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Prevalence and biopsychosocial factors associated with depressive symptoms among patients living with systemic lupus erythematosus in clinical settings in urban Thailand

BMC Psychiatry volume 22, Article number: 103 (2022) Cite this article

Abstract

Background

Depressive symptoms are globally recognized as a significant mental health problem in patients with chronic disease, particularly those with systemic lupus erythematosus (SLE). The purpose of this study was to estimate the prevalence and examine biopsychosocial factors of depressive symptoms among patients with SLE.

Methods

This cross-sectional study was conducted among 185 participants diagnosed with SLE and received treatment for at least 3 months, aged 18–59 years attending the outpatient clinic of a university hospital, Bangkok, Thailand. Depressive symptoms were measured by the Thai version of the Patient Health Questionnaire-9. We assessed Demographic data, the Systemic Lupus Erythematosus Activity Index, the Systemic Lupus International Collaborating Clinics Damage Index, Numeric Rating Scale, Fatigue Severity Scale, Body Image Scale, and the ENRICHD Social Support Instrument. Data were collected from March to May 2021. Multivariable logistic regression was used to analyze the data.

Results

The proportion of the participants with depressive symptoms was 43.2%, which 8.1% of those patients presented moderate to severe depressive symptoms. In a multivariable logistic regression model, SLE patients with depressive symptoms were more likely to be severe pain (aOR = 12.11, 95% CI: 1.35, 108.46), fatigue (aOR = 2.36, 95%CI: 1.08, 5.14), taking prednisolone ≥15 mg daily (aOR = 5.75, 95%CI: 1.76, 18.80), low satisfied of body image (aOR = 12.49, 95%CI: 2.23, 69.80), and low social support (aOR = 17.96, 95% CI: 1.86, 173.77). Disease flare, organ damage, and family income sufficiency did not significantly increase the risk of depressive symptoms in patients with SLE.

Conclusions

The findings highlight depressive symptoms in patients with SLE. Therefore, the health professional should be concerned about the perception of body image, level of social support, fatigue, and pain while treating patients with SLE. Public health screening programs to identify depressive symptoms in patients with SLE are needed. In addition, a high dose of prednisolone should be considered if required, along with monitoring.

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Introduction

Depression is the most frequent among neuropsychiatric manifestation complaints in patients with Systemic Lupus Erythematosus (SLE) [1, 2] that impairs daily living for sufferers and causes significant societal and economic burden [3, 4]. The high incidence and increasing prevalence of depression in patients with SLE has been recognized as a severe mental health problem of non-communicable diseases (NCDs) of the twenty-first century [5, 6]. Point prevalence rates range from 2 to 91.7%, depending upon the context, setting, and assessment tool [2, 7]. Eight to 24% of patients were diagnosed with depressive disorders [7, 8], and 12% had suicidal thoughts [9]. A previous study in northern Thailand revealed that the prevalence of depressive symptoms among patients with SLE was 45.2% [10]. Evidence suggests many factors are significant predictors of depression in patients with SLE [2, 11]. Therefore, including multiple factors into Engel’s biopsychosocial model of depression should create a fuller picture of the pathophysiology of depressive symptoms in patients with SLE [12].

SLE is the prototypical autoimmune disease affecting multi-organ systems. A complex interaction of genetics, environment, and hormones leads to immune dysregulation and breakdown of tolerance to self-antigens, resulting in autoantibody production, inflammation, and destruction of end-organs. It is a significant disease burden across the world among different ethnic, racial, and age groups [13]. SLE troubles up to 12 people per 5000 worldwide [14], and its incidence is 0.9 to 3.1 cases per 100,000 population per year [15]. Usually, patients with SLE are diagnosed in early adulthood. Cases of this disease are 80 to 90% female between the ages of 20 and 40 years (mean age at diagnosis: 29 years) [16]. They are more common in Afro-Caribbean, Chinese, and Asian populations than Caucasians [17].

The nature of SLE is a complex disease that can affect the body without limitation, and the disease causes many different clinical symptoms [16]. Typically, patients with SLE have an inflammatory illness that occurs in various organ systems. In patients with SLE, involvement of the central nervous system (CNS) is associated with a worse prognosis and more cumulative damage as neuropsychiatric systemic lupus erythematosus (NPSLE), with psychiatric disease manifestations [18], which are more likely to elevate serum levels of antibodies [19] and demonstrate a significant association with several genotypical pathways [20]. NPSLE is identified by the American College of Rheumatology (ACR) [21]. At the same time, patients with this disease need treatment with long-term monitoring of symptoms since the diagnosis of SLE is more accurate nowadays. SLE treatment requires adjusting the level of drug therapy per the results of biomarkers and disease manifestations and impacts on SLE that signal appropriate treatment adjustments. However, one treatment may not continuously address the patient’s overall health condition due to the generalized and chronic nature of the disease. This state has long-term effects, with significant impacts on physical and mental health, including the patient’s quality of life [16, 22]. A previous study reported that more than 2 of 3 patients with SLE experienced emotional illness such as sadness, depression, fear, anxiety, guilt, anger, and wrath [16]. These morbidities seriously affect behaviors and may lead to significant psychological problems [9].

Depression is a profoundly impactful comorbidity for SLE patients’ health and well-being [23], with common manifestations such as higher levels of fatigue, more significant pain, and poor sleep quality [24,25,26]. Pathogenesis of depressive symptoms in SLE is also expected and involves complex interactions between cytokines, antibodies, the role of genes, etc. In the same way, the result of damage accrual, cumulative glucocorticoid use, psychology status, and social-supportive condition are essentially triggered [2, 11]. Biopsychosocial factors that are critical and related to the depressive symptoms of patients with SLE are presented in Fig. 1.

Fig. 1
figure 1

Biopsychosocial factors of depressive symptoms in patients with SLE

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Malfunction and injuries in various body organs are essential factors that cause patients to face grave disease prognoses. The severity of SLE, including active disease or disease flare and disability from organ damage [27, 28], and pain and fatigue increase the risk of depressive symptoms [29]. Changes in physiology and the immune system are common in patients with SLE. Patients with SLE fear the disease progression, another aggravation or spreading to new organs, and insecurity regarding their future life. These fears are often related to unpleasant experiences [16, 30]. Fatigue and pain are common symptoms in SLE; 50 to 90% of patients with SLE experience constant fatigue [16], and over 90% of patients with SLE suffer from joint pain [16, 31]. These conditions cause patients to struggle with fatigue as paralyzing, insurmountable with sleep or rest. They limit everyday activities, often forcing patients to resign from earlier interests, hobbies, or work. Sometimes, patients feel helpless, powerless, angry, and guilty. Therefore, fatigue and pain were the two most reported symptoms affecting patients’ quality of life with SLE, limiting everyday life activities [32]. According to past findings, fatigue was a significant contributor to depression in patients with SLE [29], and over 82% of patients with depressive symptoms experienced moderate to severe pain [33].

