Hjorthoj C, Sturup AE, McGrath JJ, Nordentoft M. Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis. Lancet Psychiatry. 2017;4(4):295–301.
PubMed
Google Scholar
Correll CU, Solmi M, Veronese N, Bortolato B, Rosson S, Santonastaso P, et al. Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls. World Psychiatry. 2017;16(2):163–80.
PubMed
PubMed Central
Google Scholar
Nielsen RE, Uggerby AS, Jensen SO, McGrath JJ. Increasing mortality gap for patients diagnosed with schizophrenia over the last three decades--a Danish nationwide study from 1980 to 2010. Schizophr Res. 2013;146(1–3):22–7.
PubMed
Google Scholar
Lawrence D, Hancock KJ, Kisely S. The gap in life expectancy from preventable physical illness in psychiatric patients in Western Australia: retrospective analysis of population based registers. BMJ. 2013;346:f2539.
PubMed
PubMed Central
Google Scholar
Stubbs B, Vancampfort D, De Hert M, Mitchell AJ. The prevalence and predictors of type two diabetes mellitus in people with schizophrenia: a systematic review and comparative meta-analysis. Acta Psychiatr Scand. 2015;132(2):144–57.
CAS
PubMed
Google Scholar
Vancampfort D, Correll CU, Galling B, Probst M, De Hert M, Ward PB, et al. Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta-analysis. World Psychiatry. 2016;15(2):166–74.
PubMed
PubMed Central
Google Scholar
Rummel-Kluge C, Komossa K, Schwarz S, Hunger H, Schmid F, Lobos CA, et al. Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis. Schizophr Res. 2010;123(2–3):225–33.
PubMed
PubMed Central
Google Scholar
Lasser K, Boyd JW, Woolhandler S, Himmelstein DU, McCormick D, Bor DH. Smoking and mental illness: a population-based prevalence study. JAMA. 2000;284(20):2606–10.
CAS
PubMed
Google Scholar
Hjorthoj C, Ostergaard ML, Benros ME, Toftdahl NG, Erlangsen A, Andersen JT, et al. Association between alcohol and substance use disorders and all-cause and cause-specific mortality in schizophrenia, bipolar disorder, and unipolar depression: a nationwide, prospective, register-based study. Lancet Psychiatry. 2015;2(9):801–8.
PubMed
Google Scholar
Dipasquale S, Pariante CM, Dazzan P, Aguglia E, McGuire P, Mondelli V. The dietary pattern of patients with schizophrenia: a systematic review. J Psychiatr Res. 2013;47(2):197–207.
PubMed
Google Scholar
Fleury MJ, Grenier G, Bamvita JM, Caron J. Professional service utilisation among patients with severe mental disorders. BMC Health Serv Res. 2010;10:141.
PubMed
PubMed Central
Google Scholar
Andreassen OA, Djurovic S, Thompson WK, Schork AJ, Kendler KS, O'Donovan MC, et al. Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am J Hum Genet. 2013;92(2):197–209.
CAS
PubMed
PubMed Central
Google Scholar
Malan-Muller S, Kilian S, van den Heuvel LL, Bardien S, Asmal L, Warnich L, et al. A systematic review of genetic variants associated with metabolic syndrome in patients with schizophrenia. Schizophr Res. 2016;170(1):1–17.
PubMed
Google Scholar
Stubbs B, Firth J, Berry A, Schuch FB, Rosenbaum S, Gaughran F, et al. How much physical activity do people with schizophrenia engage in? A systematic review, comparative meta-analysis and meta-regression. Schizophr Res. 2016;176(2–3):431–40.
PubMed
Google Scholar
Andersen E, Holmen TL, Egeland J. Martinsen EW. Bang-Kittilsen G, et al. Physical activity pattern and cardiorespiratory fitness in individuals with schizophrenia compared with a population-based sample. Schizophr Res: Bigseth TT; 2018.
Google Scholar
Vancampfort D, Firth J, Schuch FB, Rosenbaum S, Mugisha J, Hallgren M, et al. Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis. World Psychiatry. 2017;16(3):308–15.
