- Open Access
European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD
BMC Psychiatry volume 10, Article number: 67 (2010)
Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe.
The European Network Adult ADHD, founded in 2003, aims to increase awareness of this disorder and improve knowledge and patient care for adults with ADHD across Europe. This Consensus Statement is one of the actions taken by the European Network Adult ADHD in order to support the clinician with research evidence and clinical experience from 18 European countries in which ADHD in adults is recognised and treated.
Besides information on the genetics and neurobiology of ADHD, three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated?
ADHD often presents as an impairing lifelong condition in adults, yet it is currently underdiagnosed and treated in many European countries, leading to ineffective treatment and higher costs of illness. Expertise in diagnostic assessment and treatment of ADHD in adults must increase in psychiatry. Instruments for screening and diagnosis of ADHD in adults are available and appropriate treatments exist, although more research is needed in this age group.
The European Network Adult ADHD
The European Network Adult ADHD was founded in 2003 and includes 40 professionals from 18 countries across Europe with an interest in and experience of ADHD in adults http://www.adult-adhd.net. This independent expert panel was set up to help improve the diagnosis and management of ADHD in adults throughout Europe. It is the opinion of the panel that today, due to lack of recognition and misunderstanding about the disorder and the use of appropriate, stimulant or non-stimulant medication, to control symptoms of ADHD, many adults with ADHD are misdiagnosed and are often prevented from receiving effective treatments. This may lead to unnecessary suffering for individual patients, their families and work colleagues.
Objectives of consensus statement
The objectives of this consensus statement are to increase awareness of the following: (1) That ADHD often presents as an impairing lifelong condition in adults, yet is currently underdiagnosed and treated in many European countries; (2) That instruments for screening and diagnosis of ADHD in adults are available; (3) That appropriate treatments exist.
Three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated?
This document is the result of three meetings between 2003 and 2009 in which the need for communication and a consensus statement in Europe were identified. A formally prepared document with consensus statements agreed by experts within the group was reviewed and discussed. Following this process the final document was circulated for written approval by all members of the European Network. For the assembly of the document, reviews and randomised controlled trials in adults were identified from Medline, Embase and the Cochrane Database, as well as from reviews on ADHD in children and cross-referencing and identification by the participating experts. Details of the clinical presentation of adults with ADHD were further informed by clinical expertise. This consensus statement is written for specialists in psychiatry but is also intended to increase the understanding of the disorder and to facilitate referral for diagnosis, treatment and follow-up from primary health care physicians and other health care providers.
ADHD is among the most common psychiatric disorders in childhood with well established diagnostic and treatment services available throughout most of Europe. Until recently, the disorder was considered by many to resolve during adolescence and young adulthood with little or no continued impact in adult life , although descriptions of the adult condition appeared in the psychiatric literature from 1976 onwards . However current evidence indicates that in the majority of cases ADHD persists into adult life where it is associated with a range of clinical and psychosocial impairments. Numerous follow-up studies of children with ADHD show that the disorder persists during adolescence and adulthood in around two-thirds of individuals [3–11] either as the full blown disorder or in 'partial remission' with persistence of some symptoms associated with continued clinical and psychosocial impairments. In the meta-analysis of these data from Faraone and colleagues it was concluded that about 15% retain the full diagnosis by age 25 years, with a further 50% in partial remission , indicating that around two-thirds of children with ADHD continue to have impairing levels of ADHD symptoms as adults.
Although in some cases the symptoms of ADHD may appear to diminish during adolescence, this may not be the case relative to controls and does not mean that functioning is unimpaired. In a follow-up study of 119 boys of 19 years of age with childhood onset ADHD, symptom levels seemed to be lower than in childhood but 90% still did not function well . Importantly, although symptoms levels appear to reduce as people grow older there are parallel changes among control groups; so that significant case-control differences are retained .
In a study from the World Health Organisation Mental Health Survey, it was found that childhood predictors of adult ADHD included the combined subtype of ADHD in childhood, symptom severity, the presence of comorbid depression, high rates of other comorbidities, social adversity and parental psychopathology ; while Biederman had previously reported family history of ADHD, psychosocial adversity and comorbidity with conduct, mood and anxiety disorders to be predictors of persistence . Nevertheless, all forms of ADHD are known to persist into adulthood including ADHD with predominantly inattentive symptoms and ADHD associated with milder levels of impairment and comorbidity.
The prevalence of ADHD in adults estimated from epidemiological studies is in the range of 2-5% [16–19]. Persistent forms of ADHD are thought to have a higher familial loading than ADHD that does not persist, with increased rates of ADHD among the parents and siblings of those with persistent ADHD and high rates of ADHD among the offspring of parents with ADHD . Twin and adoption studies indicate that the familiality of ADHD symptoms results from genetic factors rather than shared environmental risks, providing a further rationale for considering ADHD as a lifetime condition . ADHD occurs in around 10-20% of people with common mental health problems according to epidemiological and clinical research [22–27]. Further studies show that this rate may be higher in some clinical populations such as those attending forensic, addiction and personality disorder clinics, highlighting the importance of screening within such high risk populations .
There is growing recognition of the importance of diagnosing and treating the disorder in parents of children with ADHD  since around 20% of parents of children with ADHD will have ADHD themselves . Furthermore, parents with ADHD may have difficulty in implementing parent training strategies for the treatment of behavioural problems in their offspring. Since the recognition of ADHD is relatively recent throughout much of Europe there are in addition many adults with ADHD who were never diagnosed or treated for ADHD when they were children . Recent national guidelines now recommend that ADHD should be recognised and appropriately treated throughout the lifespan [32–34]. Despite this, across much of Europe many professionals working in adult mental health services remain unaware that ADHD frequently persists into adult life and remain uninformed about the clinical presentation and the consequences of ADHD across the lifespan.
Another reason for underdiagnosis and treatment of ADHD in adults is the age-dependent change in the presentation of ADHD symptoms. The more overtly impairing symptoms in childhood, hyperactivity and impulsivity, often become less obvious in adulthood, shifting the problem to more subtle symptoms such as inner restlessness, inattention, disorganisation and to impairment in behaviours related to executive functioning; and this may lead to discontinuation of treatment when they are still required [13, 31, 35–39]. Additional reasons for underdiagnosis of ADHD include the frequent presence of comorbid psychiatric syndromes, which in clinical practice may be identified as the primary or only diagnosis. Finally, stigma and myths continue to surround the condition and its treatment, particularly with stimulant medication [40, 41].
Stigma in general and among professionals
ADHD is an established disorder in childhood with child and adolescent mental health or paediatric services for ADHD available across most of Europe. Yet adult services for people with ADHD remain relatively scarce despite strong evidence for the benefits of diagnosing and treating ADHD in adults (reviewed in ). There are still many professionals that are unsure of the diagnosis and the appropriate use of ADHD medications in adult mental health. Some continue to express fears about treating a 'non-existent disease' or causing drug addiction with stimulant medication, despite evidence to the contrary . The reasons for this are likely to be based on the historical perception of ADHD as a disorder that is restricted to childhood and the continued presence of stigma and clinical mythology that surrounds the disorder and its treatment; and the traditional separation of adult from child psychiatry. What is clear is that there remains a gulf in the perception of the disorder between those working in paediatric and child and adolescent mental health services and those working in adult mental health, that cannot be explained on the basis of validated evidence based information .
Stigma related to the term ADHD is one component of the problem that nearly always arises in the context of lack of awareness or understanding of available data. Within the mental health profession stigma is further associated with the restricted regulatory status in many countries for most of the medications that treat ADHD in adults, but has other reasons as well. ADHD in adults remains a disorder which is poorly understood and where an 'emotional burden' is attached to the term especially among professionals who have not traditionally been involved in the diagnosis or treatment of ADHD [42, 44, 45]. People suffering from ADHD are often stereotyped as lazy, bad or aggressive, or considered to have a behavioural or special needs problem rather than a mental health disorder that requires treatment . The diagnosis may also be overlooked because ADHD is a highly symptomatic disorder and those less familiar with the onset, course, psychopathology and comorbidities associated with the disorder may mistake ADHD for other common mental health problems such as mood or personality disorders.
While increasing awareness and availability of accurate information is a high priority, many education programs for primary care physicians lack a component for ADHD so that a high percentage remain unaware of the way that ADHD affects people beyond the childhood years . Furthermore, education about adult ADHD has not been included in most college programs for medical and psychology students, as well as training of professionals in adult mental health. Education programs therefore need to target all stages of professional development, from students through to primary and secondary care physicians and psychologists, to ensure appropriate early recognition, diagnosis and treatment are provided. Referral to specialist clinics should be possible where secondary care physicians lack sufficient training for more complex cases.
In terms of treatment, stimulants are by far the best studied and most effective treatment for ADHD across the lifespan, yet their use in some parts of Europe remains controversial in children and more widely across Europe in adults. The recent National Institute for Health and Clinical Excellence (NICE) guidelines from the UK describes the situation in which a drug treatment is considered safe to give to children but not safe to give to adults as an "anomaly" . The NICE guidelines have been pivotal in the UK by providing national guidance for the development of clinical services for adults with ADHD and the recommendation of stimulants as the usual first line treatment. As a consequence many new clinics are being established and increasing numbers of adults are provided with effective treatment in the form of stimulants, despite the lack of formal recognition by regulatory bodies for use of medicines. The current lack of licensed indications for the use of stimulants in adults in most European countries (but not in the US) is not supported by available data, but rather results from the historical focus on ADHD as a child disorder, commercial considerations by pharmaceutical companies and caution from regulators: a situation that may be revised in the next 1-2 years in Europe as several formulations of methylphenidate and dexamphetamine are being put forward for registration. However, a recent safety review of the use of methylphenidate from the European Medicines Agency, which restricts its recommendation to children over 6 years of age and adolescents and does not mention use in adults, has led to methylphenidate no longer being licensed for use in countries such as Norway.
Genes, environment and neurobiology
Family, twin and adoption studies show that ADHD is a familial disorder with high heritability, indicating that a significant genetic component influences risk for the disorder [46–54]. Environmental factors are also likely to play a role either as main causal factors in a few cases  or by interaction with genetic risks.
Family studies indicate a risk to first degree relatives of 4 to 10 fold the population rate, with prevalence among first degree relatives in the range of 20-50% . Data from numerous twin studies of parent and teacher rated ADHD in children and adolescents indicate an average heritability (the variance explained by additive genetic factors) of around 76% , indicating that familial influences on ADHD are largely genetic. Furthermore twin studies that have investigated the continuity of ADHD at various developmental stages indicate that continuity of symptoms across the lifespan is largely the result of shared genetic effects [57–59]. Yet, studies of self-rated ADHD symptoms in adult population twin samples consistently report lower estimates of heritability, in the region of 30-40% from two published [59, 60] and one unpublished (Larsson et al., in preparation) study. The reasons for the lower heritability has not been fully investigated, but is likely to arise from the use of self-rating ADHD scales in population twin samples for two main reasons. First there may be a variable level of awareness among individuals when self-rating their own ADHD symptoms, leading to inaccurate ADHD symptom scores; and secondly self-ratings of ADHD symptoms may be confounded by adult onset conditions that generate ADHD-like symptoms, such as anxiety, depression, fatigue and drug and alcohol use. There is however as yet no empirical data to resolve these questions, so we have to conclude that further work is needed to fully understand the extent of genetic influences on ADHD in adults.
Molecular genetic studies in adults are relatively recent but are expected to confirm some genetic associations identified in childhood ADHD samples and find other genes that relate to persistence or remission of ADHD symptoms in adult life. There is a great deal of interest in the mechanisms by which the disorder persists in some individuals and remits in others, since this may identify new targets that prevent progression of the disorder into adult life. One potential mechanism is suggested by the developmental hypothesis of Jeffrey Halperin, which proposed that ADHD is linked to an early-appearing and enduring subcortical dysfunction (weak arousal mechanisms), while symptom remission is dependent on the extent of maturational changes in executive control [61, 62]. The emphasis is on the interaction between these two processes, with remission or persistence of ADHD symptoms related to the emerging balance between cortical and sub-cortical function. Whether the processes involved can be neatly separated into sub-cortical versus cortical is uncertain and requires further detailed investigations, however a recent large international study obtained evidence that the same two processes account for 85% and 12% respectively, of the genetic influences on ADHD .
Molecular genetic studies of ADHD in children provide direct support for the association of specific genes with ADHD. Genetic variants within or near to the D4 (DRD4) and D5 (DRD5) dopamine receptor genes provide the most consistent findings supported by meta-analysis . Numerous other studies find evidence of association with the dopamine transporter gene (DAT1), the dopamine beta-hydroxylase gene (DBH), the serotonergic transporter (5-HTT), the serotonergic receptor (HTR1B), and the synaptosomal-associated protein, 25 kDa (SNAP-25) . Taken together these candidate gene findings are thought to explain around 3.2% of the variance in ADHD symptoms in children . More recently whole genome association studies have identified novel genes such as CDH13 (a Cadherin gene) as potential risk factors  and rare copy number variants that confer higher risks in the order of odds ratios of 2-5, depending on general cognitive ability (Williams et al., reported at the World Congress of Psychiatric Genetics, 2009).
Molecular genetic studies have also turned to the study of ADHD in adults in recent years. Much of the current research coordinated in Europe by Barbara Franke from the Netherlands for the International Multicentre Persistent ADHD Collaboration (IMPACT) group. This collaboration has successfully generated a multi-site sample of around 3,000 patients and is continuing to develop. To date several publications highlight potential associations with ADHD in adults, some but not all of which are shared with genetic association findings in children [67–72].
Environmental factors are also associated with ADHD , particularly prenatal risk factors such as exposure to alcohol, nicotine, drugs, high blood pressure and maternal stress during pregnancy, as well as preterm birth and low birth weight [74–76]. Evidence from Romanian adoptees also suggests that severe early deprivation is causally related to ADHD . In some cases the environmental measure may be mediated by genetic effects and may not always implicate environmental exposure as the primary causal factor. For example there is new evidence that prenatal exposure to nicotine may reflect genetic effects rather than the direct toxic effects of nicotine or other constituents of tobacco smoke . Overall it is likely that environmental risk factors play an important role in the aetiology of ADHD and that in many cases the impact of the environment will be modified by genetic factors.
Neurocognitive, neurophysiological and neuroimaging studies suggest that brain dysfunctions are involved in the central components of the syndrome in children and adults [78–82]. Fronto-striatal dysfunction and increased dopamine transporter density in the striatum have both been reported [83–86] although the finding of increased dopamine transporter density remains a controversial finding, perhaps secondary to drug treatments for ADHD [87, 88]. Magnetic resonance imaging (MRI) studies indicate smaller volumes of caudate, corpus callosum, cerebellum and right frontal areas, as well as increased cortical thinning [89–97]. Functional MRI data show differences in brain functioning between ADHD and controls including some studies of drug naïve patients [91, 98–103]. Positron emission tomography (PET) shows abnormal cerebral glucose metabolism in prefrontal and premotor areas of the frontal lobe in ADHD adults [104–106]. In addition single photon emission computed tomography studies show studies show hypoperfusion and hypofunctioning of prefrontal and striatal regions in children and older adults with ADHD compared to controls [107, 108]. The immediate and marked response of ADHD symptoms to stimulant medications such as amphetamines and methylphenidate, which increase levels of synaptic dopamine, suggests that the main underlying pathophysiological process may involve deficits or imbalances in catecholaminergic, dopaminergic, and nicotinergic functioning [109–111].
Clinical Picture of ADHD in adults
Definition of ADHD
The two most frequently used diagnostic terms to describe the condition in childhood are attention-deficit/hyperactivity disorder (ADHD) and hyperkinetic disorder (HKD). For both definitions the disorder is defined as a clinical syndrome characterised by the presence of developmentally inappropriate levels of inattention, hyperactivity and impulsivity, starting in childhood and leading to impairment. The Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for ADHD as defined by the American Psychiatric Association are the most widely used criteria and describe three subtypes of ADHD based on the predominant symptom pattern: inattentive type, hyperactive-impulsive type and the combined type . The International Classification of Diseases (ICD-10) criteria for HKD as defined by the World Health Organisation (WHO) are more conservative and define a severe subgroup of people fulfilling the ADHD combined type diagnosis . This results in a lower estimated prevalence of HKD (about 1%) compared to the prevalence estimates of 4-8% for ADHD in childhood . ICD-10 criteria also exclude the presence of common co-occurring disorders including anxiety or depression  that are allowed under the DSM-IV definition of ADHD.
The next edition of the DSM (version 5) now in preparation is due to be published in 2013 and the revised ICD (version 11) for 2015. The revised DSMV criteria are expected to follow similar lines to the current criteria with the following expected changes http://www.dsm5.org:
Symptom thresholds: For older adolescents and adults (aged 17 and above) only 4 symptoms in either the inattentive or hyperactive-impulsive domain are required.
The list of hyperactive-impulsive symptoms has been increased to 13 to include 'uncomfortable doing things slowly or carefully', 'is often impatient', 'difficult to resist temptations or opportunities' and 'tends to act without thinking'.
Descriptions of symptom items have been elaborated to include more specific descriptions of behaviour, some of which are more applicable to adults.
The age of onset criteria has been broadened to include 'noticeable inattentive or hyperactive-impulsive symptoms by the age of 12 years'.
The requirement for clear evidence of impairment from the symptoms is a key part of the diagnostic criteria, but is no longer required before the age of 12 years or younger.
Autism spectrum disorder is no longer listed as an exclusion criterion.
