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Effect of a psycho-educational intervention for family members on caregiver burdens and psychiatric symptoms in patients with schizophrenia in Shiraz, Iran



This study explored the effectiveness of family psycho-education in reducing patients’ symptoms and on family caregiver burden.


Seventy Iranian outpatients with a diagnosis of schizophrenia disorder and their caregivers were randomly allocated to the experimental (n = 35) or control groups (n = 35). Patients in the experimental group received antipsychotic drug treatment and a psycho-educational program was arranged for their caregivers. The psycho-educational program consisted of ten 90-min sessions held during five weeks (two session in each week). Each caregiver attended 10 sessions (in five weeks) At baseline, immediately after intervention, and one month later. Validated tools were used to assess patients’ clinical status and caregiver burden.


Compared with the control group, the case group showed significantly reduced symptom severity and caregiver burden both immediately after intervention and one month later.


These results suggest that even need based short-term psycho-educational intervention for family members of Iranian patients with schizophrenic disorder may improve the outcomes of patients and their families.

Trial registration

IRCT Number:138809122812 N1`

Peer Review reports


Schizophrenia is a severe mental illness, which is stressful not only for the patients but also for their family members. Between 50% and 80% of patients with schizophrenia live with or have regular contact with family members [1], and rely on relatives for housing, and emotional and financial support. Therefore, the quality of their relationships greatly influences the patients’ outcomes [2]. However, these families report high levels of burden related to caring for a member with schizophrenia [3, 4]. As a result, studies have attempted to find a link between patients’ symptoms and family burden [5, 6]. Patient stressors such as negative and disruptive symptoms have been linked to increased burden in caregivers of patients with schizophrenia. Winefield and Harvey (1993) found a significant positive correlation between the level of behavioral disturbance in the patient and caregivers’ distress [5]. However, one study found no link between these patient stressors and family burden [7].

There are different types of family interventions for reducing the patient/caregiver burden such as behavioral family management, psychoeducational family intervention, family therapy, etc. In a recent study that compared different models of family interventions, the researchers concluded that psychoeducation was more useful in decreasing the burden in the mothers caring for their child suffering from schizophrenia [8]. Recent changes in the treatment of schizophrenia disorder make use of both traditional and psycho-educational interventions to treat the symptoms [914]. Several other studies have also demonstrated the efficacy of family psycho-educational interventions in reducing of relapses, re-hospitalization [1517] and family burden [1820]. The psycho-educational intervention is a set of systematic intervention based on supportive and cognitive behavior therapy approach with emphasis on patients and family needs. The intervention is focused on increasing patient and family knowledge about disease, better adjustment to illness, communication and facilitating problem solving skills [21]. Despite the current emphasis on community-based care and family psycho-education for these patients [2, 22, 23], these approaches have not been attempted in Iran yet. In a study by Mottaghipour and her colleagues, Sutherland Mental Health Service in New South Wales was used to show that organizational changes are needed to implement a “family friendly service” [24]. In an Iranian study, Malakouti and his colleagues conducted a comparative study of the clinical outcomes of mental health workers and consumers’ family members as case managers with 12 months of home-visit services for 129 patients with Schizophrenia. Burden, knowledge, quality of life and the general health condition of the care-givers, as well as positive/negative symptoms and social skills of the consumers were evaluated. Most clinical variables were improved without significant differences between groups. The hospitalization rate was reduced by 67% [25].

In addition, there are only limited studies focusing on Iranian populations with focus on patients and family need assessment, and it is unclear whether family psycho-education, which has been recognized as effective in European and American populations, can be applied successfully in Iranian family. Therefore, it is important to test the efficacy of psycho-education in enhancing family knowledge about the illness and the ability to cope with care giving role in Iranian families with a member who has schizophrenia.

Iranian families are characterized by their intimate interpersonal relationships and many interactions among family members. Therefore, illnesses in one family member results in a substantial burden for the whole family. In addition, Iranian families report a low level of formal support services as compared with their Western peers [26].

