leucht S, Kissling W: Shared decision making in psychiatry. Acta Psychiatr Scand. 2003, 107 (6): 403-409. 10.1034/j.1600-0447.2003.00130.x.View ArticlePubMedGoogle Scholar
  18. Naber D, Karow A, Lambert M: Subjective well-being under the neuroleptic treatment and its relevance for compliance. Acta Psychiatr Scand Suppl. 2005, 29-34. 10.1111/j.1600-0447.2005.00542.x.Google Scholar
  19. Morrison P, Meehan T, Gaskill D, Lunney P, Collings P: Enhancing case managers' skills in the assessment and management of antipsychotic medication side-effects. Aust N Z J Psychiatry. 2000, 34 (5): 814-821. 10.1046/j.1440-1614.2000.00821.x.View ArticlePubMedGoogle Scholar
  20. Pre-publication history

    1. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-244X/6/42/prepub

Copyright

© Helbling et al; licensee BioMed Central Ltd. 2006

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Advertisement