Patients with SLE are often treated with glucocorticoids as monotherapy or combination therapy with hydroxychloroquine, non-steroidal anti-inflammatory drugs (NSAIDs), and immunosuppressants. Studies show that immunosuppressants (methotrexate, cyclophosphamide) reduce disease activity [34]. However, the unpleasant side effects of high doses of steroid therapy can cause symptoms of neuropsychiatric lupus but more often result in milder emotional changes, such as anxiety or depression. For example, continually taking more than 15 to 40 mg of prednisolone per day predicted depression in patients with SLE [22, 27, 35].

Changing physical appearance from disease progression and its treatment leads to low self-esteem and increases the risk of depressive symptoms [36, 37]. Unsightly skin lesions such as classic erythema on the face, discoid rash, lesions with a tendency to scarring, skin atrophy, and hair loss are symptoms that cause patients with SLE to feel embarrassed. Patients also report bruising susceptibility and increased photosensitivity. In addition, the side effect of glucocorticosteroid medicine also is a cause of unsightly skin lesions and obesity [31]. Appearance changes may make patients feel less attractive and cause concern about adverse reactions from their partners [31]. As a result, many patients tend to lose confidence and have lower satisfaction with their self-image.

Living with SLE hurts partnerships, family relationships, and social life. Due to increasing disability, patients spend less overall and quality time with their partners [33]. The unpredictable course of SLE is why patients’ social life is limited, facing rejection and increasing isolation. Patients with SLE who lack good social support often face conflicts with family members that cause mental health problems, particularly depressive symptoms [28]. In contrast, relevant support ensured by the family or close persons helps patients avoid excessive burden [22].

Poor financial status or insufficiency of household income is a factor associated with depressive symptoms in patients with SLE [38]. After 5 years with SLE, 15 to 40% of patients had lost their jobs, and after 10 or 15 years, 36 and 52% were jobless [16, 39]. Many patients with SLE are distressed that the disease will adversely affect their planned development path [16]. The patients are also concerned about illness costs, such as medical and additional healthcare insurance costs [32].

Depressive symptoms in patients with SLE have been examined in previous studies; however, findings were with Caucasian patients [2] that may exhibit characteristics different than in Asian patients, including Thais [40]. Asians with SLE have more severe clinical manifestations than Caucasian patients [41,42,43]. In meta-analysis studies on various gene polymorphisms, the FcgRIIIA-F158 allele is associated with low binding affinity to IgG1 and IgG3 in Asian patients [43]. Asian patients with SLE also have higher rates of renal involvement-associated autoantibodies when compared with Caucasians, and that often exhibit a more severe disease flare [43]. Access to health care is a crucial determinant of disease progression, treatment outcome, and the management of complications, particularly in Asian patients [43]. Thus, the difference between Asians with SLE and other ethnicities may influence disease development. In addition, most studies focused on analyzing only the psychological factors [2]. The analysis of biopsychosocial factors simultaneously was rare. These kinds of results are not sufficiently conclusive for clinical application.

The main objective of the present study was to determine biopsychosocial factors associated with depressive symptoms among patients living with SLE in clinical settings in urban Thailand. In addition, the prevalence of depressive symptoms was estimated.

Methods

A cross-sectional study was conducted in three outpatient medical clinics, including the medicine, nephrology, and rheumatology clinics of a university hospital in Bangkok, Thailand.

Setting

Thailand is an upper-middle-income country located in South-East Asia. The current population of Thailand is 70,005,912 based on Worldometer elaboration of the latest United Nations data [44]. 51.1% of the population is urban, adult, with a median age of 40.1 years [44]. The National Statistical Office of Thailand (NSO) reported that more than 1 in 5 of Thailand’s population health has some chronic illness or congenital disease [45]. Most of the Thai population has government health care benefits. Most use universal health insurance (gold card), followed by social security, civil servant, or state enterprise health benefits. We conducted this study at a university hospital established in 1914 in Bangkok city, the capital of Thailand. The hospital is a tertiary hospital governed by the Thai Red Cross Society and affiliated with the faculty of medicine with inpatient services of 1435 beds. This hospital is a training institute in physical health and mental health for expertise by health professionals and readiness of medical devices for complex illness. The total number of patients with SLE (ICD-10: M32) reported by information technology data management of the hospital in 2019–2020 was more than 1098 SLE patients admitted to the outpatient department. They get a physical exam, standard treatment, and assessment by the division of rheumatology from specialists. Patients with SLE enrolled in this study were followed through the outpatient department in three clinics, internal medicine, kidney, and rheumatology clinics.

Data collection operations took place during the COVID-19 outbreak. The researcher and participants strictly complied with the rules for preventing the spread of infection by completing questionnaires and body temperature checks, always wearing masks, and keeping social distancing of at least 2 m.

Participants

Patients with SLE were recruited at the time of their routine follow-up visit. The patients were eligible if between 18 and 59 years old, both male and female, and diagnosed according to the 1997 ACR, Revised Criteria for the classification of Systemic Lupus Erythematosus and were on medication for at least 3 months, patients observed with stable treatment. All patients were Thai, and able to read and write and give informed consent in the Thai language. Those who were unable to provide essential knowledge required in the study protocol, lacked necessary communication skills, were diagnosed with psychiatric disorders, had comorbid physical illnesses of life-threatening conditions, or need urgent treatment were excluded from the study. Inclusion and exclusion criteria were affirmed for essential information by interview and medical record.

The sample size was calculated by G*Power version 3.1.9.7 program and based on the results of a study, an independent pain variable by Chang et al. [38] depression and quality of life in patients with systemic lupus erythematosus: odd = 3.477, two tails x distribution equal to the binomial, confidence level in test α = 0.05, power of test = 0.80, the relationship between other variables (R2 other X) = 0, and X parm π = 0.638, at least 168 participants were needed. Adding 10.0% to account for error during the study, at least 185 participants were required for the analysis.

Instruments

The socio-demographic and medical history questionnaire was developed by researchers and reviewed by a panel of three experts and yielded a content validity score of 1, which consisted of 19 items divided into two parts:

  • Part 1: Personal information contains items about sex, age, religion, marital status, education level, occupation, rights to medical treatment, family characteristics, number of family members, average family income per month, and the sufficiency of household income.