Currently, there are no community mental health centers specifically for following up patients with schizophrenia in Iran. The patients mainly refer to psychiatrists or Psychiatric centers or primary healthcare centers that do not clearly address the specific needs of each family. Moreover, since mental illness is considered as a taboo in our cultural settings and many families are not aware of the needs and illness of their patients, they experience a great amount of burden. Also, the patients nor their families do not receive routine non-pharmaceutical treatment such as family interventions. Moreover, we do not have trained professionals in this regard to perform such interventions.

Considering the lack of routine long term psychoeducational programs for patients with schizophrenia and their families based on their specific needs, we aimed to investigate the efficacy of family psycho-education in reducing patients’ symptoms and its efficacy of family psycho-education in reducing family caregiver burden.



This randomized controlled trial was conducted in Shiraz, a city of about 2.5 million inhabitants in southern Iran. Seventy caregivers patients with schizophrenia whose records were available at three psychiatric centers in Shiraz were randomized blindly to two groups considering the inclusion criteria and consulting with their psychiatrists. We developed our intervention based on the families’ needs and the modified existing literature in this regard [27, 28]. The psycho-educational program consisted of ten 90-min sessions held during five weeks (two sessions each week). Each caregiver attended 10 sessions (in five week) on the afternoon of their choice from the point of suitability of time. Four psycho-educational groups of eight or nine caregivers each were arranged with the same contents, and the program was conducted by a psychiatric nurse or psychiatrist.

The goals and contents of each of the ten sessions are summarized in Table 1. The beginning of the first session was practically a needs assessment session in which we asked the caregivers about the types of issues and problems they have with their patients and what they would like to know about their patient’s condition in order to better organize the interventions. After doing subjects’ need assessment,each psycho-educational session included a variety of educational techniques designed to enhance the participant's learning and maintain their attention (for example; visual aids such as charts, film presentation and Microsoft PowerPoint slideshows). The first part of each session consisted of a lecture given by a psychiatrist or psychiatric nurse and the last part of each session (30 min) consisted of a question-and-answer and group discussion period. During this period, the caregivers described situations and incidents related to their patients and discussed alternative ways of coping with and resolving their difficulties with care giving. At the second session, the guest speaker was a patient with a DSM-IV diagnosis of schizophrenia who had a clinically stable status. He related his experiences with his illness and offered insights to the caregivers. At the end of the sessions, an educational booklet was given to all family members.

Table 1 Content of psycho educational program

Approval for the study was obtained from the Ethics Committee of Shiraz University of Medical Sciences. Written consent was obtained from the patients and their families. All participants were informed about the purpose of the study and about their right to withdraw at any time, and were assured that all personal information would remain confidential.


The reviewed the records of all patients with schizophrenia which were available at the Psychiatric centers. We called those patients who met our inclusion criteria and told their family about their study and invited the patient and one of their family members who is the main caregiver to participate in our trial. The patients had lived with their families for at least two years. Therefore, seventy caregivers of outpatients with a diagnosis of schizophrenia disorder who were members of their immediate family were randomly allocated to the experimental (n = 35) or control group (n = 35). In the control group, only the patients received routine care (antipsychotic drug treatment) whereas in the experimental group, the caregivers participated in a psycho-educational program while the patients received antipsychotic drug treatment. The intervention was conducted by the same psychiatrist and psychiatric nurse. The co-researcher (assessor) was blind to study treatment and condition and completed the scales. We included caregivers whose patients had the following criteria: i) a diagnosis within the preceding 5 years of schizophrenia disorder according to DSM-IV criteria, and ii) no other Axis 1 disorder during recruitment. All caregivers who were invited to participate identified themselves as the primary caregiver with the greatest responsibility for providing care within the family, and they themselves had no known mental illness. It is necessary to mention that after the intervention a certificate of attendance was given to participant and thanked them accordingly.