These changes recognise that impairment from the symptoms of ADHD may develop later in life and that in some cases symptoms cannot be clearly identified until the early adolescent years. The reduction in the symptom threshold for adults as compared to children recognises the age-dependent changes in the course of the disorder, since the lower threshold in adults is still clinically significant where there is clear evidence of impairment from the symptoms of ADHD; and better reflects the characteristics and natural course of the disorder. These changes mean that many people who previously met the 'in partial remission criteria' will meet full criteria for ADHD under the revised DSM-V (see below for further discussion).
Clinical presentation in adults
Whereas the core symptoms of hyperactivity, impulsivity and inattention, are well characterised in children, these symptoms may have different and more subtle expressions in adult life. Comparison with the normal behaviour of age, gender and cognitive ability matched groups must be taken into account. For instance, where children with ADHD may run and climb excessively, or have difficulty in playing or engaging quietly in leisure activities, adults with ADHD are more likely to experience inner restlessness, inability to relax, or over talkativeness. Hyperactivity may also be expressed as excessive fidgeting, the inability to sit still for long in situations when sitting is expected (at the table, in the movie, in church or at symposia), or being on the go all the time. Impulsivity may be expressed as impatience, acting without thinking, spending impulsively, starting new jobs and relationships on impulse, and sensation seeking behaviours. Inattention often presents as distractibility, disorganization, being late, being bored, need for variation, difficulty making decisions, lack of overview, and sensitivity to stress. In addition, many adults with ADHD experience lifetime mood lability with frequent highs and lows, and short-fuse temper outburst [35, 37, 116–118]. Typically, adults with ADHD will not settle after the age of 30 but continue to change and/or lose jobs and relationships, either through boredom or being fired. They are usually underachievers with an estimated annual twenty two days of excess lost role performance [119–122]. As a consequence relationships and jobs are often short lived. Relationships that last are often impaired due to the inability to listen with concentration to the spouse, not finishing or procrastinating tasks, often being on a 'short fuse' and interrupting conversations . Driving accidents are increased in young adults with ADHD as a result of being distracted, impulsive and having an increased need for stimulation [124–127]. ADHD patients are also more likely to be subjected to other accidents like dog-bites and burns, and display an unhealthy lifestyle: smoking, alcohol and drug abuse, riskier sexual lifestyle, a delayed rhythm due to chronic sleep problems, lack of structure and inappropriate healthcare [128–132]. Criminality in adulthood is predicted by ADHD and comorbid conduct disorder in childhood, especially with substance abuse and antisocial personality disorder in adulthood. Among male prisoners, ADHD was found to be strongly related to the number of critical incidents involving aggression and poorly controlled behaviour even after controlling for the presence of antisocial personality disorder . ADHD patients are significantly more arrested, convicted, and incarcerated compared to normal controls, and ADHD is increasingly diagnosed in adults in forensic psychiatry [134–137].
An additional burden on family life may be the presence of one or more children with ADHD, which happens frequently due to the high familial risks of the disorder. Adults with ADHD are at risk for poorer parent-child relationships . Inattention problems often lead to inability to complete independent academic work, resulting in underachievement at school, during study and in the workplace compared to their peer group with equivalent cognitive ability. Therefore many have lower financial resources [17, 18, 139–141]. Many feel isolated and lonely due to social handicaps and shame about failures. They may have less success with personal growth, lower ability to present themselves in a socially appropriate fashion and lower mental and physical well-being, even in the presence of a high IQ [8, 121, 142–144].
The clinical picture of ADHD is also coloured by frequent co-morbidity. In childhood, as many as 65% of children with ADHD have one or more co-morbid conditions, including oppositional defiant and conduct disorder, anxiety and mood disorders, tics or Tourette syndrome, learning disorders and pervasive developmental disorders (e.g. autism) [145–147]. Similarly in adults, co-morbidity is the rule, with 75% of clinical patients having at least one other disorder, and the mean number of psychiatric comorbidities being three [41, 148]. Mood, anxiety, sleep, personality and substance use disorders are found, as well as learning and other neurodevelopmental disorders [22, 37, 41, 121, 144, 148–152]. ADHD has also been associated with earlier onset of substance abuse . In adults with ADHD, gambling and other addictions are very common [27, 154–158].
As boys dominate clinical samples of ADHD in childhood, female manifestations and gender differences have been relatively neglected in research as well as clinical practice [159–162]. In childhood ADHD is identified far more frequently in boys than girls with around a one in five ratio in most studies. However, the differences in prevalence and diagnostic rates according to gender become far less skewed with age, as more females are identified and become diagnosed in adulthood [17, 161, 163, 164]; and in some adult clinical series female cases may predominate.
Several factors may explain these observations. In childhood, girls may have less externalizing problems than boys: they suffer more from internalizing problems, chronic fatigue and inattention while boys may be more hyperactive and more aggressive [165, 166]. Girls show lower rates of hyperactivity and comorbid conduct disorder than males, and more frequently have the inattentive subtype of ADHD, with a later onset of impairment [162, 167]. For these reasons, general practitioners and health care professionals are less aware of ADHD in girls and they are thus less likely to be referred for treatment . In adulthood, the higher prevalence of anxiety and depressive disorders in women may conceal underlying ADHD and influence diagnosis and treatment. As more women seek help from psychiatrists than men, the change in referral pattern may also contribute to the change in gender ratio within clinical populations .
How can ADHD in adults be properly diagnosed?
Application of clinical criteria
Assessment starts with self-reported symptoms. The physician should perform an in depth diagnostic interview to look for the characteristic psychopathology by careful questioning about childhood and current behavioural symptoms. Although the patient appears to be the best informant, comparison with parent and partner reports in order to provide more information on severity and pervasiveness of symptoms, is desirable . Both DSM-IV and ICD-10 criteria recognise that symptoms of ADHD and HKD persist beyond childhood into adulthood, yet neither set of criteria takes account of age-dependent changes in terms of the number and severity of symptoms, or changes in the way that the symptoms of ADHD might present in adults. Rather, they stipulate the exact same criteria as that applied in children. However developmental changes occur that include an increasing role for inattention and other 'executive function' difficulties in the impairments related to the demands of adult life . The DSM-IV criteria suggest that adults who demonstrate only some of the symptoms of ADHD should be given a diagnosis of "ADHD, in partial remission". This diagnosis, however, seems to underplay the significance of impairments seen in adults who no longer meeting the full DSM-IV criteria but show persistence of some impairing symptoms from childhood. In other words adults seem to outgrow the criteria rather than the disorder.
We therefore conclude that a definition of remission based on the number of criteria that have to be met in childhood does not seem appropriate in clinical practice with adults, especially as symptoms described by both DSM-IV and ICD-10 criteria typically apply to children and are not adjusted for developmental age [13, 35, 172, 173]. Furthermore, restriction of the diagnosis to ICD-10 criteria that focused on a severe form of the combined subtype during childhood will lead to underdiagnosis of adults impaired by ADHD symptoms, especially in women. Symptoms of ADHD in adults should therefore be judged with reference to developmentally appropriate norms. Preliminary research suggests that using the current DSM-IV criteria that stipulate six of nine symptoms of either inattention or hyperactivity-impulsivity, a lower threshold of four of nine of these symptoms in either domain is sufficient to identify impairing levels of ADHD symptoms in adults [17, 174]. We therefore recommend that future criteria for ADHD are appropriately adjusted by taking into account age-related changes to symptoms and their relationship to impairment.
Further work is now required to clarify whether broadening the criteria to include those with four or more symptoms in either domain is sufficiently specific within adult mental health populations, since by lowering the threshold other acute psychiatric disorders may generate ADHD-like symptoms that reach this lower threshold. This is however mainly a problem for cross-sectional screening for ADHD, since in clinical practice the diagnosis is based on eliciting a history of ADHD symptoms that start in childhood or early adolescence and are persistent (trait-like) and impairing over time and can therefore be differentiated from adult onset disorders. The other approach under investigation is the identification of alternative descriptions of behavioural impairments seen in adults with ADHD, such as the ecological executive function deficits described by several authors in recent years [175, 176], which may show greater sensitivity and specificity for the diagnosis in adults.
As discussed, the expression of ADHD in adults is to some extent different from that in children and the diagnostic descriptions of some of the features need to be adapted to adult expressions of the disorder. For example, physical overactivity in children could be replaced in adulthood by constant mental activity, feelings of restlessness and difficulty engaging in sedentary activities. Furthermore a range of characteristics closely associated with the core ADHD syndrome often lead to some of the impairments typically seen in adults with ADHD. These include symptoms such as disorganization, short-fuse, temper, mood lability and sensitivity to stress [35, 116]. Assessment of symptoms is further complicated by the fact that adults have more ways to adapt and/or compensate for problems with attention, hyperactivity and impulsivity. For example adults with high IQ, high socio-economic status or lower levels of comorbid disorders may have better compensatory strategies.
Another difference in the evaluation of ADHD in adults is the usual reliance on self-report of symptoms rather than informant accounts of behaviour by parents and teachers. Although the validity of a retrospective diagnosis of ADHD in adults may be questioned in some cases, this is also true for other psychiatric diagnoses that are dependent on descriptions of current and past behaviour. Self-reports of past and current symptoms can however be reliable if the patient has good insight into the condition . Nevertheless, caution is needed as retrospective recall of childhood symptoms may be compromised in adults with ADHD, with under reporting found to be a common problem due to difficulties with accurate recall [9, 178]. While a diagnosis based only on self-report is possible, such an approach may lead to underdiagnosis of ADHD and it may be more reliable to use information from informants as well . Reliance on self-report alone may also risk over diagnosis in some cases, but until now, no evidence has emerged that this is the case . For these reasons it is recommended that whenever possible corroborating information is obtained from a living parent of older relative for childhood behaviour and a partner, relative or close friend for current behaviour and symptoms.
Another important criterion to evaluate is the age of onset. The DSM-IV criterion that some symptoms and impairment should be evident before the age of 7 years is difficult to assess accurately in a retrospective diagnostic assessment in adults. In fact, research has failed to validate to this criterion since it has been found that the clinical syndrome that defines ADHD has similar clinical predictions in terms of course, treatment response and associated impairments regardless of whether symptoms with impairment started before the age of 7 years or later [181–187]. This may be particularly important in relation to the inattentive type which is characterised by a later onset of impairment [172, 174, 188], as the inattentive symptoms may have been missed in the pre-school years and impairment may not have been noticed or reported until the age of secondary school.
A further problem is recall bias by parents, since after decades they may not accurately recall when symptoms or impairments started. Recent evidence found that on average parents typically report a later age of onset by around 5-years, even where earlier age of onset was known from previous health care records [170, 189, 190]. One approach to circumvent these problems is to refer to school reports which may provide more accurate and relevant information with respect to the age of onset.
For these reasons it is proposed to use a broader onset criterion, up to early to mid adolescence [186, 191] and this approach has been recommended in the recent National Institute of Health and Clinical Excellence in the UK . Clinical judgement should be used in making the diagnosis if symptoms before the age of 7-years cannot be recalled. In most cases a clear report of at least some symptoms associated with impairment is expected by early to mid-adolescence. However, even if there is no clear recall of childhood symptoms, ADHD should be considered when the typical syndrome that defines ADHD is present and there is evidence of lifetime persistence of symptoms indicative of ADHD and associated impairments. This may for instance, be the case in some inattentive but talented people in whom high general cognitive ability and a structured environment may have helped them to cope during childhood and adolescence. The problem of inattention may remain unrecognised until they tried to live independently from their parents and were faced with the organisational and attentional demands of higher education or employment .
In addition to the evaluation of symptoms, another important criterion for the clinical diagnosis of ADHD is the presence of significant levels of impairment associated with the symptoms. This is critical because the symptoms of ADHD are found to be continuously distributed throughout the population and there is no natural boundary between affected and unaffected individuals . As with symptoms of anxiety and depression, ADHD symptoms are experienced by most people at times. The disorder is therefore distinguished from the normal range by the severity (extreme nature) and persistence of symptoms, and their association with significant levels of impairment and risk for the development of co-occurring disorders. Criteria relate in part to cultural expectations and this may explain why diagnostic and treatment rates of ADHD are higher in the US than many European countries. From a mental health perspective it is however important to define the impairments from ADHD at a level that most people would consider needs some form of medical, psychological or educational intervention and represents a mental health problem . Furthermore, the diagnosis should not be applied to justify the use of stimulant medication to enhance performance in the absence of a wider range of significant impairments indicating a mental health disorder. Impairments include problems with the following: self-esteem, personal distress from the symptoms, social interactions and relationships, behavioural problems, and the development of comorbid psychiatric syndromes.
Current evidence clearly defines ADHD as a clinical syndrome associated with impairments in multiple domains including academic difficulties, impaired family relationships, social difficulties and increased rates of conduct problems. In adults with ADHD increased rates of antisocial, drug use, mood and anxiety disorders are reported in both cross-sectional and longitudinal follow-up studies; in addition to increased rates of unemployment, poor work performance, lower educational performance, increased rates of traffic violations and accidents and criminal convictions: reviewed in NICE, .
Finally, the high familial risk among first degree relatives, in the order of 20% or more [20, 194], means that a strong predictor for the ADHD in adults is having a parent, sibling or child with ADHD. Family history of ADHD should therefore raise the index of suspicion and provides further supportive evidence when evaluating individuals for ADHD.
The assessment process
Diagnosis is based on a careful and systematic assessment of a lifetime history of symptoms and impairment. It is not just based on a single clinical impression gained during consultation. Central to this process is the assessment of childhood-onset, current symptoms of ADHD and the presence of symptoms and impairment in at least two domains (school, work, home, interpersonal contacts). Associated features should be evaluated including mood lability, temper outbursts and comorbid disorders (see differential diagnosis). It is important to take a full medical history of psychiatric and somatic treatments, as well as a family history of psychiatric and neurological problems. It is useful to ask the patient about the pattern of symptoms, typical of ADHD and its co-morbidities in his/her family, taking into account familial factors and the high heritability of the symptoms. Patterns of comorbidity in children and adults with ADHD have been identified and include: mood, anxiety, sleep, conduct and substance use disorders as well as personality disorders. Some care must be taken to distinguish between symptoms that often co-occur with the core syndrome of ADHD (e.g. mood instability, ceaseless mental activity, avoiding situations such as waiting in lines when frustration may occur) from those of a separate comorbid condition (e.g. bipolar disorder, major depression, anxiety, personality disorder). Comorbidity being the rule rather than the exception, the evaluation of co-occurring symptoms, syndromes and disorders must always be part of the clinical assessment of adult ADHD [148, 150].
ADHD is also associated with increased rates of neurodevelopmental traits and disorders including autism spectrum disorder , dyslexia  and impaired motor coordination ; which are thought to arise from overlapping genetic influences. Such neurodevelopmental comorbidities are less well studied in adults with ADHD, but they are commonly observed in clinical practice and may lead to continued impairments following successful treatment of ADHD symptoms with medication. It has also been the practice in some European countries to look for soft neurological signs during the assessment of adult ADHD, in analogy with the diagnosis of DAMP in childhood (Deficits in Attention, Motor control and Perception), that often accompanies ADHD [198, 199]. However there is limited data on the DAMP syndrome in adults.
Comorbid substance use disorder (SUD) deserves special attention due to the high rates of ADHD within SUD populations. A bidirectional link between ADHD and SUD is reported [142, 200] with ADHD symptoms over represented in SUD populations  and SUD in ADHD populations . From twenty five published studies that screened for substance misuse in ADHD samples prevalence was estimated to be around 45% to 55%. Alcohol and cannabis are the most frequently abused substances in these populations  followed by lower rates of cocaine and amphetamine abuse . In contrast, from ten studies that screened for undiagnosed ADHD in SUD populations estimates of ADHD ranged from 11%  to 54% . The causes for such comorbidity are likely to be complex including altered reward processing in ADHD, increased exposure to psychosocial risk factors and self treatment. Sometimes patients with ADHD describe self-treatment with unprescribed stimulants, such as parents trying their child's medication. In some other cases, paradoxical reactions to drugs of abuse are reported by patients who feel calmer, better able to concentrate and are less impulsive. While consuming drugs with a stimulant action such as cocaine or amphetamine is described in a few cases, it is more common for adults to describe a general reduction in symptoms from alcohol and cannabis [206, 207].
Although there are many challenges in identifying undiagnosed ADHD in SUD settings, systematic screening is feasible . This is particularly important since SUD patients with comorbid ADHD often present with severe forms of SUD  characterised by early onset, extended duration of SUD, greater impairment and a shorter transition from substance use to dependence . ADHD has been found to increase suicide risk in SUD adolescents . In SUD treatment outcomes, methadone maintenance patients in the USA with significant ADHD symptoms in the two weeks prior to admission were less likely to achieve abstinence .
Close supervision is advised when treating ADHD patients with SUD with stimulants and in cases where diversion or abuse is a particular concern, atomoxetine may be selected as the first line treatment. Research in ADHD populations suggests that only a small minority divert or misuse their medication  and certain long acting formulations with a low abuse potential can be used, although studies of adolescents suggest that 75% of patients who do misuse medication have comorbid SUDs .
