Skip to main content

Multidimensional self-rating biological rhythm disorder and its association with depression and anxiety symptoms among adolescents aged 11–23 years: a school-based cross-sectional study from China

Abstract

Background

Depression and anxiety are topical concerns worldwide, especially among adolescents. Besides, biological rhythm disorder as a candidate mechanism for mood disorders is highly prevalent, but relevant research among adolescents in China is presently limited. We conducted the present study to investigate the distribution of multi-dimensional self-rating biological rhythm disorder and the association of self-rating biological rhythm disorders with depression and anxiety symptoms among Chinese adolescents in different academic stages.

Methods

In the cross-sectional study, 3693 students aged 11–23 from Zhengzhou City, Henan Province, China were included. The Patient Health Questionnaire (PHQ-9) and General Anxiety Disorder (GAD-7) were used to evaluate symptoms of depression and anxiety, respectively. Additionally, the Self-Rating of Biological Rhythm Disorder for Adolescents (SBRDA) was used to assess status of biological rhythm disorders. Multivariate logistic regression was developed to explore factors potentially associated with symptoms of depression and anxiety stratified by academic stages.

Results

Among all participants, 44.14 and 36.15% suffered from depression and anxiety symptoms, respectively. On average, participants scored 74.66 ± 19.37 on the measure of total biological rhythm disorder. Adjusted for demographic confounding factors, the logistic regression analysis showed higher scores of total biological rhythm disorder were associated with more severe depression (OR = 14.38, 95%CI: 11.38–18.16) and anxiety symptoms (OR = 11.63, 95%CI: 9.14–14.81). The similar results were also found in the stratified analysis by academic stages.

Conclusions

Self-rating biological rhythm disorders are significantly associated with depression and anxiety symptoms among adolescents. Discrepancy across academic stages should also be taken into account in establishing public health strategies.

Peer Review reports

Introduction

Depression and anxiety are major public health problems of widespread global concern and are among the top causes of disease and disability among adolescents [1]. Seriously, the novel coronavirus disease 2019 (COVID-19), which has swept large parts of the globe, has aggravated the prevalence of depression and anxiety in all populations [2]. According to recent WHO data, the global detection rates of anxiety and depression soared by a huge 25% in the first year of the COVID-19 pandemic [3]. Recent studies have shown that COVID-19 exerts detrimental effects on adolescents particularly [4, 5]. Therefore, confronting the COVID-19 pandemic, it is necessary to pay attention to the mental disorders of adolescents such as depression and anxiety. However, the underlying pathophysiological mechanisms of mood syndromes lacks clear delineation, which is a major barrier to prevention and optimized treatments. Biological rhythm disorder is a candidate mechanism for mood disorders with genetic, behavioral, and neurobiological links [6].

Biological rhythm refers to cyclical variations in physiological and behavioral functions, comprising the sleep-wake cycle, social activity, eating pattern, and other important bodily functions, modulated by a circadian clock. Almost all organisms have an endogenous rhythm pattern that circulates daily (approximately 24 hours) to accommodate the 24-hour light-dark cycle [7]. Sleep is largely regulated by the light-dark cycle and relevant circadian rhythms. Previous researches have revealed that sleep rhythm disorder is associated with worse clinical outcomes [8, 9]. For instance, a recent study reported that sleep rhythm disorder could affect the symptom manifestation and pathogenesis of digestive disorders [10]. Studies regarding biorhythm disorders have mainly focused on the sleep-wake cycle. However, in a broader sense, the role of multidimensional biological rhythm, including eating habits rhythm, activity rhythm, and so on, is less well understood. Timed meals play a significant role in synchronizing the peripheral circadian rhythms in humans [11]. Original studies and a related review have suggested that irregular eating patterns (such as eating jetlag between weekdays and weekends, mistimed eating, etc.) have deleterious consequences on metabolic health [12,13,14,15]. In terms of the rhythm of social behavior in daily life, namely activity rhythm, a related therapy called social rhythm therapy (SRT) was researched to promote the stabilization of daily behavior and thus minimize the effects of circadian rhythm disorder [16]. In addition, the use of the digital media in contemporary society has also profoundly affected biological rhythms. There is evidence that excessive screen time during digital media use can affect sleep-related factors, thereby leading to relevant rhythm disorders [17, 18]. Of note, the circadian system of adolescents will continue to change until adulthood [19] and is easily influenced by external environmental factors, so more attention should be paid to the population.

