Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, et al. Defeating Alzheimer's disease and other dementias: a priority for European science and society. Lancet Neurol. 2016;15(5):455–532.
PubMed
Google Scholar
World Health Organization. Dementia - a public health priority. Geneva: World Health Organization; 2012.
Google Scholar
Attems J, Jellinger K. Neuropathological correlates of cerebral multimorbidity. CurrAlz Res. 2013;10(6):569–77.
CAS
Google Scholar
Schneider JA, Arvanitakis Z, Bang W, Bennett DA. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology. 2007;69(24):2197–204.
PubMed
Google Scholar
James BD, Wilson RS, Boyle PA, Trojanowski JQ, Bennett DA, Schneider JA. TDP-43 stage, mixed pathologies, and clinical Alzheimer’s-type dementia. Brain. 2016;139(11):2983–93.
PubMed
PubMed Central
Google Scholar
Jellinger KA. The enigma of mixed dementia. Alzheimers Dement. 2007;3(1):40–53.
PubMed
Google Scholar
Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Lancet. 2001;357(9251):169–75.
Google Scholar
Blennow K, de Leon MJ, Zetterberg H. Alzheimer’s disease. Lancet. 2006;368(9533):387–403.
CAS
PubMed
Google Scholar
Scheltens P, Blennow K, Breteler MMB, de Strooper B, Frisoni GB, Salloway S, et al. Alzheimer's disease. Lancet. 2016;388(10043):505–17.
CAS
PubMed
Google Scholar
Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Lancet. 2017;390(10113):1–62.
Google Scholar
de Bruijn R, Bos MJ, Portegies MLP, Hofman A, Franco OH, Koudstaal PJ, et al. The potential for prevention of dementia across two decades: the prospective, population-based Rotterdam study. BMC Med. 2015;13(1):132.
PubMed
PubMed Central
Google Scholar
Beam CR, Kaneshiro C, Jang JY, Reynolds CA, Pedersen NL, Gatz M. Differences between women and men in incidence rates of dementia and Alzheimer’s disease. J Alzheimers Dis. 2018;64(4):1077–83.
PubMed
PubMed Central
Google Scholar
Ruitenberg A, Ott A, van Swieten JC, Hofman A, Breteler MM. Incidence of dementia: does gender make a difference? Neurobiol Aging. 2001;22(4):575–80.
CAS
PubMed
Google Scholar
Andersen K, Launer LJ, Dewey ME, Letenneur L, Ott A, Copeland J, et al. Gender differences in the incidence of AD and vascular dementia: the EURODEM studies. Neurology. 1999;53(9):1992.
CAS
PubMed
Google Scholar
Fratiglioni L, Launer L, Andersen K, Breteler M, Copeland J, Dartigues J, et al. Incidence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurology. 2000;54(11):10–5.
Google Scholar
Nebel RA, Aggarwal NT, Barnes LL, Gallagher A, Goldstein JM, Kantarci K, et al. Understanding the impact of sex and gender in Alzheimer's disease: a call to action. Alzheimers Dement. 2018;14(9):1171–83.
PubMed
PubMed Central
Google Scholar
Fratiglioni L, Qiu C. Epidemiology of dementia. In: Dening T, Thomas A, editors. Oxford textbook of old age psychiatry. Oxford: Oxford University Press; 2013.
Google Scholar
Seshadri S, Wolf PA. Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham study. Lancet Neurol. 2007;6(12):1106–14.
PubMed
Google Scholar
Seshadri S, Wolf P, Beiser A, Au R, McNulty K, White R, et al. Lifetime risk of dementia and Alzheimer’s disease the impact of mortality on risk estimates in the Framingham study. Neurology. 1997;49(6):1498–504.
CAS
PubMed
Google Scholar
Mazure CM, Swendsen J. Sex differences in Alzheimer’s disease and other dementias. Lancet Neurol. 2016;15(5):451.
PubMed
PubMed Central
Google Scholar
Alzheimer's Association. 2019 Alzheimer's disease facts and figures. Alzheimers Dement. 2019;15(3):321–87.
