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Mapping the literature on parents with mental illness, across psychiatric sub-disciplines: a bibliometric review



Research on parental mental illness is often carried out in disorder specific research silos. Drawing on the different research areas, it is possible to leverage and combine existing knowledge, and identify insights that can be transferred across research areas. In this study, we identify the overarching structure of research on parents with psychiatric disorders, and the structure of the different research areas, as defined by psychiatric disorder groups in ICD-10, and identify both topics that are commonly examined, and topics that received attention in only a few of the research areas.


We use bibliometric science mapping to examine keywords in 16,734 articles, showing the overarching structure of research on parents with mental illness, both overall and within ICD-10 psychiatric disorder categories. The search was conducted using the Scopus database for journal articles published between 1999 and 2018, with no restrictions on language.


Co-occurrence analysis of the keywords in the 16,734 articles on parental mental illnesses in different psychiatric disorder categories, indicate there are six general themes in the literature: ‘expectant mothers and early motherhood’, ‘substance use and abuse’, ‘Socio-economic status’ (SES) and support practices’, ‘biomedical research‘, ‘diagnoses, symptoms and treatment’, and ‘child–parent interaction and context’. Although the same themes are covered in different areas, the contexts, in terms of content and relation to other topics, vary between the research areas. Some topics are heavily researched in some areas, but seem to be neglected in others.


This study provides data both in interactive maps and an extensive table, allowing readers to dive deep into their topic of interest, and examine how this connects to other topics, which may in turn guide identification of important gaps in the literature, and ultimately inspire and generate novel research avenues.

Peer Review reports


There is a rapid increase in both the volume of research and topic specialization, where many scientists tend to focus on a narrow discipline. However, with the volumes of new research there are also ample opportunities for learning across the disciplines. A central challenge is to know what others, outside one’s own field are examining. In this report, we examine a topic in the field of psychiatry as a specific example.

Many children have a parent with a mental illness, and as a result are more likely to experience negative long-term adversities [1,2,3,4,5]. While there are well-established disciplines focusing on parents with different mental illnesses, the past decade has seen an increase in scholarship focusing on the children of parents with a mental illness (COPMI) [6,7,8]. Drawing on the different areas of research on parents with mental illnesses, it is possible to leverage and combine existing knowledge from these areas, and to identify insights that can be transferred and extended in the COPMI area. A review based on quantitative analysis of bibliographic data is well suited to realizing these opportunities and to providing a structural overview of the published research.

Although the term COPMI is relatively new, there is a wealth of literature on parents with mental illnesses for COPMI researchers to draw on, wherein the investigated outcomes range from factors related to the parents to those of the children. Research areas include parents with mood and affective disorders, anxiety disorders, psychotic disorders, personality disorders, behavioural syndromes, and substance use disorders, as defined in ICD-10’s chapter on mental disorders. The contribution of much of this research has not necessarily been to COPMI per se, but when examined in this context, it can yield valuable insights to COPMI research. This review will also illustrate to what extent there is an overlap in investigated topics across the aforementioned ICD-10 groups.

Science mapping, based on bibliometric analysis, offers a quantitative approach to analysing a large body of work and can be used to identify the central research topics and intellectual structures in a research area. In the proposed review, we intend to: first identify the overarching structure of research on parents with mental illnesses; identify the structure of each of the different research areas; and identify both topics that are commonly examined, and topics that received attention in only a few of the research areas. This shows how research topics fit together and provides an overview that cannot be obtained from other forms of reviews. Next, we present the data both in interactive maps and in an extensive table, allowing readers to dive deep into their topic of interest, and examine how this connects to other topics, which may in turn spark new ideas. Finally, by examining a few specific examples, we demonstrate the value and potential of exploring a topic through the science maps provided.

The proposed review aims to combine and synthesize existing COPMI literature with that on parents with mental illnesses and to identify topics where the latter can inform and move forward COPMI research. The results will allow COPMI scholars to see what research topics are more and less closely linked by enabling reviews of the diverse topics outside of their specific research areas and by facilitating information transfer from research outside of their own speciality. The results can help clinicians and researchers alike, researchers can obtain an overview of the key thematic area(s), guide identification of important gaps in the literature, and ultimately inspire and generate novel research avenues; and clinicians can get new insight about clinical problems they are struggling with due to limited research literature on a given topic from insights gained from a related field.