  • Part 2: Clinical information contains items about the duration of SLE disease, daily steroid dosage, disease flare, other congenital diseases, history of mental illness, weight, height, and body mass index.

Assessment of depressive symptoms

Depressive symptoms were evaluated with the Thai version of the nine-item Patient Health Questionnaire (PHQ-9) [46]. The Thai version of the PHQ-9 was translated from the original PHQ-9 [47]. The PHQ-9 is a self-report measure consisting of 9 questions based on the 9 DSM-IV criteria for major depressive episodes. The respondents rated the symptoms experienced during the prior 2 weeks. Scores for each item range from 0 (not at all) to 1 (several days), 2 (more than half of the days), and 3 (nearly every day), while summed scores range from 0 to 27. The total scores were classified as indicating the level of severity of depressive symptoms: mild (5 to 9), moderate (10 to 14), moderately severe (15 to 19), and severe depression (20 and over). The Thai version of the PHQ-9 has acceptable psychometric properties for screening for major depression in general practice, with a recommended cut-off score of nine or more. Cronbach’s alpha for the total scale was 0.79, and predictive validity was 0.96 [46].

Measures of biological predictors

The Systemic Lupus Erythematosus Activity Index (SLEDAI), developed by Bombardier et al. [48], was used to assess disease fare. This instrument collected data from participants’ medical records by the researcher trained by a nephrologist. The SLEDAI consists of 24 questions about symptoms and laboratory results. The answer characteristic is a rating scale ranging from 1, 2, 4, and 8 points. In this study, disease flare was divided into two groups: the non-disease flare group, which scored less than 3 points, and the disease flare group, three or higher.

The Systemic Lupus International Collaborating Clinics Damage Index (SLICC Damage Index) developed by Gladman et al. [49] was used to assess organ damage. The SLICC damage index consists of 12 questions about damage to 12 organ systems in the body, and the answer characteristic is a rating scale ranging from 1 to 2 points. In this study, organ damage was divided into two groups: the non-organ damaged group: 0 points, and the group with organ damage: the score was 1 point or higher. This instrument collected data from participants’ medical records by the researcher trained by a nephrologist.

The Numeric Rating Scale (NRS) was used to assess the level of pain, with a scale developed by Jensen & Karoly [50] and updated by the Thai association for the study of pain (2009). It had 1 question each on position and pain level using a numeric scale from 0 to 10. In this study, the pain was divided into four groups: the group with no pain: the score was 0 points, the group with mild pain: the score was 1 to 3 points, the group with moderate pain: the score was 4 to 6 points, and the group with severe pain: the score was 7 points or higher. The pain assessment was adjusted by self-report of participants.

Fatigue Severity Scale (FSS) developed by Krupp et al. [51] and translated into a Thai version by Sawasdee [52] measured fatigue severity. The FSS consists of 9 questions, eight levels of Likert scale from 1 to 7 points. The score is calculated based on the answers divided by the total number of questions. In this study, fatigue was split into two groups: the group without fatigue: the score was less than 4 points, and the fatigue group was 4 points or higher. Content validity by a panel of three experts yielded a CVI score of 1. The internal consistency in those living with SLE (n = 30) obtained a Cronbach’s alpha coefficient of .89. The fatigue assessment was adjusted by self-report of participants.

Measures of psychological predictor

Body Image Scale (BIS) measured the level of body-image satisfaction as developed by Hopwood et al. [53] and was translated into the Thai version by Cheewapoonpol [54]. The BIS consists of 10 negative questions about satisfaction with one’s physical image, and the answer is a rating scale of 4 levels from 1 to 4 points. In this study, there were three groups of physical image satisfaction groups: the group with low level: the score was 31 to 40 points, the group with moderate level: the score was 21 to 30 points, and the group with high level: the score was 10 to 20 points. A panel of three experts rated content validity yielded a CVI score of 1. The internal consistency in those living with SLE (n = 30) showed a Cronbach’s alpha coefficient of .89. The body image assessment was a self-report of participants.

The social predictor measure

The ENRICHD Social Support Instrument (ESSI) measured social support as developed by Mitchell et al. [55] and translated into the Thai version by Lortajakul [56]. The ESSI consists of 7 questions, and the answer is a rating scale of 5 levels from 1 to 5 points. In this study, there were two groups of social support: the group with mild social support: the score was 1 to 10 points, the group with moderate social support: the score was 11 to 20 points, and the group with high social support: the score was 21 to 30 points. Content validity by a panel of three experts yielded a CVI score of .95. The internal consistency in those living with SLE (n = 30) obtained a Cronbach’s alpha coefficient of .94. The social support assessment was adjusted by self-report of participants.

Ethical consideration

Ethical approval was granted by the Institutional Review Board Faculty of Nursing, Mahidol University (IRB-NS2020/42.3010), and the Institutional Review Board Faculty of Medicine, Chulalongkorn University, Thailand (IRB No. 099/64). In addition, the committee for research of the hospital approved the research project before working with human subjects. Participants completed informed consent forms. The researcher also asked subjects’ permission to use the data contained in their medical records. All procedures were performed following ethical guidelines and regulations. The study was conducted from November 2020 through July 2021, and participant recruitment took place from March 2021 to May 2021. The participants answered six questionnaires by themselves, including 48 questions, the data collection produced approximately 20 to 25 min for each participant.

Data analysis

Data were double entered into an Excel sheet before being transferred into the SPSS program version 22.0 for analysis. Categorical and continuous data were appropriately analyzed to present the characteristics of participants by descriptive statistics. The chi-square test assessed characteristics between patients with and without depressive symptoms. Univariate logistic regression analysis was performed per each biopsychosocial variable. The complete multivariable logistic regression analysis model included all significant independent variables at a significance level of α = 0.05.

Results

Personal characteristics of the participants

The study comprised 185 Thai men and women who were diagnosed with SLE. Most of them were female (96.2%), between 36 and 59 years old (70.3%), with an average age of 42.16 years (SD = 10.78), single (52.4%), Buddhists (95.7%), and had bachelor’s degrees (42.7%). Most of the patients work (72%) and use the social security schemes to access healthcare (38.9%). Most of the patients are dwelling in single families (81.1%) with 1 to 3 of family members (57.8%), the average household monthly incomes were between 10,000 and 25,000 baht (34.1%) and had no income leftover (51.4%) (Table 1).