Previous studies have confirmed the association between biological rhythm disorders and mood disorders. Nevertheless, a majority of researches on biological rhythms have solely focused on sleep. Individuals with an evening chronotype and high social jetlag are at increased risk of experiencing emotional problems such as depression and so on [20,21,22]. Researchers have assessed biological rhythm disorders from a multidimensional perspective using the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN), a validated instrument that evaluates the four main areas related to biological rhythm disorders, namely sleep, social rhythms, activity, and eating pattern [23]. For example, a large multi-center research conducted in Spain, Brazil and Canada showed that biological rhythm disorder may act as an independent predictor of poor psychosocial functioning in bipolar disorder [9]. Some studies among individuals aged 18–24 demonstrated higher levels of biological rhythm disorders in individuals with depression [24] or bipolar disorder [25]. However, there is a gap in the literature about biological rhythm assessing from multiple dimensions among adolescents (particularly in 11–17 years), especially in China. Notably, although BRIAN developed in 2009 had the advantage of multi-dimensional assessment, it failed to consider the emerging risk factors related to biorhythm disorders such as digital media use. One survey found that, during the COVID-19 pandemic, adolescents were more likely to spend much time using digital media to study online, play games, and chat with friends [26]. Thus, the overexposure to the digital media should also be considered in assessing biorhythm disorders.

Since adolescence is a rapidly changing phase [27], the effects of biorhythm disorders on emotion and behavior may be quite different across academic stages. Therefore, we conducted this study with the latest questionnaire scale among Chinese adolescents stratified by academic stages, aiming to investigate the distribution of multi-dimensional self-rating biological rhythm disorder (sleep rhythm, activity rhythm, eating habits rhythm, and digital media use) in Chinese adolescents, as well as the association of self-rating biological rhythm disorders with depression and anxiety symptoms across academic stages. To be noted, the definition of adolescence was prolonged in our study.

Method

Sampling and procedure

A cross-sectional survey was conducted among adolescents ranging from junior high school to university in Zhengzhou City, Henan Province, China, from September 2021 to December 2021. We selected one urban junior high school, one urban senior high school, one urban vocational high school, one rural junior high school, one rural senior high school, one rural vocational high school, and one provincial university. Using a cluster sampling method and by considering one class as a unit, we randomly selected classes from three grades (four grades for university) such that the number of students in each grade was approximately 200. All students in the selected classes were eligible to participate in the survey except for those with serious organic diseases or serious psychological disorders. For some reasons, the sampling of the third grade of the urban vocational high school was not completed, so a total of 4351 students were surveyed. The sampling process can be seen in Fig. S1. After excluding 658 students who submitted incomplete questionnaires with missing important data, the remaining 3693 participants were ultimately included in the current analysis. There was no difference in the basic characteristics between the included population and the initial population (Table S1).

Informed consent was obtained prior to participation for all participants over 16 years of age and for legal guardians of participants under 16 years of age. After describing the purpose and procedures of the study, trained investigators handed out the questionnaires to the participants and instructed them to fill out the questionnaires independently. Investigators were on hand at each site to help participants with any confusion or questions they had regarding the structured questionnaire. The study was approved by the Zhengzhou University Ethics Committee (ZZUIRB 2021–94).

Measuring sociodemographic data

Sociodemographic data for participants were collected including age, gender (male or female), grade (junior high school, vocational high school, senior high school or university), residential areas (rural or urban), the only child status (yes or no), parents’ education levels (below the elementary school, elementary school, junior high school, senior high school or technical school, or junior college or above), self-perceived family economy (under moderate, moderate or over moderate), self-perceived study burden (low, medium, high) and the number of close friends (0, 1–2, 3–5 or > 5).

Self-rating biological rhythm disorders assessment

The Self-Rating of Biological Rhythm Disorder for Adolescents (SBRDA) [28] was used to assess the current status of biological rhythm disorders in adolescents. A total of 29 items were assessed, with four dimensions considered: sleep rhythm, activity rhythm, eating habits rhythm and digital media use. The adolescents’ biological rhythm disorders were assessed using a five-point Likert scale, with scores ranging from one to five, corresponding to “completely inconsistent”, “basically inconsistent”, “somewhat consistent”, “basically consistent” and “completely consistent” respectively. Sleep rhythm scores range from 6 to 30, activity rhythm scores range from 7 to 35, eating habits rhythm scores range from 8 to 40, digital media use scores range from 8 to 40 and total rhythm disorder rhythm scores range from 29 to 145. The higher the questionnaire score, the more severe the self-rating biological rhythm disorders. According to Kelly’s recommendation [29], those who scored lower than 27% were classified in the low score group, while those who scored higher than 73% were classified in the high score group and the rest were classified in the middle score group.