Search and inclusion criteria

We developed search terms based on each of the following six ICD-10 groups of mental illnesses: F10 - F19, substance use disorders (nicotine dependence was not included; F20-F29, Schizophrenia, schizotypal, delusional, and other non-mood psychotic disorders; F30-F39, mood and affective disorders; F40–48, anxiety, dissociative, stress-related, somatoform and other nonpsychotic mental disorders; F50-F59, behavioral syndromes associated with physiological disturbances and physical factors; and F60-F69, disorders of adult personality and behavior. To include articles that refer to generic terms, rather than only specific disorders, we also included a ‘generic psychiatric disorders’ search term. Each of the search terms are bounded by parental terms, selected to focus results on how parental mental illness can affect the children, instead of the other way around (see Additional file 1 table for a complete overview of the search terms). We examined a random sample of the resulting corpus to estimate proportion of articles that fall outside the subject, and estimate the rate at 7%, which is acceptable, as any distortions are likely washed out by constraints in the analysis. The search was conducted in April and August 2019, using the Scopus database for journal articles published between 1999 and 2018, with no restrictions on language. We selected the 20 year period starting from 1998, as the bibliographic data available in the database for earlier years are incomplete [9]. We selected the Scopus database for its wide reach, including all journals indexed by PubMed [10], and the full bibliographic data on published articles, which are unavailable in most other databases. Although the resulting corpus of articles may not be complete, we compared the results with searches in the Web of Science database, and the results indicate our corpus represents a sample of above the 85% of the total population of published journal articles recommended when using the network analysis [11] employed in this study.

Table 1 Overview of major topics in the themes in the overall research on ‘parental mental illness’, in articles published from 1999 to 2018; and across the research areas

Data analysis

In this study, we employ bibliometric co-occurrence analysis on author and indexed keywords to identify how frequently topics are examined in the same article, and how keywords relate to each other in the wider context of research areas [12]. We conducted the analysis for each of the seven research areas indicated above, and on the combined areas, using the VOSviewer 1.6.12 software [13, 14]. The results enabled us to construct and understand a conceptual network structure of each of the areas and on an overarching perspective [15].

Prior to analysis, possible keywords were cleaned for generic terms such as the word ‘model’, ambiguous terms such as ‘time’, and words that do not denote a concept, such as names of countries and research methods. Finally, plural words were converted into their singulars, and synonyms were combined into a term. The principles for cleaning were devised by both authors based on past studies [16] and on independent coding of a 15% sample of all keywords. One author (IOL) constructed the thesaurus, which was subsequently verified by the other author (NA).

The bibliometric co-occurrence analysis was conducted on each of the seven research areas, with a lower limit set to 15 occurrences for each research area, and 30 for the combined search, meaning that only keywords appearing in 15 (or 30 for the combined search) or more articles are included in the analysis. The analysis yields a score for occurrence, a list of all keywords that occur together, and how the keywords cluster. To make these results accessible, keyword occurrences are presented in a table, and how they relate to each other is presented in a two-dimensional network graph. In the graph, the distance between keywords indicates relatedness, that is, the more similar keywords are, the closer together they are on the map; occurrence is reflected in the size of the circles, and the thickness of the lines indicates the number of articles the two co-occur in. Keywords that co-occur often are assigned to the same cluster. The layout and associated statistics were determined by a framework for mapping and clustering that is considered best practice [14], in the VOSviewer software [13]. The maps provide an overview of the overarching research field and the sub-domains, thus illustrating how the location of topics in relation to other topics can give an indication of possible gaps in the literature. Due to the richness of the data, we provide keyword co-occurrence maps for each of the research areas in the Additional file 1. These can be downloaded, searched, and explored interactively (see Figs. 1 and 2 as examples).

Fig. 1

Keyword Co-Occurrence Network Graph for the Overall Research Field on Parental Mental Illness in the Period from 1999 to 2018. The graph is based on keywords in articles from the following research areas: ‘substance use disorders’; ‘psychotic disorders’; ‘mood and affective disorders’; ‘anxiety disorders’; ‘behavioral syndromes’; personality disorders’; and ‘generic psychiatric disorders’. Red cluster: Expectant mothers and early motherhood; Green cluster: Diagnoses, symptoms and treatment; Yellow cluster: Child–parent interaction and context; Turquoise cluster: SES and support practices; and Blue cluster: Biomedical research. Size of circle shows the relative number of occurrences of a keyword, and weight of line indicates the frequency two keywords are linked. Please note the number of lines in the figure has been reduced for legibility in the print edition. To view all the links, please access the interactive map using the Map and Network files found at OSF: and the VOSviewer software

Fig. 2

a. Keyword Co-Occurrence Network Graph for ‘Anxiety Disorders’ Area of Research, Based on Articles Published from 1999 to 2018. Red cluster: Expectant mothers and early motherhood; Green cluster: Diagnoses, symptoms and treatment; Yellow cluster: Child–parent interaction and context; Turquoise cluster: SES and support practices; and Blue cluster: Biomedical research. Size of circle shows the relative number of occurrences of a keyword, and weight of line indicates the frequency two keywords are linked. Please note the number of lines in the figure has been reduced for legibility in the print edition. To view all the links, please access the interactive map using the Map and Network files found at OSF: and the VOSviewer software. Please see the appendix for maps of the other research areas and associated links to the interactive maps. b. A Section of Fig. 2a, Keyword Co-Occurrence Network Graph For the ‘Anxiety Disorders’ Area. This is what a section of the graph looks like when displayed in the interactive tool when ‘social support’ is selected to show other major keywords it is researched together with. The figure also show that in addition to linking with keywords within its own cluster, SES and support practices, the keyword ‘social support’ links with topics in all the other the clusters in the ‘anxiety disorders’ area

Some keywords connect the whole or parts of the network. These are termed ‘bridging keywords’ and due to their high centrality and associated relevance for a wide variety of keywords, the allocation to a given cluster is incidental. To identify keywords that act as bridges between major topics, we used the Pajek 5.05 software to calculate the betweenness centrality, a measure of how frequently a keyword is on the shortest path between other keywords [17].