Table 1 Personal characteristics of the participants with or without depressive symptoms (n = 185)
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Clinical characteristics of the participants

Most of the patients had been diagnosed with SLE for 11 to 20 years (36.8%), took prednisolone 1 to 5 mg daily (48.1%), and had disease remission (78.4%). The result showed that 161 (87% of patients) had other congenital diseases, for instance, lupus nephritis (47%), hypertension (19.5%), and dyslipidemia (13.5%). They had an average body image index of 23.10 kg/m2 (SD =5.77), 94 (50.9%) of patients were of abnormal weight, with 16.8% underweight and 34.1% overweight (Table 2).

Table 2 Clinical characteristics of the participants with or without depressive symptoms (n = 185)
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Depressive symptoms and socio-demographic or clinical characteristics of the participants

The findings showed 43.2% of the participants had depressive symptoms. Classified by severity level of depressive symptoms, 2.2% of patients had severe depression, 5.9, and 35.1% had moderate or mild levels of depression. The PHQ-9 scores were between 0 and 23 points, with an average of 7.77 points (SD = 4.79) (Fig. 2).

Fig. 2
figure 2

Prevalence of depressive symptoms in patients with SLE

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Among the socio-demographic characteristics, sex, age, religion, education, occupation, right to access healthcare, family characteristics, family members, and monthly household income were not associated with depressive symptoms in patients with SLE. Household income sufficiency was significantly associated with depressive symptoms in patients with SLE (p = 0.008), and patients of different marital statuses tended to have different levels of depressive symptoms (p = 0.051) (Table 1).

Among the clinical characteristics, disease duration was not associated with depressive symptoms in patients with SLE. Prednisolone dosage (p = 0.004), disease flares especially both in the kidney system (p = 0.007) and muscles (p = 0.044), and body mass index (p = 0.008) were significantly associated with depressive symptoms in patients with SLE. Complications of avascular necrosis tended to be associated with depressive symptoms by patients (p = 0.061) (Table 2).

Univariable logistic regression statistical analysis of depressive symptoms of the participants

Patients with disease flare (p = 0.002), organ damage (p = 0.036), moderate or severe pain (p = 0.044) (p = 0.002), fatigue (p = 0.000), taking prednisolone ≥15 mg daily (p = 0.004), moderate or low satisfaction with body image (p = 0.008) (p = 0.000), moderate or low social support (p = 0.001) (p = 0.002), and leftover of income (p = 0.009) was significantly associated with depressive symptoms in patients with SLE (Table 3).

Table 3 Univariable & Multivariable logistic regression analysis for depressive symptoms of the participants (n = 185)
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Multivariable logistic regression statistical analysis of depressive symptoms of the participants

Patients with severe pain (p = 0.026), fatigue (p = 0.031), taking prednisolone ≥15 mg daily (p = 0.004), low satisfaction with body image (p = 0.004), and moderate or low social support (p = 0.013) (p = 0.009) was significantly associated with depressive symptoms in patients with SLE. Patients who took prednisolone, 6 to 14 mg daily (p = 0.091), tended to show an associated with depressive symptoms (Table 3).

Discussion

A decade ago, depressive symptoms were considered a significant mental health problem for the whole population but were under-recognized [57], especially for patients with chronic conditions. In the current study, the proportion of the participants with depressive symptoms was 43.2%, consistent with prior studies [2, 7, 9, 10, 23]. Compared with a previous study [58] conducted in a similar context during the COVID-19 outbreak in Southeast Asia, the proportion of moderate to severe depression in Thai patients with SLE was lower than those studied. This difference may have occurred because the measures of depressive symptoms in these studies differed. This study used PHQ-9, which is specific to screening for depressive disorders. In contrast, another study used the Depression Anxiety and Stress Scale (DASS-21), where researchers assessed depression by mental health status. Our patients rated 8.1 on severity of depressive symptoms, moderate to severe depressive symptoms diagnosed as depression higher than the general Thai population [59]. This severity rating gives us sufficient reason to be concerned about the depression in our patients with SLE.

According to the results of our study, biopsychosocial factors have more influence on depressive symptom severity in patients with SLE. Notwithstanding, the association between depressive symptoms and clinical symptoms has differed in past studies. Biology factors like disease flare, organ damage, pain, fatigue, and cumulative corticosteroid dosage were all involved [2, 27, 46]. Our study found a positive association between depressive symptoms and all those factors. However, the multivariable analysis findings did not show association with either disease flare or organ damage with depressive symptoms. Like previous studies, associations between depressive symptoms and disease flare are inconsistent because of methodological differences in measuring the disease activity of SLE. Using an objective disease activity measure such as SLEDIA, there was no association between depressive symptoms and disease flare [60,61,62,63]. Simultaneously, previous studies have suggested that patients and those with disease activity, including laboratory changes or disease damage, are more likely to have increased severity of depression in patients with SLE [7, 27].

Further research with larger sample sizes and well-controlled assessments of study methodology differences may clarify and confirm these phenomena. Besides risk factor of disease activity, depression in patients with SLE could be due to immune-mediated cognitive dysfunctions, which correlate with other pathological processes like autoantibodies (Abs), inflammatory markers, and micro vasculopathy, as well as volume reduction in the white matter and grey matter of the brain [64]. SLE’s specific cognitive impairments include attention, memory, and visuospatial process impairment and can cause mental disorders (delirium, dementia, mild cognitive impairment) [65]. Further studies defining the role of depression are essential to understand the pathophysiology of SLE-related cognitive dysfunction and depressive symptoms and to develop treatment strategies.

On the other hand, the observation in the multivariable analysis showed extreme pain, severe fatigue, and high dosage of steroid use were strongly interwoven in physical and psychiatric disorders among patients with SLE [27, 29, 38]. These factors and depressive symptoms share norepinephrine or serotonin neurotransmitter pathway pathology in the central nervous system that can provoke manifestations of physiological illness. Fatigue is associated with an increased risk for depression among these patients [29], and this study confirms these association findings. Heightened pain was associated with increased depressive symptoms in this study. This evidence also confirms various studies demonstrating that increased pain is related to a greater risk of depressive symptoms in patients with SLE [66, 67]. Depressive symptoms can also be caused by corticosteroid treatment through downregulation of brain-derived neurotrophic factors [68, 69]. In our study, patients who continued taking ≥15 mg prednisolone daily had significant depressive symptoms, comparable to 18.28 to 20 mg mean doses of prednisolone in a previous study in patients with major depressive disorder (MDD) [22, 27] and 15 mg daily for patients with non-major depressive disorder [22].

Increased body mass index scores in patients correlate with depressive symptoms, and the patients with depressive symptoms demonstrate higher levels of unemployment. Those findings could be confounding factors in depression but may also indicate the risk of depressive symptoms, which cause disease manifestations, disability, and productivity [29].