The exclusion criteria for the study were: i) caregivers who had participated in another psycho educational program during the preceding year, ii) caring for more than one family member with mental illness, and iii) substance abuse problem in the patient.


Data were collected with a personal information sheet, the Iranian version of the Brief Psychiatric Rating Scale (BPRS) [29] which was completed for every patient by caregiver, and the Family Burden questionnaire [25]. The concept of family burden consists of two aspects, objective burden related to the performance of daily assistance activities, financial impact, behavior supervision and disruption of family routine, and subjective burden concerning worries about the patients and feelings of being disturbed by care giving activities.(26). A specially designed questionnaire was used to collect data on the participants’ age, sex, education, marital status, type of medication, the degree of patient compliance to taking medication, employment status, economic status, and relationship between the caregiver and the patient.

Before, immediately after and one month after the intervention, psychiatric symptoms were assessed with the BPRS. The BPRS is a widely applied instrument consisting of 16 symptom constructs for evaluating the psychiatric status of a patient and it is in four subscales: positive symptoms, negative symptoms, mania-hostility symptoms and depressive-anxiety symptoms. Each item is rated from 1 (absent) to 7 (very severe) (16 symptom constructs) [30]. This scale has been translated in persian and utilized in Fallahi’s (2007, 2011) studies. The coefficient for reliability of the tool was determined by chronbach’s alpha to be r = 0.8 in some studies [29, 31, 32]. Also Khodabakhshi Koolaee [2007] indicated satisfactory content validity and internal consistency with Cornbach’s alpha to be 0.72 [33].

The caregiver burden was estimated with the validated Persian version of the family Burden questionnaire. This instrument contains ten closed questions. It has been used in Iran and its reliability and validity has been proved by several studies. The reliability of the questionnaire was assessed by the Spearman-Brown correlation coefficient and reported to be 0.80 [26, 33, 34]. Also Schene reported the Cronbach’s alpha coefficient for reliability of the tool is based on internal consistency of 0.85 [35].

Statistical analysis

SPSS v. 15 was used for the statistical analysis. At baseline, sociodemographic characteristics in the two groups were compared with the chi-squared test. Between-group comparisons of the variables were done with Student’s t-test and repeated measurement analyses of variance were used to determine whether the improvements in these variables were changed over time.


A total of 65 families completed the study. Five participants (two from the experimental group and three from the control group) dropped out before completion of the study for different reasons unrelated to the study. The two groups of patients and their families did not differ significantly in any of the sociodemographic characteristics. Mean age of the patients in the experimental group was 32.5 years and that of their caregivers in the same group was 50.5 years. Mean age of the patients in the control group was 30 years and that of their caregiver in the same group was 52.5. Women made up 63% of the patients in the experimental group and 43% in the control group. Most of the patients in both groups were single and unemployed. The majority of caregivers in both groups were mothers of patients, most of whom had primary education and belonged to the middle class. All of the patients were on antipsychotic medication. No patient in either group was hospitalized during the study period. There were no significant differences regarding demographic data between the groups.

The patients’BPRS Means profile in experimental & control Group is shown in Figure 1 and FBS mean profiles in experimental & control Group is shown in Figure 2.

Figure 1
figure 1

BPRS Means profile in experimental & control Group.

Figure 2
figure 2

FBS Means profile in experimental & control Group.

The patients’ clinical status and family caregiver burden time 0 (baseline), time 1 (immediately after the intervention), and time 2 (one month post-intervention) is shown in Table 2.

Table 2 Patients’ clinical status and family caregiver time 0 (baseline), time 1 (immediately after the intervention), and time 2 (one month post-intervention)

Comparisons of the baseline scores of the variables (positive symptoms, negative symptoms, mania-hostility symptoms, depressive-anxiety symptoms, global BPRS score and family burden) detected no significant differences between the two groups.

