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  1. The Bipolar Comprehensive Outcomes Study (BCOS) is a 2-year, prospective, non-interventional, observational study designed to explore the clinical and functional outcomes associated with ‘real-world’ treatment...

    Authors: Jayashri Kulkarni, Sacha Filia, Lesley Berk, Kate Filia, Seetal Dodd, Anthony de Castella, Alan JM Brnabic, Amanda J Lowry, Katarina Kelin, William Montgomery, Paul B Fitzgerald and Michael Berk
    Citation: BMC Psychiatry 2012 12:228
  2. Inflammatory Bowel Disease (IBD) patients report poorer quality of life (QoL) and more anxiety and depressive symptoms than controls from the general population. Cognitive behavioral therapy (CBT) is effective...

    Authors: Floor Bennebroek Evertsz’, Claudi LH Bockting, Pieter CF Stokkers, Chris Hinnen, Robbert Sanderman and Mirjam AG Sprangers
    Citation: BMC Psychiatry 2012 12:227
  3. Prior studies have suggested that the darkness of winter impacts the level of mental distress and sleeping problems. Our study investigated whether people living in the sub-arctic had more sleeping problems or...

    Authors: May Trude Johnsen, Rolf Wynn and Trond Bratlid
    Citation: BMC Psychiatry 2012 12:225
  4. Although persistent negative symptoms (PNS) are known to contribute significantly to poor functional outcome, they remain poorly understood. We examined the heuristic value of various PNS definitions and their...

    Authors: Cindy L Hovington, Michael Bodnar, Ridha Joober, Ashok K Malla and Martin Lepage
    Citation: BMC Psychiatry 2012 12:224
  5. ADHD is a common childhood onset mental health disorder that persists into adulthood in two-thirds of cases. One of the most prevalent and impairing comorbidities of ADHD in adults are substance use disorders....

    Authors: Zoe Huntley, Stefanos Maltezos, Charlotte Williams, Alun Morinan, Amy Hammon, David Ball, E Jane Marshall, Francis Keaney, Susan Young, Patrik Bolton, Karen Glaser, Raoul Howe-Forbes, Jonna Kuntsi, Kiriakos Xenitidis, Declan Murphy and Philip J Asherson
    Citation: BMC Psychiatry 2012 12:223
  6. Little is known about the long-term outcomes for patients with schizophrenia who fail to achieve symptomatic remission. This post-hoc analysis of a 3-year study compared the costs of mental health services and...

    Authors: Virginia S Haynes, Baojin Zhu, Virginia L Stauffer, Bruce J Kinon, Michael D Stensland, Lei Xu and Haya Ascher-Svanum
    Citation: BMC Psychiatry 2012 12:222
  7. Use of amphetamine and methamphetamine is widespread in the general population and common among patients with psychiatric disorders. Amphetamines may induce symptoms of psychosis very similar to those of acute...

    Authors: Jørgen G Bramness, Øystein Hoel Gundersen, Joar Guterstam, Eline Borger Rognli, Maija Konstenius, Else-Marie Løberg, Sigrid Medhus, Lars Tanum and Johan Franck
    Citation: BMC Psychiatry 2012 12:221
  8. Numerous structurally unrelated drugs, including antipsychotics, can prolong QT interval and trigger the acquired long QT syndrome (aLQTS). All of them are thought to act at the level of KCNH2, a subunit of th...

    Authors: Maciej Jakub Lazarczyk, Zahir A Bhuiyan, Nicolas Perrin and Panteleimon Giannakopoulos
    Citation: BMC Psychiatry 2012 12:220
  9. ADHD guidelines in the UK suggest that children and adults who respond to pharmacological treatment should continue for as long as remains clinically effective, subject to regular review. To what extent patien...

    Authors: Suzanne McCarthy, Lynda Wilton, Macey L Murray, Paul Hodgkins, Philip Asherson and Ian CK Wong
    Citation: BMC Psychiatry 2012 12:219
  10. With many atypical antipsychotics now available in the market, it has become a common clinical practice to switch between atypical agents as a means of achieving the best clinical outcomes. This study aimed to...

    Authors: Jihyung Hong, Diego Novick, Roberto Brugnoli, Jamie Karagianis, Martin Dossenbach and Josep Maria Haro
    Citation: BMC Psychiatry 2012 12:218
  11. Experimental animal studies and one population-based study have suggested an increased risk for adverse neurodevelopmental outcome after prenatal exposure to SSRIs. We describe the methods and design of a popu...

    Authors: Heli Malm, Miia Artama, Alan S Brown, Mika Gissler, David Gyllenberg, Susanna Hinkka-Yli-Salomäki, Ian McKeague and Andre Sourander
    Citation: BMC Psychiatry 2012 12:217
  12. Numerous medications have been tested on patients with pervasive developmental disorder not otherwise specified (PDD-NOS) and Asperger’s disorder. Although many of these medications have been demonstrated to b...