Depression and anxiety symptoms assessment

Depression level was assessed by the Patient Health Questionnaire-9 (PHQ-9) [30], a measure that assesses the severity of depression. The PHQ-9 asks participants how frequently they have been bothered by depression symptoms in the past 2 weeks. The nine-items are rated on a four-point Likert scale from zero to three (0 = not at all, 1 = several days, 2 = more than half of the days, 3 = nearly every day). The total score was calculated by adding the scores for each question, which ranged from 0 to 27, with higher scores indicating more severe depression symptoms. Anxiety level was assessed by the 7-item Generalized Anxiety Disorder (GAD-7) [31], a measure that assesses the severity of anxiety disorders within the past 2 weeks. Similar to PHQ-9, each item was scored from 0 (not at all) to 3 (nearly every day). In the current study, samples whose total scores > 4 in PHQ-9/GAD-7 were defined as suffering from depression/anxiety symptoms respectively.

Statistical analysis

Statistical analyses were performed with SPSS 21.0. Descriptive analyses were used to show the demographic information of the sample. In sensitivity analysis, chi-square tests were used to compare differences in basic demographic characteristics between the included samples and the initial samples. Differences in demographics, total and each dimension of self-rating biological rhythm disorder scores, depression and anxiety symptoms among groups were tested using chi-squared test or Kruskal-Wallis H test. Additionally, multivariable logistic regression was used to explore the associations between self-rating biological rhythm disorders and depression and anxiety symptoms. Partial correlation analyses were used to explore bivariate relationships, adjusting for confounding factors. The logistic regression models in this study were conducted in total and stratified population of different academic stages. Models were controlled for age, gender, residential areas, parents’ educational levels, the only child status, self-perceived family economy, self-perceived study burden, and the number of close friends. Odds ratios (ORs) and their 95% confidence intervals (CIs) were calculated. The significance level was set at 0.05.

Results

Demographics of participants and the distribution of self-rating biological rhythm disorders

As displayed in Tables 1, 3693 students aged 11–23 years old (mean ± SD:16.30 ± 2.33) were included in our study. On average, the participants scored 74.66 ± 19.37(mean ± SD) on the measure of total biological rhythm disorder, and scored 18.37 ± 4.69 on the measure of sleep rhythm, 15.88 ± 4.89 on the measure of activity rhythm, 20.91 ± 7.00 on the measure of eating habits rhythm and 19.50 ± 7.42 on the measure of digital media use (Table S2). Students with high study burden, low self-perceived family economic status or a low number of close friends showed a higher proportion of high score group (p < 0.01). Moreover, compared to male students, female students showed a higher proportion of high score group (p < 0.01) (Table 1). In addition, distributions of four dimensions of self-rating biological rhythm disorder among different demographic variables were shown in Table S3-S6.

Table 1 Sample characteristics stratified by self-rating biological rhythm disorder (total) (N = 3693)a

The proportions of score group of each dimension of self-rating biological rhythm disorders among different academic stages were shown in Fig. 1. Junior high school students overall showed lower proportion of middle and high score group of biological rhythm disorder in all dimensions than students in any other academic stage, meaning that junior high school students had the mildest disorders (Fig. 1A-E). Senior high school students had the most severe disorders in sleep rhythms and activity rhythms (Fig. 1A, B). Of note, vocational and senior high school students belong to the same academic phase, but their biological rhythm disorders were distributed differently. Both vocational high school and university students had more severe disorders in the digital media use dimension (Fig. 1D). In the total biological rhythm aspect, disorders were becoming more severe as the academic stage progressed. In the high school phase, vocational high school students preseted more severe biological rhythm disorders than senior high school students (Fig. 1E).

Fig. 1
figure 1

The proportion of the score group of total and each dimension of self-rating biological rhythm disorder in different academic stages

Depression and anxiety symptoms with self-rating biological rhythm disorders

As shown in Table 2, depression symptoms were found in 44.14% (1630) of all the 3963 students; for males in 40.97% (730/1782), and females in 47.10% (900/1911). Likewise, anxiety symptoms were found in 36.15% (1335) of the total students, for males in 33.56% (598/1782), and females in 38.57% (737/1911). Overall, the positive rates of depression and anxiety symptoms were significantly higher with higher score group of total biological rhythm disorders (depression: 15.82, 43.83, 72.65%, respectively; anxiety: 12.58, 34.87, 61.62%, respectively). In particular, in activity rhythm aspect, the detection rates for depression and anxiety were both highest in the high score group among four dimensions (74.78% in depression, 63.43% in anxiety).

Table 2 Depression and anxiety symptoms with self-rating biological rhythm disorders

Adjusted associations of self-rating biological rhythm disorders with depression and anxiety symptoms

In the partial correlation analysis, a significant correlation was founded between the SBRDA score and depression and anxiety scale score after adjusting for confounders (p < 0.01) (Table S7).

