This article has Open Peer Review reports available.
Clinical and neuropsychological characteristics of general paresis misdiagnosed as primary psychiatric disease
© The Author(s). 2016
Received: 11 December 2015
Accepted: 15 June 2016
Published: 11 July 2016
Neurosyphilis is caused by the invasion of Treponema pallidum into the central nervous system. General paresis (GP) is a type of neurosyphilis. The main manifestation of general paresis is dementia; however, this is different from the other types of dementia, which can be cured by adequate doses of penicillin in the early stage. Neurosyphilis is the “great imitator” because it can mimic many types of medical disorders. In addition, the manifestations of neurosyphilis are not typical. Psychiatric disorders as a cause of general paresis have become more common due to the use of antibiotics. Patients with a psychiatric manifestation are often misdiagnosed. The purpose of this study was to explore the differences in the clinical and neuropsychological characteristics of general paresis between patients misdiagnosed as having a primary psychiatric disease and patients diagnosed correctly upon seeing a doctor. The results may assist clinicians in the early identification of neurosyphilis with a mental disorder.
The demographic and clinical manifestations, laboratory tests, and neuroimaging and neuropsychological characteristics were analysed in 55 general paresis patients with psychiatric disorders, including 29 patients misdiagnosed as primary psychiatric disease and 26 patients diagnosed as having general paresis after being seen once by a doctor.
All of the patients had positive assay results for cerebral spinal fluid (CSF) Treponema pallidum hemagglutination (TPHA). Only 43.3 % of misdiagnosed patients and 30.8 % of general paresis patients had positive results for the CSF rapid plasma reagin (RPR) test; 96.4 % patients had abnormal neuroimaging. Mood disturbances were the most common psychiatric disorder in the general paresis patients, especially agitation, between the two groups (patients with general paresis who were misdiagnosed as having primary psychiatric disease and patients who had never been misdiagnosed) (p = 0.011).
Our findings reinforce the importance of performing serologic testing for syphilis. This should be a part of the evaluation of patients with psychiatric disorders, especially patients with cognitive impairment. When the syphilis serology is positive, the patient should be examined thoroughly for neurosyphilis by lumbar puncture. Brain imaging could also aid the physician in discriminating these patients from those with a functional mental disorder.
Neurosyphilis (NS) is caused by the invasion of Treponema pallidum into the central nervous system, which can occur in any stage of syphilis, especially in the late stage . In addition, up to 40 % of untreated patients progress to NS . This includes asymptomatic NS, syphilitic meningitis, meningovascular syphilis, tabes dorsalis and general paresis (GP). GP is a type of dementia secondary to syphilis that can be cured by adequate doses of penicillin. Remission is determined by the severity and duration of the illness. Therefore, early diagnosis and early treatment are crucial. However, NS is known as the “great imitator” because it can mimic many other medical and neuropsychiatric disorders, including personality disorders, psychosis, and dementia . Typical symptoms of NS, such as Argyll-Robertson pupil, VIII cranial nerve disorders and tabetic indicators, have diminished significantly in recent years due to the use of antibiotics . In addition, NS is currently considered to be an almost forgotten disease, which leads to limited experience with its clinical manifestations for the majority of young physicians . These reasons may cause difficulty in recognizing NS in clinical practice.
In GP, patients appear irritable, forgetful and experience personality changes, headaches, and changes in sleep habits in the early stage while emotional lability, impaired memory and judgment, disorientation, confusion, delusions, and occasionally seizures occur in the late stage as other types of dementia . However, because antibiotics are widely used, psychiatric disorders have become the most common clinical manifestation for these patients . However, patients with psychiatric symptoms in these populations are often misdiagnosed as having primary psychiatric disorders. The previous literature has not reported the characteristics of GP patients who were misdiagnosed as having primary psychiatric disorders. In this study, we examine the clinical and neuropsychological characteristics of general paresis that differ between patients misdiagnosed as having primary psychiatric disease and patients diagnosed correctly once they see a doctor. This information may assist clinicians in the early identification of NS with mental disorders.