Instruments for screening and diagnosis
There are many screening instruments and diagnostic interviews available, some of which have been translated into different languages. Commonly used rating scales for screening include the ADHD Rating Scale, based on the DSM-IV criteria , and the six item World Health Organisation Adult ADHD Self-Report Scale (ASRS) Symptom Checklist (online available without limitation and in many different languages at http://www.hcp.med.harvard.edu/ncs/asrs.php. The ASRS includes questions for each of the 18 DSM-IV items, re-worded to better represent the presentation of the ADHD items in adults. The 6-item short version was selected on the basis of sequential logistic regression, to optimize concordance with the clinical classification; and was estimated to have a sensitivity of 68.7% and specificity of 99.5% with total classification accuracy of 97.9%, evaluated using population survey data . Specificity of this and other screening tools may be lower within clinical samples with high rates of other mental health disorders; and positive screens should always be followed by full diagnostic evaluations based on clinical interview data. The ASRS, for example, has been investigated in a sample with substance use disorders and the sensitivity found to be higher (87.5%) and specificity lower (68.6%) than that reported in the previous study .
To guide the diagnostic assessment process, other self-report questionnaires are available, such as the Brown ADD Scale Diagnostic Form (BADDS)  that measures only behaviours relating to executive functioning and inattention; the Conners' Adult ADHD Rating Scale that includes the DSM-IV criteria and has different versions for patients and for significant others (CAARS) ; and the Wender Utah Rating Scale (WURS)  that includes also symptoms of other, often comorbid disorders . The total symptom scores of the ADHD Rating Scale and the CAARS may be used to screen for ADHD and to evaluate treatment outcome.
For the main diagnostic assessment use of a structured diagnostic interview is advised, such as the Conners Adult ADHD Diagnostic Interview for DSM-IV (CAADID) . An alternative under development is the Diagnostic Interview for ADHD in adults (DIVA) . Although several of the rating scales and interviews are available in different languages there is a need for validating these translations for use throughout Europe.
Currently there are no neurobiological or neuropsychological tests for ADHD with sufficient sensitivity and specificity to serve as an individual diagnostic test . Functional imaging seems promising although more research is needed to establish its value [224–226]. Neuropsychological tests (e.g. the CANTAB tests, the Stop Signal Reaction Time, IQ or computerized tests of executive functions and speeded reaction time responses) may complement diagnostic assessments and can provide an objective index of cognitive functions in the patient with ADHD . There is a recent surge in interest in the use of cognitive-electrophysiology that may provide data that is more sensitive to the diagnosis than cognitive-performance data alone [228, 229]. Patients with ADHD may suffer additional cognitive deficits, which may contribute to functional impairment, such as in learning, reading, writing difficulties, in addition to impairments related to the autistic traits. As there are no established norms for learning disorders in adults, it may be difficult to distinguish these disorders from ADHD-related learning deficits. Further research is required to provide a full understanding of the cognitive impairments associated with ADHD in adults.
Despite the poor predictive value of cognitive performance tests, some experts conceptualise ADHD as primarily a deficit of executive functions. While this may not always be seen in cognitive performance deficits, impairments are usually seen in the way that people with ADHD manage daily tasks [175, 176]. Many problems reported by adults with ADHD are thought to reflect executive dysfunctions, including impaired self-organisation, attentional and emotional regulation, sustained effort and alertness; that may only been seen in performance deficits in every day life and not under test conditions. This has led to efforts to provide more sensitive behavioural descriptions of performance deficits seen in ADHD that in general reflect problems of self-control and self-regulation . These new studies are likely to lead to improved and more sensitive symptom and behavioural checklists for ADHD in adults.
It is important for the diagnosis of ADHD, as well as the correct targeting of treatments, to identify comorbid conditions such as mood, anxiety, psychotic, organic and substance use disorders; in addition to personality, tic and autistic spectrum disorders. Because adults with ADHD often exhibit low self-esteem, low mood, affective lability and irritability, these symptoms may sometimes be confused with dysthymia, cyclothymia or bipolar disorder and with borderline personality disorder. Furthermore daily mood changes in ADHD are very common, and represent a poorly regulated but essentially normal range of moods, rather than the more severe extremes of depression and elation seen in bipolar disorder; and it is argued that chronic mood instability should be considered part of the core syndrome of ADHD [118, 175, 231].
ADHD and borderline personality disorder seem to share impulsivity, affective instability, anger outbursts and feelings of boredom [35, 117, 218]. In the ADHD patient, impulsivity and anger is usually short-lived and thoughtless, rather than driven; conflict relationships, suicidal preoccupation, self-mutilation, identity disturbances and feelings of abandonment are usually less intense than in borderline personality disorder. However, the differences may not be clear-cut because in both disorders symptoms are chronic and trait-like. Importantly, individuals presenting with a diagnosis of personality disorder who present with the ADHD syndrome that started in childhood will in many cases benefit from pharmacological treatments for ADHD [232, 233]. Recent trials in ADHD patients indicate that besides ADHD symptoms, mood instability improves with both stimulant treatment and atomoxetine [234, 235]. As the order of treatment will depend on the presence of and severity of co-morbidities, evaluation of co-morbid disorders is a key component of the ADHD assessment using appropriate clinical diagnostic approaches.
How to treat adults with ADHD
The symptoms of ADHD can be treated effectively in both children and adults. The beneficial effects of stimulant medication and atomoxetine on the core symptoms of ADHD have been demonstrated in numerous studies in children. An increasing number of studies in adults demonstrate a similar clinical response to that seen in children [32, 236–239]. Due to the demands and responsibilities of adult life, adults face many problems that are different from those faced by children and they therefore need a different range of psychosocial and psychological treatments tailored to both their developmental level and ADHD. Psychological treatments in the form of psychoeducation, cognitive behaviour therapy, supportive coaching or assistance with organising daily activities are all thought to be effective [240–242]. Further research is however needed as there is an insufficient evidence base to recommend their routine use in clinical practice .
Impact of non-treatment
Long-term follow-up, epidemiological and clinical studies have shown that adults with untreated ADHD, when compared to normal controls, experience higher rates of academic failure, low occupational status, increased risk of substance use disorders (tobacco, alcohol or drugs), accidents and delinquency, and have fewer social relationships or friends [18, 121, 127, 131, 243, 244]. Patients diagnosed with ADHD in adulthood often complain that they did not receive treatment earlier in life and feel that their life would have been different if they had. Appropriate treatment could have prevented accidents and ongoing impairment at school, at work and in their peer and partner relationships. After decades of undiagnosed and unmet needs, the diagnosis offers an explanation for their problems which is valuable to a lot of patients and their family. Treatment of adult ADHD can influence psychosocial impairment that results as a consequence of 'core' ADHD symptoms, and may lead to improvements in associated features and comorbid disorders [245–247]. These include the following:
psychological functioning and self-confidence
interpersonal (broader than family) functioning
risk of substance use disorders
Optimal treatment algorithm
Similar to the treatment of ADHD in children, a multimodal approach to treatment of adults with ADHD and associated co-morbid disorders should be taken . Ideally, the treatment plan would also involve the adult's partner, family or close relationships. The multimodal approach includes:
psycho-education of ADHD and comorbid disorders
pharmacotherapy for ADHD and comorbid disorders
cognitive behaviour psychotherapy (individual and group)
Treatment focus in co-morbid ADHD
Treatment should follow careful diagnostic assessment of ADHD and associated comorbid disorders. In the case of comorbidity, the integrated treatment plan should address both ADHD and the comorbid condition, the order of pharmacological treatment depending on the type and severity of comorbidity. Generally, severe mental health disorders should be treated first, such as in-patients with psychosis, major depression, mania or drug addiction; following which the diagnosis of ADHD and need for treatment can be reviewed. However, treatment of milder depressive and anxiety disorders may be deferred until after treatment of ADHD and often needs no further treatment as the comorbid symptoms may resolve following effective treatment of ADHD. Symptoms such as demoralisation and low self-esteem following a life with ADHD, and mood instability, improve with stimulant treatment alone . It is up to the clinician to decide on what is the most important need for every patient with specialist advice being sort for more complex cases.
With respect to substance use disorders, ADHD is considered an important factor in its aetiology as the substances are often used for self-medication and may relieve symptoms like restlessness, inattention, impulsivity and sleep problems [207, 249–251]; or may be taken as part of stimulus seeking (novelty seeking) traits that are also associated with ADHD. In such cases, treatment of ADHD may help patients to stop substance use for self-medication [252–254] or may reduce impulsive stimulus seeking behaviour. However, systematic research has not provided a strong evidence base for appreciable improvements in ADHD when treated in the presence of substance use disorders [255, 256]; and drug or alcohol abuse disorders should always be targeted as a primary disorder. Treating ADHD in parallel with SUD can however be important in some cases, particularly where ADHD is severe or where there is good understanding and compliance for the treatment program.
However, in some countries, regulatory rules will not allow prescription of stimulants in patients with substance use disorders. Patients should be asked to register their drug/substance intake and be encouraged to stop their use. Despite concerns that pharmacotherapy with stimulant medication may be a risk factor for substance abuse, the literature supports the view that stimulant treatment for ADHD either has no impact in risk for substance abuse, or may even lower the risk of substance abuse by reducing the early onset of substance abuse in adolescents [206, 254, 257–259].
Psycho-education is the first step in the treatment plan and involves educating the patient and ideally also the partner or family about ADHD symptoms and impairment, the prevalence in children and adults, the frequent comorbidity, the heritability, the brain dysfunctions involved, as well as the treatment options. In many cases, simply providing the patient with this information may help the patient's understanding and bring him or her comfort. Often this process offers new insights into past difficulties. Relationship difficulties often decline after this sharing of information with family members. Feelings of guilt and remorse can be left behind, and the patient's social network may begin to be restored. This social network will prove invaluable to the patient during the treatment process. Informing the patient about the existence of self-help groups may be valuable, allowing him or her to join and share information and experiences, as well as to gain further comfort and understanding. There is a need to further develop structured psychoeducation programs with specific objectives.
Pharmacotherapy for adult ADHD in Europe
Stimulants (methylphenidate and dexamphetamine) are first choice medication treatments for ADHD in children and adults, based on an extensive and still growing body of data concerning efficacy and safety [32, 260]. Atomoxetine is usually considered the second line treatment, followed by other non-stimulants like bupropion, guanfacine, modafinil and tricyclic antidepressents, based on efficacy outcomes in controlled studies in different age groups [239, 261–264].
Stimulants are effective in about 70% of patients with ADHD in controlled studies [265–267] depending on the study design and maximum drug dosage. A recent European study of adults with ADHD showed the effectiveness of methylphenidate over a period of six months, in the longest double blind placebo controlled trial to date . Stimulant treatment not only improves the symptoms and impairing behaviours associated with ADHD, but also improves related problems such as low self-esteem, anger outbursts, mood swings, cognitive problems and social and family function. Side-effects are usually mild and transitory, mainly consisting of headache, reduced appetite, palpitations, nervousness, difficulty falling asleep, and dry mouth [148, 269, 270]. Stimulants may increase blood pressure and heart rate, and decrease weight, therefore patients should be assessed regarding these issues prior to, and monitored during treatment. Stimulants are not advised during pregnancy or breastfeeding and are contraindicated in psychotic disorders up to now; although some specialists have treated ADHD successfully in stable patients with schizophrenia maintained on antipsychotics . Relative contra-indications are hypertension, cardiac problems including angina, hypertrophic cardiomyopathy and arrhythmias, hyperthyroidism and glaucoma. For these disorders, first referral to and treatment by a specialist are needed before starting a stimulant. Stimulants may be used in autism with generally positive effects, although in some cases autistic features may worsen [272–275]. A recent meta-analysis indicated that treating ADHD in children with tic disorders is safe and effective [276, 277]. Stimulants have little impact on seizure threshold and may be used in epilepsy .
Although stimulants are by far the best studied and most effective treatment for ADHD, their use in some parts of Europe is still controversial in both children and adults. It is not yet common practice for doctors to prescribe stimulant medication to adults. As a result support services and expertise for treating ADHD in adults are not always available. As discussed earlier, the use of stimulants continues to be hampered by stigma and lack of up to date information in their use, with restricted access in many European countries .
The hesitancy and uncertainty about the appropriate use stimulant medication by both the general public and many physicians may also be related to the history of abuse with amphetamines in the past. Health authorities have given methylphenidate the same drug classification as amphetamines and they both perform similar to each other in traditional assays of abuse [280, 281]. Abuse potential has been studied by Nora Volkow (Director of the National Institute of Drug Abuse, USA) who showed that abuse potential relates to the route of administration, with rapid rise in dopamine levels following injection or snorting of stimulants. In contrast, during oral clinical use, methylphenidate elicits slow steady-state dopamine increases in the brain which mimic those of tonic neuron firing, rather than rapid dopamine changes associated with reinforcing drug-like effects . In the Volkow study it was found that intravenous methylphenidate could not be distinguished from cocaine by cocaine addicts, whereas this was not the case for oral methylphenidate. Therefore the use of extended release medications that have a slow rate of serum rise, are preferable to reduce potential for abuse and diversion.
Importantly, both clinical studies and clinical experience support the view that the methylphenidate does not lead to stimulant or drug addictions. On the contrary, it has been shown to have a neutral or reducing impact on substance abuse and the risk of relapse [206, 253, 254]. Furthermore, stimulants are not addictive from the clinical perspective. Adolescents treated from childhood generally use less stimulant medication or stop, using instead of taking more. A common problem is poor compliance or cessation of treatment during the adolescent years. There is also no clear evidence of tolerance over time. Neither has stimulant use been associated with adverse effects on driving, but rather is associated with an improvement in the concentration of ADHD patients during driving [127, 282]. The main potential problem associated with their use and reported in a number of studies from the US is the inappropriate diversion of stimulants, by parents self-treating themselves with their children's medication or as a cognitive enhancement medication for college students. This should not however detract from their specific use to reduce ADHD symptoms and associated impairments in people with ADHD .
Continued research in adult patients and education about efficacy and safety may help to overcome these problems. The non stimulant atomoxetine may be an alternative to treatment with stimulants in substance abuse patients with ADHD, although studies showing superiority over stimulants in this difficult patient population are still lacking [200, 284–286].
Types of stimulants
In the United States, more than ten different stimulant preparations have been developed for treatment of ADHD, the most recent being long acting formulations of oros-methylphenidate, mixed amphetamine salts, dexmethylphenidate and lis-dexamphetamine [265, 287, 288]. These improvements were necessary because of the very short half-life leading to relatively short duration of symptom control from immediate release methylphenidate (two to four hours) and dexamphetamine (three to five hours). The requirement for a longer duration of activity in adults, requires repetitive dosing with immediate release stimulants, of between three to four doses in most cases, and more often in others, to avoid rebound symptoms and for adequate control of ADHD symptoms during the day and evening [148, 270]. Compliance to such frequent dosing regimens is however poor in ADHD patients due to forgetfulness, inattentiveness and self-organisation problems, leading to daily instability by frequent rebound symptoms and ineffective treatment [148, 289–291].
Extended release preparations of stimulants have durations of action between 6 to 14 hours, which may permit once-daily dosing, although an adult may still need twice daily dosing of medication for a 12-16 hour day. Currently, combinations of immediate and extended release preparations are often prescribed in adults with the aim of tailoring the dose regime to the individual requirement and medication response of each patient. Dosing schemes and maximum daily dose vary across Europe (from 0.3-1.5 mg of methylphenidate/kg/day). However, the panel recommends that the dose of stimulants in adults should be individually adjusted, based on response and tolerability. The short half life of the medications suggest that it is more practical to consider maximum dose in terms of the maximum taken at each time point, the length of the effect of each dose on the control of ADHD symptoms, and the number of doses required to provide symptom control throughout the day; rather than a maximum based only on mg/kg per day. Individual differences in the optimal dose response to stimulant medication means that the best approach is to titrate the dose for each individual, starting at a low dose and increasing to an effective dose, while keeping side effects to a minimum; and should not be determined on a mg/kg basis.
In Europe, limited and different products are registered in the various countries. Some countries still only have access to immediate release methylphenidate and may or may not have access to dexamphetamine, while increasingly the longer-acting extended release preparations are being introduced. In Switzerland Dexmethylphenidate XR was licensed for use in adults in 2009 and this has been reported as a safe and effective option .
Second line pharmacotherapeutic treatments
For adults with ADHD who do not respond to stimulant therapy or who have a condition in which a stimulant is contraindicated, the non-stimulant atomoxetine that is licensed for child and adult ADHD in the USA is an appropriate alternative . Atomoxetine has an effect size of around 0.4 in adults [32, 293], a duration of action of 24 hours, and no abuse potential . Atomoxetine may be indicated in patients with comorbid substance use disorders, emotional dysregulation or social anxiety [295–297]. Other choices comprise medications like long acting bupropion, modafinil and guanfacine, that have all been investigated in ADHD [262, 298–300]. Tricyclic antidepressants like Desipramine, an imipramine metabolite, has been shown to be effective in adults with ADHD . However, these medications must be considered fourth line agents due to their side effects, limited value in treating the symptoms of inattention and relatively low effect size compared to stimulants in the treatment of ADHD .
In more complicated co-morbid cases, clinical experience indicates that treatment may be combined with antidepressants and mood stabilizers, although controlled studies are still lacking . A recent review on drug interactions in the treatment of ADHD concluded that methylphenidate appears to be more implicated in pharmacokinetic interactions suggestive of possible metabolic inhibition, while amphetamine was more involved in pharmacodynamic interactions and could potentially be influenced by medications affecting cytochrome P450 (CYP2D6) . Only monoamine oxidase inhibitors (MAOIs) are contradicted with the concomitant use of stimulants. Other drugs such as antidepressants and antipsychotics can be given at the same time as stimulants but in a few cases some adjustment in the dose of either drug might be required. Finally, there is no consistent evidence from randomised control trials for the use of food supplements, such as omega-3 fatty acids ADHD .