As shown in Fig. 2 and Table S8-S9, among the total population, the regression results of total and each dimension of self-rating biological rhythm with anxiety and depression were statistically significant (p < 0.01). In the total biological rhythm level, compared to the low score group (reference group), the aOR of middle score group was 4.33 (3.53–5.32) for depression symptoms and 3.99 (3.19–4.98) for anxiety symptoms; the aOR of high score group was 14.38 (11.38–18.16) for depression symptoms and 11.63 (9.14–14.81) for anxiety symptoms. In the activity rhythm dimension, middle and high score were associated with greater risk of depression symptoms compared with low score, with aORs of 3.90 (95% CI 3.19–4.77), 13.93 (95% CI 10.92–17.77), respectively. Similar results were found for the risk of anxiety symptoms, with aORs of 3.53 (95% CI 2.84–4.38), 10.52 (95% CI 8.22–13.46), respectively. Similarly, the risk associated with other dimensions of self-rating biological rhythm and depression and anxiety symptoms was higher among students with middle and high score than those with low score.

Fig. 2
figure 2

Multivariable-adjusted OR and 95% CI for depression and anxiety symptoms across different academic stages according to score group of total and each dimension of self-rating biological rhythm disorders (low score group as reference). Vertical lines represent the 95% CIs. Models were adjusted for age, gender, residential areas, parents’ educational levels, the only child status, self-perceived family economy, self-perceived study burden, and the number of close friends. Abbreviations: CI, confidence interval; OR, odd ratio; M, middle score group; H, high score group; J, junior high school; V, vocational high school; S, senior high school; U, university; T, total

Generally, in the stratified analysis of each academic stage, the association of each dimension of self-rating biological rhythm disorders with depression and anxiety symptoms was stronger among students with high score than those with middle or low score. In the total biological rhythm disorders aspect, junior high school students with high score were more likely to develop depression and anxiety symptoms than students with high score among other academic stages.

Discussion

In this cross-sectional study among Chinese adolescents, a significant association was observed between total and four dimensions of self-rating biological rhythm disorders and depression as well as anxiety symptoms. These findings regarding depression symptoms were consistent with several previous studies. For example, a Brazilian study of 18–24 years old participants using the BRIAN scale found that adolescents with depression had higher BRIAN scores [32]. An Australian study using Hamilton Depression Rating Scale and Young Mania Rating Scale to assess depression symptoms also suggested that delayed and disturbed circadian rhythms may be associated with worse mental health [33]. Notably, limited studies explored association between self-rating biological rhythm disorders and anxiety symptoms, so we considered it as a complement in the present study. Furthermore, of four dimensions, activity rhythm disorder was found to be most associated with depression and anxiety symptoms, while sleep rhythm disorder was found to be least. The result was similar with a cross-sectional study investigating the relationship between subjective changes in biological rhythms and worsening of depression symptoms in 83 women from pregnancy to the postpartum period. The researchers found that subjective disruptions in social, eating, and activity rhythms, as evaluated by the BRIAN scale, were more strongly associated with depression symptoms than sleep rhythm [34]. Disruptions in other rhythms such as activity, eating habits rhythm may have occluded the impact of sleep disorder on mood symptoms [35].

In the stratified analysis, the current study found that the proportion of high score group of total biological rhythm disorder increased with higher academic stages. We have tried to interpret the finding. In the middle and high school stages, behavioral and environmental factors (peer pressure, study burden, etc.) make students more inclined to sleep late and lack sleep on weekdays [36]. However, the overall sleep needs of adolescents remain constant [37], which may lead to sleep compensatory behavior at weekends and social jetlag related to the worsening of biorhythm disorders [38]. High school students, compared to middle school students, suffer more severe self-rating biological rhythm disorder due to the heavier stress and burden [39]. University students with more freedom in daily life are more likely to have access to mobile phones without restriction than middle and high school students who are not allowed to bring digital media such as smartphones to campus in China [40]. We also found that the proportion of high score group of digital media use dimension also increased with higher academic stages in the present study, which confirmed the above inference. Notably, although the proportion of high score group of activity rhythm disorders was significantly lower among university students possibly due to having more autonomy, the university students in general still had the highest proportion of high score group of total biological rhythm disorders. Similarly, at the high school phase, students from vocational schools do not face competitive study burden or college entrance examinations unlike students in senior high schools, and have a lower level of stress and higher usage of digital media than senior high school [41], therefore vocational school students have a higher proportion of high score group of total biological rhythm disorders. In the current study, junior high school students with high score were found to have the highest risk in suffering depression and anxiety symptoms among four academic stages. Junior high school students are at the onset of adolescence, and the sleep-wake cycle and melatonin rhythm begin to show a phase delay [42] which depends on the presence of gonadotropins and occurs simultaneously with sexual maturation [43, 44]. Moreover, exposure to nighttime light through lamps and luminous devices inhibits melatonin secretion and adolescents are more sensitive to light at night (23:00 to 24:00). Of note, the inhibitory effect is greater in the onset of adolescence [45].