Dissatisfaction with one’s appearance is a real problem that patients with SLE frequently face [70, 71]. However, an understanding of SLE patients’ feelings about their body image has been lacking in Thai research. This omission makes it difficult to evaluate the degree of body image dissatisfaction, with much of the research on body image only emphasizing patients with breast cancer [72]. This gap needs to be addressed through focused research on these specific issues. From the previous studies, self-perceived appearance mediated the relationship between physical health-related quality of life and depression among patients with SLE [37, 73]. Our findings corroborated previous studies. In the present study, we found that low body-image satisfaction was an enormously significant predictor of depressive symptoms in patients with SLE, both in the univariable and multivariable analysis. Thus, a psychological intervention that targets belief and perception of body image in patients with SLE can reduce depressive symptoms.

Among social factors, the findings from the multivariable analysis did not show household income sufficiency was significantly associated with depressive symptoms in patients with SLE. A consistent previous examination found poverty was a significant predictor in the bivariate analysis, but not the multivariate [61]. However, social support is a crucial resource for patients with SLE with a high disease burden [74]. Many studies have noted the importance of social support regarding depression [75,76,77]. Good social support has been shown to protect from depression and elevate an individual’s emotional state [68]. It has also been established that those depressive characteristics are associated with decreased peer-related social support [75]. The univariable and multivariable analysis results found that social support was significantly associated with depressive symptoms in patients with SLE. These findings show that social support is vital for mental health and that a decrease in relationship satisfaction is an indicator of depressive symptoms.

Our findings shed light on the need for clinical implementation to reduce depression and improve the quality of life of SLE patients. A practical approach, including medication [78, 79] and psychosocial interventions, should provide biopsychosocial management [80, 81]. Further studies to figure out the effectiveness of the implementation for reducing depressive symptoms in patients with NPSLE, both pharmacological and non-pharmacological strategies, are necessary.

Strengths and limitations

The strengths of this study include the use of psychological instruments, which are acceptable, reliable, and valid in the Thai populations. Moreover, independent variables were defined based on Engle’s biopsychological model. It is a practical way of understanding how patients suffer physical and mental illnesses from sociology to molecular biology [12, 82]. Regarding our result, preventive assessment of both psychosociological and somatic symptoms can be evaluated by clinical information and query but does not specify the neurological pathology of depression. Growing study for biomarker validation and pathophysiology elucidation for MDD gauging is incredibly challenging. Functional Near-Infrared spectroscopy (fNIRS) consistently demonstrated direct-attenuated cerebral hemodynamic changes in depressed with individual symptoms. Further evidence for fNIRS is shown in quantitative risk analysis and monitoring various treatment responses of patients with SLE who present with depressive symptoms [83, 84].

However, this present study has several limitations. Participants were selected using inclusion/exclusion criteria, and the investigation was performed at a single medical center. Therefore, it may not represent patients with initial treatment, psychiatric disorders, cognitive impairment, or life-threatening conditions. Additionally, the role of inflammation and genetic susceptibility for the emergence of depressive symptoms was not assessed. Thus, more psychoanalytic research is needed to clarify the relationship between the immune system of disease activity and a patient’s psychological function.

Conclusion

In summary, depressive symptoms are highly prevalent among Thai patients with SLE. Depressive symptoms in patients arise from various causes, including particular perceptions of individual patients. Treatments of depressive symptoms may benefit patients with extreme pain, fatigue, high prednisolone dosage, low satisfaction of body image, and low social support. Further study of biopsychosocial factors is necessary to fully address the causes and potential management of debilitating depression in patients with SLE.

Availability of data and materials

The datasets generated and/or analysed during the current study are not publicly available due to the used data protection declaration, but are available from the corresponding author on reasonable request.

Abbreviations

SLE:

Systemic Lupus Erythematosus

PHQ-9:

The Patient Health Questionnaire-9

BPS:

The Biopsychosocial Model

SLEDAI:

The Systemic Lupus Erythematosus Activity Index

SLICC Damage Index:

The Systemic Lupus International Collaborating Clinics Damage Index

NRS:

Numeric Rating Scale

FSS:

Fatigue Severity Scale

BIS:

Body Image Scale

ESSI:

The ENRICHD Social Support Instrument

NCDs:

Non-communicable Diseases

CNS:

Central Nervous System

NPSLE:

Neuropsychiatric Systemic Lupus Erythematosus

ACR:

American College of Rheumatology

NSAIDs:

Non-Steroidal Anti-Inflammatory Drugs

NSO:

The National Statistical Office of Thailand

ICD-10:

International Classification of Diseases 10th Revision

COVID-19:

Coronavirus Disease of 2019

SPSS:

Statistical Package for the Social Sciences

MDD:

Major Depressive Disorder

fNIRS:

Functional Near-Infrared spectroscopy

References

  1. The National Institute of Mental Health (NIMH). Chronic illness and mental health. https://www.nimh.nih.gov/health/publications/chronic-illness-mental-health. Accessed 8 Oct 2021.

  2. Gupta M. Depression in systemic lupus erythematosus: a systematic review. Int J Stud Res. 2015;5:21–7.

    Article  Google Scholar 

  3. Moulton VR, Suarez-Fueyo A, Meidan E, Li H, Mizui M, Tsokos GC. Pathogenesis of human systemic lupus Erythematosus: a cellular perspective. Trends Mol Med. 2017;23(7):615–35.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Lau CS, Mak A. The socioeconomic burden of SLE. Nat Rev Rheumatol. 2009;5(7):400–4.

    Article  PubMed  Google Scholar 

  5. Moussavi S, Chatterji S, Verdes E, Tandon A, Patel V, Ustun B. Depression, chronic diseases, and decrements in health: results from the world health surveys. Lancet. 2007;370(9590):851–8.

    Article  PubMed  Google Scholar 

  6. Anwar N, Kuppili PP, Balhara YPS. Depression and physical non-communicable diseases: the need for an integrated approach. WHO South East Asia J Public Health. 2017;6(1):12–7.

    Article  PubMed  Google Scholar 

  7. Bai R, Liu S, Zhao Y, Cheng Y, Li S, Lai A, et al. Depressive and anxiety disorders in systemic lupus Erythematosus patients without major neuropsychiatric manifestations. J Immunol Res. 2016;2016:2829018.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Zhang L, Fu T, Yin R, Zhang Q, Shen B. Prevalence of depression and anxiety in systemic lupus erythematosus: a systematic review and meta-analysis. BMC Psychiatry. 2017;17(1):70.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Mok CC, Chan KL, Cheung EF, Yip PS. Suicidal ideation in patients with systemic lupus erythematosus: incidence and risk factors. Rheumatology (Oxford). 2014;53(4):714–21.