Coaching and Cognitive Behavioural Therapy
Pharmacotherapy alone is usually not sufficient to stabilise the many problems of adults with ADHD. Coaching provides a structured, supportive therapy, either individually or in group sessions. Coaching aims to teach problem-solving skills for identified practical problems. Due to a lifetime history of the impairment, adults with ADHD have typically not learnt practical organisational skills [306, 307] and may have developed poor coping skills and inappropriate behaviours in response to the impairments associated with ADHD.
A coaching program may include:
acceptance of the disorder
learning to deal with time management
learning to limit activities to 'one goal at a time'
organising home, administration, finances
dealing with relationship and work difficulties
learning to initiate and complete tasks
understanding emotional responses associated with ADHD
These components of coaching are also addressed by cognitive behavioural therapy for adult ADHD [241, 308]. According to the clinical experience of the panel, many adults may benefit from supportive and/or cognitive behavioural therapy in combination with pharmacotherapy. Other forms of psycho-social or family therapy may help with impairments associated with ADHD, such as relationship problems and low self-esteem . Psychotherapy targets the adaptation of the ADHD patient to a lifelong debilitating disorder and it may relieve co-morbid symptoms.
Current research does not support the efficacy of psychotherapeutic treatments as sole treatment for adult ADHD; neither do they relieve the core symptoms of ADHD. They are however considered an import adjunctive treatment for people who prefer a psychological approach or where residual symptoms or comorbidities remain. CBT has a strong evidence base for the treatment of some of the comorbidities associated with ADHD yet there are few controlled trials in adults with ADHD. The findings in ADHD are reviewed by the Research Forum on Psychological Treatments for Adults with ADHD, who identified moderate to large effect sizes from five empirical studies. They concluded that psychological treatments may play a critical role in the management of adults with ADHD who are motivated and developmentally ready to acquire new skills as symptoms remit . Safren and colleagues  compared CBT plus medication with medication treatment alone and found significantly greater improvements for ADHD symptoms and anxiety and depression scores in the combined treatment group. Similar findings were reported by Rostain and Ramsey , while a further study reported added benefits from CBT and psychoeducation delivered in a brief intensive group format . Alternative strategies have focused on strengthening cortical (executive) function with several studies indicating treatment effects in ADHD symptoms using techniques such as working memory training and neurofeedback and cognitive remediation therapy in children [312–316] and meta-cognitive training in adults . A full review of psychological approaches for ADHD throughout the lifespan has recently be published by Young and colleagues 
Prognosis and costs
ADHD in adults presents as a lifelong condition that started during childhood. The precise details of the clinical presentation may change with age and with the demands of adult life, but are broadly similar to those seen in children. As medication treatment for ADHD does not cure the disorder and some or all symptoms may return after discontinuation of medication, long-term pharmacological and psycho-social treatment may be necessary. The poor long term prognosis of untreated ADHD has implications for the costs of illness. In children, the economic burden of ADHD has been estimated to be approximately double those of normal controls, due to substantially more inpatient as well as outpatient hospitalisations and emergency department visits . The economic burden of untreated adult ADHD has been increasingly studied and shows the same pattern as in children, with higher than normal costs of sickness leave, less productivity, more accidents and more health care costs [141, 319, 320]. Effective management of the patient with ADHD is justified from a health economic perspective since undiagnosed and untreated ADHD will lead to inefficient health care use, less satisfactory clinical outcomes, lower personal well-being and poorer social and professional interactions.
A summary of the main conclusions is listed in Table 1. ADHD persists in adults in the majority of subjects with significant psychosocial impairment and a high comorbidity rate leading to high levels of personal distress and a substantial economic burden for society if left unidentified and untreated. The lifetime persistence of symptoms and impairment of ADHD is the hallmark of this disorder in the majority of cases. Diagnosis should include extensive psychiatric work-up including a detailed account of the developmental history, both current and retrospective account of ADHD symptoms and impairment and associated co-morbidities, before starting treatment. To prevent underreporting of symptoms, external validation is desirable by collecting information from relevant informants. The panel recommends multimodal treatment, comprising of psychoeducation, pharmacotherapy, coaching and/or cognitive behavioural therapy; and ideally involving the adult patient's partner, family or close friends. Diagnostic and treatment services for adult ADHD should be established throughout Europe. European research into adult ADHD should be further developed in order to provide a better understanding of the way that ADHD presents from childhood until old age, to differentiate ADHD from common comorbidities and to improve treatment options.
Hill JC, Schoener EP: Age-dependent decline of attention deficit hyperactivity disorder. Am J Psychiatry. 1996, 153 (9): 1143-1146.
Wood DR, Reimherr FW, Wender PH, Johnson GE: Diagnosis and treatment of minimal brain dysfunction in adults: a preliminary report. Arch Gen Psychiatry. 1976, 33 (12): 1453-1460.
Lara C, Fayyad J, de Graaf R, Kessler RC, Aguilar-Gaxiola S, Angermeyer M, Demytteneare K, de Girolamo G, Haro JM, Jin R, et al: Childhood predictors of adult attention-deficit/hyperactivity disorder: results from the World Health Organization World Mental Health Survey Initiative. Biol Psychiatry. 2009, 65 (1): 46-54. 10.1016/j.biopsych.2008.10.005.
Lie N: Follow-ups of children with attention deficit hyperactivity disorder (ADHD). Review of literature. Acta Psychiatr Scand Suppl. 1992, 368: 1-40. 10.1111/j.1600-0447.1992.tb10575.x.
Gittelman R, Mannuzza S, Shenker R, Bonagura N: Hyperactive boys almost grown up. I. Psychiatric status. Arch Gen Psychiatry. 1985, 42 (10): 937-947.
Weiss G, Hechtman L, Milroy T: Psychiatric status of hyperactives as adults: A controlled prospective 15-year follow-up of 63 hyperactive children. J Am Acad Child Psychiatry. 1985, 24: 211-220. 10.1016/S0002-7138(09)60450-7.
Mannuzza S, Klein RG, Addalli KA: Young adult mental status of hyperactive boys and their brothers: a prospective follow-up study. J Am Acad Child Adolesc Psychiatry. 1991, 30 (5): 743-751. 10.1097/00004583-199109000-00008.
Mannuzza S, Klein RG, Bessler A, Malloy P, et al: Adult outcome of hyperactive boys: Educational achievement, occupational rank, and psychiatric status. Arch Gen Psychiatry. 1993, 50 (7): 565-576.
Barkley RA, Fischer M, Smallish L, Fletcher K: The persistence of attention-deficit/hyperactivity disorder into young adulthood as a function of reporting source and definition of disorder. J Abnorm Psychol. 2002, 111 (2): 279-289. 10.1037/0021-843X.111.2.279.
Mannuzza S, Klein RG, Moulton JL: Persistence of Attention-Deficit/Hyperactivity Disorder into adulthood: what have we learned from the prospective follow-up studies?. J Atten Disord. 2003, 7 (2): 93-100. 10.1177/108705470300700203.
Rasmussen P, Gillberg C: Natural outcome of ADHD with developmental coordination disorder at age 22 years: a controlled, longitudinal, community-based study. Journal of the American Academy of Child and Adolescent Psychiatry. 2000, 39 (11): 1424-1431. 10.1097/00004583-200011000-00017.
Faraone SV, Biederman J, Mick E: The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychol Med. 2006, 36 (2): 159-165. 10.1017/S003329170500471X.
Biederman J, Mick E, Faraone SV: Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type. Am J Psychiatry. 2000, 157 (5): 816-818. 10.1176/appi.ajp.157.5.816.
Taylor E, Chadwick O, Heptinstall E, Danckaerts M: Hyperactivity and conduct problems as risk factors for adolescent development. Journal of the American Academy of Child and Adolescent Psychiatry. 1996, 35 (9): 1213-1226. 10.1097/00004583-199609000-00019.
Biederman J, Faraone S, Milberger S, Curtis S, Chen L, Marrs A, Ouellette C, Moore P, Spencer T: Predictors of persistence and remission of ADHD into adolescence: results from a four-year prospective follow-up study. Journal of the American Academy of Child and Adolescent Psychiatry. 1996, 35 (3): 343-351. 10.1097/00004583-199603000-00016.
Simon V, Czobor P, Balint S, Meszaros A, Bitter I: Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. Br J Psychiatry. 2009, 194 (3): 204-211. 10.1192/bjp.bp.107.048827.
Kooij JJS, Buitelaar JK, van den Oord EJ, Furer JW, Rijnders CAT, Hodiamont PPG: Internal and external validity of Attention-Deficit Hyperactivity Disorder in a population-based sample of adults. Psychol Med. 2005, 35 (6): 817-827. 10.1017/S003329170400337X.
Kessler RC, Adler LE, Ames M, Barkley RA, Birnbaum H, Greenberg P, Johnston JA, Spencer T, Ustun TB: The prevalence and effects of adult attention deficit/hyperactivity disorder on work performance in a nationally representative sample of workers. J Occup Environ Med. 2005, 47 (6): 565-572. 10.1097/01.jom.0000166863.33541.39.
Fayyad J, de Graaf R, Kessler R, Alonso J, Angermeyer M, Demyttenaere K, De Girolamo G, Haro JM, Karam EG, Lara C, et al: Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder. Br J Psychiatry. 2007, 190: 402-409. 10.1192/bjp.bp.106.034389.
Faraone SV, Biederman J, Monuteaux MC: Toward guidelines for pedigree selection in genetic studies of attention deficit hyperactivity disorder. Genetic epidemiology. 2000, 18 (1): 1-16. 10.1002/(SICI)1098-2272(200001)18:1<1::AID-GEPI1>3.0.CO;2-X.
Faraone SV, Doyle AE, Knoerzer JA: Heritability of attention-deficit/hyperactivity disorder. Economics of Neuroscience. 2001, 3 (5): 54-57.
Kessler RC: Comorbidity patterns in a community sample of adults with ADHD: results from the National Comorbidity Survey Replication. APA 160th Annual Meeting. 2007
Mancini C, Van Ameringen M, Oakman J, Figueiredo D: Childhood attention deficit/hyperactivity disorder in adults with anxiety disorders. Psychol Med. 1999, 29 (3): 515-525. 10.1017/S0033291798007697.
Fones CS, Pollack MH, Susswein L, Otto M: History of childhood attention deficit hyperactivity disorder (ADHD) features among adults with panic disorder. J Affect Disord. 2000, 58 (2): 99-106. 10.1016/S0165-0327(99)00065-8.
Alpert JE, Maddocks A, Nierenberg AA, O'Sullivan R, Pava JA, Worthington JJ, Biederman J, Rosenbaum JF, Fava M: Attention deficit hyperactivity disorder in childhood among adults with major depression. Psychiatry Res. 1996, 62 (3): 213-219. 10.1016/0165-1781(96)02912-5.
Fossati A, Novella L, Donati D, Donini M, Maffei C: History of childhood attention deficit/hyperactivity disorder symptoms and borderline personality disorder: a controlled study. ComprPsychiatry. 2002, 43 (5): 369-377.
Goossensen M, van de Glind G, Carpentier P-J, Wijsen RM, van Duin D, Kooij J: An intervention program for ADHD in patients with substance use disorders: Preliminary results of a field trial. J Subst Abuse Treat. 2006, 30 (3): 253-259. 10.1016/j.jsat.2005.12.004.
Foreman DM, Foreman D, Prendergast M, Minty B: Is clinic prevalence of ICD-10 hyperkinesis underestimated? Impact of increasing awareness by a questionnaire screen in an UK clinic. Eur Child Adolesc Psychiatry. 2001, 10 (2): 130-134. 10.1007/s007870170036.
Weiss M, Hechtman L, Weiss G: ADHD in parents. JAmAcadChild AdolescPsychiatry. 2000, 39 (8): 1059-1061.
Faraone SV, Biederman J, Feighner JA, Monuteaux MC: Assessing symptoms of attention deficit hyperactivity disorder in children and adults: which is more valid?. J Consult Clin Psychol. 2000, 68 (5): 830-842. 10.1037/0022-006X.68.5.830.
McCarthy S, Asherson P, Coghill D, Hollis C, Murray M, Potts L, Sayal K, de Soysa R, Taylor E, Williams T, et al: Attention-deficit hyperactivity disorder: treatment discontinuation in adolescents and young adults. Br J Psychiatry. 2009, 194 (3): 273-277. 10.1192/bjp.bp.107.045245.
NICE: Attention Deficit Hyperactivity Disorder: The NICE guideline on diagnosis and managment of ADHD in children, young people and adults. 2008, The British Psychological Society and The Royal College of Psychiatrists
Ebert D, Krause J, Roth-Sackenheim C: ADHD in adulthood - guidelines based on expert consensus with DGPPN support (German). Nervenarzt. 2003, 74 (939): 946-
Nutt DJ, Fone K, Asherson P, Bramble D, Hill P, Matthews K, Morris KA, Santosh P, Sonuga-Barke E, Taylor E, et al: Evidence-based guidelines for management of attention-deficit/hyperactivity disorder in adolescents in transition to adult services and in adults: recommendations from the British Association for Psychopharmacology. J Psychopharmacol. 2007, 21 (1): 10-41. 10.1177/0269881106073219.
Wender PH, Wolf LE, Wasserstein J: Adults with ADHD. An overview. Ann NY Acad Sci. 2001, 931: 1-16. 10.1111/j.1749-6632.2001.tb05770.x.
Hart EL, Lahey BB, Loeber R, Applegate B, Frick PJ: Developmental change in attention-deficit hyperactivity disorder in boys: a four-year longitudinal study. J Abnorm Child Psychol. 1995, 23 (6): 729-749. 10.1007/BF01447474.
Kooij JJS, Aeckerlin LP, Buitelaar JK: Functioning, comorbidity and treatment of 141 adults with attention deficit hyperactivity disorder (ADHD) at a Psychiatric Outpatients' Department. [Dutch]. Nederlands Tijdschrift voor Geneeskunde. 2001, 145 (31): 1498-1501.
Fischer M, Barkley RA, Smallish L, Fletcher K: Executive functioning in hyperactive children as young adults: attention, inhibition, response perseveration, and the impact of comorbidity. Dev Neuropsychol. 2005, 27 (1): 107-133. 10.1207/s15326942dn2701_5.
Brown TE: Brown Attention-Deficit Disorder Scales. Manual. 1996, San Antonio: The Psychological Corporation
Buitelaar JK: [Discussion of attention deficit-hyperactivity disorder (ADHD): facts, opinions and emotions]. Ned Tijdschr Geneeskd. 2001, 145 (31): 1485-1489.
Biederman J, Faraone SV, Spencer T, Wilens T, et al: Patterns of psychiatric comorbidity, cognition, and psychosocial functioning in adults with attention deficit hyperactivity disorder. Am J Psychiatry. 1993, 150 (12): 1792-1798.
Stockl KM, Hughes TE, Jarrar MA, Secnik K, Perwien AR: Physician perceptions of the use of medications for attention deficit hyperactivity disorder. J Manag Care Pharm. 2003, 9 (5): 416-423.
Asherson P, Chen W, Craddock B, Taylor E: Adult attention-deficit hyperactivity disorder: recognition and treatment in general adult psychiatry. Br J Psychiatry. 2007, 190: 4-5. 10.1192/bjp.bp.106.026484.
Pescosolido BA, Jensen PS, Martin JK, Perry BL, Olafsdottir S, Fettes D: Public knowledge and assessment of child mental health problems: findings from the National Stigma Study-Children. J Am Acad Child Adolesc Psychiatry. 2008, 47 (3): 339-349. 10.1097/CHI.0b013e318160e3a0.
Lanham JS: The evaluation of attention deficit/hyperactivity disorder in family medicine residency programs. South Med J. 2006, 99 (8): 802-805. 10.1097/01.smj.0000215738.43515.c7.
Faraone SV, Doyle AE: The nature and heritability of attention-deficit/hyperactivity disorder. Child Adolesc Psychiatr Clin N Am. 2001, 10 (2): 299-292ix.
Faraone SV: Genetics of adult attention-deficit/hyperactivity disorder. Psychiatr Clin North Am. 2004, 27: 303-321. 10.1016/S0193-953X(03)00090-X.
Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, Sklar P: Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005, 57 (11): 1313-1323. 10.1016/j.biopsych.2004.11.024.
Sprich S, Biederman J, Crawford MH, Mundy E, Faraone SV: Adoptive and biological families of children and adolescents with ADHD. J Am Acad Child Adolesc Psychiatry. 2000, 39 (11): 1432-1437. 10.1097/00004583-200011000-00018.
Moore J, Fombonne E: Psychopathology in adopted and nonadopted children: a clinical sample. Am J Orthopsychiatry. 1999, 69 (3): 403-409. 10.1037/h0080415.
Gilger JW, Pennington BF, DeFries JC: A twin study of the etiology of comorbidity: attention-deficit hyperactivity disorder and dyslexia. J Am Acad Child Adolesc Psychiatry. 1992, 31 (2): 343-348. 10.1097/00004583-199203000-00023.
Sherman DK, Iacono WG, McGue MK: Attention-deficit hyperactivity disorder dimensions: a twin study of inattention and impulsivity-hyperactivity. J Am Acad Child Adolesc Psychiatry. 1997, 36 (6): 745-753. 10.1097/00004583-199706000-00010.