PubMed
PubMed Central
Google Scholar
Janney CA, Ganguli R, Richardson CR, Holleman RG, Tang G, Cauley JA, et al. Sedentary behavior and psychiatric symptoms in overweight and obese adults with schizophrenia and schizoaffective disorders (WAIST study). Schizophr Res. 2013;145(1–3):63–8.
PubMed
Google Scholar
Tremblay MS, Aubert S, Barnes JD, Saunders TJ, Carson V, Latimer-Cheung AE, et al. Sedentary behavior research network (SBRN) - terminology consensus project process and outcome. Int J Behav Nutr Phys Act. 2017;14(1):75.
PubMed
PubMed Central
Google Scholar
Vancampfort D, Rosenbaum S, Probst M, Soundy A, Mitchell AJ, De Hert M, et al. Promotion of cardiorespiratory fitness in schizophrenia: a clinical overview and meta-analysis. Acta Psychiatr Scand. 2015;132(2):131–43.
CAS
PubMed
Google Scholar
Vancampfort D, De Hert M, Sweers K, De Herdt A, Detraux J, Probst M. Diabetes, physical activity participation and exercise capacity in patients with schizophrenia. Psychiatry Clin Neurosci. 2013;67(6):451–6.
PubMed
Google Scholar
Ratliff JC, Palmese LB, Reutenauer EL, Liskov E, Grilo CM, Tek C. The effect of dietary and physical activity pattern on metabolic profile in individuals with schizophrenia: a cross-sectional study. Compr Psychiatry. 2012;53(7):1028–33.
PubMed
PubMed Central
Google Scholar
Mitchell AJ, Malone D, Doebbeling CC. Quality of medical care for people with and without comorbid mental illness and substance misuse: systematic review of comparative studies. Br J Psychiatry. 2009;194(6):491–9.
PubMed
Google Scholar
Bouchard C, An P, Rice T, Skinner JS, Wilmore JH, Gagnon J, et al. Familial aggregation of VO(2max) response to exercise training: results from the HERITAGE Family Study. J Appl Physiol (1985). 1999;87(3):1003–8.
Nokes N. Relationship between physical activity and aerobic fitness. J Sports Med Phys Fitness. 2009;49(2):136–41.
CAS
PubMed
Google Scholar
Lin X, Zhang X, Guo J, Roberts CK, McKenzie S, Wu WC, et al. Effects of Exercise Training on Cardiorespiratory Fitness and Biomarkers of Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2015;4(7).
Kim DD, Lang DJ, Procyshyn RM, Woodward ML, Kaufman K, White RF, et al. Reduced cardiovascular fitness associated with exposure to clozapine in individuals with chronic schizophrenia. Psychiatry Res. 2018;262:28–33.
CAS
PubMed
Google Scholar
Piascik MT, Perez DM. Alpha1-adrenergic receptors: new insights and directions. J Pharmacol Exp Ther. 2001;298(2):403–10.
CAS
PubMed
Google Scholar
Hermesh H, Shiloh R, Epstein Y, Manaim H, Weizman A, Munitz H. Heat intolerance in patients with chronic schizophrenia maintained with antipsychotic drugs. Am J Psychiatry. 2000;157(8):1327–9.
CAS
PubMed
Google Scholar
Herbsleb M, Schumann A, Malchow B. Puta C. Gabriel HW, et al. Chronotropic incompetence of the heart is associated with exercise intolerance in patients with schizophrenia. Schizophr Res: Schulze PC; 2018.
Google Scholar
Ostermann S, Herbsleb M, Schulz S, Donath L, Berger S, Eisentrager D, et al. Exercise reveals the interrelation of physical fitness, inflammatory response, psychopathology, and autonomic function in patients with schizophrenia. Schizophr Bull. 2013;39(5):1139–49.
PubMed
Google Scholar
Verge B, Alonso Y, Valero J, Miralles C, Vilella E, Martorell L. Mitochondrial DNA (mtDNA) and schizophrenia. Eur Psychiatry. 2011;26(1):45–56.