    Article  Google Scholar 

  10. Maneeton B, Maneeton N, Louthrenoo W. Prevalence and predictors of depression in patients with systemic lupus erythematosus: a cross-sectional study. Neuropsychiatr Dis Treat. 2013;9:799–804.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Mak A, Tang CS, Chan MF, Cheak AA, Ho RC. Damage accrual, cumulative glucocorticoid dose and depression predict anxiety in patients with systemic lupus erythematosus. Clin Rheumatol. 2011;30:795–803.

    Article  PubMed  Google Scholar 

  12. Engel GL. The need for a new medical model: a challenge for biomedicine. Science. 1977;196(4286):129–36.

    Article  CAS  PubMed  Google Scholar 

  13. Stojan G, Petri M. Epidemiology of systemic lupus erythematosus: an update. Curr Opin Rheumatol. 2018;30(2):144–50.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Ghodke-Puranik Y, Niewold TB. Immunogenetics of systemic lupus erythematosus: a comprehensive review. J Autoimmun. 2015;64:125–36.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Navarra SV, Kwon N. Systematic review of the epidemiology of systemic lupus erythematosus in the Asia-Pacific region: prevalence, incidence, clinical features, and mortality. Arthritis Care Res. 2012;64(2):159–68.

    Article  Google Scholar 

  16. Olesińska M, Saletra A. Quality of life in systemic lupus erythematosus and its measurement. Reumatologia. 2018;56(1):45–54.

    Article  PubMed  PubMed Central  Google Scholar 

  17. D'Cruz DP, Khamashta MA, Hughes GR. Systemic lupus erythematosus. Lancet. 2007;369(9561):587–96.

    Article  PubMed  Google Scholar 

  18. Mak A, Ho RCM, Lau CS. Clinical implications of neuropsychiatric systemic lupus erythematosus. Adv Psychiatr Treat. 2009;15(6):451–8.

    Article  Google Scholar 

  19. Ho RC, Thiaghu C, Ong H, Lu Y, Ho CS, Tam WW, et al. A meta-analysis of serum and cerebrospinal fluid autoantibodies in neuropsychiatric systemic lupus erythematosus. Autoimmun Rev. 2016;15(2):124–38.

    Article  CAS  PubMed  Google Scholar 

  20. Ho RC, Ong H, Thiaghu C, Lu Y, Ho CS, Zhang MW. Genetic variants that are associated with neuropsychiatric systemic lupus Erythematosus. J Rheumatol. 2016;43:541–51.

    Article  PubMed  Google Scholar 

  21. Muscal E, Brey RL. Neurologic manifestations of systemic lupus erythematosus in children and adults. Neurol Clin. 2010;28(1):61–73.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Huang X, Magder LS, Petri M. Predictors of incident depression in systemic lupus erythematosus. J Rheumatol. 2014;41(9):1823–33.

    Article  PubMed  Google Scholar 

  23. Greco CM, Li T, Sattar A, Kao AH, Danchenko N, Edmundowicz D, et al. Association between depression and vascular disease in systemic lupus erythematosus. J Rheumatol. 2012;39(2):262–8.

    Article  PubMed  Google Scholar 

  24. Dey M, Parodis I, Nikiphorou E. Fatigue in systemic lupus Erythematosus and rheumatoid arthritis: a comparison of mechanisms, measures and management. J Clin Med. 2021;10(16):3566.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Kozora E, Ellison MC, West S. Depression, fatigue, and pain in systemic lupus erythematosus (SLE): relationship to the American college of rheumatology SLE neuropsychological battery. Arthritis Rheum. 2006;55(4):628–35.

    Article  PubMed  Google Scholar 

  26. Palagini L, Tani C, Bruno RM, Gemignani A, Mauri M, Bombardieri S, et al. Poor sleep quality in systemic lupus erythematosus: does it depend on depressive symptoms? Lupus. 2014;23(13):1350–7.

    Article  CAS  PubMed  Google Scholar 

  27. Nery FG, Borba EF, Hatch JP, Soares JC, Bonfá E, Neto FL. Major depressive disorder and disease activity in systemic lupus erythematosus. Compr Psychiatry. 2007;48(1):14–9.

    Article  PubMed  Google Scholar 

  28. Mok CC, Lo LYT, Poon KS, Cheng CW. Prevalence and associated factors of depressive disorders in Chinese patient with systemic lupus erythematosus (SLE). Scientific Abstracts. 2017;76(2):589.

    Google Scholar 

  29. Figueiredo-Braga M, Cornaby C, Cortez A, Bernardes M, Terroso G, Figueiredo M, et al. Depression and anxiety in systemic lupus erythematosus: the crosstalk between immunological, clinical, and psychosocial factors. Medicine (Baltimore). 2018;97(28):e11376.

    Article  Google Scholar 

  30. Sutcliffe N, Clarke AE, Levinton C, Frost C, Gordon C, Isenberg DA. Associates of health status in patients with systemic lupus erythematosus. J Rheumatol. 1999;26(11):2352–6.

    CAS  PubMed  Google Scholar 

  31. McElhone K, Abbott J, Gray J, Williams A, Teh LS. Patient perspective of systemic lupus erythematosus in relation to health-related quality of life concepts: a qualitative study. Lupus. 2010;19(14):1640–7.

    Article  CAS  PubMed  Google Scholar 

  32. Holloway L, Humphrey L, Heron L, Pilling C, Kitchen H, Højbjerre L, et al. Patient-reported outcome measures for systemic lupus erythematosus clinical trials: a review of content validity, face validity and psychometric performance. Health Qual Life Outcomes. 2014;12:116.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Phillips RH. Coping with lupus. New York: Avery Penguin Putnam; 2001.

    Google Scholar 

  34. Tamayo T, Fischer-Betz R, Beer S, Winkler-Rohlfing B, Schneider M. Factors influencing the health related quality of life in patients with systemic lupus erythematosus: long-term results (2001--2005) of patients in the German Lupus Erythematosus Self-Help Organization (LULA Study). Lupus. 2010;19(14):1606–13.

    Article  CAS  PubMed  Google Scholar 

  35. Hospital for Special Surgery (HSS). Lupus and lupus medications on mood. https://www.hss.edu/conditions_effects-lupus-medications-mood.asp. Accessed 8 Oct 2021.