Rietveld MJ, Hudziak JJ, Bartels MvB, CE, Boomsma DI: Heritability of attention problems in children: longitudinal results from a study of twins, age 3 to 12. J Child Psychol Psychiatry. 2004, 45 (3): 577-588. 10.1111/j.1469-7610.2004.00247.x.
Levy F, Hay DA, McStephen M, Wood C, Waldman I: Attention-deficit hyperactivity disorder: a category or a continuum? Genetic analysis of a large-scale twin study. J Am Acad Child Adolesc Psychiatry. 1997, 36 (6): 737-744. 10.1097/00004583-199706000-00009.
Stevens SE, Sonuga-Barke EJ, Kreppner JM, Beckett C, Castle J, Colvert E, Groothues C, Hawkins A, Rutter M: Inattention/overactivity following early severe institutional deprivation: presentation and associations in early adolescence. J Abnorm Child Psychol. 2008, 36 (3): 385-398. 10.1007/s10802-007-9185-5.
Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, Sklar P: Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005, 57 (11): 1313-1323. 10.1016/j.biopsych.2004.11.024.
Kuntsi J, Rijsdijk F, Ronald A, Asherson P, Plomin R: Genetic influences on the stability of attention-deficit/hyperactivity disorder symptoms from early to middle childhood. Biol Psychiatry. 2005, 57 (6): 647-654. 10.1016/j.biopsych.2004.12.032.
Larsson JO, Larsson H, Lichtenstein P: Genetic and environmental contributions to stability and change of ADHD symptoms between 8 and 13 years of age: a longitudinal twin study. Journal of the American Academy of Child and Adolescent Psychiatry. 2004, 43 (10): 1267-1275. 10.1097/01.chi.0000135622.05219.bf.
van den Berg SM, Willemsen G, de Geus EJ, Boomsma DI: Genetic etiology of stability of attention problems in young adulthood. Am J Med Genet B Neuropsychiatr Genet. 2006, 141B (1): 55-60. 10.1002/ajmg.b.30251.
Boomsma DI, Saviouk V, Hottenga JJ, Distel MA, de Moor MH, Vink JM, Geels LM, van Beek JH, Bartels M, de Geus EJ, et al: Genet epidemiol of attention deficit hyperactivity disorder (ADHD index) in adults. PloS one. 2010, 5 (5): e10621-10.1371/journal.pone.0010621.
Halperin JM, Schulz KP: Revisiting the role of the prefrontal cortex in the pathophysiology of attention-deficit/hyperactivity disorder. Psychological bulletin. 2006, 132 (4): 560-581. 10.1037/0033-2909.132.4.560.
Halperin JM, Trampush JW, Miller CJ, Marks DJ, Newcorn JH: Neuropsychological outcome in adolescents/young adults with childhood ADHD: profiles of persisters, remitters and controls. Journal of child psychology and psychiatry, and allied disciplines. 2008, 49 (9): 958-966. 10.1111/j.1469-7610.2008.01926.x.
Kuntsi J, Wood AC, Rijsdijk F, Johnson KA, Andreou P, Albrecht B, Arias Vasquez A, Buitelaar J, McLoughlin G, Rommelse N, et al: Seperation of cognitive impairments in attention deficit hyperactivity disorder into two familial factors. Arch Gen Psychiatry. 2010,
Li D, Sham PC, Owen MJ, He L: Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Human molecular genetics. 2006, 15 (14): 2276-2284. 10.1093/hmg/ddl152.
Kuntsi J, Neale BM, Chen W, Faraone SV, Asherson P: The IMAGE project: methodological issues for the molecular genetic analysis of ADHD. Behav Brain Funct. 2006, 2: 27-10.1186/1744-9081-2-27.
Franke B, Neale BM, Faraone SV: Genome-wide association studies in ADHD. Human genetics. 2009, 126 (1): 13-50. 10.1007/s00439-009-0663-4.
Franke B, Hoogman M, Arias Vasquez A, Heister JG, Savelkoul PJ, Naber M, Scheffer H, Kiemeney LA, Kan CC, Kooij JJ, et al: Association of the dopamine transporter (SLC6A3/DAT1) gene 9-6 haplotype with adult ADHD. Am J Med Genet B Neuropsychiatr Genet. 2008, 147B (8): 1576-1579. 10.1002/ajmg.b.30861.
Johansson S, Halmoy A, Mavroconstanti T, Jacobsen KK, Landaas ET, Reif A, Jacob C, Boreatti-Hummer A, Kreiker S, Lesch KP, et al: Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1,636 adult cases and 1,923 controls from four European populations. Am J Med Genet B Neuropsychiatr Genet. 2010, 153B (5): 1008-15.
Landaas ET, Johansson S, Jacobsen KK, Ribases M, Bosch R, Sanchez-Mora C, Jacob CP, Boreatti-Hummer A, Kreiker S, Lesch KP, et al: An international multicenter association study of the serotonin transporter gene in persistent ADHD. Genes, brain, and behavior. 2010, 9 (5): 449-58. 10.1111/j.1601-183X.2010.00567.x.
Sanchez-Mora C, Ribases M, Ramos-Quiroga JA, Casas M, Bosch R, Boreatti-Hummer A, Heine M, Jacob CP, Lesch KP, Fasmer OB, et al: Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four European populations. Am J Med Genet B Neuropsychiatr Genet. 153B (2): 512-523.
Ribases M, Hervas A, Ramos-Quiroga JA, Bosch R, Bielsa A, Gastaminza X, Fernandez-Anguiano M, Nogueira M, Gomez-Barros N, Valero S, et al: Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. Biol Psychiatry. 2008, 63 (10): 935-945. 10.1016/j.biopsych.2007.11.004.
Ribases M, Ramos-Quiroga JA, Hervas A, Bosch R, Bielsa A, Gastaminza X, Artigas J, Rodriguez-Ben S, Estivill X, Casas M, et al: Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB. Molecular psychiatry. 2009, 14 (1): 71-85. 10.1038/sj.mp.4002100.
Banerjee TD, Middleton F, Faraone SV: Environmental risk factors for attention-deficit hyperactivity disorder. Acta Paediatr. 2007, 96 (9): 1269-1274. 10.1111/j.1651-2227.2007.00430.x.
Milberger S, Biederman J, Faraone SV, Chen L, Jones J: Further evidence of an association between attention-deficit/hyperactivity disorder and cigarette smoking. Findings from a high-risk sample of siblings. Am J Addict. 1997, 6 (3): 205-217.
Milberger S, Biederman J, Faraone SV, Guite J, Tsuang MT: Pregnancy, delivery and infancy complications and attention deficit hyperactivity disorder: issues of gene-environment interaction. Biol Psychiatry. 1997, 41 (1): 65-75. 10.1016/0006-3223(95)00653-2.
Botting N, Powls A, Cooke RW, Marlow N: Attention deficit hyperactivity disorders and other psychiatric outcomes in very low birthweight children at 12 years. J Child Psychol Psychiatry. 1997, 38 (8): 931-941. 10.1111/j.1469-7610.1997.tb01612.x.
Thapar A, Rice F, Hay D, Boivin J, Langley K, van den Bree M, Rutter M, Harold G: Prenatal smoking might not cause attention-deficit/hyperactivity disorder: evidence from a novel design. Biol Psychiatry. 2009, 66 (8): 722-727. 10.1016/j.biopsych.2009.05.032.
Bekker EM, Overtoom CC, Kenemans JL, Kooij JJ, De Noord I, Buitelaar JK, Verbaten MN: Stopping and changing in adults with ADHD. Psychol Med. 2005, 35 (6): 807-816. 10.1017/S0033291704003459.
Bekker EM, Kenemans JL, Hoeksma MR, Talsma D, Verbaten MN: The pure electrophysiology of stopping. International Journal of Psychophysiology. 2005, 55 (2): 191-8. 10.1016/j.ijpsycho.2004.07.005.
Seidman LJ, Valera EM, Bush G: Brain function and structure in adults with attention-deficit/hyperactivity disorder. Psychiatr Clin North Am. 2004, 27 (2): 323-347. 10.1016/j.psc.2004.01.002.
Seidman LJ, Doyle A, Fried R, Valera E, Crum K, Matthews L: Neuropsychological function in adults with attention-deficit/hyperactivity disorder. Psychiatr Clin North Am. 2004, 27 (2): 261-282. 10.1016/j.psc.2003.12.005.
Seidman LJ, Valera EM, Makris N: Structural brain imaging of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005, 57 (11): 1263-1272. 10.1016/j.biopsych.2004.11.019.
Krause J: SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder. Expert Rev Neurother. 2008, 8 (4): 611-625. 10.1586/14737184.108.40.2061.
Biederman J, Faraone SV: Current concepts on the neurobiology of Attention-Deficit/Hyperactivity Disorder. J Atten Disord. 2002, 6 (Suppl 1): S7-16.
Krause KH, Dresel SH, Krause J, la Fougere C, Ackenheil M: The dopamine transporter and neuroimaging in attention deficit hyperactivity disorder. Neuroscience & Biobehavioral Reviews. 2003, 27 (7): 605-613.
Spencer TJ, Biederman J, Madras BK, Dougherty DD, Bonab AA, Livni E, Meltzer PC, Martin J, Rauch S, Fischman AJ: Further evidence of dopamine transporter dysregulation in ADHD: a controlled PET imaging study using altropane. Biol Psychiatry. 2007, 62 (9): 1059-1061. 10.1016/j.biopsych.2006.12.008.
Swanson JM, Elliott GR, Greenhill LL, Wigal T, Arnold LE, Vitiello B, Hechtman L, Epstein JN, Pelham WE, Abikoff HB, et al: Effects of stimulant medication on growth rates across 3 years in the MTA follow-up. Journal of the American Academy of Child and Adolescent Psychiatry. 2007, 46 (8): 1015-1027. 10.1097/chi.0b013e3180686d7e.
Volkow ND, Wang GJ, Newcorn J, Fowler JS, Telang F, Solanto MV, Logan J, Wong C, Ma Y, Swanson JM, et al: Brain dopamine transporter levels in treatment and drug naive adults with ADHD. Neuroimage. 2007, 34 (3): 1182-1190. 10.1016/j.neuroimage.2006.10.014.
Seidman LJ, Valera EM, Makris N, Monuteaux MC, Boriel D, Kelkar K, Kennedy DN, Caviness VS, Bush G, Aleardi M, et al: Dorsolateral Prefrontal and Anterior Cingulate Cortex Volumetric Abnormalities in Adults with Attention-Deficit/Hyperactivity Disorder Identified by Magnetic Resonance Imaging. Biol Psychiatry. 2006, 60 (10): 1071-1080. 10.1016/j.biopsych.2006.04.031.
Valera EM, Faraone SV, Murray KE, Seidman LJ: Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder. Biol Psychiatry. 2007, 61 (12): 1361-1369. 10.1016/j.biopsych.2006.06.011.
Makris N, Biederman J, Valera EM, Bush G, Kaiser J, Kennedy DN, Caviness VS, Faraone SV, Seidman LJ: Cortical Thinning of the Attention and Executive Function Networks in Adults with Attention-Deficit/Hyperactivity Disorder. Cerebral Cortex. 2007, 17 (6): 1364-1375. 10.1093/cercor/bhl047.
Castellanos FX, Giedd JN, Marsh WL, Hamburger SD, Vaituzis AC, Dickstein DP, Sarfatti SE, Vauss YC, Snell JW, Lange N, et al: Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder. Arch Gen Psychiatry. 1996, 53 (7): 607-616.
Castellanos FX, Giedd JN, Berquin PC, Walter JM, Sharp W, Tran T, Vaituzis AC, Blumenthal JD, Nelson J, Bastain TM, et al: Quantitative brain magnetic resonance imaging in girls with attention- deficit/hyperactivity disorder. ArchGenPsychiatry. 2001, 58 (3): 289-295.
Castellanos FX: Anatomic magnetic resonance imaging studies of attention-deficit/hyperactivity disorder. Dialogues in Clinical Neuroscience. 2002, 4 (4): 444-448.
Semrud-Clikeman M, Filipek PA, Biederman J, Steingard R, Kennedy D, Renshaw P, Bekken K: Attention-deficit hyperactivity disorder: magnetic resonance imaging morphometric analysis of the corpus callosum. J Am Acad Child Adolesc Psychiatry. 1994, 33 (6): 875-881. 10.1097/00004583-199407000-00014.
Durston S, Pol HE, Schnack HG, Buitelaar JK, Steenhuis MP, Minderaa RB, Kahn RS, van Engeland H: Magnetic resonance imaging of boys with attention-deficit/hyperactivity disorder and their unaffected siblings. Child & Adolescent Social Work Journal. 2004, 21 (1): 332-340.
Durston S: Converging methods in studying attention-deficit/hyperactivity disorder: what can we learn from neuroimaging and genetics?. Dev Psychopathol. 2008, 20 (4): 1133-1143. 10.1017/S0954579408000539.
Makris N, Buka SL, Biederman J, Papadimitriou GM, Hodge SM, Valera EM, Brown AB, Bush G, Monuteaux MC, Caviness VS, et al: Attention and executive systems abnormalities in adults with childhood ADHD: A DT-MRI study of connections. Cereb Cortex. 2008, 18 (5): 1210-1220. 10.1093/cercor/bhm156.
Bush G, Frazier JA, Rauch SL, Seidman LJ, Whalen PJ, Jenike MA, Rosen BR, Biederman J: Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the Counting Stroop. Biol Psychiatry. 1999, 45 (12): 1542-1552. 10.1016/S0006-3223(99)00083-9.
Suskauer SJ, Simmonds DJ, Fotedar S, Blankner JG, Pekar JJ, Denckla MB, Mostofsky SH: Functional magnetic resonance imaging evidence for abnormalities in response selection in attention deficit hyperactivity disorder: differences in activation associated with response inhibition but not habitual motor response. J Cogn Neurosci. 2008, 20 (3): 478-493. 10.1162/jocn.2008.20032.
Paloyelis Y, Mehta MA, Kuntsi J, Asherson P: Functional MRI in ADHD: a systematic literature review. Expert review of neurotherapeutics. 2007, 7 (10): 1337-1356. 10.1586/14737220.127.116.117.
Pliszka SR, Glahn DC, Semrud-Clikeman M, Franklin C, Perez R, Xiong J, Liotti M: Neuroimaging of inhibitory control areas in children with attention deficit hyperactivity disorder who were treatment naive or in long-term treatment. The Am J Psychiatry. 2006, 163 (6): 1052-1060. 10.1176/appi.ajp.163.6.1052.
Rubia K, Smith AB, Brammer MJ, Toone B, Taylor E: Abnormal brain activation during inhibition and error detection in medication-naive adolescents with ADHD. The Am J Psychiatry. 2005, 162 (6): 1067-1075. 10.1176/appi.ajp.162.6.1067.
Zametkin AJ, Nordahl TE, Gross M, King A, et al: Cerebral glucose metabolism in adults with hyperactivity of childhood onset. New England Journal of Medicine. 1990, 323 (20): 1361-1366. 10.1056/NEJM199011153232001.
Zametkin AJ, Liebenauer LL, Fitzgerald GA, King AC, Minkunas DV, Herscovitch P, Yamada EM, Cohen RM: Brain metabolism in teenagers with attention-deficit hyperactivity disorder. ArchGenPsychiatry. 1993, 50 (5): 333-340.
Ernst M, Zametkin AJ, Matochik JA, Jons PH, Cohen RM: DOPA decarboxylase activity in attention deficit hyperactivity disorder adults. A [fluorine-18]fluorodopa positron emission tomographic study. J Neurosci. 1998, 18 (15): 5901-5907.
Lou HC, Henriksen L, Bruhn P, Borner H, Nielsen JB: Striatal dysfunction in attention deficit and hyperkinetic disorder. Archives of Neurology. 1989, 46 (1): 48-52.
Amen DG, Hanks C, Prunella J: Preliminary evidence differentiating ADHD using brain SPECT imaging in older patients. J Psychoactive Drugs. 2008, 40 (2): 139-146.
Wilens TE, Decker MW: Neuronal nicotinic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: Focus on cognition. Biochem Pharmacol. 2007, 7: 7-
Krause KH, Dresel SH, Krause J, Kung HF, Tatsch K, Ackenheil M: Stimulant-like action of nicotine on striatal dopamine transporter in the brain of adults with attention deficit hyperactivity disorder. Int J Neuropsychopharmacol. 2002, 5 (2): 111-113. 10.1017/S1461145702002821.
Volkow ND, Wang GJ, Kollins SH, Wigal TL, Newcorn JH, Telang F, Fowler JS, Zhu W, Logan J, Ma Y, et al: Evaluating dopamine reward pathway in ADHD: clinical implications. Jama. 2009, 302 (10): 1084-1091. 10.1001/jama.2009.1308.
APA: American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders. Washington DC. 1994, 4
Tripp G, Luk SL, Schaughency EA, Singh R: DSM-IV and ICD-10: a comparison of the correlates of ADHD and hyperkinetic disorder. JAmAcadChild AdolescPsychiatry. 1999, 38 (2): 156-164.
Faraone SV, Sergeant J, Gillberg C: The worldwide prevalence of ADHD: is it an American condition?. World Psychiatry. 2003, 2: 104-113.
Lee SI, Schachar RJ, Chen SX, Ornstein TJ, Charach A, Barr C, Ickowicz A: Predictive validity of DSM-IV and ICD-10 criteria for ADHD and hyperkinetic disorder. J Child Psychol Psychiatry. 2008, 49 (1): 70-78. 10.1111/j.1469-7610.2007.01784.x.