Google Scholar
Gorelick PB. Risk factors for vascular dementia and Alzheimer disease. Stroke. 2004;35(11):2620–2.
PubMed
Google Scholar
Stern Y. Cognitive reserve in ageing and Alzheimer's disease. Lancet Neurol. 2012;11(11):1006–12.
PubMed
PubMed Central
Google Scholar
Stern Y, Alexander GE, Prohovnik I, Stricks L, Link B, Lennon MC, et al. Relationship between lifetime occupation and, parietal flow - implications for a reserve against Alzheimers-disease pathology. Neurology. 1995;45(1):55–60.
CAS
PubMed
Google Scholar
Torssander J, Erikson R. Stratification and mortality: a comparison of education, class, status and income. Eur Sociol Rev. 2010;26(4):465–74.
Google Scholar
Lahelma E, Martikainen P, Laaksonen M, Aittomäki A. Pathways between socioeconomic determinants of health. J Epidemiol Community Health. 2004;58(4):327–32.
CAS
PubMed
PubMed Central
Google Scholar
Wilkinson R, Marmot M. Social determinants of health: the solid facts Copenhagen: World Health Organization; 2003.
Google Scholar
Dannefer D. Cumulative advantage/disadvantage and the life course: cross-fertilizing age and social science theory. J Gerontol B Psychol Sci Soc Sci. 2003;58(6):327–37.
Google Scholar
Dupre ME. Educational differences in age-related patterns of disease: reconsidering the cumulative disadvantage and age-as-leveler hypotheses. J Health Soc Behav. 2007;48(1):1–15.
PubMed
Google Scholar
Phelan JC, Link BG, Diez-Roux A, Kawachi I, Levin B. “Fundamental causes” of social inequalities in mortality: a test of the theory. J Health Soc Behav. 2004;45(3):265–85.
PubMed
Google Scholar
Livingston G, Sommerlad A, Schneider L, Mukadam N, Costafreda S. Prevention of dementia by targeting risk factors–authors’ reply. Lancet. 2018;391(10130):1575–6.
PubMed
Google Scholar
Kivimäki M, Singh-Manoux A. Prevention of dementia by targeting risk factors. Lancet. 2018;391(10130):1574–5.
PubMed
Google Scholar
Enache D, Winblad B, Aarsland D. Depression in dementia: epidemiology, mechanisms, and treatment. Curr Opin Psychiatry. 2011;24(6):461–72.
PubMed
Google Scholar
Brommelhoff JA, Gatz M, Johansson B, McArdle JJ, Fratiglioni L, Pedersen NL. Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins. Psychol Aging. 2009;24(2):373.
PubMed
PubMed Central
Google Scholar
Singh-Manoux A, Dugravot A, Fournier A, Abell J, Ebmeier K, Kivimäki M, et al. Trajectories of depressive symptoms before diagnosis of dementia: a 28-year follow-up study. JAMA Psychiatry. 2017;74(7):712–8.
PubMed
PubMed Central
Google Scholar
Dotson VM, Beydoun MA, Zonderman AB. Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment. Neurology. 2010;75(1):27–34.
PubMed
PubMed Central
Google Scholar
Barnes DE, Yaffe K, Byers AL, McCormick M, Schaefer C, Whitmer RA. Midlife vs late-life depressive symptoms and risk of dementia: differential effects for Alzheimer disease and vascular dementia. Arch Gen Psychiatry. 2012;69(5):493–8.
PubMed
PubMed Central
Google Scholar
Bennett S, Thomas AJ. Depression and dementia: cause, consequence or coincidence? Maturitas. 2014;79(2):184–90.
PubMed
Google Scholar
da Silva J, Gonçalves-Pereira M, Xavier M, Mukaetova-Ladinska EB. Affective disorders and risk of developing dementia: systematic review. Br J Psychiatry. 2013;202(3):177–86.
PubMed
Google Scholar
Byers AL, Yaffe K. Depression and risk of developing dementia. Nat Rev Neurol. 2011;7(6):323–31.
