Auditory change detection in schizophrenia: sources of activity, related neuropsychological function and symptoms in patients with a first episode in adolescence, and patients 14 years after an adolescent illness-onset

Table 3 ERP Characteristics for the Four Subject Groups

	EOS (n = 28)		C-EOS (n = 22)		S-14Y (n = 18)		C-14Y (n = 18)
	Mean	SD	Mean	SD	Mean	SD	Mean	SD
MMN trials accepted	64	10	68	9	65	13	63	10
MMN latency (at Fz, ms)	158¹	30	153¹	19	187²	26	164	32
MMN amplitude Fz, (135–165 ms)	-1.1^a	0.9	-2.1	1.1	-0.9	1.0	-1.5^b	0.9
Cz,	-0.7^a	1.1	-1.6	0.9	-0.6	1.2	-0.6^b	1.2
Right mastoid, μV	+0.9^a	0.9	+1.8	1.1	+0.9	1.7	+1.2^b	1.0

Patients with early-onset schizophrenia (EOS) and 14 years after initial diagnosis (S-14Y) and their age-matched controls (C-EOS, C-14Y) : A significant difference for MMN amplitudes (average-reference 135–165 ms) was found for 4 groups(F_3,82 = 5.1, P = .003). The effect was accounted for by the comparison between young subjects (F_1,48 = 15.2, P < .001) – with patient amplitudes reduced [a], and the comparison for young vs. older controls (F_1,38 = 6.0, P = .019) with amplitudes smaller in the older subjects [b]. Peak MMN latencies were earlier in younger than older patients¹, and later in S-14Y vs. C-14Y² (see text).

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