Asherson P: Clinical assessment and treatment of attention deficit hyperactivity disorder in adults. Expert review of neurotherapeutics. 2005, 5 (4): 525-539. 10.1586/1473718.104.22.1685.
Kooij JJS: ADHD in adults. Clinical studies on assessment and treatment. 2006, Radboud University Nijmegen
Skirrow C, McLoughlin G, Kuntsi J, Asherson P: Behavioral, neurocognitive and treatment overlap between attention-deficit/hyperactivity disorder and mood instability. Expert review of neurotherapeutics. 2009, 9 (4): 489-503. 10.1586/ern.09.2.
Biederman J, Petty CR, Fried R, Kaiser R, Dolan CR, Schoenfeld S, Doyle AE, Seidman LJ, Faraone SV: Educational and occupational underattainment in adults with attention-deficit/hyperactivity disorder: a controlled study. J Clin Psychiatry. 2008, 69 (8): 1217-1222. 10.4088/JCP.v69n0803.
de Graaf R, Kessler RC, Fayyad J, ten Have M, Alonso J, Angermeyer M, Borges G, Demyttenaere K, Gasquet I, de Girolamo G, et al: The prevalence and effects of adult attention-deficit/hyperactivity disorder (ADHD) on the performance of workers: results from the WHO World Mental Health Survey Initiative. Occup Environ Med. 2008, 65 (12): 835-842. 10.1136/oem.2007.038448.
Murphy K, Barkley RA: Attention deficit hyperactivity disorder in adults: comorbidities and adaptive impairments. ComprPsychiatry. 1996, 37 (6): 393-401.
Barkley R, Gordon M: Research on comorbidity, adaptive functioning, and cognitive impairments in adults with ADHD: Implications for a clinical practice. Clinicians' guide to adult ADHD: Assessment and intervention. Edited by: Goldstein S, Ellison AT. 2002, San Diego, CA: Academic Press, Inc, 43-69. full_text.
Robin LA: The impact of ADHD on marriage. The ADHD Report. 2002, 10 (3): 9-14. 10.1521/adhd.10.3.9.20553.
Fischer M, Barkley RA, Smallish L, Fletcher K: Hyperactive children as young adults: Driving abilities, safe driving behavior, and adverse driving outcomes. Accident; Analysis and Prevention. 2007, 39 (1): 94-105. 10.1016/j.aap.2006.06.008.
Barkley RA, Murphy KR, Kwasnik D: Motor vehicle driving competencies and risks in teens and young adults with attention deficit hyperactivity disorder. Pediatrics. 1996, 98 (6 Pt 1): 1089-1095.
Barkley RA, Murphy KR, Dupaul GJ, Bush T: Driving in young adults with attention deficit hyperactivity disorder: Knowledge, performance, adverse outcomes, and the role of executive functioning. Journal of the International Neuropsychological Society. 2002, 8 (5): 655-672. 10.1017/S1355617702801345.
Barkley RA, Cox D: A review of driving risks and impairments associated with attention-deficit/hyperactivity disorder and the effects of stimulant medication on driving performance. J Safety Res. 2007, 38 (1): 113-128. 10.1016/j.jsr.2006.09.004.
Swensen A, Birnbaum HG, Ben Hamadi R, Greenberg P, Cremieux PY, Secnik K: Incidence and costs of accidents among attention-deficit/hyperactivity disorder patients. J Adolesc Health. 2004, 35 (4): 346-349. e341
Van Veen MM, Kooij JJS, Boonstra AM, Gordijn M, Van Someren EJW: Disrupted circadian rhythm in adults with ADHD and chronic sleep onset insomnia. Biol Psychiatry. 2009, 67 (11): 1091-1096. 10.1016/j.biopsych.2009.12.032.
Gau SS, Kessler RC, Tseng WL, Wu YY, Chiu YN, Yeh CB, Hwu HG: Association between sleep problems and symptoms of attention-deficit/hyperactivity disorder in young adults. Sleep. 2007, 30 (2): 195-201.
Barkley RA: Major life activity and health outcomes associated with attention-deficit/hyperactivity disorder. J Clin Psychiatry. 2002, 63 (Suppl 12): 10-15.
Ohlmeier MD, Peters K, Kordon A, Seifert J, Wildt BT, Wiese B, Ziegenbein M, Emrich HM, Schneider U: Nicotine and alcohol dependence in patients with comorbid attention-deficit/hyperactivity disorder (ADHD). Alcohol and alcoholism (Oxford, Oxfordshire). 2007, 42 (6): 539-543. 10.1093/alcalc/agm069.
Young S, Gudjonsson G, Wells J, Asherson P, Theobald J, Oliver B, Scott C, Mooney A: Attention deficit hyperactivity disorder and critical incidents in a Scottish prison population Personality and Individual Differences. 2009, 46: 265-269.
Mannuzza S, Klein RG, Moulton JL: Lifetime criminality among boys with attention deficit hyperactivity disorder: a prospective follow-up study into adulthood using official arrest records. Psychiatry Res. 2008, 160 (3): 237-246. 10.1016/j.psychres.2007.11.003.
Foley HA, Carlton CO, Howell RJ: The relationship of attention deficit hyperactivity disorder and conduct disorder to juvenile delinquency: legal implications. Bull Am Acad Psychiatry Law. 1996, 24 (3): 333-345.
Ziegler E, Blocher D, Bro J, Rosler M: Assessment of attention deficit hyperactivity disorder (ADHD) in prison inmates. [German]. Recht & Psychiatrie. 2003, 21 (1): 17-21.
Young S, Gudjonsson G, Ball S, Lam J: Attention Deficit Hyperactivity Disorder (ADHD) in personality disordered offenders and the association with disruptive behavioural problems. Journal of Forensic Psychiatry & Psychology. 2003, 14 (3): 491-505.
Minde K, Eakin L, Hechtman L, Ochs E, Bouffard R, Greenfield B, Looper K: The psychosocial functioning of children and spouses of adults with ADHD. J Child Psychol Psychiatry. 2003, 44 (4): 637-646. 10.1111/1469-7610.00150.
Weiss G, Hechtman L: Hyperactive children grown up. ADHD in children, adolescents and adults. 1993, New York: Guilford Press, 2
Mannuzza S, Klein RG, Bessler A, Malloy P, Hynes ME: Educational and occupational outcome of hyperactive boys grown up. JAmAcadChild AdolescPsychiatry. 1997, 36 (9): 1222-1227.
Kessler RC, Lane M, Stang PE, Van Brunt DL, Trott GE: The prevalence and workplace costs of adult attention deficit hyperactivity disorder in a large manufacturing firm. Psychol Med. 2008, 21 (1): 1-11.
Antshel KM, Faraone SV, Maglione K, Doyle A, Fried R, Seidman L, Biederman J: Is adult attention deficit hyperactivity disorder a valid diagnosis in the presence of high IQ?. Psychol Med. 2008, 24: 1-11.
Mannuzza S, Klein RG: Long-term prognosis in attention-deficit/hyperactivity disorder. Child AdolescPsychiatrClinNAm. 2000, 9 (3): 711-726.
Murphy KR, Barkley RA, Bush T: Young adults with attention deficit hyperactivity disorder: subtype differences in comorbidity, educational, and clinical history. J Nerv Ment Dis. 2002, 190 (3): 147-157. 10.1097/00005053-200203000-00003.
Biederman J, Newcorn J, Sprich S: Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. Am J Psychiatry. 1991, 148 (5): 564-577.
Goldman LS, Genel M, Bezman RJ, Slanetz PJ: Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Jama: Journal of the American Medical Association. 1998, 279 (14): 1100-1107. 10.1001/jama.279.14.1100.
Pliszka SR: Comorbidity of attention-deficit/hyperactivity disorder with psychiatric disorder: an overview. J Clin Psychiatry. 1998, 59 (Suppl 7): 50-58.
Kooij JJS, Burger H, Boonstra AM, van der Linden PD, Kalma LE, Buitelaar JK: Efficacy and safety of methylphenidate in 45 adults with attention-deficit/hyperactivity disorder. A randomized placebo-controlled double-blind cross-over trial. Psychol Med. 2004, 34 (6): 973-982. 10.1017/S0033291703001776.
Shekim WO, Asarnow RF, Hess E, Zaucha K: A clinical and demographic profile of a sample of adults with attention deficit hyperactivity disorder, residual state. Comprehensive Psychiatry. 1990, 31 (5): 416-425. 10.1016/0010-440X(90)90026-O.
Biederman J: Impact of comorbidity in adults with attention-deficit/hyperactivity disorder. J Clin Psychiatry. 2004, 65 (Suppl 3): 3-7.
Rasmussen K, Almvik R, Levander S: Attention deficit hyperactivity disorder, reading disability, and personality disorders in a prison population. J Am Acad Psychiatry Law. 2001, 29 (2): 186-193.
Mannuzza S, Klein RG, Bessler A, Malloy P, LaPadula M: Adult psychiatric status of hyperactive boys grown up. AmJPsychiatry. 1998, 155 (4): 493-498.
Wilens TE, Prince JB, Biederman J, Spencer TJ, Frances RJ: Attention-deficit hyperactivity disorder and comorbid substance use disorders in adults. Psychiatr Serv. 1995, 46 (8): 761-763. 765
Wilens TE: The nature of the relationship between attention-deficit/hyperactivity disorder and substance use. J Clin Psychiatry. 2007, 68 (Suppl 11): 4-8.
Wilens TE, Biederman J, Mick E: Does ADHD affect the course of substance abuse? Findings from a sample of adults with and without ADHD. Am J Addict. 1998, 7 (2): 156-163.
Wilens TE, Hahesy AL, Biederman J, Bredin E, Tanguay S, Kwon A, Faraone SV: Influence of parental SUD and ADHD on ADHD in their offspring: preliminary results from a pilot-controlled family study. Am J Addict. 2005, 14 (2): 179-187. 10.1080/10550490590924872.
Fayyad J, De Graaf R, Kessler R, Alonso J, Angermeyer M, Demyttenaere K, De Girolamo G, Haro JM, Karam EG, Lara C, et al: Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder. Br J Psychiatry. 2007, 190: 402-409. 10.1192/bjp.bp.106.034389.
Breyer JL, Botzet AM, Winters KC, Stinchfield RD, August G, Realmuto G: Young Adult Gambling Behaviors and their Relationship with the Persistence of ADHD. J Gambl Stud. 2009, 13: 13-
Arnold LE: Sex differences in ADHD: conference summary. JAbnormChild Psychol. 1996, 24 (5): 555-569.
Biederman J, Faraone SV, Spencer T, Wilens T, Mick E, Lapey KA: Gender differences in a sample of adults with attention deficit hyperactivity disorder. Psychiatry Res. 1994, 53 (1): 13-29. 10.1016/0165-1781(94)90092-2.
Biederman J, Faraone SV, Monuteaux MC, Bober M, Cadogen E: Gender effects on attention-deficit/hyperactivity disorder in adults, revisited. Biol Psychiatry. 2004, 55 (7): 692-700. 10.1016/j.biopsych.2003.12.003.
Biederman J, Mick E, Faraone SV, Braaten E, Doyle A, Spencer T, Wilens TE, Frazier E, Johnson MA: Influence of gender on attention deficit hyperactivity disorder in children referred to a psychiatric clinic. Am J Psychiatry. 2002, 159 (1): 36-42. 10.1176/appi.ajp.159.1.36.
Kessler RC, Adler L, Berkley R, Biederman J, Conners CK, Demler O, Faraone SV, Greenhill LL, Howes MJ, Secnik K, et al: The prevalence and correlates of adult ADHD in the United States: Results from the National Comorbidity Survey Replication. Am J Psychiatry. 2006, 163 (4): 716-723. 10.1176/appi.ajp.163.4.716.
Taylor EW, Keltner NL: Messy purse girls: Adult females and ADHD. Perspectives in Psychiatric Care. 2002, 38 (2): 69-72. 10.1111/j.1744-6163.2002.tb00659.x.
Dopfner M, Pluck J, Berner W, Fegert JM, Huss M, Lenz K, Schmeck K, Lehmkuhl U, Poustka F, Lehmkuhl G: Mental disturbances in children and adolescents in Germany. Results of a representative study:age,gender and rater effects. Zeitschrift fur Kinder-und Jugendpsychiatrie und Psychotherapie. 1997, 25 (4): 218-233.
Newcorn JH, Halperin JM, Jensen PS, Abikoff HB, Arnold LE, Cantwell DP, Conners CK, Elliott GR, Epstein JN, Greenhill LL, et al: Symptom profiles in children with ADHD: effects of comorbidity and gender. JAmAcadChild AdolescPsychiatry. 2001, 40 (2): 137-146.
Nadeau KG, Quinn PO: Understanding women with AD/HD. 2002, Silver Spring: Advantage Books
Biederman J, Faraone SV, Mick E, Williamson S, Wilens TE, Spencer TJ, Weber W, Jetton J, Kraus I, Pert J, et al: Clinical correlates of ADHD in females: findings from a large group of girls ascertained from pediatric and psychiatric referral sources. J Am Acad Child Adolesc Psychiatry. 1999, 38 (8): 966-975. 10.1097/00004583-199908000-00012.
Judd F, Komiti A, Jackson H: How does being female assist help-seeking for mental health problems?. Aust N Z J Psychiatry. 2008, 42 (1): 24-29. 10.1080/00048670701732681.
Kooij JJS, Boonstra AM, Willemsen-Swinkels SHN, Bekker EM, Noord Id, Buitelaar JK: Reliability, validity, and utility of instruments for self-report and informant report regarding symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) in adult patients. Journal of Attention Disorders. 2008, 11 (4): 445-458. 10.1177/1087054707299367.
Brown TE, (Ed): Attention-deficit disorders and comorbidities in children, adolescents, and adults. 2000, Washington, DC: American Psychiatric Publishing, Inc
Applegate B, Lahey BB, Hart EL, Biederman J, Hynd GW, Barkley RA, Ollendick T, Frick PJ, Greenhill L, McBurnett K, et al: Validity of the age-of-onset criterion for ADHD: a report from the DSM-IV field trials. J Am Acad Child Adolesc Psychiatry. 1997, 36 (9): 1211-1221. 10.1097/00004583-199709000-00013.
Barkley RA: ADHD--Long-term course, adult outcome, and comorbid disorders. Attention deficit hyperactivity disorder: State of the science-best practices. Edited by: Jensen Peter S, Cooper James R. 2002, Civic Research Institute, Kington, New Jersey.
Barkley RA: Age dependent decline in ADHD: True recovery or statistical illusion?. The ADHD Report. 1997, 5: 1-5.
Brown TE: Executive functions and attention deficit hyperactivity disorder: Implications of two conflicting views. Internationalo Journal of Disability, Development and Education. 2006, 53 (1): 35-46. 10.1080/10349120500510024.
Barkley R, Murphy KR, Fischer M: ADHD in adults: what the science says. 2007, New York: Guilford Press
Murphy P, Schachar R: Use of self-ratings in the assessment of symptoms of attention deficit hyperactivity disorder in adults. Am J Psychiatry. 2000, 157 (7): 1156-1159. 10.1176/appi.ajp.157.7.1156.
Zucker M, Morris MK, Ingram SM, Morris RD, Bakeman R: Concordance of self- and informant ratings of adults' current and childhood attention-deficit/hyperactivity disorder symptoms. Psychol Assess. 2002, 14 (4): 379-389. 10.1037/1040-3522.214.171.1249.
Danckaerts M, Heptinstall E, Chadwick O, Taylor E: Self-report of attention deficit and hyperactivity disorder in adolescents. Psychopathology. 1999, 32 (2): 81-92. 10.1159/000029071.
Sciutto MJ, Eisenberg M: Evaluating the evidence for and against the overdiagnosis of ADHD. J Atten Disord. 2007, 11 (2): 106-113. 10.1177/1087054707300094.
Hesslinger B, Tebartz van Elst L, Mochan F, Ebert D: Attention deficit hyperactivity disorder in adults - early vs. late onset in a retrospective study. Psychiatry Res. 2003, 119: 217-223. 10.1016/S0165-1781(03)00105-7.
Karam RG, Bau CH, Salgado CA, Kalil KL, Victor MM, Sousa NO, Vitola ES, Picon FA, Zeni GD, Rohde LA, et al: Late-onset ADHD in adults: milder, but still dysfunctional. J Psychiatr Res. 2009, 43 (7): 697-701. 10.1016/j.jpsychires.2008.10.001.
Faraone SV, Kunwar A, Adamson J, Biederman J: Personality traits among ADHD adults: implications of late-onset and subthreshold diagnoses. Psychol Med. 2009, 39 (4): 685-693. 10.1017/S0033291708003917.
Reinhardt MC, Benetti L, Victor MM, Grevet EH, Belmonte-de-Abreu P, Faraone SV, Rohde LA: Is age-at-onset criterion relevant for the response to methylphenidate in attention-deficit/hyperactivity disorder?. J Clin Psychiatry. 2007, 68 (7): 1109-1116. 10.4088/JCP.v68n0720.
Faraone SV, Biederman J, Doyle A, Murray K, Petty C, Adamson JJ, Seidman L: Neuropsychological studies of late onset and subthreshold diagnoses of adult attention-deficit/hyperactivity disorder. Biol Psychiatry. 2006, 60 (10): 1081-1087. 10.1016/j.biopsych.2006.03.060.