To name the identified clusters based on prevalent themes, we followed the coding principles of grounded theory [18], where both authors independently undertook the steps of open and axial coding, to find common topics in the clusters. To reach a consensus, we conducted the selective coding process together and identified the final theme names (please see the Additional file 1 for more on the coding steps). The process included examining a more fine-grained cluster analysis of each co-occurrence map, and the use of network centrality measures to identify the most prominent terms.

Definitions: We use the term ‘area’ to describe an ICD-10 category, ‘themes’ to describe the general content clusters, ‘topics’ to describe individual parts of a theme, and ‘keyword’ to describe a specific concept, as used in articles.


Identification of literatures

The combined search returned 16,734 articles, and for each area, returned: 2257 articles for ‘substance use disorders‘; 2568 for ‘psychotic disorders’; 3938 for ‘mood and affective disorders’; 3602 for ‘anxiety disorders’; 3861 for ‘behavioral syndromes’; 1166 for ‘adult personality and behavioral disorders’; and 5082 for ‘generic psychiatric disorders’. There is overlap between the areas, which explains why the total is less than the sum of the individual searches. There is a 53% overlap between the articles in the ‘generic psychiatric disorders’ search and the other searches; and a 16% overlap between all the other groups in total. The overlap is not corrected, as the aim is to identify topics examined in each domain. An article that contributes to more than one domain is therefore counted in each associated domain.

Introduction to how themes are covered in different areas

A co-occurrence and cluster analysis of the keywords in the 16,734 articles on parental mental illnesses in the seven research areas, as defined by ICD-10, and the ‘generic psychiatric disorder’ search, indicate there are six general themes in the literature.

Figure 1 provides an overall structure of the research, based on the combined search. The analysis of each of the individual research areas shows large variations in focus, content and structure. Examining the results, we identified a set of themes that is prevalent to a greater or lesser extent in the different research areas. These are: ‘expectant mothers and early motherhood’, ‘substance use and abuse’, ‘SES and support practices’, ‘biomedical research’, ‘diagnoses, symptoms and treatment’, and ‘child–parent interaction and context’. Some themes such as ‘diagnoses, symptoms and treatment’ are covered in most of the research areas, while others, such as ‘substance use’, is only a distinct theme in some areas. Further, although the same theme is covered in different areas, the contexts, in terms of content and relation to other topics, tend to vary between the research areas. See Fig. 2, the keyword co-occurrence map for ‘mood’ disorder area, as an example.

In the following sections, we first outline the main themes, the central topics in each (see Table 1 for an overview), and how they relate to other topics and themes in the various research areas. Next, we provide a short description of the major bridging keywords. Finally, we present examples of keywords that are examined to varying extents in the different research areas, indicating both potential for cross areas learning, and identification of possible gaps in the literatures. A table of the 1408 keywords in Fig. 1 is available in the Additional file 1.

Theme 1: expectant mothers and early motherhood

The theme, ‘expectant mothers and early motherhood’, is distinct in all research areas apart from ‘personality’, and includes topics relating to the period from conception to the early period after birth, including pregnancy complications and related challenges. Other topics include: follow-up during pregnancy, description of birth, maternal and neonatal outcomes; and risk factors, such as substance use, and the role of health services and treatment of pregnant women, mothers and young children.

The role of prenatal exposure to legal and illegal substances is central in all areas. Prescription drug use during pregnancy is a dominant focus also in the ‘psychotic’, ‘mood’, ‘anxiety’, ‘generic psychiatric disorders’ areas. For example, in the ‘mood’ and ‘anxiety’ disorder areas, research is conducted on the safety of prescription drugs, such as antidepressants or anxiolytics, during pregnancy [19]. Illegal substance use is a dominant focus in both the ‘substance use disorders’ and ‘generic psychiatric disorder’ area. For example, opioid dependence, and the associated use of both legal and illegal opioids during pregnancy, is often studied in conjunction with maternal outcomes and the developing fetus and birth outcomes [20]. Topics in this theme frequently co-occur with topics in the ‘animal and genetics’ theme, for example on the effect of prenatal exposure to cocaine on the developing fetus and on brain development in animals [21]. A similar co-occurrence frequency is found in the safety of prescription drug use during pregnancy [22].

We also find that the role of social support is part of this theme in the ‘behavior syndromes’ and ‘generic psychiatric disorders’ research areas, such as social support interventions aimed at improving child outcomes [23].

Theme 2: child–parent interaction and contextual factors

The central topics in the ‘Child–parent interaction and contextual factors’ theme include various types of parental and child behaviors and mental disorders, and how these can influence the relationship between parents and their children. The role of contextual factors that can manifest as both risk and protective factors, and the role of comorbidity and other risk factors that can cause poor family functioning, are also central in this theme.

