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Digital interventions for subjective and objective social isolation among individuals with mental health conditions: a scoping review



Social isolation encompasses subjective and objective concepts. Both are associated with negative health consequences and are more prevalent among people with mental health problems than among the general population. To alleviate social isolation, digital interventions have potential as accessible alternatives or adjuncts to face-to-face interventions. This scoping review aimed to describe the types of digital interventions evaluated for feasibility, acceptability and effectiveness in alleviating social isolation among individuals with mental health problems, and to present an overview of the quantitative evidence yielded to inform future intervention design.


We searched five electronic databases for quantitative and mixed methods studies published between January 2000 and July 2020. Studies were included if they evaluated digital interventions for individuals with mental health conditions, had subjective and/or objective social isolation as their primary outcome, or as one of their outcomes if no primary outcome was specified. Feasibility studies were included if feasibility outcomes were the primary outcomes and social isolation was among their secondary outcomes. A narrative synthesis was conducted to present our findings. The protocol was registered on Open Science Framework (doi:


Thirty-two studies were included for our review: 16 feasibility studies, seven single-group studies and nine effectiveness trials. There was great variation in the interventions, study designs and sample populations. Interventions included web-based programmes, phone-based programmes, blended interventions, socially assistive robots and virtual reality interventions. Many were feasibility studies, or otherwise not fully powered to detect an effect if one were present, thus preventing clear conclusions about clinical effectiveness. Satisfactory feasibility outcomes indicated potential for future trials to assess these interventions.


Our scoping review identified a range of digital approaches utilized to alleviate social isolation among individuals with mental health disorders. Conclusions regarding clinical effectiveness cannot be reached due to variability of approaches and lack of large-scale randomized controlled trials. To make clear recommendations for digital social isolation interventions, future research needs to be based on rigorous methods and larger samples. Future studies should also focus on utilizing theory-driven approaches and improving existing approaches to advance the field.

Peer Review reports


Social isolation can be defined as “a state in which the individual lacks a sense of belonging socially, lacks engagement with others, has a minimal number of social contacts and they are deficient in fulfilling and quality relationships” [1]. A distinction is often made between objective social isolation, where an individual has a small social network, or has infrequent contact with other people [2], and subjective social isolation, which is a perceived mismatch between an individual’s actual and desired social relationships, and which may include a perception of inadequate social support, leading to feelings of loneliness [3, 4]. Subjective and objective social isolation are conceptually distinct [5] and coincide to only a limited degree – it is possible to feel lonely while surrounded by many friends, but also to feel satisfied with one’s social life despite few social interactions [6].

Poor subjective and objective social isolation are associated with poor physical and mental ill-health [7]. Beyond cross-sectional findings that describe associations between subjective social isolation and cancer [8], depression symptom severity [9] and psychosis [10], longitudinal associations are also described between loneliness and the onset of depression [11]. Similarly, there is evidence to support cross-sectional associations between objective social isolation and poor health outcomes such as being diagnosed with “borderline personality disorder” [12], increased mortality rate [13] and higher risk of dementia [14]. In contrast, social support can be protective, being associated with better health outcomes such as improved immune function [15] and decreased likelihood of suicide attempts [16]. Greater perceived social support has also been found to buffer the rate and severity of psychological distress, depression, and anxiety [17, 18].

Compared to the general population, subjective and objective social isolation are found to be more prevalent among individuals with mental health disorders. Loneliness was more prevalent among people diagnosed with schizophrenia [19], while having fewer friends (i.e., smaller social network size) is also found to be more common among people with mental health problems, including people with adolescent-onset psychosis [20] and veterans with post-traumatic stress disorder (PTSD) [21]. Given these associations, the alleviation of social isolation is a potentially promising way of improving people’s mental health in both general and clinical populations. With the backdrop of the COVID-19 pandemic, the implementation of physical distancing rules to curb the spread of the virus has further heightened the need to understand both the impact of social isolation and how to reduce it effectively.

Despite the associations between social isolation and mental ill-health, interventions that target social isolation for people with mental health problems are still at the more preliminary stages of development [2, 22]. Many of these are in-person social interventions, which make use of peer support, increasing social and physical activities, interacting with animals and psychological therapies such as mindfulness-based and reminiscence therapies [23]. However, in part due to the longstanding stigma surrounding both mental health issues and loneliness, accessing in-person, face-to-face treatments for mental health-related issues can be difficult, whereas lack of resources and treatment delays also impede access [24]. Digital or technology-based approaches are thus potentially useful alternatives to face-to-face approaches, as digital literacy and usage are increasingly widespread, and individuals may feel more comfortable discussing sensitive and personal issues in the relative anonymity of an online context [25]. Well-developed digital interventions also have potential to be cost-effective [26], and to be scaled rapidly at low cost [27]. Twenty-four-hour availability is a further advantage, together with accessibility for people encountering barriers to help-seeking such as geographical location, disabilities or lockdown restrictions [28]. In relation to the issue of social isolation, digital technology such as social media and online communities have been shown to alleviate feelings of social isolation by facilitating feelings of social connectedness and reducing loneliness among young adults [29] and older adults [30]. Associations between greater internet use and increased social connectedness have also been demonstrated in older adults [31]. Thus, there is a growing body of research developing and assessing the use of digital interventions for social isolation. Providing an up-to-date appraisal of the extent and strength of this evidence is important given rapid technological advances and the possibilities for development and testing of novel tools.

Previous reviews of digital interventions for social isolation reviewed different types of digital interventions – some reviewed specific tools such as video calls [32], communication technologies [33], social robots [34] or computer and internet-training programmes [35], while some did not focus on any specific intervention and reviewed various forms of digital tools [3638]. These reviews, however, focussed on subjective social isolation, older adults and/or general population samples. Only one review has examined the effects of computer- and internet-based training interventions on depression levels (in addition to loneliness) among older adults in the general population [35], but otherwise there has been relative neglect of populations diagnosed with mental health conditions.