The patients diagnosed with GP were recruited from March 2011 to May 2015. The diagnostic criteria for NS complied with the Centers for Disease Control (CDC) guidelines  and the European Guidelines . The criteria included positive serologies and one or more of the following: positive cerebral spinal fluid (CSF) rapid plasma regain (RPR), positive CSF Treponema pallidum hemagglutination assay (TPHA) and increased CSF protein (protein >500 mg/L) or white blood cells (WBC) (WBC .10 × 10^6 cells/L), and an otherwise unexplained neurological manifestation consistent with NS. GP fulfilled the DSM-IV criteria of dementia. The history and treatment were used to determine whether the patient was misdiagnosed. The patients who were misdiagnosed as having primary psychiatric disease were our focus. These patients were diagnosed as having a primary psychiatric disorder, but their symptoms did not go into remission following use of psychotropic medication. In addition, their symptoms improved with adequate doses of penicillin and small quantities of psychotropic medication. This study was approved by the ethics committees of the Guangzhou Brain Hospital (Number 32, 2009). The participants’ relative or legal guardian signed the informed consent to participate in the study.
Each participant underwent clinical evaluation, including obtaining their history, physical and neurological examinations, neuroimaging and laboratory testing. Once the patients were identified as NS, we conducted the neuropsychological test and performed computed tomography (CT) or magnetic resonance imaging (MRI) scans in a week. The Mini Mental State Examination (MMSE) was used to evaluate cognitive function, and the cut-off scores were adjusted by education levels . The Chinese version of neuropsychiatric inventory (NPI) was used to evaluate neuropsychiatric symptoms. The total score was calculated by the sum of the 12 items in the NPI as frequency*severity .
The gender distribution between the groups was evaluated using a chi-squared test. The duration from the symptoms onset to correct diagnosis and MMSE were presented as the median and range (min, max). Differences between the groups were analysed using the nonparametric Mann–Whitney U test. The age, education and total score of the NPI were presented as the mean ± SD. Differences between the groups were analysed using the independent-samples t test. Spearman’s correlation was used to assess the correlation between cortical atrophy and hippocampus atrophy. All of the statistical analyses were performed using SPSS 17.0 (SPSS Inc., Chicago, IL, USA), and P values < 0.05 were considered statistically significant.
A total of 92 in-patients with NS were identified from the Guangzhou Brain Hospital. Seventy-six patients (82.6 %) had psychiatric symptoms. Twenty-nine patients (38.2 %) had been misdiagnosed as having primary psychiatric disease, including schizophrenia (15 patients), mania (6 patients), bipolar disorder (5 patients), acute stress disorder (1 patient), anxiety (1 patient), and psychomotor attack (1 patient). Twenty-six patients were definitively diagnosed once they saw a doctor. The remaining 21 patients were misdiagnosed with other types of diseases, such as Alzheimer’s disease, Lewy body dementia, ataxia, cerebral ischemia, encephalitis, epilepsy and substance abuse.
Demographic and clinical characteristics
The demographic and clinical information for the participants between GP misdiagnosed as primary psychiatric disease and the patients diagnosed definitely once seeing a doctor
GP misdiagnosed (n = 29)
GP not misdiagnosed (n = 26)
Number of male
26 (89.7 %)
23 (88.5 %)
48.2 ± 8.4
55.0 ± 8.2
8.9 ± 2.3
8.7 ± 1.8
The duration (month)
16 (from 1 to 96)
12 (from 1 to 72)
Positive sucking reflex
12 (41.4 %)
12 (46.2 %)
CSF-protein (>500 mg)
18 (62.1 %)
10 (38.5 %)
14 (48.3 %)
8 (30.8 %)
29 (100 %)
26 (100 %)
The neuroimaging characteristics
The neuroimaging of the patients
GP misdiagnosed (n = 29)
GP not misdiagnosed (n = 26)
25 (86.2 %)
22 (84.6 %)
subcortical white matter ischemic
23 (79.3 %)
16 (61.5 %)
9 (64.3 %)
5 (41.7 %)
(n = 14)
(n = 12)
Hippocampus metabolism abnormity
9 (64.3 %)
4 (33.3 %)
(n = 14)
(n = 12)
The neuropsychology of the patients
GP misdiagnosed (n = 19)
GP not misdiagnosed (n = 18)
11 (range 0 to 23)
15 (range 0 to 23)
10 (52.6 %)
8 (42.1 %)
5 (27.8 %)
16 (84.2 %)
8 (44.4 %)
11 (57.9 %)
5 (27.8 %)
11 (57.9 %)
6 (33.3 %)
10 (52.6 %)
4 (22.2 %)
13 (68.4 %)
9 (50 %)
5 (26.3 %)
4 (22.2 %)
12 (63.2 %)
10 (55.6 %)
Abnormal motor behavior
8 (42.1 %)
3 (16.7 %)
10 (52.6 %)
5 (27.8 %)
Appetite and eating disorders
4 (21.1 %)
3 (16.7 %)
36.6 ± 1.8
18.2 ± 3.0