The theme is also distinct in the ‘substance use’, ‘mood’, ‘anxiety’ and ‘personality’ disorder areas; and receives somewhat less attention in the ‘psychotic’, ‘behavior syndromes’ and ‘generic psychiatric disorders’ areas, where the topic is covered as part of the ‘diagnoses, symptoms and treatment’ theme.

The ways that various externalizing behaviors affect the relationship between parents and their children are central in the ‘substance use’, ‘moods’, ‘anxiety’, ‘personality’ and ‘generic psychiatric disorders’ areas; for instance, in the ‘personality’ area, this theme is often studied in conjunction with keywords such as ‘violence’, ‘antisocial behavior’ and ‘conduct disorder’, and how these factors influence child outcomes [24, 25].

The role substance use and abuse has on the child–parent relation is prominent in the areas of ‘substance use’ and ‘personality disorders’. For example, keywords such as ‘, ‘substance abuse’, ‘alcohol abuse’, ‘cannabis addiction’, ‘opiate addiction’ and ‘cocaine-related disorders’, are examples of exposure variables related to outcomes such as family functioning [26,27,28].

Protective factors are frequently examined within this theme, in the ‘substance use’, ‘personality’, ‘behavior syndromes’ and ‘generic psychiatric disorders’ areas. One such protective factor is social support, which can act as a buffer against the influence of difficult family situations and upbringing and reduce stress and tensions in the family [23].

Theme 3: biomedical research

In the theme ‘biomedical research’ there are two distinct but connected topics; namely, research on animals, and on genetics. They are grouped as a theme in all the research areas.

There are two main foci within animal research: the first is on brain studies, the second on exposure to drugs. Brain research indicates a biological focus, with keywords such as dopamine, nerve cell, and prefrontal cortex. The second focus is on exposure, primarily on prenatal exposure to illegal and legal substances, including prescription drugs used to treat mental disorders. Animal studies are used to examine brain development and cognitive outcomes in the ‘psychotic’, ‘mood’, ‘anxiety’ and ‘generic psychiatric disorders’ area and often in relation to exposure variables, such as ‘cocaine’, ‘morphine’, ‘alcohol’ and dose-response of various types of substances in the ‘substance use’ area. Animal studies are often conducted to examine outcomes from exposure to various forms of stress in the ‘mood’, ‘anxiety’, ‘behavior’, ‘generic psychiatric disorders’, and ‘psychotic’ areas, with research on, for example, the associations between maternal stress during pregnancy and child emotional and cognitive problems [29], and on social behaviors in the ‘psychotic’ area [30].

The second focus in the theme is genetics. Keywords such as ‘twins’, ‘siblings’, and ‘gene-environment interaction’, are often studied in conjunction with intergenerational transmission of risk for mental disorders. For example, in the ‘personality’ area, genetics is often studied in conjunction with antisocial behavior and psychopathy, and in the ‘behavior syndromes’ area, sleep and eating disorders are heavily researched [31]. The genetic predisposition for developing alcohol and other substance use disorders is examined in the ‘substance use’ and ‘personality disorders’ areas [32]. The influence of genetic and environmental factors on child–parent relation is often studied in the ‘psychotic’ and ‘personality disorders’ areas [33].

Genetics research is also conducted using animal studies in the ‘substance use’, ‘psychotic’, ‘moods’, ‘anxiety’ and ‘generic psychiatric disorders’ areas. This includes research on the role of genetic animal models in developing and testing the safety of prescription drugs used for treating mental disorders [34, 35].

Theme 4: diagnoses, symptoms and treatment

The theme ‘Diagnoses, symptoms and treatment’ is a distinct theme in all but the ‘substance use disorders’ area. The central topics include various types of mental disorders and treatments, as well as topics related to health care. These topics are frequently related to comorbidity and various risk factors, such as substance use and abuse.

There are substantial variations across the areas, as to with which topics the theme is studied. Socioeconomic factors and demographic variables are common in the ‘psychotic’ and ‘generic psychiatric disorders’ areas, with research on, for example, how demographic factors are associated with higher prevalence of mental disorders. ‘Violence’ is a frequently associated topic in the ‘anxiety’, ‘personality’ and ‘behavioral syndromes’ areas, including keywords such as ‘domestic violence’, ‘child abuse’, ‘sexual abuse’, and ‘physical abuse’. For example, child abuse is examined as a risk factor for mental illness [36, 37] in the ‘personality’ area.

‘Social support’ is a prominent topic in the ‘psychotic’ area, with research on the extent social support provided to families with parental mental illness is associated with child behavior outcomes and child mental health and child–parent relationship [23].

In the ‘behavioral syndromes’ area, the theme is spread over three clusters. The first on eating disorders, often with a family focus [38]. The second on sleep disorders, often studied in conjunction with cognitive outcomes [39], and the third on ‘other mental disorders’, often studied in conjunction with comorbidity and externalizing problems [40].