While our initial intention was to conduct a systematic review, we decided to conduct a scoping review instead, as our preliminary scan of literature showed that potentially eligible studies used diverse study designs, involved clinical populations with a wide range of mental health conditions and used a variety of outcome measures. Compared to systematic reviews, scoping reviews are used to map the evidence in a field of study available to answer broader research questions [39], especially where ‘an area is complex or has not been reviewed comprehensively before’ [40]. In providing such a wide-ranging overview of the evidence, we aimed to identify studies on which future research and intervention development work might build. We widened our inclusion criteria beyond randomised controlled trials (RCTs) to other forms of experimental studies, including single-group studies and feasibility studies, as we anticipated few RCTs in an emerging research field addressing digital interventions for social isolation among people with mental health problems. The purpose of this scoping review was to stimulate future research in this digitalised age by mapping the available quantitative research evidence. We have included studies which yield data on the effectiveness of digital approaches in a mental health context, and papers that yield evidence on the feasibility and acceptability of studies on this topic as a potential prelude to investigate the effectiveness of the respective approaches. We pre-registered the review protocol with the Open Science Framework (OSF) online public database (doi:


As our initial intention was to conduct a systematic review, our review protocol and inclusion/exclusion criteria were developed based on a systematic review framework. However, on commencing the systematic review, the studies retrieved were noted to have a high degree of heterogeneity, making it hard to answer our specific questions about intervention effectiveness and study feasibility. We therefore made a team decision to change our approach to that of a scoping review, restricted to quantitative studies, whilst using the same search criteria. Scoping reviews vary in the nature and types of evidence they include, depending on the research questions the review focuses on [41], as has been demonstrated in previous published reviews [42, 43]. We confined our review to include only quantitative studies, as this approach aligned with our objective of understanding the current state of evidence by examining quantitative work that has been done to date to assess the effectiveness of digital interventions for reducing social isolation, and the feasibility of carrying out such studies. Our review methodology aligns with a six-stage methodological framework adapted from Arksey and O’Malley [39] as well as Levac, Colquhoun and O’Brien [44]. We did not carry out the optional sixth stage that involves consulting stakeholders to validate study findings.

Stage 1: identifying clear research question(s)

Our scoping review focused on three research questions: (i) for individuals with mental health problems, what are the types of digital interventions available to alleviate subjective and objective social isolation (encompassing concepts such as loneliness, perceived social support, social network size and social participation)? (ii) what have the research studies demonstrated about feasibility, acceptability and effectiveness of these interventions? and (iii) what type(s) of intervention(s) show promise for further testing in future large-scale trials?

Stage 2: identifying relevant studies

Inclusion/exclusion criteria

To answer our research questions, we included studies that involved populations with mental health disorder(s) – this meant their eligibility criteria for recruitment included mental health conditions, assessed with diagnostic/symptom measures or diagnosed by mental health professionals, and including subsyndromal symptoms of mental health conditions. We included studies that either, within the context of social isolation, investigated the effectiveness of a digital intervention or assessed the feasibility of trialling the digital intervention in future large-scale studies. We included feasibility studies, where the primary aim is to assess whether and how future RCTs can or should be done [13], as well as RCTs, as this scoping review was aimed not only at assessing evidence of effectiveness, but also at exploring digital tools that are potential candidates for future research. We also included blended interventions (digital and face-to-face components) if the digital component of the intervention was delivered during 50% or more of the intervention period. No limits were placed on the forms of technologies or the scope of ‘digital’ approaches.

In terms of outcomes, studies were included if they reported outcomes related to subjective and/or objective social isolation as one of the primary outcomes, or as one of the outcomes in a study where the primary outcome was not specified. Studies that stated their main aim as investigating feasibility, acceptability or usability were also included if methods for the evaluation of the intervention’s clinical effectiveness regarding social isolation were being tested. For comprehensiveness we included studies measuring social isolation using validated outcome measures such as the Multidimensional Scale of Perceived Social Support (MSPSS), Lubben Social Network Scale (LSNS), single-item measures, and unvalidated outcome measures.

Search strategy

We included studies that were published from 01 January 2000 until July 2020 and used quantitative or mixed methods (extracting only quantitative data from mixed-methods studies). There was no restriction on the comparator or control condition. We excluded qualitative studies, case reports/series, reviews, meta-analyses and conference abstracts. Studies were excluded if the eligibility criteria required, alongside mental health conditions, a comorbid diagnosis of dementia, intellectual disability, autistic spectrum disorders, other neurological, organic or physical health problems.

Searches were conducted for relevant articles in five databases: Association for Computing Machinery Digital Library (ACM), Institute of Electrical and Electronics Engineers (IEEE) Xplore digital libraries, Embase, MEDLINE® and PsycINFO. The OVID interface was used to combine and search the latter three databases. Searches were limited to research carried out on humans. There were no language or geographical limitations to ensure a good representation of the target population by including all relevant studies. The complete list of search terms is provided in Supplementary file 1. Reference lists from all included studies were manually searched by the primary reviewer (GT). A second reviewer (SI) reviewed the reference lists from a randomly chosen 15% of the included studies, to check inter-rater reliability.

Stage 3: selecting studies

Search results were imported into Endnote X9 software package for screening. GT reviewed all titles and abstracts from the retrieved articles and SI screened a random selection of titles and abstracts of 15% of the articles. All full-text articles for the candidate articles were then screened by GT using the agreed inclusion and exclusion criteria. At the same stage, SI randomly screened 15% of the candidate articles in full text. Any discrepancy regarding inclusion was resolved through discussion to reach consensus. When necessary, a third reviewer was involved to reach consensus.

Stage 4: extracting and charting the data

Data extraction for included articles was conducted using a standardised proforma developed for the review, including publication year and country, participants’ demographics, sample size, study setting, study design, the nature of the intervention, details of follow-up, primary and secondary outcomes (including any feasibility outcomes), exclusion of participants, and the reasons for exclusion. GT carried out the data extraction of all articles and SI extracted data independently from a randomly chosen 15% of the included articles. Any discrepancy regarding data extraction was resolved through discussion and consensus, involving a third reviewer where necessary.

Quality assessment

Although quality assessment is not mandatory in scoping reviews, we conducted a quality assessment of included studies in order to explore strength of evidence in the current evidence base pertaining to our research questions, especially in studies where effectiveness was assessed. Following previous scoping reviews that also included quality assessment [4550], we used the Mixed Methods Appraisal Tool (MMAT) [51] for quality assessment due to the inclusion of quantitative and mixed methods study in this review. We set the threshold for complete outcome data at 80% for this review, as per precedent in the literature [52]. Each domain was rated with ‘yes’, ‘no’ or ‘unclear’ in response to each statement. Each study was then rated to be at ‘high’, ‘moderate’ or ‘low’ risk of bias based on the number of domains that were fulfilled. Studies were rated as ‘low risk’ if four or five domains were fulfilled, ‘moderate’ if two or three were fulfilled, and ‘high’ if one or none of the domains were fulfilled. GT carried out quality assessment for all included articles, and SI randomly assessed 15% of the articles. Any discrepancy between the two reviewers was resolved through discussion and consensus, involving a third reviewer if necessary. Studies with low methodological quality were not excluded from the final synthesis, apart from those that failed to meet the two MMAT screening criteria (whether there are clear research questions, and whether the collected data address the research questions).