  36. Beckerman NL, Auerbach C, Blanco I. Psychosocial dimensions of SLE: implications for the health care team. J Multidiscip Healthc. 2011;4:63–72.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Ji L, Lili S, Jing W, Yanyan H, Min W, Juan X, et al. Appearance concern and depression in adolescent girls with systemic lupus erythematous. Clin Rheumatol. 2012;31(12):1671–5.

    Article  PubMed  Google Scholar 

  38. Chang SH, Cho JH, Shin NH, Oh HJ, Choi BY, Yoon MJ, et al. Depression and quality of life in patient with systemic lupus erythematosus. J Rheum Dis. 2015;22(6):346–55.

    Article  Google Scholar 

  39. Danchenko N, Satia JA, Anthony MS. Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden. Lupus. 2006;15(5):308–18.

    Article  CAS  PubMed  Google Scholar 

  40. Maningding E, Dall'Era M, Trupin L, Murphy LB, Yazdany J. Racial and ethnic differences in the prevalence and time to onset of manifestations of systemic lupus Erythematosus: the California lupus surveillance project. Arthritis Care Res. 2020;72(5):622–9.

    Article  Google Scholar 

  41. Thumboo J, Wee HL. Systemic lupus erythematosus in Asia: is it more common and more severe? APLAR J Rheumatol. 2006;9:320–36.

    Article  Google Scholar 

  42. Jakes RW, Bae SC, Louthrenoo W, Mok CC, Navarra SV, Kwon N. Systematic review of the epidemiology of systemic lupus erythematosus in the Asia-Pacific region: prevalence, incidence, clinical features, and mortality. Arthritis Care Res. 2012;64(2):159–68.

    Article  Google Scholar 

  43. Yap DY, Chan TM. Lupus nephritis in Asia: clinical features and management. Kidney Dis (Basel). 2015;1(2):100–9.

    Article  Google Scholar 

  44. Worldometer. Thailand population. https://www.worldometers.info/world-population/thailand-population/. Accessed 8 Oct 2021.

  45. Thai Health Report. Physical health. https://www.thaihealthreport.com/th/index.php. Accessed 8 Oct 2021.

  46. Lotrakul M, Sumrithe S, Saipanish R. Reliability and validity of the Thai version of the PHQ-9. BMC Psychiatry. 2008;8:46.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH. Derivation of the SLEDAI. A disease activity index for lupus patients. The committee on prognosis studies in SLE. Arthritis Rheum. 1992;35(6):630–40.

    Article  CAS  PubMed  Google Scholar 

  49. Gladman D, Ginzler E, Goldsmith C, Fortin P, Liang M, Urowitz M, et al. The development and initial validation of the systemic lupus international collaborating clinics/American College of Rheumatology damage index for systemic lupus erythematosus. Arthritis Rheum. 1996;39(3):363–9.

    Article  CAS  PubMed  Google Scholar 

  50. Jensen MP, Karoly P. Self-report scales and procedures for assessing pain in adults. In: Turk DC, Melzack R, editors. Handbook of pain assessment. 3rd ed. New York: Guilford Press; 2011. p. 15–34.

    Google Scholar 

  51. Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989;46(10):1121–3.

    Article  CAS  PubMed  Google Scholar 

  52. Sawasdee A. Factors associated with fatigue in post-stroke patients [master's thesis]. Bangkok: Chulalongkorn University; 2014.

    Article  CAS  PubMed  Google Scholar 

  53. Hopwood P, Fletcher I, Lee A, Al GS. A body image scale for use with cancer patients. Eur J Cancer. 2001;37(2):189–97.

    Article  Google Scholar 

  54. Cheewapoonpol B. Relationships between personal factors, fear of reactions of significant persons, coping strategies, social support, and body image of post-mastectomy patients [master's thesis]. Bangkok: Chulalongkorn University; 2004.

    Article  PubMed  Google Scholar 

  55. Mitchell PH, Powell L, Blumenthal J, Norten J, Ironson G, Pitula CR, et al. A short social support measure for patients recovering from myocardial infarction: the ENRICHD social support inventory. J Cardpulm Rehabil. 2003;23(6):398–403.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Lortajakul C. The development of the quality of life instrument in Thai patients with post myocardial infarction [dissertation]. Bangkok: Chulalongkorn University; 2006.

  57. Kongsuk T, Supanya S, Kenbubpha K, Phimtra S, Sukhawaha S, Leejongpermpoon J. Services for depression and suicide in Thailand. WHO South East Asia J Public Health. 2017;6(1):34–8.

    Article  CAS  PubMed  Google Scholar 

  58. Tee CA, Salido EO, Reyes PWC, Ho RC, Tee ML. Psychological state and associated factors during the 2019 coronavirus disease (COVID-19) pandemic among Filipinos with rheumatoid arthritis or systemic lupus Erythematosus. Open Access Rheumatol. 2020;12:215–22.

    Article  Google Scholar 

  59. Department of Mental Health (DMH). Major Depressive disorder. https://www.dmh.go.th/news-dmh/view.asp?id=30114. Accessed 8 Oct 2021.

  60. Palagini L, Mosca M, Tani C, Gemignani A, Mauri M, Bombardieri S. Depression and systemic lupus erythematosus: a systematic review. Lupus. 2013;22(5):409–16.

    Article  PubMed  Google Scholar 

  61. Julian LJ, Tonner C, Yelin E, Yazdany J, Trupin L, Criswell LA, et al. Cardiovascular and disease-related predictors of depression in systemic lupus erythematosus. Arthritis Care Res. 2011;63(4):542–9.

    Google Scholar 

  62. Moldovan I, Katsaros E, Carr FN, Cooray D, Torralba K, Shinada S, et al. The patient reported outcomes in lupus (PATROL) study: role of depression in health-related quality of life in a Southern California lupus cohort. Lupus. 2011;20(12):1285–92.

    Article  PubMed  PubMed Central  Google Scholar 

  63. van Exel E, Jacobs J, Korswagen LA, Voskuyl AE, Stek M, Dekker J, et al. Depression in systemic lupus erythematosus, dependent on or independent of severity of disease. Lupus. 2013;22(14):1462–9.

    Article  PubMed  Google Scholar 

  64. Ho RC, Husain SF, Ho CS. Cognitive dysfunction in patients with systemic lupus erythematosus: the challenge in diagnosis and management. Rheumatol Pract Res. 2018;3:1–12.

    Article  PubMed  Google Scholar 

  65. Seet D, Allameen NA, Tay SH, Cho J, Mak A. Cognitive dysfunction in systemic lupus Erythematosus: immunopathology, clinical manifestations, Neuroimaging and Management. Rheumatol Ther. 2021;8(2):651–79.