Theme 5: substance use and abuse

Various types of substance use and substance use disorders make up the theme ‘substance use’, topics often studied in conjunction with socioeconomic and demographic factors, mental disorders, comorbidity, family relationships, violence and prenatal exposure.

As an independent theme, it is only present in two areas: ‘substance use disorders’ and ‘generic psychiatric disorders’, but it is present as topics in all of the areas. In both the ‘substance use disorders’ and the ‘generic psychiatric disorder’ areas, ‘substance use and abuse’ is often studied in conjunction with socioeconomic variables. For example identifying socioeconomic status, and financial strain as risk factors for substance use disorders [41], and violent communities as a risk factor for developing substance use disorders [42]. Further, research on the association between family environment, such as child abuse, and the risk of developing substance use and other mental disorders [37, 43] are common in the ‘generic psychiatric disorders’ area.

Theme 6: SES and support practices

The theme ‘SES, demography and health support’ is largely comprised of contextual topics, most often found as control variables or to frame a study, and while present in all areas, is only identified as an independent theme in two areas, namely ‘mood’ and ‘anxiety’ disorders. The theme has two main foci, the first relates to support practices, such as social support, community care and psychosocial care and various forms of support offered by professional health service providers. The second focus relates to the support programs, such as intended benefits, like prevention and risk reduction, and outcome measures, such as cost of illness and wellbeing.

In all the areas, SES and support practices are frequently studied with topics in the ‘child–parent interaction and context’ theme, specifically on topics such as education, social support and mental health. An example is how families in low SES neighborhoods experience more life stressors, and have less access to resources to deal with them [44]. In the ‘substance use’ and ‘psychotic disorders’ areas, SES is often included as both a risk factor, and control variable, for example, in conjunction with various mental disorders and treatments, [45] and with topics in the ‘expectant mothers and early motherhood’ theme, especially relating to post birth topics, such as postpartum depression [46].

Bridging keywords

Some keywords are often used to describe a study setting, such as denoting a sample or general topic, and represent bridges between other keywords. We identified nine such keywords in this study (See Table 2). Five refer to sample characteristics in terms of child age groups, namely ‘infant’, ‘preschool child’, ‘child’, ‘school child’, ‘adolescent’ and ‘young adult’. Many studies take a risk perspective and the keyword ‘risk factor’ thus indicates such an approach. For example, parental age, SES and mental health are examined as risk factors for child maltreatment [47], and parental mental illness as a risk factor for offspring mental illness [48]. Similarly, ‘Mental disorders’ is a general and common term in the field; and ‘Depression’ is one of the most prevalent and debilitating health problems, often co-occurring with other mental health problems [49, 50] and extensively researched [51].

Table 2 Number occurrences of a selection of keywords in each of the research areas a

Interacting with the results

A main aim of this study is to enable researchers to explore the extent to which specific topics occur across the different areas, and how they co-occur with other topics. To do so, we provide a table with the occurrence across the different areas of the 1408 keywords with more than 30 occurrences in the combined search results in the Additional file 1. We have extracted example terms for Table 2, such as social support, which occurs in more than 900 articles. However, the amount of attention received by the topic varies across the areas, and it is most extensively researched in the ‘behavior syndromes’, ‘mood’ and the ‘generic psychiatric disorders’ areas. The term ‘child abuse’, occurs in more than 800 articles in the overall search, with substantially more research conducted in the ‘moods‘and ‘generic psychiatric disorder‘areas than in the ‘psychotic disorders’ area.

For researchers interested in particular stages of child development, Table 2 also illustrates substantial variation regarding which age groups most often constitutes the study sample in different areas. For instance, preschool children receive more attention in the mood, anxiety, behavior syndromes and generic psychiatric disorders areas, than in the other areas.

To identify what other keywords a given term is most frequently researched with, it is possible to locate the term in the interactive network maps, and highlight the associated terms, either for each individual research area, or for the field in total.


We identified the overarching structure of research on parents with mental illnesses, and identified similarities and differences in the structure of the different research areas. Our search returned the majority of results when using disorder-specific keywords, suggesting that most research focuses on a parent’s specific diagnosis rather than generic psychiatric disorders and that the literatures are separate. With the interactive network maps and the table of keyword occurrences across the research areas, this review is the first to identify topics commonly examined across areas and those primarily studied in a few areas. As such, the review shows how the research fits together and provides an overview that cannot be obtained from other types of reviews.

Based on co-occurrence analysis of keywords from more than 16,000 articles, we show that the literature consists of six major themes. There are clear differences in the different areas, awareness of which can help researchers identify and connect results from studies in areas outside of their own; and may spark new research ideas. This may be of particular value for emerging fields such as COPMI.

Comparing how the various themes are covered in individual research areas, we see substantial variation in both the number of articles and the topics they are studied in conjunction with. ‘Social support’ represents an example, where the topic has received significant attention in the ‘mood’, ‘behavioral syndromes’ and ‘generic psychiatric disorder’ (more than 200 articles), while it has received scant attention in the ‘substance use’ and ‘personality disorders’ areas. A second example is that ‘child abuse’, is studied most frequently in the ‘mood’ and ‘generic psychiatric disorders’ areas, and less so in the ‘psychotic disorders’ and ‘behavioral syndromes’ areas. These, and other similarly skewed topics, represent potentially valuable avenues of research. Social support can help most psychiatric patients and their family members; and knowledge is needed on how to best facilitate it in all the research areas on parental mental illness. As for child abuse, we can think of no good reasons why this is less of an issue in some research areas than in others; knowledge on how to prevent such cases is important across all research areas on parental mental illness.