Stage 5: collating, summarizing and reporting findings

As recommended in scoping review methodology frameworks, extracted data were collated and summarized into a descriptive and narrative summary of study characteristics [39, 44]. Comparisons across studies were made relating to their design and methodology, target populations with different mental health conditions, as well as characteristics and components of the interventions that were investigated. Using a thematic approach, we then classified the interventions evaluated in the included studies into groups to explore the nature of the interventions, feasibility to be conducted in future trials and potential effectiveness of the interventions [53]. To facilitate comparisons, we also presented the studies’ characteristics, intervention characteristics and findings in tables (Tables 1, 2, 3, 4, 5, 6 and 7).

Table 1 The study characteristics of feasibility studies, stratified by study design
Table 2 The study characteristics of single-group studies, stratified by study design
Table 3 The study characteristics of effectiveness trials, stratified by study design
Table 4 Characteristics of interventions, stratified by types of interventions
Table 5 Results of the feasibility studies, stratified by study design
Table 6 Results of the single-group studies
Table 7 Results of the effectiveness trials, stratified by study design


We identified 8819 articles from the search of five databases. We conducted full text screening of 175 articles, finding 31 to be eligible. One other article was identified through reviewing the reference lists, bringing the total to 32 included articles (Fig. 1).

Fig. 1
figure 1

PRISMA flow diagram describing the selection of articles

A total of 1945 participants were involved in the 32 studies, with individual sample sizes ranging from 4 to 300.Footnote 1 Twenty-six studies had fewer than 100 participants. The target populations involved individuals with depressive symptoms (n = 12) [55•, 57•, 58•, 60•, 63•, 67•, 68•, 72•, 75•, 78•, 80•, 81•], psychotic symptoms (n = 7) [54•, 56•, 62•, 64•, 66•, 73•, 77•], trauma (n = 4) [61•, 70•, 71•, 84•], social anxiety disorder (n = 2) [59•, 65•], suicidal intent (n = 1) [82•] and elevated levels of distress (n = 1) [85•]. Five other studies involved participants with a variety of mental health conditions, including bipolar disorder, mood disorders and affective disorders [69•, 74•, 76•, 79•]. Some studies recruited individuals from more than one diagnostic group, for example individuals with diagnosis of schizophrenia, major depressive disorder, or bipolar disorder [76•], or individuals with schizophrenia or affective disorder [79•].

Of the total of 32 studies, 16 (50%) were feasibility or pilot studies [54•, 55•, 56•, 57•, 58•, 59•, 60•, 61•, 62•, 63•, 64•, 65•, 66•, 67•, 68•, 69•]. Most were uncontrolled, pre-post measures pilot studies and four were pilot RCTs [54•, 55•, 67•, 73•]. We grouped these studies as feasibility studies as their primary aim was to assess the feasibility and preliminary evidence of conducting future definitive trials utilizing the same interventions [86]. All feasibility studies also reported effectiveness outcomes. Seven other studies (21.9%) [69•, 70•, 71•, 72•, 73•, 74•, 75•] used the single-group/pre-post measures design. Nine included studies were effectiveness trials (28.1%) [77•, 78•, 79•, 80•, 81•, 82•, 83•, 84•, 85•], of which three were fully powered RCTs and six were RCTs that were not fully powered; all with the primary aim of assessing intervention effectiveness. Overall, nine of 32 studies used mixed methods (36%).

Twelve studies were carried out in the United States [54•, 57•, 58•, 61•, 67•, 72•, 76•, 79•, 80•, 81•, 83•, 84•], 11 in Australia [59•, 60•, 62•, 63•, 64•, 65•, 66•, 68•, 69•, 74•, 85•], two in Netherlands [54•, 56•], one in China [70•], one in Iran [78•], one in Korea [71•], one in Portugal [73•], one in Sri Lanka [82•], one in Taiwan [75•] and one in the United Kingdom [55•]. Only four studies (12.5%) were conducted between 2000 and 2010 [54•, 58•, 68•, 80•]; the others were conducted between years 2011–2020, among which 21 studies were conducted within the last 5 years (2016–2020) at the time of conducting this review.

The interventions evaluated used technology to relay therapeutic content, to provide social support and as a tool for distance follow-up or monitoring. Although there were interventions designed specifically to reduce loneliness (n = 2) [65•, 66•], most aimed to promote the well-being of participants, such as improving social functioning or mental and physical health outcomes. In these studies, social isolation was not the primary outcome, but was included among a range of psychosocial outcomes instead. Only four studies explicitly stated their primary and secondary outcomes – among these, one listed loneliness and perceived social support among their primary outcomes [62•], and another listed objective social participation [77•]. Other studies did not explicitly differentiate between primary and secondary outcomes, although six studies did lay out their primary objectives/hypotheses [63•, 65•, 66•, 67•, 79•, 83•].

Among the digital elements incorporated, most studies reported using asynchronous digital content (communication between participants and clinicians not occurring at the same time), including online intervention programs [54•, 55•, 58•, 70•, 78•, 79•, 80•, 81•, 83•, 84•, 85•], peer support via email listservs [79•] and symptom monitoring via text messages or smartphone apps [56•, 61•, 62•, 66•, 73•, 82•]. Some studies reported enhancing peer support via online chatroom features and social networking elements in their interventions [59•, 60•, 62•, 63•, 64•], but it is unclear whether the use of these online social support elements was synchronous (live communication happening in real time). Only three studies stated clearly that the intervention incorporated a synchronous digital component, in which participants received real time peer support via phone calls [57•, 67•] or received therapeutic feedback in virtual reality sessions with a clinician [77•].

Of the 32 studies, 29 assessed subjective social isolation, two measured objective social isolation [71•, 77•] and one assessed both subjective and objective social isolation outcomes [59•]. Overall, loneliness and perceived social support were the most assessed dimensions of social isolation, whereas for objective social isolation specifically, social network size and time spent with others were assessed. Commonly used validated outcome measures included the: University of California Los Angeles Loneliness Scale (UCLA-LS) (n = 7) [59•, 62•, 64•, 65•, 66•, 68•, 75•], Medical Outcomes Trial-Social Support Scale (MOS-SSS) (n = 7) [54•, 60•, 61•, 67•, 79•, 82•, 83•], Social Provisions Scale (SPS) (n = 4) [55•, 62•, 64•, 79•], Multidimensional Scale of Perceived Social Support (MSPSS) (n = 3) [57•, 69•, 84•] and Social Connectedness Scale (SCS) (n = 2) [59•, 63•]. Seven studies used more than one social isolation measure [54•, 59•, 60•, 62•, 64•, 67•, 72•]. Four studies used unvalidated outcome measures including single-item measures, multiple-item measures and questionnaires administered via the Experience Sampling Method (ESM) [54•, 56•, 67•, 81•]. Detailed characteristics of studies, including study aims, sample sizes, study designs and outcome measures, are outlined in Table 1 (feasibility studies), Table 2 (single-group studies) and Table 3 (effectiveness trials).