The findings after completion of the psycho educational program indicated statistically significant differences between the two groups for negative symptoms (especially uncooperativeness) and depressive-anxiety symptoms, an improvement in the global BPRS score, and a reduction in the family burden score, with respect to the baseline (Table 2). One month post-intervention, there were statistically significant differences between the two groups in negative symptoms (especially uncooperativeness), depressive-anxiety symptoms and positive symptoms. In addition, we found major improvements in the global BPRS score as well as a greater reduction in family burden score with respect to the baseline. The mean scores at time 0 (baseline) and time 2 (one month post-intervention) indicated that the experimental group had improved steadily in the global BPRS score (P < 0.037) and family burden (P < 0.0001).


The family psychoeducation in this study demonstrated positive effects in reduction of family burden and patients symptoms immediately and one month after the intervention. Most previous family psychoeducational studies have focused on European and American populations [35], whereas some studies have been carried out in Asian populations including the Iranian population. Nevertheless, Iranian families are characterized by their intimate interpersonal relationships and many interactions among family members. Therefore, illnesses in one family member results in a substantial burden for the whole family. In addition, some Western studies reported formal support services for their patients [26, 36]. The present study focused on the impact of psycho educational intervention in Iranian families in which one member has schizophrenia. The results of our psycho educational intervention were encouraging and the caregivers in the experimental group indicated a significant decrease in family burden. Also, there was an improvement in most aspects of the BPRS in the patients they took care of. Improvement in the patient’s clinical status and decreases in family burden may be related to the family’s awareness of strategies for dealing with daily problematic situations [37]. In addition, our results may be related to family orientation to the patient’s symptoms and behavior, and to their skills of coping with them, consistent with other studies [38]. As a result of our intervention, family members may have learned to understand effective ways of expressing emotions in the family context. Also Xiong and her colleagues in their study about family-based intervention for schizophrenic patients in china mentioned that improvements in patients’ symptoms may have been related to enhanced treatment compliance because families were better able to supervise the patient’s use of antipsychotic drugs [36]. Also Niksalehi and colleagues (2011) reported that nursing home care services were more effective than telephone follow-ups for schizophrenic mental conditions [32].

The findings of this study are consistent with those of earlier research in other countries suggesting that participation in an educational and supportive group for caregivers of patients with schizophrenia results in better acceptance of the illness, and enhanced adaptability to their care giving role [38]. Medvene and Krauss found that mutual aid groups for caregivers of the mentally ill resulted in increased comfort in talking with other caregivers about their problems in care giving situations [39]. In addition, several studies have reported that the interactions between caregivers in groups may give rise to emotional support and practical help, which is extended to the post-intervention period [40]. Family psycho educational intervention may have a positive effect on family burden by reducing many patient risk factors of burden. This is consistent with the positive therapeutic effects of psycho education on family burden reported by other authors [41, 42]. Also Reza and colleagues (2004) in their study indicated that psycheducational programs can facilitate social adjustment of Iranian psychiatric patients [43].

Our control group, which received routine care, showed little improvement in the patient’s clinical status and family burden. These results may reflect the fact that routine services for schizophrenia patients and their families in Iran do not meet the patients’ and families’ needs.

Our study had some limitations. The sample size was relatively small, so larger studies are needed to confirm these results. The improvements in the patients’ symptoms and family burden were confirmed for a relatively short follow-up period of one month. Therefore, further studies are needed to confirm the long-term effects of this family psycho-educational intervention. Also more studies are recommended to perform and apply different models of psychoeducation, family to family intervention, etc.


The present findings show the efficacy of a family psycho-educational intervention both in improving the patient’s clinical status and in reducing the family caregiver burden in an Iranian sample. These results suggest that even a short-term psycho-educational intervention for family members of patients with schizophrenia can improve the outcomes for patients and their families. In addition, our results showed a correlation between symptoms of schizophrenia and family burden. Further research on this approach is needed for family caregivers from culturally different backgrounds in the Iranian population as well as the populations of other countries. One of the differences of this study compared with other studies in Iran is that we have performed needs assessment before intervention. Longer follow-up periods are recommended to determine the long-term effects of family psycho educational intervention on outcomes for patients and their families.