Some research areas are more similar than others: ‘mood’ and ‘anxiety’ look similar both in terms of structure and topics. However, close examination reveals substantial variation in the topics that are most commonly examined and what topics are studied in conjunction with each other. For instance, social support is covered in both research areas. However, in the ‘moods’ area, it is often studied in conjunction with socioeconomics and pregnancy topics, which is not the case in the ‘anxiety’ research area.

These examples further illustrate that knowledge on a given topic may be dominated by research in a single, or few areas. Such skewness may represent a source of bias emanating from idiosyncrasies in a given area, not necessarily evident to a specialist researcher. The results presented in this review may offer an indication as to whether this is the case.


Several limitations should be mentioned. First, a bibliometric review can only provide an overview of a research area; thus it is no substitute for extensive reading, and should be seen as a complement, not a replacement of narrative, scoping or systematic reviews. More in-depth reviews are necessary when the aim is to identify specific mechanisms and evaluate the strength and quality of the research articles included in the review. Second, there are no quality measures of the journals and articles included, apart from requirements to be indexed by Scopus. Third, despite our best efforts, the data represents a sample, rather than all published articles on parents with a mental illness in the time period 1999 and 2018.


The present study is the first review, to our knowledge, to map the structure of research on parents with mental illnesses as a whole; as well as similarities and differences in the structure and research focus in the various areas as defined by the ICD-10. The study can help both scholars and clinicians get an overview of the entire research field, and it can facilitate identifying important gaps in the literature, and promising new research avenues. Although we only presented a few examples, the results present a wealth of data, from which a range inferences and inspirations may be drawn. We hope to facilitate utilization of the results for these purposes by providing interactive and searchable network maps and a complete overview of keywords and their occurrence across the research areas, thus provoking thought in the reader and inspiration for scholars to identify, examine and explore novel and valuable ways to advance the area.

Availability of data and materials

Raw data can be accessed by using the search strings we made available in the Additional file 1, and repeating the search in Scopus. In addition, all the files needed to access the network graph files can be accessed through the project folder at the open science framework (OSF) site: These files can be opened in the freely available VOSviewer software.



Children of parents with a mental illness


International classification of diseases, tenth revision


Socio-economic status


  1. 1.

    Berg L, Back K, Vinnerljung B, Hjern A. Parental alcohol-related disorders and school performance in 16-year-olds-a Swedish national cohort study. Addiction. 2016;111:1–1803795.

    Article  Google Scholar 

  2. 2.

    Christoffersen MN, Soothill K. The long-term consequences of parental alcohol abuse: a cohort study of children in Denmark. J Subst Abus Treat. 2003;25(2):107–16.

    Article  Google Scholar 

  3. 3.

    Shen H, Magnusson C, Rai D, et al. Associations of parental depression with child school performance at age 16 years in Sweden. JAMA Psychiatry. 2016;73(3):239.

    Article  PubMed  Google Scholar 

  4. 4.

    Ramchandani P, Psychogiou L. Paternal psychiatric disorders and children’s psychosocial development. Lancet. 2009;374:646–53.

    Article  PubMed  Google Scholar 

  5. 5.

    Lewis G, Neary M, Polek E, Flouri E, Lewis G. The association between paternal and adolescent depressive symptoms: evidence from two population-based cohorts. Lancet Psychiatry. 2017;4:920–6.

    Article  PubMed  Google Scholar 

  6. 6.

    Maziade M. At risk for serious mental illness - screening children of patients with mood disorders or schizophrenia. N Engl J Med. 2017;376(10):910–2.

    Article  PubMed  Google Scholar 

  7. 7.

    Siegenthaler E, Munder T, Egger M. Effect of preventive interventions in mentally ill parents on the mental health of the offspring: systematic review and meta-analysis. J Am Acad Child Adolesc Psychiatry. 2012;51(1):8–17.e8.

    Article  PubMed  Google Scholar 

  8. 8.

    Solantaus T, Paavonen EJ, Toikka S, Punamäki RL. Preventive interventions in families with parental depression: children’s psychosocial symptoms and prosocial behaviour. Eur Child Adolesc Psychiatry. 2010.

  9. 9.

    Li J, Burnham JF, Lemley T, Britton RM. Citation analysis: comparison of web of science®, Scopus™, SciFinder®, and Google scholar. J Electron Resour Med Libr. 2010;7(3):196–217.

  10. 10.

    Rodrigues SP, Van Eck NJ, Waltman L, Jansen FW. Mapping patient safety: a large-scale literature review using bibliometric visualisation techniques. BMJ Open. 2014.

  11. 11.