To answer our research questions, we structured our findings based on 1) nature of the interventions evaluated, 2) quality assessment, and 3) strength of evidence. We first describe the range of intervention types and their main components, then summarise the available evidence on feasibility and on effectiveness.

Types of intervention

Characteristics of all interventions are outlined in Table 4, stratified by types of intervention.

Web-based interventions

In this review, we adopted the definition of a web-based interventions as ‘a primarily self-guided intervention programme that is executed by means of a prescriptive online programme operated through a website and used by consumers seeking health- and mental-health related assistance’ [87]. Overall, 16 out of 32 studies (50%) utilized web-based programmes, including eight feasibility/pilot studies [54•, 55•, 59•, 60•, 62•, 63•, 64•, 69•], three pre-post measure studies [70•, 71•, 72•], and five effectiveness trials [78•, 79•, 83•, 84•, 85•]. Of the eight feasibility studies, two were pilot RCTs that mainly aimed to examine feasibility and acceptability outcomes [54•, 55•]. All studies delivered web-based programmes in a multicomponent format.

Access to therapeutic content, peer support and clinical/peer moderation were frequently reported as part of the intervention. Therapeutic content was delivered in forms of therapy courses or modules consisting of core concept explanations, skill- or strength-building exercises and psychoeducational resources. Some also incorporated interactive content in forms of online games or comic strips [59•, 60•, 62•, 63•, 64•]. All studies provided therapeutic content to various degrees, including studies that assessed internet peer support groups [72•, 79•, 85•]. As an example, Goodwin et al. (n = 34) [72•] mainly investigated the role of online peer support via an established Internet Support Group (ISG) called the ‘Psycho-Babble’. Participants, with depressive symptoms, were given access to an Internet portal that contained the ISG as well as fact-based content related to mental health and depression.

Peer support was also a common element, incorporated in forms of group discussion forums, online chatrooms, existing social media (e.g., Telegram®) and email listservs. Online peer support was the main element investigated in three studies [72•, 79•, 85•] whereas nine other studies also incorporated peer support as part of the interventions, but not as the main element [55•, 59•, 60•, 62•, 63•, 64•, 69•, 78•]. Participants were able to interact with peers who had experienced the same difficulties using the online platforms under safety monitoring from the researchers. This was proposed to promote a sense of community, thus fostering social support and mental wellbeing.

We also identified eight studies that explicitly reported embedding moderation by peers [55•, 59•, 60•, 62•, 63•, 64•, 69•, 78•]; six of these also incorporated clinical moderation by professionals [59•, 60•, 62•, 63•, 64•, 69•]. The researchers reported the role of peer moderators to be promoting engagement and providing support when needed. Expert moderators were tasked with providing clinical guidance, monitoring the clinical status of participants and monitoring the safety of the online environment. Most other studies also made mention of monitoring from experts or clinicians. Among the three studies that did not report clinical or peer moderation, one was an underpowered RCT by Kaplan and colleagues (n = 60) [83•] which aimed to examine unmoderated and unstructured internet support for participants with schizophrenia or affective disorders. In the other two studies, interventions were designed as self-help, take-home resources [70•, 71•], thus the research focus was on assessing treatment courses that could be entirely self-facilitated by the participants. There was no mention of expert moderation/monitoring or additional social support component in either of these studies. For example, Lee et al.’s study (n = 35) [71•], conducted in South Korea, consisted of an online imagery-based program that was developed based on the cognitive model of PTSD. The main therapeutic objective was to utilize guided imagery techniques to help participants modify traumatic memories. Training sessions were made up of auditory guidance and background music to enhance imagery experience, supplemented by mind-body training techniques such as relaxation and meditation.

Apart from two studies [54•, 69•], the online programmes were individual-level interventions and were self-directed by the participants. Campbell et al.’s study (n = 105) [69•], the only feasibility study that recruited more than 100 participants, used an online platform (‘Kids Helpline Circle’) to conduct group counselling with young adults with mild depressive or anxiety symptoms. Rotondi et al. (n = 30) [54•] conducted therapy groups facilitated by mental health professionals using online bulletin boards. This feasibility study involved persons with schizophrenia and provided problem-solving group therapy to the participants and their family members. In both studies, while the online counselling/therapy was facilitated by the researchers, participants had access to other aspects of the intervention that also contained psychoeducational resources.

In 10 of the 16 studies (62.5%), researchers aimed to develop their interventions based on specific theoretical frameworks, including Cognitive Behavioural Therapy (CBT) [83•, 85•], Social Cognitive Theory (SCT) [78•], Behavioural Activation (BA) [55•] and the cognitive model of PTSD [71•]. It is also noteworthy that the web-based programmes (‘MOMENTUM’, ‘Affinity’, ‘Horyzons’, ‘Rebound’ and ‘Entourage’) in five feasibility studies [59•, 60•, 62•, 63•, 64•] were based on the MOST (Moderated Online Social Therapy) model developed by Orygen, a mental health organization based in Australia. The MOST model has its theoretical basis in Self-Determination Theory, positive psychology and mindfulness [88]. The interventions incorporated self-help therapy modules, a moderated social network, and personalised suggestions for therapy content from clinicians. Behavioural prompts were also included as a feature of persuasive systems – recommendations for behaviour change were given to users to implement in the real world. These interactive online platforms aimed to foster self-efficacy and social support for users in a safe environment. They are intended to supplement face-to-face treatments, therefore participants in these studies are recruited from local clinics and continued their in-person treatments during the study periods.

Telephone-based programmes

We identified seven studies, including six feasibility studies [56•, 57•, 61•, 65•, 66•, 67•] and one single-group study [73•] that delivered interventions using mobile telephones. Of the six feasibility studies, two were pilot RCTs with the primary aim to test feasibility and acceptability outcomes [56•, 67•]. More specifically, four utilized smartphone apps [56•, 65•, 66•, 73•], two used telephone calls [57•, 67•], and the other used text messages [61•]. Studies that utilized smartphone apps mentioned monitoring by clinical professionals while the others did not. Although each intervention provided certain degrees of therapeutic support that had their basis in concepts such as positive psychology, the theoretical basis for the formation of these interventions was not outlined in detail.