Biological rhythms of organisms are controlled by circadian clocks, most obviously via the sleep-wake cycle, which can respond to external time and assist biological rhythms in regulating biological processes [46]. The suprachiasmatic nucleus (SCN) in the hypothalamus acts as the master pacemaker, setting the timing of rhythms by regulating neuronal activity, body temperature, and hormonal signals [47]. Circadian rhythms and sleep disruption may play a role in susceptibility to mood disorders [48, 49], of which the mechanisms involved is being studied. For example, disruption of circadian rhythms impacts endogenous melatonin homeostasis which is strongly associated with the onset, exacerbation, and recovery of depression symptoms [50]. Circadian rhythms disruption may also affect synaptic pruning and maturation of neural circuits during adolescence, leading to the development of psychological disorders [51]. Sleep-wake cycle is a primary part of biorhythm disorder and it’s also interrelated with other dimensions. For instance, UK National Diet and Nutrition Survey showed that scores of healthy eating patterns dropped when people slept 1 h and 45 minutes more on weekends than on weekdays [52]. Also, individuals presenting irregular sleep-wake cycles were more likely to present different times for meals and socialization [24]. Besides, using digital media before bedtime can affect sleep as well. Not only can the usage of digital media before bedtime delay sleep onset [53], but also the short wavelengths of light emitted from screens at night may suppress melatonin secretion to increase alertness [54], which will influence circadian rhythms. With the increasing popularity of electronic media in recent years, excessive electronic device use should be taken into account as an emerging risk factor. There was research that suggested that any harm caused by digital media use appears to come from the consumption of harmful content or healthy lifestyle substitutions with health effects, rather than just the frequent use of digital social media itself [55]. In the future, hopefully more research will focus on the use of electronic devices.

To the best of our knowledge, this is the first study to explore the association between self-rating biological rhythm disorders and depression and anxiety by academic stages, and one of the few studies on biological rhythm disorders among Chinese adolescents. Besides, unlike previous studies that assessed biorhythm disorders by BRIAN, the current study used the newly developed SBRDA, which not only evaluated from multiple dimensions but also was more suitable for Chinese adolescents in the contemporary, in order to make the assessment more accurate. Furthermore, this study was based on a large population covering 11–23 years old.

Despite these advantages, some limitations need to be noted. Firstly, as all data were self-reported by participants, there is inevitably information bias. However, the present study took some measures to minimize this problem. For example, we selected measurement tools with certain reliability and validity, ensured that students completed questionnaires independently in the classroom, and reviewed questionnaires for completeness promptly. Secondly, the cross-sectional study design can only explore correlations, hampering our ability to assess causal relationships. Thirdly, the sample for this study was collected from only one city in Henan Province of China, and the generalizability to the total population of China remains to be verified. Nevertheless, the fact that the city of Zhengzhou in Henan Province is located in central China mitigates this limitation to some extent. It should be also noted that the questionnaire used in the study was developed for Chinese adolescents, so its external validity abroad has yet to be verified.

Conclusions

In this study, we found significant associations between self-rating biological rhythm disorders and both depression and anxiety symptoms. Junior high school students were found to have the highest risk in suffering depression and anxiety symptoms among four academic stages. We should also take discrepancy across academic stages into consideration in establishing public health strategies. Owing to the cross-sectional design of the current study, large-scale prospective studies are proposed to confirm these associations.

Availability of data and materials

The datasets generated and/or analysed during the current study are not publicly available due to privacy/ ethical restrictions but are available from the corresponding author on reasonable request.

Abbreviations

CI:

confidence interval

OR:

odd ratio

COVID-19:

coronavirus disease 2019

SD:

standard deviation

SPSS:

Statistics Package for Social Science

M:

middle score group

H:

high score group

J:

junior high school

V:

vocational high school

S:

senior high school

U:

university

T:

total

GAD-7:

the 7-item Generalized Anxiety Disorder

PHQ-9:

the Patient Health Questionnaire-9

BRIAN:

the Biological Rhythms Interview of Assessment in Neuropsychiatry

SBRDA:

the Self-Rating of Biological Rhythm Disorder for Adolescents.

References

  1. Adolescent mental health. Available from: https://www.who.int/zh/news-room/fact-sheets/detail/adolescent-mental-health Accessed 17 Nov 2021.

  2. Xiang YT, Yang Y, Li W, Zhang L, Zhang Q, Cheung T, et al. Timely mental health care for the 2019 novel coronavirus outbreak is urgently needed. Lancet Psychiatry. 2020;7(3):228–9.

    Article  PubMed  PubMed Central  Google Scholar 

  3. COVID-19 pandemic triggers 25% increase in prevalence of anxiety and depression worldwide. Available from: https://www.who.int/news/item/02-03-2022-covid-19-pandemic-triggers-25-increase-in-prevalence-of-anxiety-and-depression-worldwide Accessed 2 Mar 2022.