    Authors: Tsuyoshi Miyaoka, Rei Wake, Motohide Furuya, Kristian Liaury, Masa Ieda, Kazunori Kawakami, Keiko Tsuchie, Takuji Inagaki and Jun Horiguchi
    Citation: BMC Psychiatry 2012 12:215
  13. “Neuroleptic malignant syndrome” (NMS) is a potentially fatal idiosyncratic reaction to any medication which affects the central dopaminergic system. Between 0.5% and 1% of patients exposed to antipsychotics d...

    Authors: Julie Langan, Daniel Martin, Polash Shajahan and Daniel J Smith
    Citation: BMC Psychiatry 2012 12:214
  14. Synchronous neural oscillatory activity in the gamma range (30–80 Hz) has been shown to be abnormal in individuals with autism spectrum disorders (ASD) and their first-degree relatives in response to simple au...

    Authors: Kristina L McFadden, Susan Hepburn, Erin Winterrowd, Gwenda L Schmidt and Donald C Rojas
    Citation: BMC Psychiatry 2012 12:213
  15. Children with attention-deficit/hyperactivity disorder (ADHD) are two to three times more likely to experience sleep problems. The purpose of this study is to determine the relative contributions of circadian ...

    Authors: Reut Gruber, Laura Fontil, Lana Bergmame, Sabrina T Wiebe, Rhonda Amsel, Sonia Frenette and Julie Carrier
    Citation: BMC Psychiatry 2012 12:212
  16. Post-traumatic stress disorder (PTSD) is an anxiety disorder that develops after exposure to a life-threatening traumatic experience. Meta-analyses of the brainstem showed that midsagittal area of the pons was...

    Authors: Dongjuan Liu, Bing Xiao, Fang Han, Enhua Wang and Yuxiu Shi
    Citation: BMC Psychiatry 2012 12:211
  17. Polydipsia frequently occurs in schizophrenia patients. The excessive water loading in polydipsia occasionally induces a hyponatremic state and leads to water intoxication. Whether polydipsia in schizophrenic ...

    Authors: Tomohisa Nagashima, Makoto Inoue, Soichiro Kitamura, Kuniaki Kiuchi, Jun Kosaka, Koji Okada, Naoko Kishimoto, Toshiaki Taoka, Kimihiko Kichikawa and Toshifumi Kishimoto
    Citation: BMC Psychiatry 2012 12:210
  18. Treatment disengagement and non-completion poses a major problem for the successful treatment of patients with severe mental illness. Motivation for treatment has long been proposed as a major determinant of t...

    Authors: Eline C Jochems, Cornelis L Mulder, Arno van Dam, Hugo J Duivenvoorden, Sylvia CM Scheffer, Willem van der Spek and Christina M van der Feltz-Cornelis
    Citation: BMC Psychiatry 2012 12:209
  19. The everyday practical capabilities of dementia patients have a direct influence on a patient’s independence and thus on the person’s quality of life and on the amount of care needed. These capabilities are th...

    Authors: Katharina Luttenberger, Anke Schmiedeberg and Elmar Gräßel
    Citation: BMC Psychiatry 2012 12:208
  20. With an ageing population in most Western countries, people are living longer but often with one or more chronic physical health problems. Older people in physically poor health are at greater risk of developi...

    Authors: Louise Sharpe, Catherine B Gittins, Helen M Correia, Tanya Meade, Michael K Nicholas, Patrick J Raue, Sarah McDonald and Patricia A Areán
    Citation: BMC Psychiatry 2012 12:207
  21. Anxiety disorders are highly prevalent in primary care and cause a substantial burden of disease. Screening on risk status, followed by preventive interventions in those at risk may prevent the onset of anxiet...

    Authors: Neeltje M Batelaan, Jan H Smit, Pim Cuijpers, Harm WJ van Marwijk, Berend Terluin and Anton JLM van Balkom
    Citation: BMC Psychiatry 2012 12:206
  22. Patients with schizophrenia and their families have suffered greatly from stigmatizing effects. Although many efforts have been made to eradicate both prejudice and stigma, they still prevail even among medica...

    Authors: Ataru Omori, Amane Tateno, Takashi Ideno, Hidehiko Takahashi, Yoshitaka Kawashima, Kazuhisa Takemura and Yoshiro Okubo
    Citation: BMC Psychiatry 2012 12:205
  23. There is increasing evidence for the effectiveness of structured psychological therapies for bipolar disorder. To date however there have been no psychological interventions specifically designed for individua...