Of these studies, six studies shared a common component of symptom assessment and monitoring [56•, 57•, 61•, 65•, 66•, 73•]. Symptom monitoring was a feature in Hanssen and colleagues’ (n = 64) [56•] pilot feasibility RCT conducted with individuals with schizophrenia in the Netherlands. The researchers assessed the SMARTapp (Schizophrenia Mobile Assessment and RealTime feedback application), which was mainly designed for participants to carry out real-time monitoring of their symptoms by answering multiple questionnaires daily using the app. The app was personalized for the users at baseline assessment – e.g., users had in-app access to their preferred relaxation activities or comforting thoughts at any time. Participants in the intervention group received additional personalized feedback (suggestions for a certain activity or behaviour change) from the SMARTapp based on their questionnaire responses, whereas those in the control group used the app without individual feedback. In another study, Price et al. (n = 29) [61•] assessed a symptom-monitoring intervention utilizing text messages. Recruited after experiencing a traumatic injury, participants received daily messages that contained assessments of different symptom domains, including social support, hypervigilance and re-experiencing. Symptom assessment and monitoring was the main objective for these studies. The main aim of the +Connect app, which was used in two other feasibility studies [65•, 66•], was to reduce loneliness by conveying evidence-based concepts of positive psychology to users, in order to build on their strengths and empower them to engage in meaningful social interactions. Content was delivered in a multimedia format (via short videos or via text and images) and participants had to answer content-based quizzes afterwards. Through answering questions, completing daily mood tracking and progressing through various levels of content, participants also obtained points and badges. The addition of this gamification element was intended to promote participants’ engagement.

Social support was integrated in the two studies utilizing phone calls [57•, 67•]. In a pilot feasibility RCT, Gjerdingen et al. (n = 39) [67•] compared the effects of support from peer volunteers via phone calls versus in-person support from certified postpartum doulas versus usual care. In contrast, Pfeiffer et al. (n = 48) [57•] assessed a more complex digital intervention: the researchers used an automated telephone monitoring system to assess veteran patients’ depressive symptoms and medication adherence, while also providing social support to the participants via weekly phone calls/meetings with either a friend, a family member or a trained and certified peer specialist, depending on the participant’s choice. The automated phone system utilized interactive voice response technology (IVR) and consisted of scripted voice recordings to which participants responded. The family member/friend received a report on the participant’s responses and tips on how to interact with the participant during the meetings, while the peer specialist was instructed to guide interactions based on the participants’ responses using their own skills.

Blended interventions

A total of seven studies employed a blended approach by combining digital with face-to-face components in therapy. These were two feasibility studies [58•, 68•], two single-group studies [74•, 76•] and three effectiveness trials [80•, 81•, 82•]. The role of the digital component varied – some studies utilized technology as the main instrument to convey therapeutic content (n = 3) [58•, 80•, 81•] while in others it served as a monitoring/follow-up tool (n = 2) [76•, 82•]. Two other studies [68•, 74•] conducted in-person, group training sessions during which participants were trained to use a computer and the Internet. As an example, Dow and colleagues (n = 14) [68•] conducted a computer-training programme for rural carers with subsyndromal depressive symptoms. Participants were given a recycled personal computer and trained on how to use the computer, send and receive emails and to navigate the Internet. It was proposed that such training programmes may facilitate more social connections for the participants as they learn to connect with others online, thus reducing social isolation.

Another three studies – a feasibility study [58•] and two randomized comparative trials (not fully powered) [80•, 81•] – examined the effects of using face-to-face motivational interviews (MI) to complement the web-based programme (Competent Adulthood Transition with Cognitive-behavioural and Interpersonal Training – CATCH-IT), which was based on CBT and Interpersonal Therapy (IPT) principles. The web-based programme was the main component, while an in-person, 10- to 15-min MI was conducted once before and once after the online intervention. CATCH-IT was used for depression prevention with adolescents who had been experiencing persistent sub-threshold depressive symptoms, whereas the role of MI was proposed to enhance the users’ willingness for behaviour change, leading to increased effectiveness of the internet intervention.

It was unclear from the description of most studies whether there was any moderation for the digital component. In contrast, Aschbrenner and colleagues (n = 25) [76•] reported safety monitoring of the private Facebook group that participants were introduced to in their lifestyle intervention. This was a group intervention designed to promote the overall well-being of participants via weekly weight management sessions and the use of social media. Along with Marasinghe et al.,‘s (n = 68) [82•] RCT, the digital components in this study were implemented during more than half of the intervention period and served as an adjunct to complement the face-to-face intervention. The main purpose of the technology components was to monitor or facilitate participants’ self-monitoring of symptoms, as well as provide informational and social support.

Although there was some level of description regarding the theoretical basis of each individual component, the theoretical basis of using a blended approach of these components was unclear.

Social robots

Socially assistive robots are designed to interact with people in a socio-emotional way during interpersonal interactions to improve recovery and health outcomes [89]. Recently social robots have been increasingly utilized to alleviate psychological distress and reduce social isolation among elderly adults with dementia [90]. In this review, we identified one single-group study conducted by Chen et al. (n = 20) [75•] who delivered a social robot intervention involving elderly adults with depression. Participants were each allocated an animal companion robot (Personal Assistive RobOt – ‘Paro’) to keep throughout the intervention. They were encouraged to interact with it through touch and verbally, whenever they preferred to. Paro is shaped like a baby harp seal, equipped with tactile sensors and could show human-like emotional reactions. Paro and other animal robot interventions are aimed at encouraging human-animal interactions that can improve psychological and social functioning through the comfort and emotional attachment derived from close interactions and commitment to the animal companion robot.

Virtual reality

Virtual reality (VR) is utilized in therapy by allowing participants to complete therapeutic exercises in the virtual social world with the guidance of a therapist. In a fully powered RCT, Pot-Kolder and colleagues (n = 116) [77•] assessed the effectiveness of a virtual-reality-based CBT (VR-CBT) to enhance positive social participation (operationalised as time spent with others) among individuals with psychotic disorders who experienced paranoid ideation and social avoidance. Participants communicated with therapists in each session where they were exposed to virtual simulations of social situations. Based on individualised case formulations, each participant experienced exposure to different social environmental cues that elicited paranoid thoughts and safety behaviours. The participants worked with the therapists during these sessions to explore and challenge their safety behaviours and negative thoughts.

Quality assessment

Out of the 16 included feasibility studies (all of which provided data collected with aim of assessing effectiveness) we judged six to be at moderate risk of bias, five at low risk of bias and five at high risk of bias. None of these studies accounted for confounders in the study design or data analysis. Of these 16 studies, five did not report complete outcome data (completion rates below 80%) and one did not specify completion rates.