    Article  PubMed  Google Scholar 

  66. Karol DE, Criscione-Schreiber LG, Lin M, Clowse ME. Depressive symptoms and associated factors in systemic lupus erythematosus. Psychosomatics. 2013;54(5):443–50.

    Google Scholar 

  67. Xie X, Wu D, Chen H. Prevalence and risk factors of anxiety and depression in patients with systemic lupus erythematosus in Southwest China. Rheumatol Int. 2016;36(12):1705–10.

    Article  CAS  PubMed  Google Scholar 

  68. Huang TL, Lee CT, Liu YL. Serum brain-derived neurotrophic factor levels in patients with major depression: effects of antidepressants. J Psychiatr Res. 2008;42(7):521–5.

    Article  PubMed  Google Scholar 

  69. Varghese GH, Alexande H, Swethalekshmi, Tom NR. Case report on steroid induce psychosis. World J Pharm Pharm Sci. 2015;4(8):769–74.

    Article  PubMed  Google Scholar 

  70. Hale ED, Treharne GJ, Norton Y, Lyons AC, Douglas KM, Erb N, et al. 'Concealing the evidence': the importance of appearance concerns for patients with systemic lupus erythematosus. Lupus. 2006;15(8):532–40.

    Article  PubMed  Google Scholar 

  71. Jolly M, Pickard AS, Mikolaitis RA, Cornejo J, Sequeira W, Cash TF, et al. Body image in patients with systemic lupus erythematosus. Int J Behav Med. 2012;19(2):157–64.

    Article  CAS  PubMed  Google Scholar 

  72. Todorov N, Sherman KA, Kilby CJ, Breast Cancer Network Australia. Self-compassion and hope in the context of body image disturbance and distress in breast cancer survivors. Psychooncology. 2019;28:2025–32.

    Article  PubMed  Google Scholar 

  73. Monaghan SM, Sharpe L, Denton F, Levy J, Schrieber L, Sensky T. Relationship between appearance and psychological distress in rheumatic diseases. Arthritis Rheum. 2007;57(2):303–9.

    Article  PubMed  Google Scholar 

  74. Jordan J, Thompson NJ, Dunlop-Thomas C, Lim SS, Drenkard C. Relationships among organ damage, social support, and depression in African American women with systemic lupus erythematosus. Lupus. 2019;28(2):253–60.

    Article  CAS  Google Scholar 

  75. Stice E, Ragan J, Randall P. Prospective relations between social support and depression: differential direction of effects for parent and peer support? J Abnorm Psychol. 2004;113(1):155–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Kendler KS, Myers J, Prescott CA. Sex differences in the relationship between social support and risk for major depression: a longitudinal study of opposite-sex twin pairs. Am J Psychiatry. 2005;162(2):250–6.

  77. Wang X, Cai L, Qian J, Peng J. Social support moderates stress effects on depression. Int J Ment Heal Syst. 2014;8(1):41.

    Article  PubMed  Google Scholar 

  78. Alpay M, Cassem EH. Diagnosis and treatment of mood disorders in patients with rheumatic disease. Ann Rheum Dis. 2000;59(1):2–4.

    Article  PubMed  Google Scholar 

  79. Hospital for Special Surgery (HSS). Systemic Lupus Erythematosus (SLE) and Depression. https://www.hss.edu/conditions_systemic-lupus-erythematosus-sle-and-depression.asp. Accessed 24 Dec 2021.

  80. Conceição CTM, Meinão IM, Bombana JA, Sato EI. Psychoanalytic psychotherapy improves quality of life, depression, anxiety and coping in patients with systemic lupus erythematosus: a controlled randomized clinical trial. Adv Rheumatol. 2019;59(1):4.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Dobkin PL, Da Costa D, Joseph L, Fortin PR, Edworthy S, Barr S, et al. Counterbalancing patient demands with evidence: results from a pan-Canadian randomized clinical trial of brief supportive-expressive group psychotherapy for women with systemic lupus erythematosus. Ann Behav Med. 2002;24(2):88–99.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. Borrell-Carrió F, Suchman AL, Epstein RM. The biopsychosocial model 25 years later: principles, practice, and scientific inquiry. Ann Fam Med. 2004;2(6):576–82.

  83. Ho CSH, Lim LJH, Lim AQ, Chan NHC, Tan RS, Lee SH, et al. Diagnostic and predictive applications of functional near-infrared spectroscopy for major depressive disorder: a systematic review. Front Psychiatry. 2020;11:378.

  84. Husain SF, Yu R, Tang TB, Tam WW, Tran B, Quek TT, et al. Validating a functional near-infrared spectroscopy diagnostic paradigm for major depressive disorder. Sci Rep. 2020;10(1):9740.

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Acknowledgments

The staff of a university hospital supported this research for facilitating data collection. The authors wish to thank Associate Professor Dr. Nopporn Vongsirimas and Mr. Sutthisak Srisawad for their help with statistical analysis. The authors also want to thank Mr. Stephen Hamann for English language editing.

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Authors and Affiliations

  1. M.N.S. Candidate, Faculty of Nursing, Mahidol University, Bangkok, Thailand

    Nirunya Narupan

  2. Department of Mental Health and Psychiatric Nursing, Faculty of Nursing, Mahidol University, Bangkok, Thailand

    Nirunya Narupan, Acharaporn Seeherunwong & Walailak Pumpuang

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  1. Nirunya Narupan
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  3. Walailak Pumpuang
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Contributions

All authors made substantial contributions to the study concept, design, and data acquisition. NN1 did the initial analysis, interpretation of data and drafted the initial manuscript. AS2 provided feedback on the initial investigation. NN1, AS2, WP2 were involved in developing and revising the manuscript. All authors read and approved the final manuscript before submission.

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Correspondence to Acharaporn Seeherunwong.

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Ethical approval of this study was granted by the Institutional Review Board Faculty of Nursing, Mahidol University (IRB-NS2020/42.3010), and the Institutional Review Board Faculty of Medicine, Chulalongkorn University, Thailand (IRB No. 099/64). Written informed consent was obtained from all study participants. All procedures were performed in accordance with ethical guidelines and regulations.

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Narupan, N., Seeherunwong, A. & Pumpuang, W. Prevalence and biopsychosocial factors associated with depressive symptoms among patients living with systemic lupus erythematosus in clinical settings in urban Thailand. BMC Psychiatry 22, 103 (2022). https://doi.org/10.1186/s12888-022-03739-z

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BMC Psychiatry

ISSN: 1471-244X

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