  4. Chen F, Zheng D, Liu J, Gong Y, Guan Z, Lou D. Depression and anxiety among adolescents during COVID-19: a cross-sectional study. Brain Behav Immun. 2020;88:36–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Wang C, Pan R, Wan X, Tan Y, Xu L, McIntyre RS, et al. A longitudinal study on the mental health of general population during the COVID-19 epidemic in China. Brain Behav Immun. 2020;87:40–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Carpenter JS, Crouse JJ, Scott EM, Naismith SL, Wilson C, Scott J, et al. Circadian depression: a mood disorder phenotype. Neurosci Biobehav Rev. 2021;126:79–101.

    Article  PubMed  Google Scholar 

  7. Orozco-Solis R, Sassone-Corsi P. Circadian clock: linking epigenetics to aging. Curr Opin Genet Dev. 2014;26:66–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Duarte Faria A, Cardoso Tde A, Campos Mondin T, Souza LD, Magalhaes PV, Patrick Zeni C, et al. Biological rhythms in bipolar and depressive disorders: a community study with drug-naive young adults. J Affect Disord. 2015;186:145–8.

    Article  PubMed  Google Scholar 

  9. Pinho M, Sehmbi M, Cudney LE, Kauer-Sant'anna M, Magalhaes PV, Reinares M, et al. The association between biological rhythms, depression, and functioning in bipolar disorder: a large multi-center study. Acta Psychiatr Scand. 2016;133(2):102–8.

    Article  CAS  PubMed  Google Scholar 

  10. Orr WC, Fass R, Sundaram SS, Scheimann AO. The effect of sleep on gastrointestinal functioning in common digestive diseases. Lancet Gastroenterol Hepatol. 2020;5(6):616–24.

    Article  PubMed  Google Scholar 

  11. Wehrens SMT, Christou S, Isherwood C, Middleton B, Gibbs MA, Archer SN, Skene DJ, Johnston JD: Meal timing regulates the human circadian system. Curr Biol 2017, 27(12):1768–1775 e1763.

  12. St-Onge MP, Ard J, Baskin ML, Chiuve SE, Johnson HM, Kris-Etherton P, Varady K, American Heart Association Obesity Committee of the Council on L, Cardiometabolic H, Council on Cardiovascular Disease in the Y et al. Meal Timing and Frequency: Implications for Cardiovascular Disease Prevention: A Scientific Statement From the American Heart Association. Circulation. 2017;135(9):e96-e121.

  13. Makarem N, Sears DD, St-Onge MP, Zuraikat FM, Gallo LC, Talavera GA, et al. Variability in daily eating patterns and eating jetlag are associated with worsened Cardiometabolic risk profiles in the American Heart Association go red for women strategically focused research network. J Am Heart Assoc. 2021;10(18):e022024.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Challet E. The circadian regulation of food intake. Nat Rev Endocrinol. 2019;15(7):393–405.

    Article  PubMed  Google Scholar 

  15. Garaulet M, Lopez-Minguez J, Dashti HS, Vetter C, Hernandez-Martinez AM, Perez-Ayala M, et al. Interplay of dinner timing and MTNR1B type 2 diabetes risk variant on glucose tolerance and insulin secretion: a randomized crossover trial. Diabetes Care. 2022;45(3):512–9.

    Article  CAS  PubMed  Google Scholar 

  16. Haynes PL, Gengler D, Kelly M. Social rhythm therapies for mood disorders: an update. Curr Psychiatry Rep. 2016;18(8):75.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Alonzo R, Hussain J, Stranges S, Anderson KK. Interplay between social media use, sleep quality, and mental health in youth: a systematic review. Sleep Med Rev. 2021;56:101414.

    Article  PubMed  Google Scholar 

  18. Hjetland GJ, Skogen JC, Hysing M, Sivertsen B. The association between self-reported screen time, social media addiction, and sleep among Norwegian University students. Front Public Health. 2021;9:794307.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Shimizu M, Zeringue MM, Erath SA, Hinnant JB, El-Sheikh M. Trajectories of sleep problems in childhood: associations with mental health in adolescence. Sleep. 2021;44(3):zsaa190.

  20. Van den Berg JF, Kivela L, Antypa N. Chronotype and depressive symptoms in students: an investigation of possible mechanisms. Chronobiol Int. 2018;35(9):1248–61.

    Article  PubMed  Google Scholar 

  21. Li T, Xie Y, Tao S, Yang Y, Xu H, Zou L, et al. Chronotype, sleep, and depressive symptoms among Chinese college students: a cross-sectional study. Front Neurol. 2020;11:592825.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Taillard J, Sagaspe P, Philip P, Bioulac S. Sleep timing, chronotype and social jetlag: impact on cognitive abilities and psychiatric disorders. Biochem Pharmacol. 2021;191:114438.