Of the seven single-group, pre-post measures studies, four were judged to be at moderate risk of bias, two at low risk of bias and one at high risk of bias. Of these seven studies, two did not report complete outcome data and three did not specify completion rates.

There were three fully powered RCTs, one of each judged to be at high, moderate and low risk of bias respectively. The six other randomised trials that were not fully powered were all judged to be at moderate risk of bias. Eight out of nine randomized trials described methods of randomization. However, descriptions of concealment and blinding were unclear or missing on six randomized trials. Out of nine randomized trials, all specified completion rates but three did not report complete outcome data. Results of quality assessment are presented in Supplementary file 2.

Strength of evidence

Although the heterogeneity of studies and lack of studies assessing social isolation as the primary outcome (in contrast, being included among a range of outcomes instead) make it difficult to form firm conclusions, we present a summary of the efficacy and feasibility outcomes of the included studies to provide a preliminary overview of the current state of evidence, categorised by respective study designs. We also outlined the participants’ characteristics, effectiveness and feasibility outcomes (for feasibility studies only) as well as intervention duration in Tables 5, 6 and 7 (for feasibility studies, single-group/pre-post measures studies and effectiveness trials respectively).

Feasibility and pilot studies

While their primary stated purpose was to obtain data to test the feasibility of conducting a full trial, all 16 feasibility studies aimed to provide data relevant to effectiveness. In a pilot RCT, Hanssen and colleagues (n = 64) [56•] found statistically significant decreases in loneliness scores across all participants using the SMARTapp intervention, but no difference was found between the intervention and control groups, hence effectiveness is not known. Rotondi and colleagues (n = 51) [54•] showed a non-significant trend towards greater perceived social support for participants in the web-based intervention group compared to the control group. The other two pilot RCTs [55•, 67•] did not report significant findings.

Although Van Voorhees and colleagues (n = 14) [58•] found a non-significant trend toward increasing social support scores among participants, this was a single- group study that did not include a control group to compare the effects of the online CATCH-IT intervention and so does not pertain to effectiveness. Using an online intervention based on the MOST model (‘Entourage’) and single-group design, Rice and colleagues (n = 89) [59•] showed statistically significant improvements in social connectedness and loneliness among participants at post-intervention compared to baseline, but no significant differences on social network scores; the lack of a control group means no conclusions can be drawn regarding effectiveness. Three studies did not report tests of significance but reported improvements in social isolation outcomes using different statistical tests [62•, 65•, 66•], such as latent trajectory models. The other seven single-group feasibility studies reporting effectiveness data did not find significant changes in social isolation outcomes [55•, 60•, 63•, 64•] or did not report statistical analysis testing for significant differences [61•, 68•, 69•].

Feasibility outcomes from the studies generally favoured proceeding to a full trial, as most studies (n = 11) [55•, 56•, 59•, 60•, 62•, 63•, 64•, 65•, 66•, 67•, 68•] reported satisfactory retention rates at above 70%. Among these, all studies utilizing web-based programmes based on the MOST model (n = 5) [59•, 60•, 62•, 63•, 64•] reported retention rates over 80%. Another pilot feasibility RCT conducted by Gjerdingen et al. (n = 39) [67•] compared the effects of telephone peer support vs face-to-face postpartum doula support and reported retention rates to be over 90%. However, the only feasibility study that recruited more than 100 participants reported a dropout rate as high as 92.4% [69•]. The study sought to assess an online group counselling platform (Kids Helpline Circle).

Acceptability outcomes were difficult to compare as different scales and methods of rating were utilized in each study. Generally, satisfaction ratings and feedback regarding the usefulness/helpfulness of the interventions were favourable, but there were also some mixed findings. For example, participants in Hanssen’s study (n = 64) [56•], with retention rate over 70%, rated the SMARTapp as easy to use (94%) and appealing (95%) but also annoying (38% in the comparison group and 73% in the intervention group) due to the frequent reminder beeps to prompt questionnaire completion. In two out of seven studies (28.6%) that involved both digital and face-to-face components, researchers reported lower satisfaction ratings for the digital component. This was observed in Van Voorhees and colleagues’ blended intervention (n = 14) [58•] and Gjerdingen et al’s (n = 39) [67•] study comparing telephone peer support vs face-to-face postpartum doula support. Lastly, eight feasibility studies also assessed safety outcomes [59•, 60•, 63•, 64•, 65•, 66•, 72•, 79•]. None reported adverse events that were attributed to the interventions assessed. All eight studies reported that all participants reported feeling safe while using the interventions.

Our reporting of findings from feasibility studies was intended to help identify new approaches for future research. Whilst findings demonstrate the variety of potentially feasible and acceptable interventions to be tested in large-scale trials, we cannot form firm conclusions about the interventions’ effectiveness in improving social connectedness and loneliness.

Uncontrolled studies providing pre/post comparisons

Mixed findings were demonstrated from the seven single-group studies. Chen and colleagues (n = 20) [75•] found significant decreases in loneliness scores among the elderly participants in the middle of, and at the end of, the 8-week social robot intervention compared to pre-intervention. De Almeida and colleagues (n = 9) [73•], using the weCOPE application, also demonstrated statistically significant increases in social support among individuals with schizophrenia over 8 weeks. Due to the lack of control groups in these studies, the findings should be taken, at best, as an indicator for a possibility of an intervention effect.

Among the other studies, one did not conduct a statistical test of significance [76•], while three did not find significant changes in the social isolation outcomes [71•, 72•, 74•]. Wang and colleagues [70•] reported correlations between usage and social support scores. Using a web-based intervention (the Chinese version of My Trauma Recovery - CMTR), the authors found statistically significant negative findings: decreases in social support scores correlated with increased uses of one of the program modules (the relaxation module), but only on the first day of the intervention, and there was no control group to compare this to. There were no significant correlations between social support scores and the use other five modules. Of all the studies, there was no report of adverse events related to the respective interventions. Together these studies do not provide strong evidence to support any of the interventions evaluated given that they lack control or comparison conditions.

Effectiveness trials

Three fully powered RCTs showed varying findings. Moeini et al. (n = 128) [78•] reported statistically significant improvements in social support among female adolescents with mild to moderate depressive symptoms in the intervention group compared to controls after a 24-week web-based intervention (Dorehye Amozeshie Dokhtaran – DAD). Conversely, studies from Pot-Kolder et al. (n = 116) [77•] and Kaplan et al. (n = 300) [79•] reported no significant differences between treatment and control groups. Pot-Kolder et al. [77•] conducted a VR-CBT intervention with participants with psychotic disorder, while Kaplan et al. [79•] involved individuals diagnosed with schizophrenia or an affective disorder to compare social support outcomes between three conditions: Internet peer support via a listserv, Internet peer support via a bulletin board, and a waitlist control condition.