CAS
PubMed
PubMed Central
Google Scholar
Stansfeld S, Head J, Fuhrer R, Wardle J, Cattell V. Social inequalities in depressive symptoms and physical functioning in the Whitehall II study: exploring a common cause explanation. J Epidemiol Community Health. 2003;57(5):361–7.
CAS
PubMed
PubMed Central
Google Scholar
Huurre T, Eerola M, Rahkonen O, Aro H. Does social support affect the relationship between socioeconomic status and depression? A longitudinal study from adolescence to adulthood. J Affect Disord. 2007;100(1–3):55–64.
PubMed
Google Scholar
Ferrari AJ, Charlson FJ, Norman RE, Patten SB, Freedman G, Murray CJ, et al. Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010. PLoS Med. 2013;10(11):e1001547.
PubMed
PubMed Central
Google Scholar
World Health Organization. Social determinants of mental health. Geneva: World Health Organization; 2014.
Google Scholar
Gecková A, Van Dijk JP, Stewart R, Groothoff JW, Post D. Influence of social support on health among gender and socio-economic groups of adolescents. Eur J Pub Health. 2003;13(1):44–50.
Google Scholar
Mickelson KD, Kubzansky LD. Social distribution of social support: the mediating role of life events. Am JCommunity Psychol. 2003;32(3–4):265–81.
Google Scholar
Kawachi I, Berkman LF. Social ties and mental health. J Urban Health. 2001;78(3):458–67.
CAS
PubMed
PubMed Central
Google Scholar
Stansfeld SA, Fuhrer R, Shipley M. Types of social support as predictors of psychiatric morbidity in a cohort of British civil servants (Whitehall II study). Psychol Med. 1998;28(4):881–92.
CAS
PubMed
Google Scholar
Amieva H, Stoykova R, Matharan F, Helmer C, Antonucci TC, Dartigues JF. What aspects of social network are protective for dementia? Not the quantity but the quality of social interactions is protective up to 15 years later. Psychosom Med. 2012;72(9):905–11.
Google Scholar
Kuiper JS, Zuidersma M, Oude Voshaar RC, Zuidema SU, van den Heuvel ER, Stolk RP, et al. Social relationships and risk of dementia: a systematic review and meta-analysis of longitudinal cohort studies. Ageing Res Rev. 2015;22:39–57.
PubMed
Google Scholar
Marmot M. Status syndrome. London: Bloomsbury; 2004.
Google Scholar
McDonough P, Walters V. Gender and health: reassessing patterns and explanations. Soc Sci Med. 2001;52(4):547–59.
CAS
PubMed
Google Scholar
World Health Organization. Strategic action plan for the health of women in Europe. Copenhagen: WHO Regional Office for Europe; 2001.
Google Scholar
Matud MP. Gender differences in stress and coping styles. Pers Individ Differ. 2004;37(7):1401–15.
Google Scholar
Johansson L, Guo X, Waern M, Ostling S, Gustafson D, Bengtsson C, et al. Midlife psychological stress and risk of dementia: a 35-year longitudinal population study. Brain. 2010;133(8):2217–24.
PubMed
Google Scholar
Sindi S, Hagman G, Håkansson K, Kulmala J, Nilsen C, Kåreholt I, et al. Midlife work-related stress increases dementia risk in later life: the CAIDE 30-year study. J Gerontol B Psychol Sci Soc Sci. 2016;72(6):1044–53.
Google Scholar
Johansson L, Skoog I, Gustafson DR, Olesen PJ, Waern M, Bengtsson C, et al. Midlife psychological distress associated with late-life brain atrophy and white matter lesions: a 32-year population study of women. Psychosom Med. 2012;74(2):120–5.
PubMed
Google Scholar
Andel R, Crowe M, Hahn EA, Mortimer JA, Pedersen NL, Fratiglioni L, et al. Work-related stress may increase the risk of vascular dementia. J Am Geriatr Soc. 2012;60(1):60–7.
PubMed
Google Scholar
Johansson L, Guo X, Hällström T, Norton MC, Waern M, Ostling S, et al. Common psychosocial stressors in middle-aged women related to longstanding distress and increased risk of Alzheimer's disease: a 38-year longitudinal population study. BMJ Open. 2013;3(9):1–7.