    Article  CAS  PubMed  Google Scholar 

  23. Giglio LM, Magalhaes PV, Andreazza AC, Walz JC, Jakobson L, Rucci P, et al. Development and use of a biological rhythm interview. J Affect Disord. 2009;118(1–3):161–5.

    Article  PubMed  Google Scholar 

  24. Mondin TC, Cardoso TA, Souza LDM, Jansen K, da Silva Magalhaes PV, Kapczinski F, et al. Mood disorders and biological rhythms in young adults: a large population-based study. J Psychiatr Res. 2017;84:98–104.

    Article  PubMed  Google Scholar 

  25. Moreira FP, Jansen K, Mondin TC, Cardoso Tde A, Magalhaes PV, Kapczinski F, et al. Biological rhythms, metabolic syndrome and current depressive episode in a community sample. Psychoneuroendocrinol. 2016;72:34–9.

    Article  Google Scholar 

  26. Dong H, Yang F, Lu X, Hao W. Internet addiction and related psychological factors among children and adolescents in China during the coronavirus disease 2019 (COVID-19) epidemic. Front Psychiatry. 2020;11:00751.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Kail R. Developmental change in speed of processing during childhood and adolescence. Psychol Bull. 1991;109(3):490–501.

    Article  CAS  PubMed  Google Scholar 

  28. Xie Y, Wu X, Tao S, Wan Y, Tao F. Development and validation of the self-rating of biological rhythm disorder for Chinese adolescents. Chronobiol Int. 2022;39(2):198–204.

    Article  PubMed  Google Scholar 

  29. Kelley TL. The selection of upper and lower groups for the validation of test items. J Educ Psychol. 1939;30(1):17–24.

    Article  Google Scholar 

  30. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Spitzer RL, Kroenke K, Williams JB, Lowe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006;166(10):1092–7.

    Article  PubMed  Google Scholar 

  32. Mondin TC, de Azevedo CT, Moreira FP, Wiener C, Oses JP, de Mattos Souza LD, et al. Circadian preferences, oxidative stress and inflammatory cytokines in bipolar disorder: a community study. J Neuroimmunol. 2016;301:23–9.

    Article  CAS  PubMed  Google Scholar 

  33. Robillard R, Carpenter JS, Rogers NL, Fares S, Grierson AB, Hermens DF, et al. Circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders. Transl Psychiatry. 2018;8(1):213.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Krawczak EM, Minuzzi L, Hidalgo MP, Frey BN. Do changes in subjective sleep and biological rhythms predict worsening in postpartum depressive symptoms? A prospective study across the perinatal period. Arch Womens Ment Health. 2016;19(4):591–8.

    Article  PubMed  Google Scholar 

  35. Simpson W, Frey BN, Steiner M. Mild depressive symptoms during the third trimester of pregnancy are associated with disruptions in daily rhythms but not subjective sleep quality. J Women's Health (Larchmt). 2016;25(6):594–8.

    Article  Google Scholar 

  36. Bartel KA, Gradisar M, Williamson P. Protective and risk factors for adolescent sleep: a meta-analytic review. Sleep Med Rev. 2015;21:72–85.

    Article  PubMed  Google Scholar 

  37. Carskadon MA. Sleep in adolescents: the perfect storm. Pediatr Clin N Am. 2011;58(3):637–47.

    Article  Google Scholar 

  38. Caliandro R, Streng AA, van Kerkhof LWM, van der Horst GTJ. Chaves I: social jetlag and related risks for human health: a timely review. Nutrients. 2021;13(12):4543.

  39. Gao R, He T, Liao Y, Liu X, Fan Y, Su Y, et al. An investigation on the academic burden of Chinese students ranging from primary schools to universities based on a word association test in Guangdong Province. Int J Environ Res Public Health. 2022;19(4):2481.

  40. Notice from the General Office of the Ministry of Education on Strengthening the Management of Mobile Phones for Primary and Secondary School Students. Available from: http://www.moe.gov.cn/srcsite/A06/s7053/202101/t20210126_511120.html Accessed 18 Jan 2021.

  41. Wang H, Zhong J, Hu R, Fiona B, Yu M, Du H. Prevalence of high screen time and associated factors among students: a cross-sectional study in Zhejiang, China. BMJ Open. 2018;8(6):e021493.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Roenneberg T, Kuehnle T, Pramstaller PP, Ricken J, Havel M, Guth A, et al. A marker for the end of adolescence. Curr Biol. 2004;14(24):R1038–9.