Two randomized comparative trials that were not fully powered used blended interventions. Both trials did not find significant differences between the comparison groups. Involving adolescents at high risk of depression, Van Voorhees and colleagues (n = 83) [80•] compared CATCH-IT with motivational interviewing (MI) and CATCH-IT with brief advice. Similarly, Saulsberry et al. (n = 83) [81•] examined the effects of CATCH-IT with MI vs CATCH-IT with brief advice in a one-year follow up study of a RCT that also investigated the CATCH-IT intervention. As these studies did not report significant differences between intervention and control groups, we cannot reach conclusions about clinical effectiveness of the interventions.

The four pilot RCTs included also reported mixed findings. Kaplan et al. (n = 60) [83•] reported no significant differences in social isolation outcomes after an online parenting intervention involving mothers with mood disorder and schizophrenia. In a web-based intervention involving university students with elevated levels of distress, Ellis and colleagues (n = 39) [85•] found that perceived social support scores among participants in the online peer support group were significantly improved compared to online CBT and no-treatment control groups. Using a blended intervention involving individuals with suicidal ideation, Marasinghe et al. (n = 68) [82•] also reported significant improvements in social support in the intervention group compared to waitlist control. However, this study did not clarify their threshold of significance or p-value. Lastly, Interian and colleagues (n = 206) [84•] found that the veteran participants in the intervention group were significantly more likely to report a decrease in perceived family support compared to the control group. This was demonstrated at a 2-month follow up after a single-session one-hour web-based intervention (‘Family of Heroes’). Clear conclusions cannot be drawn due to the small sample sizes and lack of power calculations in the trials. Regarding safety, none of these four pilot RCTs reported adverse events related to the interventions in each study.


Given the rapidly evolving field of digital technology, this scoping review aimed to fill a gap in the evidence base by drawing together current findings on the effectiveness and feasibility of digital interventions for subjective and objective social isolation among individuals with mental health conditions. We found a very diverse body of literature: the characteristics of interventions and data analysis methods were found to vary across studies; participants were also from different age groups, recruited from a variety of settings and had a range of mental health conditions.

Among all included studies, half used web-based interventions while others used phone-based interventions (i.e., via smartphone applications, phone calls or text messages) or blended interventions combining digital and face-to-face components. The main components of the interventions included peer support, therapeutic content and symptom management. There were also two studies utilizing socially assistive robots and virtual reality respectively, demonstrating very limited evidence for the use of these technologies in this field. While VR is increasingly being used with individuals with mental health conditions, particularly those with a history of trauma [91], most studies did not investigate its effectiveness in relation to social isolation outcomes [92, 93]. Instead, the main focus was placed on other psychological outcomes such as anxiety and stress. Similarly, while previous research has consistently found positive effects from using socially assistive robots such as the robotic seal ‘Paro’ [94] and the robotic dog ‘Aibo’ [95] to tackle social isolation among the elderly, Chen and colleagues’ [75•] study, included in our review, was the first to use Paro in an intervention with individuals with mental health conditions.

The studies described in our scoping review identified a variety of approaches that have been successfully implemented in research and appear feasible. Hence, we propose that there is a range of different potential mechanisms for the further development and testing of digital interventions for social isolation in a mental health context. Regarding clinical effectiveness, we cannot draw conclusions for the overall effectiveness of digital interventions to alleviate social isolation from results of the included studies. Only one out of three fully powered RCTs [78•] delivering a web-based intervention provided significant supportive evidence that digital interventions may be able to reduce subjective social isolation. For the other studies, feasibility studies suffer from power limitations while many single-group studies and effectiveness trials were of low to moderate quality due to small sample sizes, lack of power calculations and lack of control groups. Evidence for alleviating objective social isolation is particularly insufficient due to the small number of studies that included it as an outcome, none of which reported significant findings. Nevertheless, the low proportion of high-quality studies in this review was balanced against the wide inclusion criteria to identify potentially promising approaches. Although not designed to evaluate clinical effectiveness and not generally demonstrating this, most included feasibility studies reported favourable retention rates and satisfaction ratings, particularly in those using smartphone apps and those utilizing web-based interventions based on the MOST model. Despite being at relatively higher risk of bias in study design features, the inclusion of these feasibility studies allowed us to identify feasible approaches to be tested in future research in an emerging field.

In the studies included in our review, there was a lack of evidence comparing different elements in each type of digital intervention, despite the promising variety of approaches. While synchronous communication has been well-described in the literature and is associated with good psychological outcomes [96], asynchronous communication in digital mental health care is not as sophisticated as that used in other clinical fields such as cardiology, radiology and dermatology [97]. Most included studies in this review used asynchronous technologies, yet none of the studies considered the differential effects that asynchronous and synchronous technologies might have had, including clinical effectiveness, adherence to the treatment or strength of therapeutic alliance between clients and clinicians [98, 99]. We also noted very little discussion within included studies about the differential effects of in-person versus digital elements in blended interventions. This aligns with the current state of the evidence, as little is known about the optimal ratio of face-to-face and digital elements in mental health interventions, or the compatibility of different in-person and digital components [100]. For future research, adequately powered trials could be carried out to distinguish these effects, to provide insight on how integrating different elements could impact the mechanisms and outcomes of each intervention.

We also identified a gap in the evidence regarding theory-based approaches, as half of the studies included did not specify a theory on which the interventions were based. None of the interventions using social robots, phone calls/messages and internet training programmes described theoretical bases. Among the 16 studies that conducted a theory-driven intervention, five were based on the self-determination theory (SDT) [59•, 60•, 62•, 63•, 64•], which proposes that developing a sense of autonomy, competence and relatedness are critical to the process of health behaviour change [101]. According to this model, treatment environments that enhance autonomy, competence and relatedness lead to increased engagement in the intervention, and in turn, result in better health outcomes and social functioning [88]. The shared components of these interventions include individually tailored therapy content, online social network and safety moderation. The clinical moderators of these studies also checked-in regularly with inactive participants to encourage their involvement with the intervention. The act of regular check-ins, as well as implementation of tailored content by moderators or clinicians, is also an element of persuasive technology, which previous research has also found to be effective in increasing user engagement [102, 103]. In all five trials, the retention rates were promising (over 80%), demonstrating support for the theory to facilitate engagement with the interventions. However, their clinical effectiveness of the interventions remains uncertain, as these studies did not include control or comparator groups. A few trials described approaches such as CBT and mindfulness theories underlying the design, whereas others were vague in articulating a theoretical basis. This lack of theory-driven approaches is problematic due to the importance of a clear theory of change in informing the development of health interventions [104]. While there is evidence to support the beneficial effects of digital interventions in alleviating social isolation, the lack of clear theory-driven approaches and the preliminary nature of many studies prevent definitive conclusions from being made.