  1. Lehman AF, Steinwachs DM: The schizophrenia patient outcomes research team(PORT) treatment recommendations. Schizophr Bull. 1998, 24 (1): 1-10. 10.1093/oxfordjournals.schbul.a033302.

    Article  CAS  PubMed  Google Scholar 

  2. Dixon L, Adams C, Lucksted A: Update on family psycho education for schizophrenia. Schizophr Bull. 2000, 26 (1): 5-20. 10.1093/oxfordjournals.schbul.a033446.

    Article  CAS  PubMed  Google Scholar 

  3. Asen E: Multiple Family therapies: an overview. J Fam Ther. 2002, 24: 3-16. 10.1111/1467-6427.00197.

    Article  Google Scholar 

  4. Solomon P, Draine J: Subjective burden among family members of mentally ill adults. Am J Orthopsychiatry. 1995, 65: 419-427.

    Article  CAS  PubMed  Google Scholar 

  5. Winefield HR, Harvey E: Determinants of psychological distress in relatives of people with chronic schizophrenia. Schizophr Bull. 1993, 19 (3): 619-625.

    Article  CAS  PubMed  Google Scholar 

  6. McDonell MG, Short RA, Berry CM, Dyck DG: Burden in Schizophrenia caregivers: impact of family psycho education and awareness of patient suicidality. Fam Process. 2003, 42 (1): 91-103. 10.1111/j.1545-5300.2003.00091.x.

    Article  PubMed  Google Scholar 

  7. Lowyck B, De Hert M, Peeters E, Gilis P, Peuskens J: Can we identify the factors influencing the burden on family members of patients with schizophrenia?. Int J Psychiatry Clin Pract. 2001, 5: 89-96. 10.1080/136515001300374812.

    Article  Google Scholar 

  8. Khodabakhshi Koolaee A, Etemadi A: The outcome of family interventions for the mothers of schizophrenia patients in Iran. Int J Soc Psychiatr. 2010, 56 (6): 634-646. 10.1177/0020764009344144.

    Article  Google Scholar 

  9. Falloon IRH, Montero I, Sungur M, et al: Implementation of evidence-based treatment for schizophrenic disorders: two-year outcome of an international field trial of optimal treatment. World Psychiatry. 2004, 3 (1): 104-109.

    PubMed  PubMed Central  Google Scholar 

  10. Bustillo J, Lauriello J, Horan W, Keith S: The psychosocial treatment of schizophrenia: an update. Am J Psychiatry. 2001, 158: 163-175. 10.1176/appi.ajp.158.2.163.

    Article  CAS  PubMed  Google Scholar 

  11. Falloon IRH, Held T, Roncone R, Coverdale JH, Laidlaw TM: Optimal treatment strategies to enhance recovery from schizophrenia. Aust N Z J Psychiatry. 1998, 32 (1): 43-49. 10.3109/00048679809062704.

    Article  CAS  PubMed  Google Scholar 

  12. Sherman MD: Updates and five-year evaluation of the S.A.F.E. program: A family psycho educational program for serious mental illness. Community Ment Health J. 2006, 42: 213-219. 10.1007/s10597-005-9018-3.

    Article  PubMed  Google Scholar 

  13. Motlova L: Psycho education as an indispensable complement to pharmacotherapy in schizophrenia. Pharmacopsychiatry. 2000, 33: 47-48.

    Article  PubMed  Google Scholar 

  14. National Institute for Clinical Excellence: Clinical Guideline 1: Core interventions in the treatment and management of schizophrenia in primary and secondary care. 2002, NICE, London

    Google Scholar 

  15. Mueser KT, Sengupta A, Schooler NR, et al: Family treatment and medication dosage reduction in schizophrenia: effects on patient social functioning, family attitudes, and burden. J Consult Clin Psychol. 2001, 69: 3-12.