All of the patients in our study suffered from GP. They had no personal or family history of psychiatric disorders. We found that up to 82.6 % of patients had psychiatric symptoms. With the widespread use of antibiotics, neuropsychiatric symptoms have become more common in NS, especially in general paresis, the late stage of NS . In the 1980s, only 17 % of NS patients presented with psychiatric disorders . Currently, mental disorders occur in approximately 85.7 % of patients . Young psychiatric physicians may be inexperienced in recognizing NS. It was often misdiagnosed as a primary psychiatric disorder. In our study, 29 patients (38.2 %) with mental disorders had been misdiagnosed as having a primary psychiatric disease, including schizophrenia (15 patients), mania (6 patients), bipolar disorder (5 patients), acute stress disorder (1 patient), anxiety (1 patient), and psychomotor attack (1 patient). All of these were common psychiatric disorders in the psychiatry clinic. In the misdiagnosed group, neuropsychiatric disorder was more severe than in the control group. Mood disturbances, such as depression, anxiety, apathy, irritability and agitation, were common. In addition, the agitation is the most common mood disturbance. As we know, delusions and hallucinations are the critical diagnosis standard for schizophrenia; however, in patients with GP, these symptoms were relatively rare . This is in agreement with our study. Roberts et al. also reported on 21 patients with NS presenting with psychiatric manifestations and suggested that agitation could serve as an indicator for the diagnosis of NS . The average age was 48.2 years old in the patients who were misdiagnosed, which is older than the average age of the onset of primary psychiatric disorders. The mean age was older in patients who were not misdiagnosed (55 years old). Cognitive impairment was obvious in our study but was often overlooked by the physicians, as the relatives were more concerned about their psychiatric symptoms. We found that cognitive impairment was more severe in the misdiagnosed group than in the control group when conducting the MMSE, although it was not statistically significant. The psychiatric and neurological symptoms may present as a consequence of extensively damaged parenchyma in cortical regions of the brain . The duration from onset to correct diagnosis was longer for the patients who were misdiagnosed. When the neurophysical examination was performed, the only positive sign in our patients was a positive sucking reflex. Argyll-Robertson pupil is a characteristic of NS in which the pupil is unresponsive to light but constricts with accommodation or convergence. This symptom was not found in the patients in our study. Research found that Argyll-Robertson pupil is not common in GP, but is more often observed in tabes dorsalis , and in our study, none of the patients had tabes dorsalis.
Generally, CSF abnormalities, including pleocytosis, elevated protein, RPR, and TPHA, are crucial for reliably assessing the clinical stage of NS . We found that the treponemal-specific test for TPHA in CSF was positive in all of the patients in our study, while the nonspecific lipoidal tests for RPR had a positive rate of 48.3 % in the misdiagnosed group and 30.8 % in the patients diagnosed correctly once seen by a doctor. Over time, the sensitivity of the lipoidal test to detect untreated late syphilis diminishes . Meanwhile, all of the patients in our study had GP, the late stage of NS. Although some patients had negative RPR results, we combined the clinical manifestations and diagnosed them as NS. As a result, we should perform the treponemal-specific test even if the screening test was negative. Although nonspecific lipoidal tests for RPR were an important index for the activity of NS, antisyphilitic treatment should be given even if the patient had negative RPR results.
Brain imaging is important for the differential diagnosis of GP, especially to distinguish GP from functional disease. Currently, most reports about the brain imaging of NS are nonspecific. Cerebral atrophy  and subcortical white matter lesions  are the most common abnormalities. In our study, only two patients had normal neuroimaging. One was misdiagnosed as having bipolar disorder after conducting CT scans. The other was screened because her husband was a GP in our department. These nonspecific characteristics cannot provide more information about whether NS should be considered. However, it can provide a sign that this is not a functional disorder. We also carried out hippocampal structure and MRS scans, which mimicked those of Alzheimer’s disease (AD) in the imaging, such as hippocampus atrophy [18, 19]. Our team study also found that patients with general paresis had Alzheimer-type biomarker Ab42 changes, while the asymptomatic neurosyphilis patients did not have this change . The hippocampus MRS was conducted to analyse its metabolism. Our findings suggest that the neuronal loss was in the hippocampus. A recent report also found that patients with mixed HIV infection and NS had substantial metabolic changes in the bilateral hippocampus, despite the paucity of MRI abnormalities in the structural scans . Upon further study, we found that the patients who had hippocampal atrophy also had cerebral atrophy. We believe that the hippocampal atrophy was the result of global brain atrophy, which can be distinguished from early AD where hippocampal atrophy was obvious in the early stage. As a consequence, some researchers consider the hippocampus as indicative of a poor prognosis of NS .
