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Table 2 RNFL thickness and macular thickness in different groups

From: Factors related to retinal nerve fiber layer thickness in bipolar disorder patients and major depression patients

Thickness (Mean ± SD)

Bipolar disorder group

Depression group

Normal Control group

F

P/p (post-hoc)

P′

Right RNFL

 Total thickness (μm)

90.69 ± 19.97

100.18 ± 14.12

102.13 ± 14.32

12.29

< 0.001/< 0.001a/0.593b/0.016c

0.004

 Superior thickness (μm)

110.34 ± 29.22

123.59 ± 23.53

120.13 ± 14.32

3.14

0.045/0.022a/0.607b/0.067c

0.017

 Inferior thickness (μm)

116.72 ± 33.32

122.05 ± 23.05

130.17 ± 22.37

6.75

0.001/< 0.001a/0.168b/0.401c

0.823

 Disc area (mm2)

2.35 ± 1.15

2.62 ± 0.63

2.34 ± 0.67

1.17

0.313

0.202

 Cup volume (mm3)

0.10 ± 0.12

0.26 ± 0.24

0.11 ± 0.13

11.55

< 0.001/0.697a/< 0.001bc

0.934

Left RNFL

 Total thickness (μm)

91.61 ± 14.85

97.27 ± 16.71

103.71 ± 11.94

19.73

< 0.001/< 0.001a/0.033b/0.084c

0.001

 Superior thickness (μm)

115.13 ± 25.36

129.95 ± 21.32

128.55 ± 22.51

8.12

< 0.001/< 0.001a/0.788b/0.01c

0.010

 Inferior thickness (μm)

119.13 ± 26.78

115.45 ± 34.02

133.88 ± 18.68

13.65

< 0.001/< 0.001ab/0.513c

0.010

 Disc area (mm2)

2.24 ± 1.17

2.32 ± 0.64

2.24 ± 0.57

0.11

0.899

0.224

 Cup volume (mm3)

0.08 ± 0.11

0.18 ± 0.12

0.11 ± 0.13

5.16

0.006/0.150a/0.011b/0.001c

0.252

Right macular (μm)

 Average thickness

255.24 ± 14.47

287.34 ± 26.01

263.82 ± 41.93

1.79

0.168

0.688

 Central thickness

220.06 ± 48.22

215.67 ± 25.45

227.03 ± 23.87

3.10

0.046

0.218

 Inner superior

273.49 ± 70.54

271.97 ± 71.62

302.54 ± 16.22

20.45

< 0.001/< 0.001ab/0.855c

0.001

 Inner inferior

263.52 ± 68.68

257.86 ± 70.50

293.47 ± 19.67

23.55

< 0.001/< 0.001ab/0.499

0.001

 Inner nasal

271.97 ± 71.02

271.03 ± 70.95

298.85 ± 30.97

13.33

< 0.001/< 0.001a/0.001b/0.921

0.001

 Inner temporal

262.11 ± 76.56

255.37 ± 66.42

287.27 ± 15.86

16.94

< 0.001/< 0.001ab/0.431

< 0.001

 Outer ring superior

246.61 ± 62.93

241.34 ± 63.01

267.60 ± 14.81

15.72

< 0.001/< 0.001ab/0.739

0.013

 Outer inferior

234.05 ± 61.13

236.46 ± 61.03

255.79 ± 15.11

13.73

< 0.001/< 0.001a/0.002b/0.739c

0.005

 Outer nasal

257.19 ± 65.72

257.49 ± 66.69

283.07 ± 16.44

17.69

< 0.001 < 0.001ab/0.970

0.002

 Outer temporal

225.22 ± 61.27

226.51 ± 58.73

248.99 ± 16.62

16.83

< 0.001/< 0.001ab0.858c

0.002

Left macular (μm)

 Average thickness

253.15 ± 48.47

266.40 ± 18.28

263.91 ± 36.37

2.53

0.081/0.033a/0.722b/0.097c

0.858

 Central thickness

221.58 ± 45.12

225.85 ± 28.21

224.19 ± 21.71

0.33

0.718

0.620

 Inner superior

285.56 ± 54.35

295.82 ± 20.27

302.96 ± 17.16

10.69

< 0.001/< 0.001a/0.177b/0.089c

0.038

 Inner inferior

274.90 ± 51.80

287.97 ± 28.25

292.06 ± 20.18

9.45

< 0.001/< 0.001a/0.456b/0.037c

0.515

 Inner nasal

286.60 ± 54.18

293.18 ± 27.48

298.44 ± 26.10

3.63

0.027/0.008a/0.396b/0.351c

0.700

 Inner temporal

270.56 ± 53.12

271.39 ± 25.46

282.70 ± 18.62

6.24

0.002/0.002a/0.037b/0.891c

0.081

 Outerring superior

248.63 ± 52.68

268.39 ± 16.24

267.11 ± 17.73

12.83

< 0.001/< 0.001a/0.804b/0.001c

0.096

 Outer inferior

241.28 ± 50.35

252.82 ± 21.51

255.43 ± 18.16

7.39

0.001/< 0.001a/0.610b/0.048c

0.094

 Outer nasal

264.64 ± 50.12

277.97 ± 23.37

279.0 ± 25.18

5.96

0.003/0.001a/0.859b/0.045c

0.174

 Outer temporal

235.64 ± 48.95

248.03 ± 18.28

247.96 ± 18.87

5.89

0.003/0.001a/0.989b/0.032c

0.605

  1. P′: adjusted p for analysis of covariance after controlling for smoker, ALT, AST, Glucose, Cholesterol, Triglyceride, Uric acid (left eye also controlling for left eye pressure) with Ancova
  2. P (post-hoc)
  3. acomparison between Bipolar disorder group and Normal Control group
  4. bcomparison between Depression group and Normal Control group
  5. ccomparison between Bipolar disorder group and Depression group
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BMC Psychiatry

ISSN: 1471-244X

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