CAS
Google Scholar
Johansson L. Can stress increase Alzheimer's disease risk in women? Expert Rev Neurother. 2014;2:123–5. https://doi.org/10.1586/14737175.2014.878651.
Article
CAS
Google Scholar
Skoog I, Nilsson L, Persson G, Lernfelt B, Landahl S, Palmertz B, et al. 15-year longitudinal study of blood pressure and dementia. Lancet. 1996;347(9009):1141–5.
CAS
PubMed
Google Scholar
Kivipelto M, Helkala E-L, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, et al. Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study. BMJ. 2001;322(7300):1447–51.
CAS
PubMed
PubMed Central
Google Scholar
Bremner DJ. Stress and brain atrophy. CNS Neurol Disord Drug Targets. 2006;5(5):503–12.
PubMed
PubMed Central
Google Scholar
Lupien S, Nair N, Briere S, Maheu F, Tu M, Lemay Μ, et al. Increased cortisol levels and impaired cognition in human aging: implication for depression and dementia in later life. Rev Neurosci. 1999;10(2):117–40.
CAS
PubMed
Google Scholar
Sapolsky RM. Why stress is bad for your brain. Science. 1996;273(5276):749–50.
CAS
PubMed
Google Scholar
Rocca WA, Mielke MM, Vemuri P, Miller VM. Sex and gender differences in the causes of dementia: a narrative review. Maturitas. 2014;79(2):196–201.
PubMed
PubMed Central
Google Scholar
Karlsson B, Klenfeldt IF, Sigström R, Waern M, Östling S, Gustafson D, et al. Prevalence of social phobia in non-demented elderly from a Swedish population study. Am J Geriatr Psychiatry. 2009;17(2):127–35.
PubMed
Google Scholar
Kline RB. Principles and practice of structural equation modeling. New York: Guilford publications; 2015.
Google Scholar
Stephan BCM, Minett T, Pagett E, Siervo M, Brayne C, McKeith IG. Diagnosing mild cognitive impairment (MCI) in clinical trials: a systematic review. BMJ Open. 2013;3(2):e001909.
Google Scholar
Wang H-X, Karp A, Winblad B, Fratiglioni L. Late-life engagement in social and leisure activities is associated with a decreased risk of dementia: a longitudinal study from the Kungsholmen project. Am J Epidemiol. 2002;155(12):1081–7.
PubMed
Google Scholar
Karp A, Paillard-Borg S, Wang H-X, Silverstein M, Winblad B, Fratiglioni L. Mental, physical and social components in leisure activities equally contribute to decrease dementia risk. Dement Geriatr Cogn Disord. 2006;21(2):65–73.
PubMed
Google Scholar
Guo X, Waern M, Sjögren K, Lissner L, Bengtsson C, Björkelund C, et al. Midlife respiratory function and incidence of Alzheimer’s disease: a 29-year longitudinal study in women. Neurobiol Aging. 2007;28(3):343–50.
PubMed
Google Scholar
Skoog I, Nilsson L, Palmertz B, Andreasson L-A, Svanborg A. A population-based study of dementia in 85-year-olds. N Engl J Med. 1993;328(3):153–8.
CAS
PubMed
Google Scholar
Skoog I, Waern M, Duberstein P, Blennow K, Zetterberg H, Börjesson-Hanson A, et al. A 9-year prospective population-based study on the association between the APOE* E4 allele and late-life depression in Sweden. Biol Psychiatry. 2015;8(10):730–6.
Google Scholar
APA. Diagnostic and statistical manual of mental disorders. 3rd ed. Washington DC: American Psychiatric Association; 1987.
Google Scholar
Blennow K, Ricksten A, Prince J, Brookes A, Emahazion T, Wasslavik C, et al. No association between the α2-macroglobulin (A2M) deletion and Alzheimer's disease, and no change in A2M mRNA, protein, or protein expression. J Neural Transm. 2000;107(8–9):1065–79.
CAS
PubMed
Google Scholar
Suri S, Heise V, Trachtenberg AJ, Mackay CE. The forgotten APOE allele: a review of the evidence and suggested mechanisms for the protective effect of APOE ɛ2. Neurosci Biobehav Rev. 2013;37(10):2878–86.