    Article  CAS  PubMed  Google Scholar 

  43. Hagenauer MH, Lee TM. The neuroendocrine control of the circadian system: adolescent chronotype. Front Neuroendocrinol. 2012;33(3):211–29.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Hagenauer MH, Lee TM. Adolescent sleep patterns in humans and laboratory animals. Horm Behav. 2013;64(2):270–9.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Crowley SJ, Cain SW, Burns AC, Acebo C, Carskadon MA. Increased sensitivity of the circadian system to light in early/mid-puberty. J Clin Endocrinol Metab. 2015;100(11):4067–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Ko CH, Takahashi JS. Molecular components of the mammalian circadian clock. Hum Mol Genet. 2006;15 Spec No 2:R271–7.

    Article  PubMed  Google Scholar 

  47. Colwell CS. Linking neural activity and molecular oscillations in the SCN. Nat Rev Neurosci. 2011;12(10):553–69.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Raniti MB, Allen NB, Schwartz O, Waloszek JM, Byrne ML, Woods MJ, et al. Sleep duration and sleep quality: associations with depressive symptoms across adolescence. Behav Sleep Med. 2017;15(3):198–215.

    Article  PubMed  Google Scholar 

  49. Lunsford-Avery JR, Goncalves B, Brietzke E, Bressan RA, Gadelha A, Auerbach RP, et al. Adolescents at clinical-high risk for psychosis: circadian rhythm disturbances predict worsened prognosis at 1-year follow-up. Schizophr Res. 2017;189:37–42.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Onaolapo OJ, Onaolapo AY. Melatonin, adolescence, and the brain: an insight into the period-specific influences of a multifunctional signaling molecule. Birth Defects Res. 2017;109(20):1659–71.

    Article  CAS  PubMed  Google Scholar 

  51. Logan RW, McClung CA. Rhythms of life: circadian disruption and brain disorders across the lifespan. Nat Rev Neurosci. 2019;20(1):49–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Almoosawi S, Palla L, Walshe I, Vingeliene S, Ellis JG. Long sleep duration and social jetlag are associated inversely with a healthy dietary pattern in adults: results from the UK National Diet and nutrition survey rolling Programme Y1(−)4. Nutrients. 2018;10(9):1131.

  53. Scott H, Woods HC. Fear of missing out and sleep: cognitive behavioural factors in adolescents' nighttime social media use. J Adolesc. 2018;68:61–5.

    Article  PubMed  Google Scholar 

  54. Dijk DJ, Cajochen C. Melatonin and the circadian regulation of sleep initiation, consolidation, structure, and the sleep EEG. J Biol Rhythm. 1997;12(6):627–35.

    Article  CAS  Google Scholar 

  55. Viner RM, Gireesh A, Stiglic N, Hudson LD, Goddings A-L, Ward JL, et al. Roles of cyberbullying, sleep, and physical activity in mediating the effects of social media use on mental health and wellbeing among young people in England: a secondary analysis of longitudinal data. Lancet Child Adolescent Health. 2019;3(10):685–96.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors want to express their sincere gratitude to all the participants and school staffs for their great support in the current study.

Funding

This work was supported by the National Natural Science Foundation of China (Grant No.82003478).

Author information

Authors and Affiliations

Authors

Contributions

XZ conceived and designed the research, performed the analyses, and drafted the manuscript. YC designed the research, collected the data, and drafted the manuscript. QZ, YJ, YS, KX, HL, RL, XL and XW contributed to the visualization and investigation of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Xian Wang.

Ethics declarations

Ethics approval and consent to participate

The study received ethics approval from Zhengzhou University Ethics Committee (number: ZZUIRB 2021–94). The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. Written informed consent was obtained from all participants or their legal guardians prior to enrollment in the study.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Additional file 1: Fig. S1.

Study participant flow diagram.

Additional file 2: Table S1.

Sensitivity analysis. Table S2. The distribution of the score of the Self-Rating of Biological Rhythm Disorder for Adolescents (SBRDA). Table S3. Sample characteristics stratified by sleep rhythm disorder (N = 3693). Table S4. Sample characteristics stratified by activity rhythm disorder (N = 3693). Table S5. Sample characteristics stratified by eating habits rhythm disorder (N = 3693). Table S6. Sample characteristics stratified by digital media use (N = 3693). Table S7. Partial coefficients between self-rating biological rhythm disorders and Depression and anxiety symptoms. Table S8. Adjusted associations between self-rating biological rhythm disorders and depression symptoms. Table S9. Adjusted associations between self-rating biological rhythm disorders and anxiety symptoms.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Zeng, X., Chen, Y., Zhang, Q. et al. Multidimensional self-rating biological rhythm disorder and its association with depression and anxiety symptoms among adolescents aged 11–23 years: a school-based cross-sectional study from China. BMC Psychiatry 22, 700 (2022). https://doi.org/10.1186/s12888-022-04354-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s12888-022-04354-8

Keywords

  • Biological rhythm disorder
  • Depression
  • Anxiety
  • Adolescents
  • China