    Burt R. Studying status/role-sets as ersatz network positions in mass surveys. Sociol Methods Res 1981;9(3):313–337. doi:

  12. 12.

    Callon M, Courtial J-P, Turner WA, Bauin S. From translations to problematic networks: An introduction to co-word analysis. Inf (International Soc Sci Counc). 1983;22(2):191–235.

    Article  Google Scholar 

  13. 13.

    van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010;84(2):523–38.

    Article  PubMed  Google Scholar 

  14. 14.

    Waltman L, van Eck NJ, Noyons ECM. A unified approach to mapping and clustering of bibliometric networks. J Inf Secur. 2010;4(4):629–35.

    Article  Google Scholar 

  15. 15.

    Börner K, Chen C, Boyack KW. Visualizing knowledge domains. Annu Rev Inf Sci Technol. 2003;37(1):179–255.

    Article  Google Scholar 

  16. 16.

    Zupic I, Čater T. Bibliometric methods in management and organization. Organ Res Methods. 2015;18(3):429–72.

    Article  Google Scholar 

  17. 17.

    Kadushin C. Understanding social networks: theories, concepts, and findings. OUP USA; 2012.

  18. 18.

    Corbin J, Strauss A. Basics of qualitative research: Techniques and procedures for developing grounded theory. Thousand Oaks: Sage publications; 2014.

  19. 19.

    El Marroun H, White T, Verhulst FC, Tiemeier H. Maternal use of antidepressant or anxiolytic medication during pregnancy and childhood neurodevelopmental outcomes: a systematic review. Eur Child Adolesc Psychiatry. 2014;23(10):973–92.

  20. 20.

    Jones HE, Heil SH, Baewert A, et al. Buprenorphine treatment of opioid-dependent pregnant women: a comprehensive review. Addiction. 2012;107:5–27.

    Article  PubMed  PubMed Central  Google Scholar 

  21. 21.

    Buckingham-Howes S, Berger SS, Scaletti LA, Black MM. Systematic review of prenatal cocaine exposure and adolescent development. Pediatrics. 2013;131(6):e1917–36.

    Article  PubMed  PubMed Central  Google Scholar 

  22. 22.

    Zucker I. Risk mitigation for children exposed to drugs during gestation: a critical role for animal preclinical behavioral testing. Neurosci Biobehav Rev. 2017;77:107–21.

    Article  PubMed  CAS  Google Scholar 

  23. 23.

    Marie-Mitchell A, Kostolansky R. A systematic review of trials to improve child outcomes associated with adverse childhood experiences. Am J Prev Med. 2019;56(5):756–64.

    Article  PubMed  Google Scholar 

  24. 24.

    Fountoulakis KN, Leucht S, Kaprinis GS. Personality disorders and violence. Curr Opin Psychiatry. 2008;21(1):84–92.

    Article  PubMed  Google Scholar 

  25. 25.

    McEwan M, Friedman SH. Violence by parents against their children: reporting of maltreatment suspicions, child protection, and risk in mental illness. Psychiatr Clin North Am. 2016;39(4):691–700.

  26. 26.

    Finan LJ, Schulz J, Gordon MS, Ohannessian CM. Parental problem drinking and adolescent externalizing behaviors: the mediating role of family functioning. J Adolesc. 2015;43:100.

  27. 27.

    Moreland AD, McRae-Clark A. Parenting outcomes of parenting interventions in integrated substance-use treatment programs: a systematic review. J Subst Abus Treat. 2018.

  28. 28.

    Mirick RG, Steenrod SA. Opioid use disorder, attachment, and parenting: key concerns for practitioners. Child Adolesc Soc Work J. 2016;33(6):547–57.

    Article  Google Scholar 

  29. 29.

    Talge NM, Neal C, Glover V. Antenatal maternal stress and long-term effects on child neurodevelopment: how and why? J Child Psychol Psychiatry. 2007;48(3–4):245–61.

    Article  PubMed  Google Scholar 

  30. 30.

    Flores G, Morales-Medina JC, Diaz A. Neuronal and brain morphological changes in animal models of schizophrenia. Behav Brain Res. 2016;301:190–203.

  31. 31.

    Kessler RM, Hutson PH, Herman BK, Potenza MN. The neurobiological basis of binge-eating disorder. Neurosci Biobehav Rev. 2016;63:223–38.

  32. 32.

    Yohn NL, Bartolomei MS, Blendy JA. Multigenerational and transgenerational inheritance of drug exposure: the effects of alcohol, opiates, cocaine, marijuana, andnicotine. Prog Biophys Mol Biol. 2015.

  33. 33.

    Adshead G. Parenting and personality disorder: clinical and child protection implications. BJPsych Adv. 2015;21(1):15–22.

  34. 34.

    Yadid G, Nakash R, Deri I, et al. Elucidation of the neurobiology of depression: insights from a novel genetic animal model. Prog Neurobiol. 2000;62(4):353–78.

  35. 35.

    Ng RC, Hirata CK, Yeung W, Haller E, Finley PR. Pharmacologic treatment for postpartum depression: a systematic review. Pharmacotherapy. 2010;30(9):928–41.