CAS
PubMed
Google Scholar
Rosenfeld M, Brenner-Lavie H, Ari SG, Kavushansky A, Ben-Shachar D. Perturbation in mitochondrial network dynamics and in complex I dependent cellular respiration in schizophrenia. Biol Psychiatry. 2011;69(10):980–8.
CAS
PubMed
Google Scholar
Firth J, Cotter J, Elliott R, French P, Yung AR. A systematic review and meta-analysis of exercise interventions in schizophrenia patients. Psychol Med. 2015;45(7):1343–61.
CAS
PubMed
Google Scholar
Vancampfort D, Rosenbaum S, Ward PB, Stubbs B. Exercise improves cardiorespiratory fitness in people with schizophrenia: a systematic review and meta-analysis. Schizophr Res. 2015;169(1–3):453–7.
PubMed
Google Scholar
Strassnig MT, Newcomer JW, Harvey PD. Exercise improves physical capacity in obese patients with schizophrenia: pilot study. Schizophr Res. 2012;141(2–3):284–5.
PubMed
Google Scholar
Bredin SS, Warburton DE, Lang DJ. The health benefits and challenges of exercise training in persons living with schizophrenia: a pilot study. Brain Sci. 2013;3(2):821–48.
PubMed
PubMed Central
Google Scholar
Rosenbaum S, Lagopoulos J, Curtis J, Taylor L, Watkins A, Barry BK, et al. Aerobic exercise intervention in young people with schizophrenia spectrum disorders; improved fitness with no change in hippocampal volume. Psychiatry Res. 2015;232(2):200–1.
PubMed
Google Scholar
Dodd KJ, Duffy S, Stewart JA, Impey J, Taylor N. A small group aerobic exercise programme that reduces body weight is feasible in adults with severe chronic schizophrenia: a pilot study. Disabil Rehabil. 2011;33(13–14):1222–9.
PubMed
Google Scholar
Heggelund J, Nilsberg GE, Hoff J, Morken G, Helgerud J. Effects of high aerobic intensity training in patients with schizophrenia: a controlled trial. Nord J Psychiatry. 2011;65(4):269–75.
PubMed
PubMed Central
Google Scholar
Scheewe TW, Takken T, Kahn RS, Cahn W, Backx FJ. Effects of exercise therapy on cardiorespiratory fitness in patients with schizophrenia. Med Sci Sports Exerc. 2012;44(10):1834–42.
PubMed
Google Scholar
Cassidy S, Thoma C, Houghton D, Trenell MI. High-intensity interval training: a review of its impact on glucose control and cardiometabolic health. Diabetologia. 2017;60(1):7–23.
PubMed
Google Scholar
Weston KS, Wisloff U, Coombes JS. High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis. Br J Sports Med. 2014;48(16):1227–34.
PubMed
Google Scholar
Engh JA, Andersen E, Holmen TL, Martinsen EW, Mordal J, Morken G, et al. Effects of high-intensity aerobic exercise on psychotic symptoms and neurocognition in outpatients with schizophrenia: study protocol for a randomized controlled trial. Trials. 2015;16:557.
PubMed
PubMed Central
Google Scholar
AmericanPsychiatricAssociation. Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub. 2013.
Bandura A. Health promotion by social cognitive means. Health Educ Behav. 2004;31(2):143–64.
PubMed
Google Scholar
Willems M, Bond T. Comparison of physiological and metabolic responses to playing Nintendo Wii sports and brisk treadmill walking. J Human Kinet. 2009;22:43–50.
Google Scholar
Balke B, Ware RW. An experimental study of physical fitness of air force personnel. U S Armed Forces Med J. 1959;10(6):675–88.
CAS
PubMed
Google Scholar
Carter J, Jeukendrup AE. Validity and reliability of three commercially available breath-by-breath respiratory systems. Eur J Appl Physiol. 2002;86(5):435–41.
PubMed
Google Scholar
Howley ET, Bassett DR Jr, Welch HG. Criteria for maximal oxygen uptake: review and commentary. Med Sci Sports Exerc. 1995;27(9):1292–301.
CAS
PubMed
Google Scholar
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J. 2005;26(2):319–38.
CAS
PubMed
Google Scholar
Quanjer PH, Stanojevic S, Cole TJ, Baur X, Hall GL, Culver BH, et al. Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations. Eur Respir J. 2012;40(6):1324–43.