NS is the “great imitator” because it can mimic many types of medical disorders. Inexperienced physicians often have difficulty in recognizing NS due to its plentiful clinical manifestations. Most NS manifestations are potentially reversible , especially in its early stage. Considering the diversity of the clinical manifestations of NS, we should combine clinical symptoms, blood screening and CSF tests when carrying out a diagnosis of NS. As psychiatric symptoms become more common in the antibiotic era, we should pay attention to the patients whose psychiatric symptoms begin later in life and who have no personal or family history of psychiatric disorders. Although screening all psychiatric patients for syphilis has been thought to be too costly , we should screen the patients with a high risk. This would include individuals whose partner(s) have tested positive for syphilis, who abuse drugs and alcohol or who are engaging in commercial or coerced sex . We should be more concerned about the cognitive functioning in patients with psychiatric disorders. Brain imaging, although not specific, also provides a method to discriminate NS from primary psychiatric disease.
Our study had a cross-sectional design. In additional, selection bias is of concern. The patients in our study all had GP, the late stage of NS. Therefore, whether neuropsychiatric disorders such as agitation are common in the early stage of NS is unknown. In addition, the data in some patients were incomplete.
GP is a potentially treatable type of dementia, and early diagnosis and early treatments are crucial for prognosis. Neuropsychiatric symptoms are the most common symptoms, especially mood disturbances, such as agitation. When we come across a patient with agitation in middle and old age, we should pay attention to his cognitive function. Blood screening is essential for high-risk patients. Reliable assessments should combine clinical manifestations and blood and CSF laboratory tests. Brain imaging may also provide an indicator for the diagnosis of NS.
The authors are grateful for the physicians’ assistance from the Department of Neurology of Guangzhou Brain Hospital.
Guangzhou municipal key discipline in medicine for Guangzhou Brain Hospital (GBH2014-QN07).
Chinese National Science Foundation (No. 30970902).
Availability of data and materials
All relevant data are within the manuscript.
Conceived and designed the experiments: NY, WY. Performed the experiments: WY conducted the neuropsychological assessment; LL collected the clinical data, WZ and LS exported the neuroimaging data, CX recorded all of the data and checked the data. Analysed the data: WY Contributed reagents/materials/analysis tools: SH, HL, ZX, LX, ZD, ZY, TY; Wrote the paper: WY, NY. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Consent for publication
Relative or legal guardians of all the participants who were recruited in the study provided a specific and separate consent to publication of data in an anonymous way.
Ethics approval and consent to participate
This study was approved by the ethics committees of the Guangzhou Brain Hospital (Number 32, 2009). The participants’ relative or legal guardian signed the informed consent to participate in the study.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Timmermans M, Carr J. Neurosyphilis in the modern era. J Neurol Neurosurg Psychiatry. 2004;75(12):1727–30.View ArticlePubMedPubMed CentralGoogle Scholar
- Workowski KA, Bolan GA, Centers for Disease C, Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR-03):1–137.PubMedGoogle Scholar
- Guler E, Leyhe T. A late form of neurosyphilis manifesting with psychotic symptoms in old age and good response to ceftriaxone therapy. Int Psychogeriatr. 2011;23(4):666–9.View ArticlePubMedGoogle Scholar