    Article  PubMed  CAS  Google Scholar 

  36. 36.

    Fossati A, Madeddu F, Maffei C. Borderline personality disorder and childhood sexual abuse: a meta-analytic study. J Personal Disord. 1999;13(3):268–80.

    Article  CAS  Google Scholar 

  37. 37.

    Hailes HP, Yu R, Danese A, Fazel S. Long-term outcomes of childhood sexual abuse: an umbrella review. Lancet Psychiatry. 2019;0(0). doi:

  38. 38.

    Forsberg S, Lock J. Family-based treatment of child and adolescent eating disorders. Child Adolesc Psychiatr Clin N Am. 2015;24(3):617–29.

    Article  PubMed  Google Scholar 

  39. 39.

    McCoy JG, Strecker RE. The cognitive cost of sleep lost. Neurobiol Learn Mem. 2011;96(4):564–82.

    Article  PubMed  PubMed Central  Google Scholar 

  40. 40.

    Long CG, Hollin CR. Assessing comorbid substance use in detained psychiatric patients: issues and instruments for evaluating treatment outcome. Subst Use Misuse. 2009;44(11):1602–41.

  41. 41.

    Toumbourou JW, Hemphill SA, Tresidder J, Humphreys C, Edwards J, Murray D. Mental health promotion and socio-economic disadvantage: lessons from substance abuse, violence and crime prevention and child health. Heal Promot J Aust. 2007;18(3):184–90.

    Article  CAS  Google Scholar 

  42. 42.

    Aisenberg E, Herrenkohl T. Community violence in context. J Interpers Violence. 2008;23(3):296–315.

    Article  PubMed  Google Scholar 

  43. 43.

    Kumpfer KL, Bluth B. Parent/Child Transactional Processes Predictive of Resilience or Vulnerability to “Substance Abuse Disorders.”. Subst Use Misuse. 2004;39(5):671–98.

  44. 44.

    Richardson R, Westley T, Gariépy G, Austin N, Nandi A. Neighborhood socioeconomic conditions and depression: a systematic review and meta-analysis. Soc Psychiatry Psychiatr Epidemiol. 2015;50(11):1641–56.

  45. 45.

    Sendt K-V, Tracy DK, Bhattacharyya S. A systematic review of factors influencing adherence to antipsychotic medication in schizophrenia-spectrum disorders. Psychiatry Res. 2015;225(1–2):14–30.

  46. 46.

    Howard LM, Oram S, Galley H, Trevillion K, Feder G. Domestic violence and perinatal mental disorders: a systematic review and meta-analysis. Tsai AC, ed. PLoS Med. 2013;10(5):e1001452. doi:

  47. 47.

    Sidebotham P, Golding J. Child maltreatment in the “children of the nineties”: a longitudinal study of parental risk factors. Child Abuse Negl. 2001;25(9):1177–200.

  48. 48.

    Lawrence PJ, Murayama K, Creswell C. Systematic review and meta-analysis: anxiety and depressive disorders in offspring of parents with anxiety disorders. J Am Acad Child Adolesc Psychiatry. 2019;58(1):46–60.

  49. 49.

    Plana-Ripoll O, Pedersen CB, Holtz Y, et al. Exploring comorbidity within mental disorders among a Danish National Population. JAMA Psychiatry. 2019;76(3):259.

  50. 50.

    Edlund MJ, Forman-Hoffman VL, Winder CR, et al. Opioid abuse and depression in adolescents: results from the National Survey on drug use and health. Drug Alcohol Depend. 2015;152:131–8.

  51. 51.

    Van Noorden R, Maher B, Nuzzo R. The top 100 papers. Nature. 2014;514(7524):550–3.

    Article  PubMed  CAS  Google Scholar 

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We would like to acknowledge librarian at NIPH, for quality control of our search strategy. Thank you to the Village research group, Bente Weimand and Brenda Gladstone for reading and commenting on an early draft of this manuscript. Thank you to Jasmina Burdzovic Andreas, for constructive feedback on the final version of the manuscript.


This review was conducted as part of the Ludwig Boltzmann Gesellschaft Research Group Village in cooperation with the Medical University of Innsbruck funded by the Austrian Federal Ministry of Education, Science and Research. The funders were not involved in design of the study, data collection, analysis or interpretation of data or writing of the manuscript.

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NA and IOL conceptualized and designed the study, IOL acquired the data, NA analyzed the data, NA and IOL jointly interpreted the data and drafted and polished the article. Both authors read and approved the final version of the manuscript and agree to be personally accountable for all aspects of the work.

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Correspondence to Ingunn Olea Lund.

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Supplementary information

Additional file 1.

Search terms, complete set of bibliometric network diagrams, and extended table comparing keyword occurrences in each of the research areas.

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Andersen, N., Lund, I.O. Mapping the literature on parents with mental illness, across psychiatric sub-disciplines: a bibliometric review. BMC Psychiatry 20, 468 (2020).

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  • Bibliometric
  • Science mapping
  • Mental illness
  • Parent
  • Child