PubMed
PubMed Central
Google Scholar
Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS, Committee GS. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO global initiative for chronic obstructive lung disease (GOLD) workshop summary. Am J Respir Crit Care Med. 2001;163(5):1256–76.
CAS
PubMed
Google Scholar
Wolff-Hughes DL, Bassett DR, Fitzhugh EC. Population-referenced percentiles for waist-worn accelerometer-derived total activity counts in U.S. youth: 2003–2006 NHANES. PLoS One. 2014;9(12):e115915.
Hart TL, Swartz AM, Cashin SE, Strath SJ. How many days of monitoring predict physical activity and sedentary behaviour in older adults? Int J Behav Nutr Phys Act. 2011;8:62.
PubMed
PubMed Central
Google Scholar
Matthews CE, Ainsworth BE, Thompson RW, Bassett DR Jr. Sources of variance in daily physical activity levels as measured by an accelerometer. Med Sci Sports Exerc. 2002;34(8):1376–81.
PubMed
Google Scholar
Rowe DA, Kemble CD, Robinson TS, Mahar MT. Daily walking in older adults: day-to-day variability and criterion-referenced validity of total daily step counts. J Phys Act Health. 2007;4(4):434–46.
PubMed
Google Scholar
Matthews CE, Chen KY, Freedson PS, Buchowski MS, Beech BM, Pate RR, et al. Amount of time spent in sedentary behaviors in the United States, 2003-2004. Am J Epidemiol. 2008;167(7):875–81.
PubMed
Google Scholar
Troiano RP. A timely meeting: objective measurement of physical activity. Med Sci Sports Exerc. 2005;37(11 Suppl):S487–9.
PubMed
Google Scholar
Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13(2):261–76.
CAS
PubMed
Google Scholar
Firth J, Stubbs B, Rosenbaum S, Vancampfort D, Malchow B, Schuch F, et al. Aerobic exercise improves cognitive functioning in people with schizophrenia: a systematic review and meta-analysis. Schizophr Bull. 2017;43(3):546–56.
PubMed
Google Scholar
Correll CU, Detraux J, De Lepeleire J, De Hert M. Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder. World Psychiatry. 2015;14(2):119–36.
PubMed
PubMed Central
Google Scholar
Vancampfort D, Stubbs B, Mitchell AJ, De Hert M, Wampers M, Ward PB, et al. Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis. World Psychiatry. 2015;14(3):339–47.
PubMed
PubMed Central
Google Scholar
Myers J, Prakash M, Froelicher V, Do D, Partington S, Atwood JE. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346(11):793–801.
PubMed
Google Scholar
Wasserman K, Hansen J, Sue D, Stringer W, Whipp B. Principles of exercise testing and interpretation. 5 ed: Lippincott Williams & Wilkins; 2012.
Bouchard C, Rankinen T. Individual differences in response to regular physical activity. Med Sci Sports Exerc. 2001;33(6 Suppl):S446–51; discussion S52–3.
Bassett DR Jr, Howley ET. Limiting factors for maximum oxygen uptake and determinants of endurance performance. Med Sci Sports Exerc. 2000;32(1):70–84.
PubMed
Google Scholar
Williams CJ, Williams MG, Eynon N, Ashton KJ, Little JP, Wisloff U, et al. Genes to predict VO2max trainability: a systematic review. BMC Genomics. 2017;18(Suppl 8):831.
PubMed
PubMed Central
Google Scholar
Brobakken MF, Nygard M, Guzey IC, Morken G, Reitan SK, Heggelund J, et al. Aerobic interval training in standard treatment of out-patients with schizophrenia: a randomized controlled trial. Acta Psychiatr Scand. 2019;140(6):498–507.
CAS
PubMed
Google Scholar
Beavers KM, Beavers DP, Nesbit BA, Ambrosius WT, Marsh AP, Nicklas BJ, et al. Effect of an 18-month physical activity and weight loss intervention on body composition in overweight and obese older adults. Obesity (Silver Spring). 2014;22(2):325–31.
Google Scholar