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Table 2 RNFL thickness and macular thickness in different groups

From: Factors related to retinal nerve fiber layer thickness in bipolar disorder patients and major depression patients

Thickness (Mean ± SD) Bipolar disorder group Depression group Normal Control group F P/p (post-hoc) P′
Right RNFL
 Total thickness (μm) 90.69 ± 19.97 100.18 ± 14.12 102.13 ± 14.32 12.29 < 0.001/< 0.001a/0.593b/0.016c 0.004
 Superior thickness (μm) 110.34 ± 29.22 123.59 ± 23.53 120.13 ± 14.32 3.14 0.045/0.022a/0.607b/0.067c 0.017
 Inferior thickness (μm) 116.72 ± 33.32 122.05 ± 23.05 130.17 ± 22.37 6.75 0.001/< 0.001a/0.168b/0.401c 0.823
 Disc area (mm2) 2.35 ± 1.15 2.62 ± 0.63 2.34 ± 0.67 1.17 0.313 0.202
 Cup volume (mm3) 0.10 ± 0.12 0.26 ± 0.24 0.11 ± 0.13 11.55 < 0.001/0.697a/< 0.001bc 0.934
Left RNFL
 Total thickness (μm) 91.61 ± 14.85 97.27 ± 16.71 103.71 ± 11.94 19.73 < 0.001/< 0.001a/0.033b/0.084c 0.001
 Superior thickness (μm) 115.13 ± 25.36 129.95 ± 21.32 128.55 ± 22.51 8.12 < 0.001/< 0.001a/0.788b/0.01c 0.010
 Inferior thickness (μm) 119.13 ± 26.78 115.45 ± 34.02 133.88 ± 18.68 13.65 < 0.001/< 0.001ab/0.513c 0.010
 Disc area (mm2) 2.24 ± 1.17 2.32 ± 0.64 2.24 ± 0.57 0.11 0.899 0.224
 Cup volume (mm3) 0.08 ± 0.11 0.18 ± 0.12 0.11 ± 0.13 5.16 0.006/0.150a/0.011b/0.001c 0.252
Right macular (μm)
 Average thickness 255.24 ± 14.47 287.34 ± 26.01 263.82 ± 41.93 1.79 0.168 0.688
 Central thickness 220.06 ± 48.22 215.67 ± 25.45 227.03 ± 23.87 3.10 0.046 0.218
 Inner superior 273.49 ± 70.54 271.97 ± 71.62 302.54 ± 16.22 20.45 < 0.001/< 0.001ab/0.855c 0.001
 Inner inferior 263.52 ± 68.68 257.86 ± 70.50 293.47 ± 19.67 23.55 < 0.001/< 0.001ab/0.499 0.001
 Inner nasal 271.97 ± 71.02 271.03 ± 70.95 298.85 ± 30.97 13.33 < 0.001/< 0.001a/0.001b/0.921 0.001
 Inner temporal 262.11 ± 76.56 255.37 ± 66.42 287.27 ± 15.86 16.94 < 0.001/< 0.001ab/0.431 < 0.001
 Outer ring superior 246.61 ± 62.93 241.34 ± 63.01 267.60 ± 14.81 15.72 < 0.001/< 0.001ab/0.739 0.013
 Outer inferior 234.05 ± 61.13 236.46 ± 61.03 255.79 ± 15.11 13.73 < 0.001/< 0.001a/0.002b/0.739c 0.005
 Outer nasal 257.19 ± 65.72 257.49 ± 66.69 283.07 ± 16.44 17.69 < 0.001 < 0.001ab/0.970 0.002
 Outer temporal 225.22 ± 61.27 226.51 ± 58.73 248.99 ± 16.62 16.83 < 0.001/< 0.001ab0.858c 0.002
Left macular (μm)
 Average thickness 253.15 ± 48.47 266.40 ± 18.28 263.91 ± 36.37 2.53 0.081/0.033a/0.722b/0.097c 0.858
 Central thickness 221.58 ± 45.12 225.85 ± 28.21 224.19 ± 21.71 0.33 0.718 0.620
 Inner superior 285.56 ± 54.35 295.82 ± 20.27 302.96 ± 17.16 10.69 < 0.001/< 0.001a/0.177b/0.089c 0.038
 Inner inferior 274.90 ± 51.80 287.97 ± 28.25 292.06 ± 20.18 9.45 < 0.001/< 0.001a/0.456b/0.037c 0.515
 Inner nasal 286.60 ± 54.18 293.18 ± 27.48 298.44 ± 26.10 3.63 0.027/0.008a/0.396b/0.351c 0.700
 Inner temporal 270.56 ± 53.12 271.39 ± 25.46 282.70 ± 18.62 6.24 0.002/0.002a/0.037b/0.891c 0.081
 Outerring superior 248.63 ± 52.68 268.39 ± 16.24 267.11 ± 17.73 12.83 < 0.001/< 0.001a/0.804b/0.001c 0.096
 Outer inferior 241.28 ± 50.35 252.82 ± 21.51 255.43 ± 18.16 7.39 0.001/< 0.001a/0.610b/0.048c 0.094
 Outer nasal 264.64 ± 50.12 277.97 ± 23.37 279.0 ± 25.18 5.96 0.003/0.001a/0.859b/0.045c 0.174
 Outer temporal 235.64 ± 48.95 248.03 ± 18.28 247.96 ± 18.87 5.89 0.003/0.001a/0.989b/0.032c 0.605
  1. P′: adjusted p for analysis of covariance after controlling for smoker, ALT, AST, Glucose, Cholesterol, Triglyceride, Uric acid (left eye also controlling for left eye pressure) with Ancova
  2. P (post-hoc)
  3. acomparison between Bipolar disorder group and Normal Control group
  4. bcomparison between Depression group and Normal Control group
  5. ccomparison between Bipolar disorder group and Depression group