    Authors: Steven Jones, Lee D Mulligan, Heather Law, Graham Dunn, Mary Welford, Gina Smith and Anthony P Morrison
    Citation: BMC Psychiatry 2012 12:204
  24. The Brief Symptom Inventory (BSI), Mood & Anxiety Symptom Questionnaire −30 (MASQ-D30), Short Form Health Survey 36 (SF-36), and Dimensional Assessment of Personality Pathology-Short Form (DAPP-SF) are generic...

    Authors: Yvonne WM Schulte-van Maaren, Ingrid VE Carlier, Frans G Zitman, Albert M van Hemert, Margot WM de Waal, Martijn S van Noorden and Erik J Giltay
    Citation: BMC Psychiatry 2012 12:203
  25. Depression is a highly prevalent and disabling mental disorder with an incidence rate which appears to be increasing in the developed world. This fact seems to be at least partially related to lifestyle factor...

    Authors: Mauro Garcia-Toro, Miquel Roca, Saray Monzón, Margalida Vives, Bárbara Oliván, Enric Vicens, Joan Salva and Margalida Gili
    Citation: BMC Psychiatry 2012 12:201
  26. Our objective was to determine antioxidant defence activity in healthy controls (HC) and healthy unaffected second-degree relatives of patients with early onset psychosis (HC-FHP), and to assess its relationsh...

    Authors: Ana Gonzalez-Pinto, Monica Martinez-Cengotitabengoa, Celso Arango, Immaculada Baeza, Soraya Otero-Cuesta, Montserrat Graell-Berna, César Soutullo, Juan Carlos Leza and Juan Antonio Micó
    Citation: BMC Psychiatry 2012 12:200
  27. Antipsychotic drugs are considered a trigger factor for autonomic dysregulation, which has been shown to predict potentially fatal arrhythmias in schizophrenia. However, the dose-dependent effect of antipsycho...

    Authors: Yohko Iwamoto, Chiaki Kawanishi, Ikuko Kishida, Taku Furuno, Mami Fujibayashi, Chie Ishii, Norio Ishii, Toshio Moritani, Masataka Taguri and Yoshio Hirayasu
    Citation: BMC Psychiatry 2012 12:199
  28. Depression is predicted to become one of the two most burdensome diseases worldwide by 2020 and is common in people with chronic physical conditions. However, depression is relatively uncommon in Asia. Family ...

    Authors: Hairong Nan, Paul H Lee, Ian McDowell, Michael Y Ni, Sunita M Stewart and Tai Hing Lam
    Citation: BMC Psychiatry 2012 12:198
  29. The situation for older persons with mental disorders other than dementia disorders has scarcely been studied. The older population is increasing worldwide and along with this increase the prevalence of mental...

    Authors: Gunilla Martinsson, Ingegerd Fagerberg, Lena Wiklund-Gustin and Christina Lindholm
    Citation: BMC Psychiatry 2012 12:197
  30. The increasing burden on mental health services has led to the growing use of peer support in psychological interventions. Four theoretical mechanisms have been proposed to underpin effective peer support: adv...

    Authors: Judith G Proudfoot, Amisha Jayawant, Alexis E Whitton, Gordon Parker, Vijaya Manicavasagar, Meg Smith and Jennifer Nicholas
    Citation: BMC Psychiatry 2012 12:196
  31. Symptoms such as medically unexplained vaginal discharge (MUVD) are common and bothersome, leading to potentially unnecessary use of resources.

    Authors: Loulou Kobeissi, Ziyad Mahfoud, Brigitte Khoury, Fayssal El Kak, Zeina Ghantous, Marwan Khawaja, Rima Nakkash, Sami Ramia, Huda Zurayk, Ricardo Araya and Tim J Peters
    Citation: BMC Psychiatry 2012 12:195
  32. Methylphenidate (MPH), a psycho-stimulant, is the most widely administered drug for the pharmacological management of patients with attention deficit hyperactivity disorder (ADHD). This study attempts to deter...

    Authors: Yu-Shu Huang, Liang-Jen Wang and Chih-Ken Chen
    Citation: BMC Psychiatry 2012 12:194
  33. Schizophrenia is a significantly disabling disease that affects all major areas of life. There is a lack of comprehensive synthesis of research findings on the full extent of psychosocial difficulties (PSDs) e...

    Authors: Piotr Świtaj, Marta Anczewska, Anna Chrostek, Carla Sabariego, Alarcos Cieza, Jerome Bickenbach and Somnath Chatterji
    Citation: BMC Psychiatry 2012 12:193
  34. Treatment guidelines for major depressive disorder (MDD) are based on results from randomized clinical trials, among others in psychotherapy efficacy trials. However, patients in these trials differ from routi...

    Authors: Rosalind van der Lem, Wouter WH de Wever, Nic JA van der Wee, Tineke van Veen, Pim Cuijpers and Frans G Zitman
    Citation: BMC Psychiatry 2012 12:192
  35. Suicide is the leading cause of death among Japanese adolescents, and they may commit suicide differently from adults. However, there are few studies in medical-based data concerning adolescent patients seriou...