Faraone SV, Biederman J, Spencer T, Mick E, Murray K, Petty C, Adamson JJ, Monuteaux MC: Diagnosing adult attention deficit hyperactivity disorder: are late onset and subthreshold diagnoses valid?. Am J Psychiatry. 2006, 163 (10): 1720-1729. 10.1176/appi.ajp.163.10.1720.
Kieling C, Kieling RR, Rohde LA, Frick PJ, Moffitt T, Nigg JT, Tannock R, Castellanos FX: The age at onset of attention deficit hyperactivity disorder. The Am J Psychiatry. 167 (1): 14-16. 10.1176/appi.ajp.2009.09060796.
Willoughby MT, Curran PJ, Costello EJ, Angold A: Implications of early versus late onset of attention-deficit/hyperactivity disorder symptoms. Journal of the American Academy of Child & Adolescent Psychiatry. 2000, 39 (12): 1512-1519.
Todd RD, Huang H, Henderson CA: Poor utility of the age of onset criterion for DSM-IV attention deficit/hyperactivity disorder: recommendations for DSM-V and ICD-11. J Child Psychol Psychiatry. 2008, 49 (9): 942-949. 10.1111/j.1469-7610.2008.01892.x.
Barkley RA, Murphy KR, Fischer M: ADHD in adults. What the science says. 2007, New York: The Guilford Press
Barkley RA, Biederman J: Toward a broader definition of the age-of-onset criterion for attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 1997, 36 (9): 1204-1210. 10.1097/00004583-199709000-00012.
Antshel KM: Attention-Deficit Hyperactivity Disorder in the context of a high intellectual quotient/giftedness. Dev Disabil Res Rev. 2008, 14 (4): 293-299. 10.1002/ddrr.34.
Chen W, Zhou K, Sham P, Franke B, Kuntsi J, Campbell D, Fleischman K, Knight J, Andreou P, Arnold R, et al: DSM-IV combined type ADHD shows familial association with sibling trait scores: a sampling strategy for QTL linkage. Am J Med Genet B Neuropsychiatr Genet. 2008, 147B (8): 1450-1460. 10.1002/ajmg.b.30672.
Biederman J, Faraone SV, Mick E, Spencer T, Wilens T, Kiely K, Guite J, Ablon JS, Reed E, Warburton R: High risk for attention deficit hyperactivity disorder among children of parents with childhood onset of the disorder: a pilot study. The Am J Psychiatry. 1995, 152 (3): 431-435.
Ronald A, Simonoff E, Kuntsi J, Asherson P, Plomin R: Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample. Journal of child psychology and psychiatry, and allied disciplines. 2008, 49 (5): 535-542. 10.1111/j.1469-7610.2007.01857.x.
Willcutt EG, Pennington BF, Olson RK, DeFries JC: Understanding comorbidity: a twin study of reading disability and attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2007, 144B (6): 709-714. 10.1002/ajmg.b.30310.
Francks C, Fisher SE, Marlow AJ, MacPhie IL, Taylor KE, Richardson AJ, Stein JF, Monaco AP: Familial and genetic effects on motor coordination, laterality, and reading-related cognition. The Am J Psychiatry. 2003, 160 (11): 1970-1977. 10.1176/appi.ajp.160.11.1970.
Landgren M, Pettersson R, Kjellman B, Gillberg C: ADHD, DAMP and other neurodevelopmental/psychiatric disorders in 6-year- old children: epidemiology and co-morbidity. Dev Med Child Neurol. 1996, 38 (10): 891-906. 10.1111/j.1469-8749.1996.tb15046.x.
Gillberg C: Deficits in attention, motor control, and perception: a brief review. Arch Dis Child. 2003, 88 (10): 904-910. 10.1136/adc.88.10.904.
Upadhyaya HP: Substance use disorders in children and adolescents with attention-deficit/hyperactivity disorder: implications for treatment and the role of the primary care physician. Primary care companion to the Journal of clinical psychiatry. 2008, 10 (3): 211-221. 10.4088/PCC.v10n0306.
Asherson P, Brookes K, Franke B, Chen W, Gill M, Ebstein RP, Buitelaar J, Banaschewski T, Sonuga-Barke E, Eisenberg J, et al: Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD. The Am J Psychiatry. 2007, 164 (4): 674-677. 10.1176/appi.ajp.164.4.674.
Sobanski E: Psychiatric comorbidity in adults with attention-deficit/hyperactivity disorder (ADHD). Eur Arch Psychiatry Clin Neurosci. 2006, 256 (Suppl 1): i26-31. 10.1007/s00406-006-1004-4.
Sullivan MA, Rudnik-Levin F: Attention deficit/hyperactivity disorder and substance abuse. Diagnostic and therapeutic considerations. Annals of the New York Academy of Sciences. 2001, 931: 251-270. 10.1111/j.1749-6632.2001.tb05783.x.
Modestin J, Matutat B, Wurmle O: Antecedents of opioid dependence and personality disorder: attention-deficit/hyperactivity disorder and conduct disorder. Eur Arch Psychiatry Clin Neurosci. 2001, 251 (1): 42-47. 10.1007/s004060170067.
Ohlmeier MD, Peters K, Te Wildt BT, Zedler M, Ziegenbein M, Wiese B, Emrich HM, Schneider U: Comorbidity of alcohol and substance dependence with attention-deficit/hyperactivity disorder (ADHD). Alcohol and alcoholism (Oxford, Oxfordshire). 2008, 43 (3): 300-304. 10.1093/alcalc/agn014.
Wilson JJ, Levin FR: Attention deficit hyperactivity disorder (ADHD) and substance use disorders. Curr Psychiatry Rep. 2001, 3 (6): 497-506. 10.1007/s11920-001-0044-8.
Wilens TE, Upadhyaya HP, Faraone SV, Biederman J: Impact of substance use disorder on ADHD and its treatment. J Clin Psychiatry. 2007, 68 (8): e20-10.4088/JCP.0807e20.
Goossensen MA, van de Glind G, Carpentier PJ, Wijsen RM, van Duin D, Kooij JJ: An intervention program for ADHD in patients with substance use disorders: preliminary results of a field trial. J Subst Abuse Treat. 2006, 30 (3): 253-259. 10.1016/j.jsat.2005.12.004.
Flory K, Lynam DR: The relation between attention deficit hyperactivity disorder and substance abuse: what role does conduct disorder play?. Clin Child Fam Psychol Rev. 2003, 6 (1): 1-16. 10.1023/A:1022260221570.
Kelly TM, Cornelius JR, Clark DB: Psychiatric disorders and attempted suicide among adolescents with substance use disorders. Drug and alcohol dependence. 2004, 73 (1): 87-97. 10.1016/j.drugalcdep.2003.10.004.
Kolpe M, Carlson GA: Influence of attention-deficit/hyperactivity disorder symptoms on methadone treatment outcome. Am J Addict. 2007, 16 (1): 46-48. 10.1080/10601330601080073.
Faraone SV, Wilens TE: Effect of stimulant medications for attention-deficit/hyperactivity disorder on later substance use and the potential for stimulant misuse, abuse, and diversion. The Journal of clinical psychiatry. 2007, 68 (Suppl 11): 15-22.
Wilens TE: Attention deficit hyperactivity disorder and substance use disorders. The Am J Psychiatry. 2006, 163 (12): 2059-2063. 10.1176/appi.ajp.163.12.2059.
DuPaul GJ, Power TJ, Anastopoulos AD, Reid R: ADHD Rating Scale-IV. Checklists, Norms and Clinical Interpretation. 1998, New York: The Guilford Press
Kessler RC, Adler L, Ames M, Demler O, Faraone S, Hiripi E, Howes MJ, Jin R, Scnik K, Spencer T, et al: The World Health Organization adult ADHD self-report scale (ASRS): A short screening scale for use in the general population. Psychol Med. 2005, 35 (2): 245-256. 10.1017/S0033291704002892.
Kessler RC, Adler L, Ames M, Demler O, Faraone S, Hiripi E, Howes MJ, Jin R, Secnik K, Spencer T, et al: The World Health Organization Adult ADHD Self-Report Scale (ASRS): a short screening scale for use in the general population. Psychol Med. 2005, 35 (2): 245-256. 10.1017/S0033291704002892.
Daigre C, Ramos-Quiroga JA, Valero S, Bosch R, Roncero C, Gonzalvo B, Nogueira M, Casas M: Adult ADHD Self-Report Scale (ASRS-v1.1) symptoms checklist in patients with substance use disorders. Actas Esp Psiquiatr. 2009, 6 (37): 299-305.
Conners CK, Erhardt D, Sparrow E: Conners Adult ADHD Rating Scales (CAARS). Technical Manual. 1999, New York: Multi Health Systems Inc
Ward MF, Wender PH, Reimherr FW: The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. Am J Psychiatry. 1993, 150 (6): 885-890.
Rosler M, Retz W, Thome J, Schneider M, Stieglitz RD, Falkai P: Psychopathological rating scales for diagnostic use in adults with attention-deficit/hyperactivity disorder (ADHD). Eur Arch Psychiatry Clin Neurosci. 2006, 256 (Suppl 1): i3-i11. 10.1007/s00406-006-1001-7.
Epstein JN, Johnson DE, Conners CK: CAADID. The Conner's Adult ADHD Diagnostic Interview for DSM-IV. 2001, MHS Inc
Diagnostisch Interview voor ADHD (DIVA) bij volwassenen. [http://www.kenniscentrumadhdbijvolwassenen.nl]
Boonstra AM, Oosterlaan J, Sergeant JA, Buitelaar JK: Executive functioning in adult ADHD: a meta-analytic review. PsycholMed. 2005
Krause J, Dresel SH, Krause KH, La Fougere C, Zill P, Ackenheil M: Striatal dopamine transporter availability and DAT-1 gene in adults with ADHD: no higher DAT availability in patients with homozygosity for the 10-repeat allele. World J Biol Psychiatry. 2006, 7 (3): 152-10.1080/15622970500518444.
Snyder SM, Hall JR: A meta-analysis of quantitative EEG power associated with attention-deficit hyperactivity disorder. J Clin Neurophysiol. 2006, 23 (5): 440-455.
Jucaite A, Fernell E, Halldin C, Forssberg H, Farde L: Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/hyperactivity disorder: association between striatal dopamine markers and motor hyperactivity. Biol Psychiatry. 2005, 57 (3): 229-238. 10.1016/j.biopsych.2004.11.009.
McLean A, Dowson J, Toone B, Young S, Bazanis E, Robbins T, Sahakian B: Characteristic neurocognitive profile associated with adult attention-deficit/hyperactivity disorder. Psychol Med. 2004, 34 (4): 681-692. 10.1017/S0033291703001296.
Liotti M, Pliszka SR, Perez R, Luus B, Glahn D, Semrud-Clikeman M: Electrophysiological correlates of response inhibition in children and adolescents with ADHD: influence of gender, age, and previous treatment history. Psychophysiology. 2007, 44 (6): 936-948. 10.1111/j.1469-8986.2007.00568.x.
Kuntsi J, McLoughlin G, Asherson P: Attention deficit hyperactivity disorder. Neuromolecular Med. 2006, 8 (4): 461-484. 10.1385/NMM:8:4:461.
Barkley RA, Murphy KR: Impairment in occupational functioning and adult ADHD: the predictive utility of executive function (EF) ratings versus EF tests. Arch Clin Neuropsychol. 2010, 25 (3): 157-173. 10.1093/arclin/acq014.
Barkley RA, Fischer M: The unique contribution of emotional impulsiveness to impairment in major life activities in hyperactive children as adults. Journal of the American Academy of Child and Adolescent Psychiatry. 2010, 49 (5): 503-513. 10.1097/00004583-201005000-00011.
Golubchik P, Sever J, Zalsman G, Weizman A: Methylphenidate in the treatment of female adolescents with cooccurrence of attention deficit/hyperactivity disorder and borderline personality disorder: a preliminary open-label trial. Int Clin Psychopharmacol. 2008, 23 (4): 228-231. 10.1097/YIC.0b013e3282f94ae2.
Hooberman D, Stern TA: Treatment of attention deficit and borderline personality disorders with psychostimulants: case report. J Clin Psychiatry. 1984, 45 (10): 441-442.
Reimherr FW, Williams ED, Strong RE, Mestas R, Soni P, Marchant BK: A double-blind, placebo-controlled, crossover study of osmotic release oral system methylphenidate in adults with ADHD with assessment of oppositional and emotional dimensions of the disorder. J Clin Psychiatry. 2007, 68 (1): 93-101. 10.4088/JCP.v68n0113.
Rosler M, Fischer R, Ammer R, Ose C, Retz W: A randomised, placebo-controlled, 24-week, study of low-dose extended-release methylphenidate in adults with attention-deficit/hyperactivity disorder. Eur Arch Psychiatry Clin Neurosci. 2009, 31: 31-
Koesters M, Becker T, Kilian R, Fegert JM, Weinmann S: Limits of meta-analysis: methylphenidate in the treatment of adult attention-deficit hyperactivity disorder. J Psychopharmacol. 2009, 23 (7): 733-744. 10.1177/0269881108092338.
Meszaros A, Czobor P, Balint S, Komlosi S, Simon V, Bitter I: Pharmacotherapy of adult attention deficit hyperactivity disorder (ADHD): a meta-analysis. The international journal of neuropsychopharmacology/official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). 2009, 12 (8): 1137-1147.
Prince JB: Pharmacotherapy of attention-deficit hyperactivity disorder in children and adolescents: update on new stimulant preparations, atomoxetine, and novel treatments. Child Adolesc Psychiatr ClinNAm. 2006, 15 (1): 13-50. 10.1016/j.chc.2005.08.002.
Banaschewski T, Roessner V, Dittmann RW, Santosh PJ, Rothenberger A: Non-stimulant medications in the treatment of ADHD. Eur Child Adolesc Psychiatry. 2004, 13 (Suppl 1): I102-116.
Young S, Amarasinghe J: Practioner review: Non-pharmacological treatments for ADHD: A lifespan perspective. Journal of Child Psychology and Psychiatry. 2009,
Safren SA: Cognitive-behavioral approaches to ADHD treatment in adulthood. J Clin Psychiatry. 2006, 67 (Suppl 8): 46-50.
Ramsay JR: Current status of cognitive-behavioral therapy as a psychosocial treatment for adult attention-deficit/hyperactivity disorder. Curr Psychiatry Rep. 2007, 9 (5): 427-433. 10.1007/s11920-007-0056-0.
Able SL, Johnston JA, Adler LA, Swindle RW: Functional and psychosocial impairment in adults with undiagnosed ADHD. Psychol Medicine. 2007, 37 (1): 1-11. 10.1017/S0033291706008713.
Biederman J, Faraone SV, Spencer TJ, Mick E, Monuteaux MC, Aleardi M: Functional impairments in adults with self-reports of diagnosed ADHD: A controlled study of 1001 adults in the community. J Clin Psychiatry. 2006, 67 (4): 524-540. 10.4088/JCP.v67n0403.
Torgersen T, Gjervan B, Rasmussen K: ADHD in adults: a study of clinical characteristics, impairment and comorbidity. Nord J Psychiatry. 2006, 60 (1): 38-43. 10.1080/08039480500520665.
Murphy K, Barkley RA: Attention deficit hyperactivity disorder adults: comorbidities and adaptive impairments. Compr Psychiatry. 1996, 37 (6): 393-401. 10.1016/S0010-440X(96)90022-X.
Rostain AL: Attention-deficit/hyperactivity disorder in adults: evidence-based recommendations for management. Postgrad Med. 2008, 120 (3): 27-38. 10.3810/pgm.2008.09.1905.
Murphy K: Psychosocial treatments for ADHD in teens and adults: a practice-friendly review. J Clin Psychol. 2005, 61 (5): 607-619. 10.1002/jclp.20123.
Biederman J, Wilens T, Mick E, Faraone SV, Weber W, Curtis S, Thornell A, Pfister K, Jetton JG, Soriano J: Is ADHD a risk factor for psychoactive substance use disorders? Findings from a four-year prospective follow-up study. J Am Acad Child Adolesc Psychiatry. 1997, 36 (1): 21-29. 10.1097/00004583-199701000-00013.
Faraone SV, Biederman J, Wilens TE, Adamson J: A naturalistic study of the effects of pharmacotherapy on substance use disorders among ADHD adults. Psychol Med. 2007, 37 (12): 1743-1752. 10.1017/S0033291707000335.
Wilens TE, Monuteaux MC, Snyder LE, Moore H, Whitley J, Gignac M: The clinical dilemma of using medications in substance-abusing adolescents and adults with attention-deficit/hyperactivity disorder: what does the literature tell us?. J Child Adolesc Psychopharmacol. 2005, 15 (5): 787-798. 10.1089/cap.2005.15.787.
Wilens TE: Does the medicating ADHD increase or decrease the risk for later substance abuse?. Rev Bras Psiquiatr. 2003, 25 (3): 127-128. 10.1590/S1516-44462003000300001.
Biederman J, Wilens T, Mick E, Spencer T, Faraone SV: Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder. Pediatrics. 1999, 104 (2): e20-10.1542/peds.104.2.e20.
Wilens TE, Faraone SV, Biederman J, Gunawardene S: Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature. Pediatrics. 2003, 111 (1): 179-185. 10.1542/peds.111.1.179.