    Article  CAS  PubMed  Google Scholar 

  16. McFarlane WR, Dixon L, Lukens E, et al: Family psycho education and schizophrenia: a review of the literature. J Marital Fam Ther. 2003, 29: 223-245. 10.1111/j.1752-0606.2003.tb01202.x.

    Article  PubMed  Google Scholar 

  17. Falloon IRH: Family interventions for mental disorders: efficacy and effectiveness. World Psychiatry. 2003, 2: 20-28.

    PubMed  PubMed Central  Google Scholar 

  18. Stam H, Cuijpers P: Effects of family interventions on burden of relatives of psychiatric patients in the Netherlands: a pilot study. Community Ment Health J. 2001, 37: 179-187. 10.1023/A:1002717917019.

    Article  CAS  PubMed  Google Scholar 

  19. Berglund N, Vahlne JO, Edman A: Family intervention in schizophrenia: impact on family burden and attitude. Soc Psychiatr Psychiatr Epidemiol. 2003, 38: 116-121. 10.1007/s00127-003-0615-6.

    Article  Google Scholar 

  20. Bauml J, et al: A basic psychotherapeutic intervention for patients with Schizophrenia and their families. Schizophr Bull. 2006, 32: 51-59.

    Article  Google Scholar 

  21. Hazel NA, McDonell MG, Short RA: Impact of multiple-family groups for outpatients with schizophrenia on caregivers’ distress and resources. Psychiatr Serv. 2004, 55: 35-41. 10.1176/

    Article  PubMed  Google Scholar 

  22. Magliano L, Fiorillo A, Fadden G, Gair F, Economou M, Kallert T, Schellong J, et al: Effectiveness of a psycho educational intervention for families of patients with schizophrenia. World Psychiat. 2000, 4: 45-49.

    Google Scholar 

  23. Mottaghipour Y, et al: Working with families of patients within an adult mental health service: development of a programme model. Australian Psychiat. 2006, 14 (3): 267-271.

    Article  Google Scholar 

  24. Sun Kyung S, Ellen P: Effects of psycho education for Korean American with chronic mental illness. Psychiatr Serv J. 2002, 53: 1125-1131. 10.1176/

    Article  Google Scholar 

  25. Malakouti SK, et al: Case management for patients with Schizophrenia in Iran: a comparative study of the clinical outcomes of mental health workers and consumers’ family members as case managers. Community Ment Health. 2009, 45: 447-452. 10.1007/s10597-009-9197-4.

    Article  Google Scholar 

  26. Zoladl M, Sharif F, Kazemnejad A: Shared experiences of families with a mentally ill member. 2009, Tarbiat Modaress University, Tehran

    Google Scholar 

  27. Anderson CM, Reiss DJ, Hogarty GE: Schiziphrenia and Family: A practioner’s Guide to psychoeducation and management. , Guilford Press, New York

  28. Stengard E: Educational intervention for the relatives of schizophrenia patients in Finland. (Nord J Psychiatr. 2003, 57: 271-277. 10.1080/08039480310002093.

    Article  Google Scholar 

  29. Fallahi M: Effect of home-based psychiatric care on psychiatric symptoms of schizophrenic patients. J Rehabil. 2009, 6 (29): 75-79.

    Google Scholar 

  30. Overall JE, Gorham DR: Psychol Rep. 1962, 10: 799-812. 10.2466/pr0.1962.10.3.799. (Original 16-item version of BPRS)

    Article  Google Scholar 

  31. Fallahi M: Assessing the effects of psychiatric nursing home care services on mental status of schizophrenic patients. J Rehabil. 2006, 8: 75-79.

    Google Scholar 

  32. Niksalehi S, Fallahi M, Rahgo A, Rahgozar M, Khankeh HR, Bamdad M: Comparison the impact of home care services and Telephone Follow up on Rehospitalization and Mental condition of Schizophrenic patients. Res J Biol Sci. 2011, 6 (9): 440-445.