- Mitsonis CH, Kararizou E, Dimopoulos N, Triantafyllou N, Kapaki E, Mitropoulos P, Sfagos K, Vassilopoulos D. Incidence and clinical presentation of neurosyphilis: a retrospective study of 81 cases. Int J Neurosci. 2008;118(9):1251–7.View ArticlePubMedGoogle Scholar
- Friedrich F, Aigner M, Fearns N, Friedrich ME, Frey R, Geusau A. Psychosis in neurosyphilis -- clinical aspects and implications. Psychopathology. 2014;47(1):3–9.View ArticlePubMedGoogle Scholar
- Jackson R. The Green Monster: Stokes's 1944 Modern Clinical Syphilology. J Cutan Med Surg. 2010;14(3):147–50.View ArticlePubMedGoogle Scholar
- Roberts MC, Emsley RA. Psychiatric manifestations of neurosyphilis. S Afr Med J. 1992;82(5):335–7.PubMedGoogle Scholar
- Workowski KA. The 1998 CDC Sexually Transmitted Diseases Treatment Guidelines. Curr Infect Dis Rep. 2000;2(1):44–50.View ArticlePubMedGoogle Scholar
- Zhang ZX, Zahner GE, Roman GC, Liu J, Hong Z, Qu QM, Liu XH, Zhang XJ, Zhou B, Wu CB et al. Dementia subtypes in China: prevalence in Beijing, Xian, Shanghai, and Chengdu. Arch Neurol. 2005;62(3):447–53.View ArticlePubMedGoogle Scholar
- Wang T, Xiao S, Li X, Wang H, Liu Y, Su N, Fang Y. Reliability and validity of the Chinese version of the neuropsychiatric inventory in mainland China. Int J Geriatr Psychiatry. 2012;27(5):539–44.View ArticlePubMedGoogle Scholar
- French P, Gomberg M, Janier M, Schmidt B, van Voorst VP, Young H. Iust: IUSTI: 2008 European Guidelines on the Management of Syphilis. Int J STD AIDS. 2009;20(5):300–9.View ArticlePubMedGoogle Scholar
- Marra CM. Update on neurosyphilis. Curr Infect Dis Rep. 2009;11(2):127–34.View ArticlePubMedGoogle Scholar
- Danielsen AG, Weismann K, Jorgensen BB, Heidenheim M, Fugleholm AM. Incidence, clinical presentation and treatment of neurosyphilis in Denmark 1980–1997. Acta Derm Venereol. 2004;84(6):459–62.View ArticlePubMedGoogle Scholar
- Kent ME, Romanelli F. Reexamining syphilis: an update on epidemiology, clinical manifestations, and management. Ann Pharmacother. 2008;42(2):226–36.View ArticlePubMedGoogle Scholar
- Ghanem KG. REVIEW: Neurosyphilis: A historical perspective and review. CNS Neurosci Ther. 2010;16(5):e157–168.View ArticlePubMedGoogle Scholar
- Luger AF, Schmidt BL, Kaulich M. Significance of laboratory findings for the diagnosis of neurosyphilis. Int J STD AIDS. 2000;11(4):224–34.View ArticlePubMedGoogle Scholar
- Kodama K, Okada S, Komatsu N, Yamanouchi N, Noda S, Kumakiri C, Sato T. Relationship between MRI findings and prognosis for patients with general paresis. J Neuropsychiatry Clin Neurosci. 2000;12(2):246–50.View ArticlePubMedGoogle Scholar
- Wang X, Yang Y, Wang X, Li C. MRI findings and early diagnosis of general paresis of the insane. Neurol Res. 2014;36(2):137–42.View ArticlePubMedGoogle Scholar
- Peng F, Hu X, Zhong X, Wei Q, Jiang Y, Bao J, Wu A, Pei Z. CT and MR findings in HIV-negative neurosyphilis. Eur J Radiol. 2008;66(1):1–6.View ArticlePubMedGoogle Scholar
- Luo X, Shi H, Hou L, Zhong X, Chen X, Zhang Y, Zheng D, Tan Y, Hu G, Mu N et al. Different cerebrospinal fluid levels of Alzheimer-type biomarker Abeta42 between general paresis and asymptomatic neurosyphilis. Eur J Neurol. 2015;22(5):853–8.View ArticlePubMedGoogle Scholar
- Chiu PW, Mak HK, Chan Y, Chan T, Ho KM. Hippocampal MR spectroscopic abnormalities in a cohort of syphilitic patients with HIV and neurosyphilis infection. Am J Nucl Med Mol Imaging. 2015;5(1):83–94.PubMedGoogle Scholar
- Stefani A, Riello M, Rossini F, Mariotto S, Fenzi F, Gambina G, Zanusso G, Monaco S. Neurosyphilis manifesting with rapidly progressive dementia: report of three cases. Neurol Sci. 2013;34(11):2027–30.View ArticlePubMedGoogle Scholar
- Saik S, Kraus JE, McDonald A, Mann SG, Sheitman BB. Neurosyphilis in newly admitted psychiatric patients: three case reports. J Clin Psychiatry. 2004;65(7):919–21.View ArticlePubMedGoogle Scholar
- Calonge N, Force USPST. Screening for syphilis infection: recommendation statement. Ann Fam Med. 2004;2(4):362–5.View ArticlePubMedGoogle Scholar