Also noteworthy is the lack of interventions specifically designed to alleviate social isolation outcomes, apart from the two studies [65•, 66•] utilizing the +Connect app, which was designed to reduce loneliness among young adults. Most studies used broadly oriented interventions, assessing a number of therapeutic targets related to the mental health conditions of the sample populations involved. In these studies, social isolation was not the primary outcome, but instead it was included among a range of psychosocial outcomes. These findings indicate that the true effect of using technology to alleviate social isolation among individuals with mental health conditions might be masked due to the less-focused designs and broader approaches.


This scoping review addresses an important gap in the literature by synthesizing a wide body of evidence assessing digital interventions for social isolation among individuals with mental health conditions. However, there is a lack of research for social isolation interventions using novel technologies (e.g., VR and robotics) and targeting those with mental health problems. While we have found a variety of feasible approaches to be tested in future studies, evidence of the effectiveness of these approaches used in digital interventions was insufficient. The lack of high-quality studies and the lack of theory-driven approaches in the current evidence base limits our ability to make clear recommendations for effective interventions. As such, future research using larger-scale RCTs and assessing interventions with a clear underlying theoretical basis is needed to further explore the potential of these approaches, subject to evidence of the feasibility of those trials.

Furthermore, there is scope to explore the effects of digital interventions on other objective social isolation outcomes, such as social network sizes or social connections for people with mental health problems [105]. Future studies are needed to capture the effectiveness of elements of persuasive technology, including reminders, regular check-ins and tailored content, which have been found to increase the engagement of users. This is a potential way to reduce the high attrition rates consistently found in digital interventions and should be further developed in future research [101, 102]. Based on this review, the existing evidence does not currently support implementing these interventions on a large scale in clinical practice, though studies included in this review provide a starting point for future research in this area.


The methodological limitations identified in the existing evidence should be taken into consideration when reviewing the findings. The major limitations include the lack of fully powered RCTs, studies with clearly specified primary outcome(s) and interventions specifically designed to alleviate social isolation, and prevent definitive conclusions to be made, particularly in relation to clinical effectiveness of the different types of interventions. In addition, several other limitations should be considered when interpreting our findings. First, the exclusion of qualitative studies, grey literature and unpublished studies mean that we might have overlooked findings from other potentially relevant studies that might have allowed us to obtain a more comprehensive view of current evidence in an emerging field, including on experiences of using the interventions. Second, although our decision to include feasibility trials may have allowed us to examine more novel approaches, this introduced greater heterogeneity of studies, limiting the comparability of findings across studies. As expected, due to the variations in study characteristics, meta-analysis was judged unsuitable. Third, despite not using geographical or language restrictions during our search, we did not retrieve eligible articles in languages other than English, although we may have missed some written in other languages. This also limits the generalisability of findings to other cultures as most included trials were conducted in the United States or in Australia.


Our scoping review identified web-based programmes, phone-based programmes, blended interventions, socially assistive robot and virtual reality as the types of digital intervention used for addressing social isolation in individuals with mental health conditions. The lack of studies of high methodological quality limited our ability to make firm conclusions about their clinical effectiveness. Therefore, this review has identified the need to conduct high-quality studies to improve the evidence base in this area. We also identified a need for research to assess and develop theoretically-driven approaches, as well as interventions that specifically target social isolation for individuals with mental health conditions.

Availability of data and materials

All data generated or analysed during this study are included in this published article [and its supplementary information files].


  1. One trial involved the same sample population as another trial [53•, 75•]. Thus, the participants were only counted once. Two trials involved dyads of participants consisting of persons with mental health disorders and their family members/support persons – each individual is counted as individual participants [60, 81].



Association of Computing Machinery


Behavioural Activation


Body Mass Index


Competent Adulthood Transition with Cognitive-behavioural and Interpersonal Training


Cognitive Behavioural Therapy


Center for Epidemiological Studies-Depression


Connecting to Help After Trauma


Chinese version of My Trauma Recovery


Dorehye Amozeshie Dokhtaran


Duke Social Support Index


Experience Sampling Method


Economic and Social Research Council


Family of Heroes


Functional Social Support Questionnaire


Institute of Electrical and Electronics Engineers


Interpersonal Needs Questionnaire


Interpersonal Therapy


Internet Support Group


Interactive Voice Response


Kids Helpline


Lubben Social Network Scale


Major Depressive Disorder


Motivational Interviewing


Mixed Methods Appraisal Tool


Medical Outcomes Trial-Social Support Scale


Moderated Online Social Therapy


Multidimensional Scale of Perceived Social Support


Open Science Framework


Psychiatry Access, Continuity, and Evaluation


Personal Assistant Robot


Population, Intervention, Comparison and Outcomes


Perceived Social Support Scale


Post-Traumatic Stress Disorder


Person(s) with Schizophrenia


Randomised controlled trial


Social Anxiety Disorder


Social Connectedness Scale


Social Cognitive Theory


Self-Determination Theory


Schizophrenia Mobile Assessment and RealTime feedback application


Social networking service


Social Provisions Scale


Social Support Questionnaire




Touch technology


University of California, Los Angeles-Loneliness Scale


Ultra-high risk


United Kingdom


United Kingdom Research and Innovation


United States of America


Website Evaluation Instrument


Virtual reality


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The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by Economic and Social Research Council (ESRC) (UKRI cross-disciplinary) Mental Health Network Plus call [grant reference number ES/S004440/1].

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GT, SJ, EP, MB and JV conceived the research questions and agreed on the search strategy while GT developed the search terms in consultation with the wider team. GT also searched for articles, critically appraised the included articles and conducted a narrative synthesis of the findings. SI independently screened a proportion of articles. GT drafted the initial manuscript and co-ordinated the later drafts. EP, JV, MB, AP and SJ contributed comments and suggestions to the drafts. All authors read and approved the final manuscript.

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Correspondence to Gigi Toh or Sonia Johnson.

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Toh, G., Pearce, E., Vines, J. et al. Digital interventions for subjective and objective social isolation among individuals with mental health conditions: a scoping review. BMC Psychiatry 22, 331 (2022).

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