    Google Scholar 

  33. Khodabakhshi Koolaee A: Educational Programme for the Relatives of Schizophrenia. 2007, The third National Congress of Cultural and Social Psychiatry, Tehran

    Google Scholar 

  34. Azhar M: Comparative performance of chronic schizophrenia patients and their families before and after treatment [Thesis]. 2000, Isfahan University of Medical Sciences, Isfahan-Iran, 31-32.

    Google Scholar 

  35. Schene AH, Tessler RC, Ganache GM: Instrument measuring family or care giver burden in severe mental illness. Soc Psychiatr Psychiatr Epidemiol. 1994, 29: 228-240. 10.1007/BF00796381.

    Article  CAS  Google Scholar 

  36. Xiong W, Phillips MR, Wang R, et al: Family based intervention for schizophrenic patients in china. Br J Psychiatry. 1994, 165: 239-247. 10.1192/bjp.165.2.239.

    Article  CAS  PubMed  Google Scholar 

  37. Bandeira M, et al: Family burden interview scale for relatives of psychiatric patients: reliability study of the Brazilian version. Rev Bras Psiquiat. 2007, 29 (1): 47-50. 10.1590/S1516-44462006005000015.

    Article  Google Scholar 

  38. Borkman TJ: Understanding self-help/mutual aid: Experiential learning in the commons. 1999, Rutgers University Press, New Brunswick, NJ

    Google Scholar 

  39. Medvene L, Krauss DH: Causal attributions and parent-child relationships in a self-help group for families of the mentally ill. J Appl Soc Psychol. 1989, 19: 1413-1430. 10.1111/j.1559-1816.1989.tb01456.x.

    Article  Google Scholar 

  40. Citron M, Solomon P, Draine J: Self-help groups for families of persons with mental illness: perceived benefits of helpfulness. Commun Ment Health J. 1999, 35: 15-30. 10.1023/A:1018791824546.

    Article  CAS  Google Scholar 

  41. Dyck DG, Hendryx MS, Short RA, Voss WD, McFarlane WR: Service use among patients with schizophrenia in psycho educational multiple-family group treatment. Psychiatr Serv. 2002, 53 (6): 749-754. 10.1176/

    Article  PubMed  Google Scholar 

  42. Dyck DG, Short RA, Hendryx MS, Norell D, et al: Management of negative symptoms among patients with schizophrenia attending multiple-family groups. Psychiatr Serv. 2000, 51 (4): 513-519. 10.1176/

    Article  CAS  PubMed  Google Scholar 

  43. Reza GG, Shikha M, Habibollah AG: Efficacy of a psychoeducational programme for the social adjustment of psychiatric patients. Hong Kong J Psychiatry. 2004, 14 (3): 7-14.

    Google Scholar 

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The authors thank the patients and their families for their active contribution and participation in this research. We thank Dr Afshari, Assistant Professor of Statistics, Bushehr University of Medical Sciences and Dr Vosough from Biostatistics Department of Shiraz University of Medical Sciences, for the data analysis and statistical advice. We also thank the Vice-Chancellor for Research, Shiraz University of Medical Sciences for financial support for this research, which was done in partial fulfillment of the requirements for the M.Sc. degree awarded to M. Shaygan. We thank K. Shashok (Author AID in the Eastern Mediterranean) and Sarah Masoumi for improving the use of English in the manuscript, and M. Gholami at the Center for Development of Clinical Research of Nemazee Hospital for research assistance.

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Correspondence to Farkhondeh Sharif.

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FS, the main investigator, coordinated the research and wrote the first draft of the manuscript. MSH was responsible for data collection and contributed to the data analysis. AM assisted in the study design and liaised with the patients for the intervention. All the authors read and approved the final manuscript.

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Sharif, F., Shaygan, M. & Mani, A. Effect of a psycho-educational intervention for family members on caregiver burdens and psychiatric symptoms in patients with schizophrenia in Shiraz, Iran. BMC Psychiatry 12, 48 (2012).

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