Kalbag AS, Levin FR: Adult ADHD and substance abuse: diagnostic and treatment issues. Substance use & misuse. 2005, 40 (13-14): 1955-1981. 2043-1958
Mariani JJ, Levin FR: Treatment strategies for co-occurring ADHD and substance use disorders. Am J Addict. 2007, 16 (Suppl 1): 45-54. 10.1080/10550490601082783. quiz 55-46
Volkow ND, Swanson JM: Variables that affect the clinical use and abuse of methylphenidate in the treatment of ADHD. Am J Psychiatry. 2003, 160 (11): 1909-1918. 10.1176/appi.ajp.160.11.1909.
Volkow ND, Wang GJ, Telang F, Fowler JS, Logan J, Childress AR, Jayne M, Ma Y, Wong C: Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues. Neuroimage. 2008, 39 (3): 1266-1273. 10.1016/j.neuroimage.2007.09.059.
Faraone SV, Upadhyaya HP: The effect of stimulant treatment for ADHD on later substance abuse and the potential for medication misuse, abuse, and diversion. J Clin Psychiatry. 2007, 68 (11): e28-10.4088/JCP.1107e28.
Banaschewski T, Coghill D, Santosh P, Zuddas A, Asherson P, Buitelaar J, Danckaerts M, Dopfner M, Faraone SV, Rothenberger A, et al: Long-acting medications for the hyperkinetic disorders. A systematic review and European treatment guideline. Eur Child Adolesc Psychiatry. 2006, 15 (8): 476-495. 10.1007/s00787-006-0549-0.
Adler LA, Spencer T, Brown TE, Holdnack J, Saylor K, Schuh K, Trzepacz PT, Williams DW, Kelsey D: Once-daily atomoxetine for adult attention-deficit/hyperactivity disorder: a 6-month, double-blind trial. J Clin Psychopharmacol. 2009, 29 (1): 44-50. 10.1097/JCP.0b013e318192e4a0.
Wilens TE, Haight BR, Horrigan JP, Hudziak JJ, Rosenthal NE, Connor DF, Hampton KD, Richard NE, Modell JG: Bupropion XL in adults with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled study. Biol Psychiatry. 2005, 57 (7): 793-801. 10.1016/j.biopsych.2005.01.027.
Turner D: A review of the use of modafinil for attention-deficit hyperactivity disorder. Expert Rev Neurother. 2006, 6 (4): 455-468. 10.1586/14737126.96.36.1995.
Kendall T, Taylor E, Perez A, Taylor C: Diagnosis and management of attention-deficit/hyperactivity disorder in children, young people, and adults: summary of NICE guidance. Bmj. 2008, 337 (337): a1239-10.1136/bmj.a1239.
Biederman J, Mick E, Surman C, Doyle R, Hammerness P, Harpold T, Dunkel S, Dougherty M, Aleardi M, Spencer T: A randomized, placebo-controlled trial of OROS methylphenidate in adults with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2006, 59 (9): 829-835. 10.1016/j.biopsych.2005.09.011.
Biederman J, Spencer T, Wilens T: Evidence-based pharmacotherapy for attention-deficit hyperactivity disorder. Int J Neuropsychopharmacol. 2004, 7 (1): 77-97. 10.1017/S1461145703003973.
Spencer T, Biederman J, Wilens T, Doyle R, Surman C, Prince J, Mick E, Aleardi M, Herzig K, Faraone S: A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005, 57 (5): 456-463. 10.1016/j.biopsych.2004.11.043.
Rosler M, Fischer R, Ammer R, Ose C, Retz W: A randomised, placebo-controlled, 24-week, study of low-dose extended-release methylphenidate in adults with attention-deficit/hyperactivity disorder. Eur Arch Psychiatry Clin Neurosci. 2009, 259 (2): 120-129. 10.1007/s00406-008-0845-4.
Bouffard R, Hechtman L, Minde K, Iaboni-Kassab F: The efficacy of 2 different dosages of methylphenidate in treating adults with attention-deficit hyperactivity disorder. Can J Psychiatry. 2003, 48 (8): 546-554.
Wilens TE, Spencer TJ: The stimulants revisited. Child AdolescPsychiatrClinNAm. 2000, 9 (3): 573-603. viii
Tossell JW, Greenstein DK, Davidson AL, Job SB, Gochman P, Lenane M, Nugent Iii TF, Gogtay N, Sporn AL, Rapoport JL: Stimulant drug treatment in childhood-onset schizophrenia with comorbid ADHD: an open-label case series. Journal of child and adolescent psychopharmacology. 2004, 14 (3): 448-454. 10.1089/cap.2004.14.448.
Nickels K, Katusic SK, Colligan RC, Weaver AL, Voigt RG, Barbaresi WJ: Stimulant medication treatment of target behaviors in children with autism: a population-based study. J Dev Behav Pediatr. 2008, 29 (2): 75-81. 10.1097/DBP.0b013e31815f24f7.
Posey DJ, Aman MG, McCracken JT, Scahill L, Tierney E, Arnold LE, Vitiello B, Chuang SZ, Davies M, Ramadan Y, et al: Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures. Biol Psychiatry. 2007, 61 (4): 538-544. 10.1016/j.biopsych.2006.09.028.
Santosh PJ, Baird G, Pityaratstian N, Tavare E, Gringras P: Impact of comorbid autism spectrum disorders on stimulant response in children with attention deficit hyperactivity disorder: a retrospective and prospective effectiveness study. Child: care, health and development. 2006, 32 (5): 575-583. 10.1111/j.1365-2214.2006.00631.x.
Randomized, controlled, crossover trial of methylphenidate in pervasive developmental disorders with hyperactivity. Arch Gen Psychiatry. 2005, 62 (11): 1266-1274. 10.1001/archpsyc.62.11.1266.
Bloch MH, Panza KE, Landeros-Weisenberger A, Leckman JF: Meta-analysis: treatment of attention-deficit/hyperactivity disorder in children with comorbid tic disorders. Journal of the American Academy of Child and Adolescent Psychiatry. 2009, 48 (9): 884-893. 10.1097/CHI.0b013e3181b26e9f.
Poncin Y, Sukhodolsky DG, McGuire J, Scahill L: Drug and non-drug treatments of children with ADHD and tic disorders. European child & adolescent psychiatry. 2007, 16 (Suppl 1): 78-88.
Kanner AM: The use of psychotropic drugs in epilepsy: what every neurologist should know. Seminars in neurology. 2008, 28 (3): 379-388. 10.1055/s-2008-1079342.
Ashton H, Gallagher P, Moore B: The adult psychiatrist's dilemma: psychostimulant use in attention deficit/hyperactivity disorder. J Psychopharmacol. 2006, 20 (5): 602-610. 10.1177/0269881106061710.
Kollins SH: Comparing the abuse potential of methylphenidate versus other stimulants: a review of available evidence and relevance to the ADHD patient. J Clin Psychiatry. 2003, 64 (Suppl 11): 14-18.
Volkow ND, Ding YS, Fowler JS, Wang GJ, Logan J, Gatley JS, Dewey S, Ashby C, Lieberman J, Hitzemann R: Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain. Arch Gen Psychiatry. 1995, 52 (6): 456-463.
Cox DJ, Humphrey JW, Merkel RL, Penberthy JK, Kovatchev B: Controlled-release methylphenidate improves attention during on-road driving by adolescents with attention-deficit/hyperactivity disorder. Journal of the American Board of Family Practice. 2004, 17 (4): 235-239. 10.3122/jabfm.17.4.235.
Larriviere D, Williams MA, Rizzo M, Bonnie RJ: Responding to requests from adult patients for neuroenhancements: guidance of the Ethics, Law and Humanities Committee. Neurology. 2009, 73 (17): 1406-1412. 10.1212/WNL.0b013e3181beecfe.
Schubiner H: Substance abuse in patients with attention-deficit hyperactivity disorder: therapeutic implications. CNS Drugs. 2005, 19 (8): 643-655. 10.2165/00023210-200519080-00001.
Wilens TE, Adler LA, Weiss MD, Michelson D, Ramsey JL, Moore RJ, Renard D, Brady KT, Trzepacz PT, Schuh LM, et al: Atomoxetine treatment of adults with ADHD and comorbid alcohol use disorders. Drug Alcohol Depend. 2008, 96 (1-2): 145-154. 10.1016/j.drugalcdep.2008.02.009.
Adler LA: Pharmacotherapy for adult ADHD. J Clin Psychiatry. 2009, 70 (5): e12-10.4088/JCP.7129br5c.
Madaan V: Lisdexamfetamine dimesylate for childhood ADHD. Drugs Today (Barc). 2008, 44 (5): 319-324. 10.1358/dot.2008.44.5.1215724.
Weisler RH, Biederman J, Spencer TJ, Wilens TE, Faraone SV, Chrisman AK, Read SC, Tulloch SJ: Mixed amphetamine salts extended-release in the treatment of adult ADHD: a randomized, controlled trial. CNS Spectr. 2006, 11 (8): 625-639.
Schachar RJ, Tannock R, Cunningham C, Corkum PV: Behavioral, situational, and temporal effects of treatment of ADHD with methylphenidate. JAmAcadChild AdolescPsychiatry. 1997, 36 (6): 754-763.
Garland EJ: Pharmacotherapy of adolescent attention deficit hyperactivity disorder: challenges, choices and caveats. JPsychopharmacol. 1998, 12 (4): 385-395. 10.1177/026988119801200410.
Ramos-Quiroga JA, Bosch R, Castells X, Valero S, Nogueira M, Gomez N, Yelmo S, Ferrer M, Martinez Y, Casas M: Effect of switching drug formulations from immediate-release to extended-release OROS methylphenidate: a chart review of Spanish adults with attention-deficit hyperactivity disorder. CNS Drugs. 2008, 22 (7): 603-611. 10.2165/00023210-200822070-00005.
Adler LA, Spencer T, McGough JJ, Jiang H, Muniz R: Long-term effectiveness and safety of dexmethylphenidate extended-release capsules in adult ADHD. J Atten Disord. 2009, 12 (5): 449-459. 10.1177/1087054708320397.
Faraone SV, Biederman J, Spencer T, Michelson D, Adler L, Reimherr F, Glatt SJ: Efficacy of atomoxetine in adult attention-deficit/hyperactivity disorder: a drug-placebo response curve analysis. Behav Brain Funct. 2005, 1: 16-10.1186/1744-9081-1-16.
Kollins SH, Wilens TE, Fusillo S, Faraone SV, Upadhyaya HP: ADHD, substance use disorders, and psychostimulant treatment: current literature and treatment guidelines. J Atten Disord. 2008, 12 (2): 115-125. 10.1177/1087054707311654.
Jasinski DR, Faries DE, Moore RJ, Schuh LM, Allen AJ: Abuse liability assessment of atomoxetine in a drug-abusing population. Drug Alcohol Depend. 2008, 95 (1-2): 140-146. 10.1016/j.drugalcdep.2008.01.008.
Reimherr FW, Marchant BK, Strong RE, Hedges DW, Adler L, Spencer TJ, West SA, Soni P: Emotional dysregulation in adult ADHD and response to atomoxetine. Biol Psychiatry. 2005, 58 (2): 125-131. 10.1016/j.biopsych.2005.04.040.
Adler LA, Liebowitz M, Kronenberger W, Qiao M, Rubin R, Hollandbeck M, Deldar A, Schuh K, Durell T: Atomoxetine treatment in adults with attention-deficit/hyperactivity disorder and comorbid social anxiety disorder. Depress Anxiety. 2009, 26 (3): 212-221. 10.1002/da.20549.
Biederman J, Melmed RD, Patel A, McBurnett K, Donahue J, Lyne A: Long-term, open-label extension study of guanfacine extended release in children and adolescents with ADHD. CNS Spectr. 2008, 13 (12): 1047-1055.
Reimherr FW, Hedges DW, Strong RE, Marchant BK, Williams ED: Bupropion SR in adults with ADHD: A short-term, placebo-controlled trial. Neuropsychiatric Disease And Treatment. 2005, 1 (3): 245-251.
Wilens TE, Spencer TJ, Biederman J, Girard K, Doyle R, Prince J, Polisner D, Solhkhah R, Comeau S, Monuteaux MC, et al: A controlled clinical trial of bupropion for attention deficit hyperactivity disorder in adults. AmJPsychiatry. 2001, 158 (2): 282-288.
Wilens TE, Biederman J, Prince J, Spencer TJ, Faraone SV, Warburton R, Schleifer D, Harding M, Linehan C, Geller D: Six-week, double-blind, placebo-controlled study of desipramine for adult attention deficit hyperactivity disorder. Am J Psychiatry. 1996, 153 (9): 1147-1153.
Popper CW: Antidepressants in the treatment of attention-deficit/hyperactivity disorder. JClinPsychiatry. 1997, 58 (Suppl 14): 14-29.
Adler LA, Reingold LS, Morrill MS, Wilens TE: Combination pharmacotherapy for adult ADHD. Curr Psychiatry Rep. 2006, 8 (5): 409-415. 10.1007/s11920-006-0044-9.
Markowitz JS, Patrick KS: Pharmacokinetic and pharmacodynamic drug interactions in the treatment of attention-deficit hyperactivity disorder. Clinical pharmacokinetics. 2001, 40 (10): 753-772. 10.2165/00003088-200140100-00004.
Ross BM, Seguin J, Sieswerda LE: Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty acid?. Lipids Health Dis. 2007, 6 (21): 21-10.1186/1476-511X-6-21.
Nadeau KG: Life management skills for the adult with ADD. A comprehensive guide to attention deficit disorder in adults: Research, diagnosis, and treatment. Edited by: Nadeau KG. 1995, Philadelphia, PA: Brunner/Mazel, Inc, 191-217.
Nadeau KG: ADD in the workplace: Career consultation and counseling for the adult with ADD. A comprehensive guide to attention deficit disorder in adults: Research, diagnosis, and treatment. Edited by: Nadeau KG. 1995, Philadelphia, PA: Brunner/Mazel, Inc, 308-334.
Safren SA, Otto MW, Sprich S, Winett CL, Wilens TE, Biederman J: Cognitive-behavioral therapy for ADHD in medication-treated adults with continued symptoms. Behaviour Research and Therapy. 2005, 43 (7): 831-842. 10.1016/j.brat.2004.07.001.
Aim B: Psychotherapy of attention deficit hyperactivity disorder in adults. Nervenheilkunde: Zeitschrift fur interdisziplinaere Fortbildung. 2006, 25 (6): 459-464.
Weiss M, Safren SA, Solanto MV, Hechtman L, Rostain AL, Ramsay JR, Murray C: Research forum on psychological treatment of adults with ADHD. J Atten Disord. 2008, 11 (6): 642-651. 10.1177/1087054708315063.
Bramham J, Young S, Bickerdike A, Spain D, McCartan D, Xenitidis K: Evaluation of group cognitive behavioral therapy for adults with ADHD. J Atten Disord. 2009, 12 (5): 434-441. 10.1177/1087054708314596.
O'Connell RG, Bellgrove MA, Dockree PM, Robertson IH: Cognitive remediation in ADHD: effects of periodic non-contingent alerts on sustained attention to response. Neuropsychological rehabilitation. 2006, 16 (6): 653-665. 10.1080/09602010500200250.
Gevensleben H, Holl B, Albrecht B, Vogel C, Schlamp D, Kratz O, Studer P, Rothenberger A, Moll GH, Heinrich H: Is neurofeedback an efficacious treatment for ADHD? A randomised controlled clinical trial. Journal of child psychology and psychiatry, and allied disciplines. 2009, 50 (7): 780-789. 10.1111/j.1469-7610.2008.02033.x.
Butnik SM: Neurofeedback in adolescents and adults with attention deficit hyperactivity disorder. J Clin Psychol. 2005, 61 (5): 621-625. 10.1002/jclp.20124.
Klingberg T, Fernell E, Olesen PJ, Johnson M, Gustafsson P, Dahlstrom K, Gillberg CG, Forssberg H, Westerberg H: Computerized training of working memory in children with ADHD--a randomized, controlled trial. Journal of the American Academy of Child and Adolescent Psychiatry. 2005, 44 (2): 177-186. 10.1097/00004583-200502000-00010.
Arns M, de Ridder S, Strehl U, Breteler M, Coenen A: Efficacy of neurofeedback treatment in ADHD: the effects on inattention, impulsivity and hyperactivity: a meta-analysis. Clin EEG Neurosci. 2009, 40 (3): 180-189.
Solanto MV, Marks DJ, Wasserstein J, Mitchell K, Abikoff H, Alvir JM, Kofman MD: Efficacy of Meta-Cognitive Therapy for Adult ADHD. The Am J Psychiatry. 2010, 167 (8): 958-68. 10.1176/appi.ajp.2009.09081123.
Chan E, Zhan C, Homer CJ: Health care use and costs for children with attention-deficit/hyperactivity disorder: national estimates from the medical expenditure panel survey. Arch Pediatr Adolesc Med. 2002, 156 (5): 504-511.
Birnbaum HG, Kessler RC, Lowe SW, Secnik K, Greenberg PE, Leong SA, Swensen AR: Costs of attention deficit-hyperactivity disorder (ADHD) in the US: excess costs of persons with ADHD and their family members in 2000. Curr Med Res Opin. 2005, 21 (2): 195-206. 10.1185/030079904X20303.
Bernfort L, Nordfeldt S, Persson J: ADHD from a socio-economic perspective. Acta Paediatr. 2008, 97 (2): 239-245. 10.1111/j.1651-2227.2007.00611.x.
The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-244X/10/67/prepub
We thank Janssen-Cilag who provided support for meeting costs of the European Network Adult ADHD.