CAS
PubMed
Google Scholar
Hasselgren C, Ekbrand H, Fässberg MM, Zettergren A, Zetterberg H, Blennow K, et al. APOE ε4 and the long arm of social inequity: estimated effects of socio-economic status and sex on the timing of dementia onset. Ageing Soc. 2018;39(9):1951–75.
Google Scholar
Byrne BM. Structural equation modeling with Mplus: basic concepts, applications, and programming. New York: Routledge; 2013.
Google Scholar
Halleröd B, Seldén D. The multi-dimensional mharacteristics of wellbeing: how different aspects of wellbeing interact and do not interact with each other. Soc Indic Res. 2013;113(3):807–25.
Google Scholar
Bruijn R, Schrijvers E, Groot K, Witteman J, Hofman A, Franco O, et al. The association between physical activity and dementia in an elderly population: the Rotterdam study. Eur J Epidemiol. 2013;28(3):277–83.
PubMed
Google Scholar
Kivimäki M, Luukkonen R, Batty GD, Ferrie JE, Pentti J, Nyberg ST, et al. Body mass index and risk of dementia: analysis of individual-level data from 1.3 million individuals. Alzheimers Dement. 2018;14(5):601–9.
PubMed
PubMed Central
Google Scholar
Brown TA. Confirmatory factor analysis for applied research. New York: Guilford Publications; 2015.
Google Scholar
Beauducel A, Herzberg PY. On the performance of maximum likelihood versus means and variance adjusted weighted least squares estimation in CFA. Struct Equ Model. 2006;13(2):186–203.
Google Scholar
Asparouhov T, Muthén B. Weighted least squares estimation with missing data. Mplus Tech Appendix. 2010;2010:1–10.
Google Scholar
Asparouhov T, Muthén B. Multiple imputation with Mplus; 2010. MPlus Web Notes, [http://statmodel.com/download/Imputations7.pdf].
Google Scholar
Iacobucci D. Structural equations modeling: fit indices, sample size, and advanced topics. J Consum Psychol. 2010;20(1):90–8.
Google Scholar
Browne MW, Cudeck R. Alternative ways of assessing model fit. In: Bollen KA, Long JS, editors. Testing structural equation models. Newbury Park: Sage Publications Inc; 1993. p. 136–62.
Google Scholar
Yu C-Y. Evaluating cutoff criteria of model fit indices for latent variable models with binary and continuous outcomes, vol. 30. Los Angeles: University of California; 2002.
Google Scholar
DiStefano C, Liu J, Jiang N, Shi D. Examination of the weighted root mean square residual: evidence for trustworthiness? Struct Equ Model. 2018;25(3):453–66.
Google Scholar
Marsh HW, Hau K-T, Wen Z. In search of golden rules: comment on hypothesis-testing approaches to setting cutoff values for fit indexes and dangers in overgeneralizing Hu and Bentler's (1999) findings. Struct Equ Model. 2004;11(3):320–41.
Google Scholar
Bentler PM. Comparative fit indexes in structural models. Psychol Bull. 1990;107(2):238.
CAS
PubMed
Google Scholar
Hu L, Bentler PM. Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives. Struct Equ Model. 1999;6(1):1–55.
Google Scholar
Wang H-X, Gustafson DR, Kivipelto M, Pedersen NL, Skoog I, Windblad B, et al. Education halves the risk of dementia due to apolipoprotein ε4 allele: a collaborative study from the Swedish brain power initiative. Neurobiol Aging. 2012;33(5):1007.e1001–7.
Google Scholar
Altmann A, Tian L, Henderson VW, Greicius MD. Sex modifies the APOE-related risk of developing Alzheimer disease. Ann Neurol. 2014;75(4):563–73.
CAS
PubMed
PubMed Central
Google Scholar
Dupre ME. Educational differences in health risks and illness over the life course: a test of cumulative disadvantage theory. Soc Sci Res. 2008;37(4):1253–66.
PubMed
Google Scholar