    Authors: Yoshitaka Kawashima, Takao Ito, Ryuichiro Narishige, Takuya Saito and Yoshiro Okubo
    Citation: BMC Psychiatry 2012 12:191
  36. Symptoms of hyperactivity are believed to fade with age leaving ADHD adults mostly inattentive and impulsive. Our aim was to test this assertion using objective measures of hyperactivity, impulsivity and inatt...

    Authors: Martin H Teicher, Ann Polcari, Nikolaos Fourligas, Gordana Vitaliano and Carryl P Navalta
    Citation: BMC Psychiatry 2012 12:190
  37. Depression is one of the most common mental disorders with a high prevalence among the older adults. In recent years, after realizing some side effects of the antidepressants, non-pharmacological psychological...

    Authors: Ting-ji Chen, Hui-jie Li and Juan Li
    Citation: BMC Psychiatry 2012 12:189
  38. Parental history of mood or anxiety disorders is one of the strongest and most consistent risk factors for the development of these disorders in offspring. Gaps remain however in our knowledge of whether mater...

    Authors: Nancy CP Low, Erika Dugas, Evelyn Constantin, Igor Karp, Daniel Rodriguez and Jennifer O’Loughlin
    Citation: BMC Psychiatry 2012 12:188
  39. Given the high prevalence of depression in primary health care (PHC), the use of screening instruments has been recommended. Both brief and long depression screening instruments have been validated in low and ...

    Authors: Dickens Akena, John Joska, Ekwaro A Obuku, Taryn Amos, Seggane Musisi and Dan J Stein
    Citation: BMC Psychiatry 2012 12:187
  40. Suicidal patients admitted to a psychiatric hospital are considered to be at risk of suicidal behavior (SB) and suicide. The present study aimed to seek predictors of SB recurrence of the high-risk patients by...

    Authors: Naoki Hayashi, Miyabi Igarashi, Atsushi Imai, Yuka Yoshizawa, Kaori Utsumi, Yoichi Ishikawa, Taro Tokunaga, Kayo Ishimoto, Hirohiko Harima, Yoshitaka Tatebayashi, Naoki Kumagai, Makoto Nozu, Hidetoki Ishii and Yuji Okazaki
    Citation: BMC Psychiatry 2012 12:186
  41. Cognitive behavioral therapy (CBT) with exposure and response prevention (ERP) is the first-line treatment for patients with obsessive-compulsive disorder (OCD). However, not all of them achieve remission on a...

    Authors: Elisabeth Hertenstein, Nina Rose, Ulrich Voderholzer, Thomas Heidenreich, Christoph Nissen, Nicola Thiel, Nirmal Herbst and Anne Katrin Külz
    Citation: BMC Psychiatry 2012 12:185
  42. This report presents the initial results of the first Epidemiological Catchment Area Study in mental health in Canada. Five neighbourhoods in the South-West sector of Montreal, with a population of 258,000, we...

    Authors: Jean Caron, Marie-Josée Fleury, Michel Perreault, Anne Crocker, Jacques Tremblay, Michel Tousignant, Yan Kestens, Margaret Cargo and Mark Daniel
    Citation: BMC Psychiatry 2012 12:183
  43. A few recent studies have found indications of the effectiveness of inpatient psychotherapy for depression, usually of an extended duration. However, there is a lack of controlled studies in this area and to d...

    Authors: Gilles Ambresin, Jean-Nicolas Despland, Martin Preisig and Yves de Roten
    Citation: BMC Psychiatry 2012 12:182
  44. Subthreshold depressive disorders (minor and subthrehold depression) have been defined in a wide range of forms, varying on the number of symptoms and duration required. Disability associated with these condit...

    Authors: Mar Rivas Rodríguez, Roberto Nuevo, Somnath Chatterji and José Luis Ayuso-Mateos
    Citation: BMC Psychiatry 2012 12:181
  45. Assessment of comorbid personality disorders (PDs) in patients with substance use disorders (SUDs) is challenging due to symptom overlap, additional mental and physical disorders, and limitations of the assess...

    Authors: Anne-Marit Langås, Ulrik Fredrik Malt and Stein Opjordsmoen
    Citation: BMC Psychiatry 2012 12:180
  46. In clinical practice, sleep disturbance is often regarded as an epiphenomenon of the primary mental disorder. The aim of this study was to test if sleep disturbance, independently of primary mental disorders, ...

    Authors: Håvard Kallestad, Bjarne Hansen, Knut Langsrud, Torleif Ruud, Gunnar Morken, Tore C Stiles and Rolf W Gråwe
    Citation: BMC Psychiatry 2012 12:179

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